Interleukin-6 production by brain tissue and cultured astrocytes infected with Theiler's murine encephalomyelitis virus.

Abstract:

:Theiler's murine encephalomyelitis virus (TMEV) is known to interact with cells of the central nervous system (CNS). Here we report that, interestingly, it is a potent inductor of interleukin-6 (IL-6) in the CNS of infected animals and in pure cultures of astrocytes. Maximal IL-6 gene transcription in glial cells, as detected by bioassay and ELISA, was observed at 6 and 24 h after infection. Astrocytes from both SJL/J and Balb/c (strains of mice susceptible and resistant, respectively, to TMEV-induced demyelination) produced similar amounts of IL-6, measured in tissue culture supernatants. These results indicate that although an immunomodulatory effect can be exercised by IL-6 synthesized by astrocytes, it does not play a crucial role in immune-mediated demyelination induced by TMEV.

journal_name

Glia

journal_title

Glia

authors

Rubio N,Sierra A

doi

10.1002/glia.440090106

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

41-7

issue

1

eissn

0894-1491

issn

1098-1136

journal_volume

9

pub_type

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