Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system.

abstract：:Schwann cells (SCs) and olfactory ensheathing glia (OEG) have shown promise for spinal cord injury repair. We sought their in vivo identification following transplantation into the contused adult rat spinal cord at 1 week post-injury by: (i) DNA in situ hybridization (ISH) with a Y-chromosome specific probe to identif...

journal_title：Glia

authors： Pearse DD,Sanchez AR,Pereira FC,Andrade CM,Puzis R,Pressman Y,Golden K,Kitay BM,Blits B,Wood PM,Bunge MB

更新日期：2007-07-01 00:00:00

abstract：:We investigated the effect of receptor blockade induced by an angiotensin II type-1 receptor antagonist (AT(1)-RB) on glial and vascular changes in oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity (ROP). OIR was induced in Sprague-Dawley rats by exposure to 80% oxygen from postnatal (P) days 0-1...

journal_title：Glia

authors： Downie LE,Pianta MJ,Vingrys AJ,Wilkinson-Berka JL,Fletcher EL

更新日期：2008-08-01 00:00:00

abstract：:Neuropsin and protease M/neurosin are serine proteases expressed by neurons and glial cells, and serve a variety of functions in the central nervous system (CNS). The current study demonstrates changes in the expression of these proteases following hemisection of the mouse spinal cord. Within unlesioned spinal cord, n...

journal_title：Glia

authors： Terayama R,Bando Y,Takahashi T,Yoshida S

更新日期：2004-11-01 00:00:00

abstract：:Two types of glial cells occur in the retina, Müller cells and astrocytes. These cells share several structural features such as extending endfeet onto blood vessels of the retina. Retinal vessels express a tight blood-retinal barrier which is comparable to the blood-brain barrier (BBB) of the CNS. While astrocytes ha...

journal_title：Glia

authors： Small RK,Watkins BA,Munro PM,Liu D

更新日期：1993-02-01 00:00:00

abstract：:Microglia transform from homeostatic to disease-associated-microglia (DAM) profiles in neurodegeneration. Within DAM, we recently identified distinct pro-inflammatory and anti-inflammatory sub-profiles although transcriptional regulators of homeostatic and distinct DAM profiles remain unclear. Informed by these studie...

journal_title：Glia

authors： Gao T,Jernigan J,Raza SA,Dammer EB,Xiao H,Seyfried NT,Levey AI,Rangaraju S

更新日期：2019-10-01 00:00:00

abstract：:Alzheimer's disease (AD) and prion disease are characterized neuropathologically by extracellular deposits of Abeta and PrP amyloid fibrils, respectively. In both disorders, these cerebral amyloid deposits are co-localized with a broad variety of inflammation-related proteins (complement factors, acute-phase protein, ...

journal_title：Glia

authors： Eikelenboom P,Bate C,Van Gool WA,Hoozemans JJ,Rozemuller JM,Veerhuis R,Williams A

更新日期：2002-11-01 00:00:00

abstract：:Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures, but neither oligodendrocytes nor neurons, constitutively expressed cell surface MHC class I molecules. Interferon-gamma (IFN-gamma) treatment led to induction of ...

journal_title：Glia

authors： Massa PT,Ozato K,McFarlin DE

更新日期：1993-07-01 00:00:00

abstract：:N-myc downstream-regulated gene 1 (NDRG1)/RTP/Drg1/Cap43/rit42/TDD5/Ndr1 is expressed ubiquitously and has been proposed to play a role in growth arrest and cell differentiation. A recent study showed that mutation of this gene is responsible for hereditary motor and sensory neuropathy-Lom. However, the role of this g...

journal_title：Glia

authors： Hirata K,Masuda K,Morikawa W,He JW,Kuraoka A,Kuwano M,Kawabuchi M

更新日期：2004-09-01 00:00:00

abstract：:Although the peripheral anti-inflammatory effect of norepinephrine (NE) is well documented, the mechanism by which this neurotransmitter functions as an anti-inflammatory/neuroprotective agent in the central nervous system (CNS) is unclear. This article aimed to determine the anti-inflammatory/neuroprotective effects ...

journal_title：Glia

authors： Jiang L,Chen SH,Chu CH,Wang SJ,Oyarzabal E,Wilson B,Sanders V,Xie K,Wang Q,Hong JS

更新日期：2015-06-01 00:00:00

abstract：:Microglia are the predominant resident immune cells of the brain and can assume a range of phenotypes. They are critical for normal brain development and function but can also contribute to many disease processes. Although they are widely studied, the transcriptional control of microglial phenotype and activation requ...

journal_title：Glia

authors： Smith AM,Gibbons HM,Oldfield RL,Bergin PM,Mee EW,Faull RL,Dragunow M

更新日期：2013-06-01 00:00:00

abstract：:Simvastatin, a lipophilic statin that crosses the blood-brain barrier, is being evaluated as a potential therapy for multiple sclerosis (MS) due to its anti-inflammatory properties. We assessed the effects of simvastatin on cultures of rat newborn and human fetal oligodendrocyte progenitor cells (OPCs) and human adult...

journal_title：Glia

authors： Miron VE,Rajasekharan S,Jarjour AA,Zamvil SS,Kennedy TE,Antel JP

更新日期：2007-01-15 00:00:00

abstract：:The possible consequences of activating bradykinin (Bk) receptors on identified astrocyte subtypes derived from rat cortex have been investigated in terms of: 1) mobilization of intracellular Ca2+; and 2) electrophysiological response. Bk induced a rapid, transient rise in intracellular Ca2+ in 63% of cortical type-1-...

journal_title：Glia

authors： Stephens GJ,Cholewinski AJ,Wilkin GP,Djamgoz MB

更新日期：1993-12-01 00:00:00

abstract：:Microglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic "modal shifts", purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y(12) receptors, they are transformed into a moving phenotype, showing process ...

journal_title：Glia

authors： Koizumi S,Ohsawa K,Inoue K,Kohsaka S

更新日期：2013-01-01 00:00:00

abstract：:In the brain, glycogen metabolism has been implied in synaptic plasticity and learning, yet the distribution of this molecule has not been fully described. We investigated cerebral glycogen of the mouse by immunohistochemistry (IHC) using two monoclonal antibodies that have different affinities depending on the glycog...

journal_title：Glia

authors： Oe Y,Baba O,Ashida H,Nakamura KC,Hirase H

更新日期：2016-09-01 00:00:00

abstract：:Cannabinoid agonists might serve as neuroprotective agents in neurodegenerative disorders. Here, we examined this hypothesis in a rat model of Huntington's disease (HD) generated by intrastriatal injection of the mitochondrial complex II inhibitor malonate. Our results showed that only compounds able to activate CB2 r...

journal_title：Glia

authors： Sagredo O,González S,Aroyo I,Pazos MR,Benito C,Lastres-Becker I,Romero JP,Tolón RM,Mechoulam R,Brouillet E,Romero J,Fernández-Ruiz J

更新日期：2009-08-15 00:00:00

abstract：:Cells of the adaptive and innate immune systems in the brain parenchyma and in the meningeal spaces contribute to physiologic functions and disease states in the central nervous system (CNS). Animal studies have demonstrated the involvement of immune constituents, along with major histocompatibility complex (MHC) mole...

journal_title：Glia

authors： Healy LM,Yaqubi M,Ludwin S,Antel JP

更新日期：2020-04-01 00:00:00

abstract：:A growth cone-enriched fraction was prepared from 3-4 day rat cerebra. Examination of the growth cone fraction by electron microscopy revealed numerous structures circular in appearance that contain a number of features common to neuronal growth cones in vivo. The isolated growth cones stimulated a dose-dependent inco...

journal_title：Glia

authors： Dent EW,Ida JA Jr,Yoshino JE

更新日期：1992-01-01 00:00:00

abstract：:A major role for Müller cells in the retina is to buffer changes in the extracellular K+ concentration ([K+]o) resulting from light-evoked neuronal activity. The primary K+ conductance in Müller cells is the inwardly rectifying K+ channel Kir4.1. Since this channel is constitutively active, K+ can enter or exit Müller...

journal_title：Glia

authors： Connors NC,Kofuji P

更新日期：2006-01-15 00:00:00

abstract：:Hyperpolarization-activated currents were recorded from rat brain cortical and spinal cord astrocytes maintained in culture. Spinal cord astrocytes expressed primarily an inward rectifier potassium current characterized by time-dependent inactivation, a strong dependence on extracellular Na+ and insensitivity to intra...

journal_title：Glia

authors： Guatteo E,Stanness KA,Janigro D

更新日期：1996-03-01 00:00:00

abstract：:Injury to the preterm brain has a particular predilection for cerebral white matter. White matter injury (WMI) is the most common cause of brain injury in preterm infants and a major cause of chronic neurological morbidity including cerebral palsy. Factors that predispose to WMI include cerebral oxygenation disturbanc...

journal_title：Glia

authors： Back SA,Rosenberg PA

更新日期：2014-11-01 00:00:00

abstract：:ATP stimulates arachidonic acid mobilization and eicosanoid production in cultured astrocytes via P2Y-purinergic receptors. To assist in determining the mechanism of phospholipase A2 activation and the role of calcium in eicosanoid production, cultures were pretreated with pertussis toxin (PTx). ATP-evoked eicosanoid ...

journal_title：Glia

authors： Bruner G,Murphy S

更新日期：1993-03-01 00:00:00

abstract：:The production of insulin-like growth factor (IGF)-I and -II and their binding proteins (BPs) has been studied in new-born rat astroblasts at confluency in primary culture. Under the influence of fibroblast growth factors (FGFs) (acidic and basic), the morphology of the astroblasts was altered, 125I-deoxyuridine incor...

journal_title：Glia

authors： Loret C,Janet T,Labourdette G,Schneid H,Binoux M

更新日期：1991-01-01 00:00:00

abstract：:We have identified a developmentally regulated, oligodendrocyte-specific protein, designated microtubule-associated protein-2 expressing exon 13 (MAP-2+13), in the human central nervous system (CNS). Monoclonal antibodies directed against MAP-2+13 labeled oligodendrocytes in the white matter of human fetal spinal cord...

journal_title：Glia

authors： Shafit-Zagardo B,Davies P,Rockwood J,Kress Y,Lee SC

更新日期：2000-02-01 00:00:00

abstract：:The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble amyloid β (Aβ) is an initiator of a cascade of events eventually leading to neurodegeneration. Recently, we reported that Aβ deranged Ca(2+) homeostasis specifically in hippocampal astrocytes by targeting key elements of Ca(2+) signaling, such as...

journal_title：Glia

authors： Lim D,Iyer A,Ronco V,Grolla AA,Canonico PL,Aronica E,Genazzani AA

更新日期：2013-07-01 00:00:00

abstract：:The consequences of sublytic terminal complement complex (TCC) assembly on Schwann cell proliferation and apoptosis were examined by using purified complement proteins (C5*-9) or antibody-sensitized Schwann cells in the presence of a serum that was depleted of the seventh component of complement (C7dHS) and reconstitu...

journal_title：Glia

authors： Dashiell SM,Rus H,Koski CL

更新日期：2000-04-01 00:00:00

abstract：:Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport, and cytoskeletal dynamics. Although abnormalities of myelin are common in lysosomal storage diseases, our understanding of the role of lysosomes in the formation and maintenance of myelin is still limited. Here, we sh...

journal_title：Glia

authors： Chen G,Zhang Z,Wei Z,Cheng Q,Li X,Li W,Duan S,Gu X

更新日期：2012-02-01 00:00:00

abstract：:Glial cells play a crucial role in the organization and function of the nervous system. Cell-cell adhesion receptors of the cadherin family have been shown to participate in distinct morphogenetic processes throughout the development of the CNS, but little is known about glial expression of cadherins. Applying immunof...

journal_title：Glia

authors： Gerhardt H,Rascher G,Schuck J,Weigold U,Redies C,Wolburg H

更新日期：2000-08-01 00:00:00

abstract：:Glial cells from different brain regions and species are depolarized by the neurotransmitter glutamate. The depolarization or, if voltage-clamped at the resting membrane potential, the inward current induced by glutamate could be due either to activation of receptor-coupled ion channels or electrogenic uptake of the t...

journal_title：Glia

authors： Sontheimer H,Kettenmann H,Backus KH,Schachner M

更新日期：1988-01-01 00:00:00

abstract：:Despite decades of research, primary brain tumors, gliomas, lack effective treatment options and present a huge clinical challenge. Particularly, the most malignant subtype, Glioblastoma multiforme, proliferates extensively and cells often undergo incomplete cell divisions, resulting in multinucleated cells. We now pr...

journal_title：Glia

authors： Bomben VC,Sontheimer H

更新日期：2010-08-01 00:00:00

abstract：:It has become evident recently only that microglia are not only responsible for immunomodulatory functions in the brain but represent vital components of the larger synaptic formation, which also includes pre and postsynaptic neurones as well as astrocytes. Microglia critically contribute to CNS homeostasis by their a...

journal_title：Glia

authors： Blank T,Prinz M

更新日期：2013-01-01 00:00:00