Abstract:
:Alzheimer's disease (AD) and prion disease are characterized neuropathologically by extracellular deposits of Abeta and PrP amyloid fibrils, respectively. In both disorders, these cerebral amyloid deposits are co-localized with a broad variety of inflammation-related proteins (complement factors, acute-phase protein, pro-inflammatory cytokines) and clusters of activated microglia. The present data suggest that the cerebral Abeta and PrP deposits are closely associated with a locally induced, non-immune-mediated chronic inflammatory response. Epidemiological studies indicate that polymorphisms of certain cytokines and acute-phase proteins, which are associated with Abeta plaques, are genetic risk factors for AD. Transgenic mice studies have established the role of amyloid associated acute-phase proteins in Alzheimer amyloid formation. In contrast to AD, there is a lack of evidence that cytokines and acute-phase proteins can influence disease progression in prion disease. Clinicopathological and neuroradiological studies have shown that activation of microglia is a relatively early pathogenetic event that precedes the process of neuropil destruction in AD patients. It has also been found that the onset of microglial activation coincided in mouse models of prion disease with the earliest changes in neuronal morphology, many weeks before neuronal loss and subsequent clinical signs of disease. In the present work, we review the similarities and differences between the involvement of inflammatory mechanisms in AD and prion disease. We also discuss the concept that the demonstration of a chronic inflammatory-like process relatively early in the pathological cascade of both diseases suggests potential therapeutic strategies to prevent or to retard these chronic neurodegenerative disorders.
journal_name
Gliajournal_title
Gliaauthors
Eikelenboom P,Bate C,Van Gool WA,Hoozemans JJ,Rozemuller JM,Veerhuis R,Williams Adoi
10.1002/glia.10146subject
Has Abstractpub_date
2002-11-01 00:00:00pages
232-9issue
2eissn
0894-1491issn
1098-1136journal_volume
40pub_type
杂志文章,评审相关文献
GLIA文献大全abstract::Olfactory ensheathing cells (OECs) are a unique type of macroglia required for normal olfactory axonal regeneration throughout the lifetime of an individual. Recent evidence in the literature suggests that OECs transplanted into injured spinal cords may facilitate axonal regeneration. In this study, we evaluated the n...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::Astrocytes can experience large intracellular Na+ changes following the activation of the Na+-coupled glutamate transport. The present study investigated whether cytosolic Na+ changes are transmitted to mitochondria, which could therefore influence their function and contribute to the overall intracellular Na+ regulat...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20387
更新日期:2006-10-01 00:00:00
abstract::Heterosynaptic long-term depression (hLTD) at untetanized synapses accompanying the induction of long-term potentiation (LTP) spatially sharpens the activity-induced synaptic potentiation; however, the underlying mechanism remains unclear. We found that hLTD in the hippocampal CA1 region is caused by stimulation-induc...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22425
更新日期:2013-02-01 00:00:00
abstract::Olfactory ensheathing cells (OECs) are candidates for therapeutic approaches for neural regeneration due to their ability to assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells. We report here that novel lame...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20586
更新日期:2007-12-01 00:00:00
abstract::Inflammatory changes have been found in Parkinson's disease, in humans intoxicated with the parkinsonian toxin MPTP, and in animal models of the disease. However, it is still not known whether inflammatory changes are responsible for active nerve cell death or if they have a protective role against neurodegeneration. ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20015
更新日期:2004-05-01 00:00:00
abstract::Assembly of the extracellular matrix (ECM) has been tightly linked to compact myelin formation in the peripheral nervous system. We recently demonstrated that myelination of dorsal root ganglion (DRG) axons by Schwann cells may occur in the absence of basal lamina. We have now determined whether laminin deposition occ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.1068
更新日期:2001-07-01 00:00:00
abstract::Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures, but neither oligodendrocytes nor neurons, constitutively expressed cell surface MHC class I molecules. Interferon-gamma (IFN-gamma) treatment led to induction of ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440080307
更新日期:1993-07-01 00:00:00
abstract::VEGF is an important factor in tumor vascularization and used as target for anti-angiogenic treatment strategies in glioma. In this study, we demonstrate for the first time that VEGF is a modulator of the innate immune response with suppressive effects on the immunologic and pro-angiogenic function of microglia/macrop...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23234
更新日期:2018-01-01 00:00:00
abstract::alpha-Synuclein, a gene whose mutations, duplication, and triplication has been linked to autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the pathogenesis of sporadic PD (sPD) as well. Enhancement of neurodegeneration induced by mutant alpha-synuclein has been attributed to dat...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20532
更新日期:2007-08-15 00:00:00
abstract::Glial cells play a crucial role in the organization and function of the nervous system. Cell-cell adhesion receptors of the cadherin family have been shown to participate in distinct morphogenetic processes throughout the development of the CNS, but little is known about glial expression of cadherins. Applying immunof...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::Glial cell-mediated potassium and glutamate homeostases play important roles in the regulation of neuronal excitability. Diminished potassium and glutamate buffering capabilities of astrocytes result in hyperexcitability of neurons and abnormal synaptic transmission. The role of the different K+ channels in maintainin...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20455
更新日期:2007-02-01 00:00:00
abstract::Minocycline, a derivative of the antibiotic tetracycline, displays neuroprotective properties in various models of neurodegenerative diseases and is now used in clinical trials, because of its relative safety and tolerability. Minocycline passes the blood-brain barrier and is presumed to inhibit microglial activation....
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20268
更新日期:2006-02-01 00:00:00
abstract::Segments from adult fish and rat retinae were explanted on myelin-marker expressing oligodendrocytes derived from the regenerating goldfish optic nerve. Fish axons grew in high density and even rat retinal axons regenerated to considerable length on the surface of the fish oligodendrocytes, suggesting that this type o...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440080102
更新日期:1993-05-01 00:00:00
abstract::Previous in vitro studies using cell cultures or brain slices have demonstrated that phospholipase D (PLD) in the nervous system is involved in the signaling mechanism in response to a variety of agonists. However, little is known about the pathophysiological role of PLD-mediated signaling in the adult brain. We exami...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(200005)30:3<311::aid-glia1
更新日期:2000-05-01 00:00:00
abstract::Gliomas are a heterogenous group of malignant primary brain tumors that arise from glia cells or their progenitors and rely on accurate diagnosis for prognosis and treatment strategies. Although recent developments in the molecular biology of glioma have improved diagnosis, classical histological methods and biomarker...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23594
更新日期:2019-08-01 00:00:00
abstract::Astrocytes are the most numerous cell type within the central nervous system (CNS) and perform a variety of tasks, from axon guidance and synaptic support, to the control of the blood brain barrier and blood flow. To perform these roles, there is a great variety of astrocytes. In this review, we summarize the function...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.20848
更新日期:2009-09-01 00:00:00
abstract::The role of microglia, the brain resident macrophages, in glioma biology is still ill-defined. Despite their cytotoxic potential, these cells that significantly infiltrate the tumor mass seem to support tumor growth rather than tumor eradication. A proper activation of microglia anti-tumor activities within the tumor ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20785
更新日期:2009-04-01 00:00:00
abstract::There is increasing evidence that chemokines, specialized regulators of the peripheral immune system, are also involved in the physiology and pathology of the CNS. It is known that glial cells (astrocytes and microglia) express various chemokine receptors like CCR1, -3, -5, and CXCR4. We have investigated the possible...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.10156
更新日期:2003-03-01 00:00:00
abstract::Measurements of extracellular space volume and imaging of intrinsic optical signals (IOSs) have shown that neuronal activity increases light transmittance by causing cellular swelling. However, the cellular mechanisms underlying these volume changes and the contribution of astrocyte swelling to the changes in tissue v...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.10023
更新日期:2002-02-01 00:00:00
abstract::The reaction of astroglia was investigated after unilateral destruction of the dorsal lateral geniculate nucleus in the primary visual cortex of adult albino rats. The destruction of the dorsal lateral geniculate nucleus was performed by stereotaxic injections of ibotenic acid, and the location was verified in Nissl s...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440030410
更新日期:1990-01-01 00:00:00
abstract::The Alzheimer disease-associated multifunctional low-density lipoprotein receptor-related protein-1 is expressed in the brain. Recent studies uncovered a role of this receptor for the appropriate functioning of neural stem cells, oligodendrocytes, and neurons. The constitutive knock-out (KO) of the receptor is embryon...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23869
更新日期:2020-12-01 00:00:00
abstract::Much current knowledge of oligodendrocyte biology, the myelin-forming cells in the central nervous system, comes from cell culture studies mainly from postnatal rat tissue but mouse cells have been much more difficult to produce in large quantities. We have developed a high yield protocol for production of oligodendro...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20702
更新日期:2008-09-01 00:00:00
abstract::The pro-apoptotic sphingolipid ceramide plays an emergent role in the etiology of Alzheimer's disease (AD), although its function for neurodegeneration is not known. We determined the concentration and composition of ceramide in hippocampal tissue from newborn presenilin 1 (PS1) knock-in (PS1M146V) mice, a mouse model...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20626
更新日期:2008-03-01 00:00:00
abstract::Extracellular matrix molecules are involved in the cellular functions of proliferation, migration, morphological differentiation, and synaptic plasticity. One candidate molecule of the extracellular matrix is the chondroitin sulfate proteoglycan neurocan. To determine whether neurocan expression is regulated by neuron...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20329
更新日期:2006-05-01 00:00:00
abstract::Microglia can be isolated with high purity but low yield by shaking off loosely adherent cells from mixed glial cultures. Here we describe a new technique for isolating microglia with an average yield close to 2,000,000 microglial cells/mouse pup, more than five times higher than that of the shaking method. Confluent ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.10274
更新日期:2003-12-01 00:00:00
abstract::Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain macrophage (microgl...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22754
更新日期:2015-04-01 00:00:00
abstract::Loss of axons is a major contributor to nonremitting deficits in the inflammatory demyelinating disease multiple sclerosis (MS). Based on biophysical studies showing that activity of axonal sodium channels can trigger axonal degeneration, recent studies have tested sodium channel-blocking drugs in experimental autoimm...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20112
更新日期:2005-01-15 00:00:00
abstract::Our knowledge of multiple sclerosis (MS) neuropathology has benefited from a number of studies that provided an in-depth description of plaques and, more recently, diffuse alterations of the normal-appearing white or grey matter. However, there have been few studies focusing on the periplaque regions surrounding demye...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22705
更新日期:2014-10-01 00:00:00
abstract::Astrocytes extend thin lamellate processes in the neuropil, in particular around synapses, where they can modulate synaptic function or mediate glial-neuronal communication. Previous studies have shown that these lamellate perisynaptic processes change their shape in response to neuronal activity, but the underlying m...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.1120
更新日期:2001-12-01 00:00:00
abstract::Based on their typical pattern of membrane currents, four populations of glial cells could be identified in thin brain slices of the postnatal hippocampus. In the present study, we applied the patch-clamp technique to glial cells in the hippocampal CA1 region, which are characterized by a complex pattern of different ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1136(199607)17:3<181::AID-GLIA1
更新日期:1996-07-01 00:00:00