Abstract:
:Olfactory ensheathing cells (OECs) are a unique type of macroglia required for normal olfactory axonal regeneration throughout the lifetime of an individual. Recent evidence in the literature suggests that OECs transplanted into injured spinal cords may facilitate axonal regeneration. In this study, we evaluated the neurotrophic properties of OECs using a homogeneous clonal cell line (nOEC), which does not contain contaminating cell types found in all primary OEC cultures. The results indicate that nOECs express mRNA for NGF, BDNF, NT-4/5, and neuregulins, but not for NT-3 or CNTF. In addition, nOECs secrete NGF, BDNF, and neuregulin, but retain NT-4/5 intracellularly. Finally, prelabeled nOECs derived from rat survived transplantation into a dorsal hemisected region of the hamster spinal cord and migrated only in the injured, dorsal portion of the spinal cord. This migratory pattern suggests that the nOECs are viable in vivo and respond to signals originating from the injured neuronal cells and their processes.
journal_name
Gliajournal_title
Gliaauthors
Boruch AV,Conners JJ,Pipitone M,Deadwyler G,Storer PD,Devries GH,Jones KJsubject
Has Abstractpub_date
2001-03-01 00:00:00pages
225-9issue
3eissn
0894-1491issn
1098-1136pii
10.1002/1098-1136(200103)33:3<225::AID-GLIA1021>3.journal_volume
33pub_type
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