Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490.

abstract：:Astrocytes express gap junction proteins and multiple types of P2Y receptors (P2YRs) that contribute to the propagation of intercellular Ca(2+) waves (ICW). To gain access to the role played by gap junctional communication in ICW propagation generated by P2YR activation, we selectively expressed P2Y(1,2,4)R subtypes a...

journal_title：Glia

authors： Suadicani SO,Flores CE,Urban-Maldonado M,Beelitz M,Scemes E

更新日期：2004-11-15 00:00:00

abstract：:Acute liver failure (ALF) is consistently accompanied by alterations in brain energy metabolites and recent nuclear magnetic resonance (NMR) studies suggest disturbances in brain oxidative metabolism in experimental ALF. Glucose transport across the blood-brain barrier is essential to sustain brain energy metabolism a...

journal_title：Glia

authors： Bélanger M,Desjardins P,Chatauret N,Butterworth RF

更新日期：2006-04-01 00:00:00

abstract：:Endothelins are potent vasoactive peptides that bind to their specific receptors, playing an important role in the CNS under physiological and pathophysiological conditions. Astrocytes, which have been shown to express these receptors, also have a considerable role to play under physiological and pathophysiological co...

journal_title：Glia

authors： Shibaguchi H,Himeno A,Shigematsu K,Kataoka Y,Niwa M

更新日期：2000-07-01 00:00:00

abstract：:By promoting cell proliferation, survival and maturation insulin-like growth factor (IGF)-I is essential to the normal growth and development of the central nervous system. It is clear that IGF-I actions are primarily mediated by the type I IGF receptor (IGF1R), and that phosphoinositide 3 (PI3)-Akt kinases and MAP ki...

journal_title：Glia

authors： Ye P,Hu Q,Liu H,Yan Y,D'ercole AJ

更新日期：2010-07-01 00:00:00

abstract：:Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, localized in the astrocyte plasma membrane. The regulation of AQP4 is believed to be important for the homeostasis of water in the brain, but the AQP4 regulatory mechanisms are not yet known. In this study, we investigated the effect of a p...

journal_title：Glia

authors： Nakahama K,Nagano M,Fujioka A,Shinoda K,Sasaki H

更新日期：1999-02-01 00:00:00

abstract：:Individuals with neurofibromatosis 1 (NF1) develop low-grade astrocytomas at an increased frequency. To gain insight into the function of the Nf1 gene product as a growth regulator for astrocytes, we examined mice heterozygous for a targeted Nf1 mutation. In our previous studies, we demonstrated increased numbers of p...

journal_title：Glia

authors： Bajenaru ML,Donahoe J,Corral T,Reilly KM,Brophy S,Pellicer A,Gutmann DH

更新日期：2001-03-15 00:00:00

abstract：:Astrocytes play an important role in neuroprotective responses. Recent studies indicate that endothelin-1, a neuropeptide upregulated during brain injury, increases levels of the endocannabinoid anandamide, a lipid with neuroprotective properties, in astrocytes in primary cultures. However, whether this neuropeptide a...

journal_title：Glia

authors： Walter L,Stella N

更新日期：2003-10-01 00:00:00

abstract：:The present study was focused on identifying the expression of N-methyl D-aspartate receptor (NMDAR) subunits on activated microglia and to determine their role in the pathogenesis of periventricular white matter damage (PWMD) in neonatal rats following hypoxia. One day old wistar rats were subjected to hypoxia (5% O(...

journal_title：Glia

authors： Murugan M,Sivakumar V,Lu J,Ling EA,Kaur C

更新日期：2011-04-01 00:00:00

abstract：:Astrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor the spatial relationship between astrocytes and injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions in a mouse amyotrophic lateral sclerosis (AL...

journal_title：Glia

authors： Levine JB,Kong J,Nadler M,Xu Z

更新日期：1999-12-01 00:00:00

abstract：:Type I interferons (IFNs), IFN-α and IFN-β, represent the major effector cytokines of the host immune response against viruses and other intracellular pathogens. These cytokines are produced via activation of numerous pattern recognition receptors, including the Toll-like receptor signaling network, retinoic acid-indu...

journal_title：Glia

authors： Blank T,Prinz M

更新日期：2017-09-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP-1) is a ubiquitous nuclear enzyme involved in genomic stability. Excessive oxidative DNA strand breaks lead to PARP-1-induced depletion of cellular NAD(+), glycolytic rate, ATP levels, and eventual cell death. Glutamate neurotransmission is tightly controlled by ATP-dependent astroc...

journal_title：Glia

authors： Tang KS,Suh SW,Alano CC,Shao Z,Hunt WT,Swanson RA,Anderson CM

更新日期：2010-03-01 00:00:00

abstract：:Oligodendrocytes, the myelinating cells of the CNS, are derived postnatally from oligodendrocyte precursors (OPs) of the subventricular zone (SVZ). However, the mechanisms that regulate their generation from SVZ neural stem cells (NSC) are poorly understood. Here, we have examined the role of glycogen synthase kinase ...

journal_title：Glia

authors： Azim K,Rivera A,Raineteau O,Butt AM

更新日期：2014-05-01 00:00:00

abstract：:Hypotonic challenge induces transient swelling in glial cells, which is typically followed by a regulatory volume decrease (RVD). In contrast, lactic acidosis (lactacidosis) induces persistent cell swelling in astrocytes without an accompanying RVD. In the present study, we studied the mechanisms by which lactacidosis...

journal_title：Glia

authors： Nabekura T,Morishima S,Cover TL,Mori S,Kannan H,Komune S,Okada Y

更新日期：2003-02-01 00:00:00

abstract：:Astrocytes are the most abundant cell type of the central nervous system and cover a broad range of functionalities. We report here the generation of a novel monoclonal antibody, anti-astrocyte cell surface antigen-2 (Anti-ACSA-2). Flow cytometry, immunohistochemistry and immunocytochemistry revealed that Anti-ACSA-2 ...

journal_title：Glia

authors： Kantzer CG,Boutin C,Herzig ID,Wittwer C,Reiß S,Tiveron MC,Drewes J,Rockel TD,Ohlig S,Ninkovic J,Cremer H,Pennartz S,Jungblut M,Bosio A

更新日期：2017-06-01 00:00:00

abstract：:Blood macrophages and brain macrophages (microglia) have been implicated in demyelination and destruction of the oligodendrocyte in multiple sclerosis (MS), a disease affecting primarily white matter of the central nervous system (CNS). In this study, we demonstrate that at high effector to target cell ratios, normal ...

journal_title：Glia

authors： Merrill JE,Zimmerman RP

更新日期：1991-01-01 00:00:00

abstract：:alpha-Synuclein, a gene whose mutations, duplication, and triplication has been linked to autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the pathogenesis of sporadic PD (sPD) as well. Enhancement of neurodegeneration induced by mutant alpha-synuclein has been attributed to dat...

journal_title：Glia

authors： Zhang W,Dallas S,Zhang D,Guo JP,Pang H,Wilson B,Miller DS,Chen B,Zhang W,McGeer PL,Hong JS,Zhang J

更新日期：2007-08-15 00:00:00

abstract：:The interactions between migrating glioma cells and myelinated fiber tracts are poorly understood. We identified that C6 glioma cells can migrate along myelinated chicken retinal axons in a novel coculture, thereby expressing small GTPases of the Rho family and serine/threonine Rho-associated kinases (ROCKs). We found...

journal_title：Glia

authors： Oellers P,Schröer U,Senner V,Paulus W,Thanos S

更新日期：2009-04-01 00:00:00

abstract：:The interface between the blood and the cerebrospinal fluid (CSF) is formed by the choroid plexuses (CPs), which are specialized structures located within the brain ventricles. They are composed of a vascularized stroma surrounded by a tight epithelium that controls molecular and cellular traffic between the blood and...

journal_title：Glia

authors： Nataf S,Strazielle N,Hatterer E,Mouchiroud G,Belin MF,Ghersi-Egea JF

更新日期：2006-08-15 00:00:00

abstract：:Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of gray matter. This phenomenon is believed to underlie the migraine aura and similar waves of depolarization may exacerbate injury in a number of neurological disease states. CSD is characterized by massive ion dyshomeostasis, cell swe...

journal_title：Glia

authors： Rosic B,Dukefoss DB,Åbjørsbråten KS,Tang W,Jensen V,Ottersen OP,Enger R,Nagelhus EA

更新日期：2019-06-01 00:00:00

abstract：:Microglial cells are the resident macrophages that are involved in brain injuries and infections. Recent studies using transcranial two-photon microscopy have shown that ATP and P2Y receptors mediated rapid chemotactic responses of miroglia to local injury. However, the molecular mechanism for microglial chemotaxis to...

journal_title：Glia

authors： Wu LJ,Vadakkan KI,Zhuo M

更新日期：2007-06-01 00:00:00

abstract：:The floor plate (FP), a signaling center and a structure rich in radial glia-like cells, has been traditionally thought to be devoid of neurons and neuronal progenitors. However, in the midbrain, the FP contains neurons of the dopaminergic (DA) lineage that require contact with radial glia-like cells for their inducti...

journal_title：Glia

authors： Bonilla S,Hall AC,Pinto L,Attardo A,Götz M,Huttner WB,Arenas E

更新日期：2008-06-01 00:00:00

abstract：:Accumulating evidence supports the idea that synapses are tripartite, whereby perisynaptic astrocytes modulate both pre- and postsynaptic function. Although some of these features have been uncovered by using electrophysiological methods, less is known about the structural interplay between synapses and glial processe...

journal_title：Glia

authors： Verbich D,Prenosil GA,Chang PK,Murai KK,McKinney RA

更新日期：2012-07-01 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is a major output nucleus of the basal ganglia circuitry particularly sensitive to pathological dopamine depletion. Indeed, hyperactivity of SNr neurons is known to be responsible for some motor disorders characteristic of Parkinson's disease. The neuronal processing of basal...

journal_title：Glia

authors： Bosson A,Boisseau S,Buisson A,Savasta M,Albrieux M

更新日期：2015-04-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the main component of intermediate filaments in astrocytes. To assess its function in astrocyte swelling, we compared astrocyte membrane properties and swelling in spinal cord slices of 8- to 10-day-old wild-type control (GFAP(+/+)) and GFAP-knockout (GFAP(-/-)) mice. Membrane...

journal_title：Glia

authors： Anderová M,Kubinová S,Mazel T,Chvátal A,Eliasson C,Pekny M,Syková E

更新日期：2001-09-01 00:00:00

abstract：:Extracellular matrix molecules are involved in the cellular functions of proliferation, migration, morphological differentiation, and synaptic plasticity. One candidate molecule of the extracellular matrix is the chondroitin sulfate proteoglycan neurocan. To determine whether neurocan expression is regulated by neuron...

journal_title：Glia

authors： Schwarzacher SW,Vuksic M,Haas CA,Burbach GJ,Sloviter RS,Deller T

更新日期：2006-05-01 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor Ascl1 plays crucial roles in both oligodendrocyte development and neuronal development; however, the molecular target of Ascl1 in oligodendrocyte progenitor cells (OPCs) remains elusive. To identify the downstream targets of Ascl1 in OPCs, we performed gene expres...

journal_title：Glia

authors： Ueno T,Ito J,Hoshikawa S,Ohori Y,Fujiwara S,Yamamoto S,Ohtsuka T,Kageyama R,Akai M,Nakamura K,Ogata T

更新日期：2012-10-01 00:00:00

abstract：:To investigate the possible role of neurons and astrocytes for oligodendrocyte development we prepared a pure population of precursor cells positive for the precursor marker GD3 with the help of fluorescence-activated cell sorting (FACS). Large numbers of highly purified cells were obtained from postnatal day 1 rat br...

journal_title：Glia

authors： Dutly F,Schwab ME

更新日期：1991-01-01 00:00:00

abstract：:Neuronal activity leads to arteriole dilation and increased blood flow in retinal vessels. This response, termed functional hyperemia, is diminished in the retinas of diabetic patients, possibly contributing to the development of diabetic retinopathy. The mechanism responsible for this loss is unknown. Here we show th...

journal_title：Glia

authors： Mishra A,Newman EA

更新日期：2010-12-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) immunoreactivity has been used to study the astroglial response in the rat spinal cord to long-term portacaval shunt (PCS). The astroglial response in PCS rats is heterogeneous. In general, astrocytes show a loss of GFAP immunoreactivity, as well as shrinking and pyknosis in thei...

journal_title：Glia

authors： Bodega G,Suárez I,Arilla E,Rubio M,Fernández B

更新日期：1991-01-01 00:00:00

abstract：:Even though the immune privileged status of the central nervous system (CNS) limits access of systemic immune cells through the blood brain barrier (BBB), an immune response can occur in this compartment with or without major breach of the BBB. In this review, we consider properties of resident cells of the CNS, that ...

journal_title：Glia

authors： Becher B,Prat A,Antel JP

更新日期：2000-02-15 00:00:00