Abstract:
:Astrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor the spatial relationship between astrocytes and injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions in a mouse amyotrophic lateral sclerosis (ALS) model. The initial increase in astrogliosis coincided with the onset of clinical disease and massive mitochondrial vacuolation in motor neurons. After disease onset, astrogliosis increased further in parallel with the number of degenerating motor neurons. Examination of individual astrocytes by three-dimensional reconstruction revealed that astrocytes extended their processes toward, wrapped around, and sometimes penetrated vacuoles derived from neuronal mitochondria. These results show a close temporal correlation between the onset of neuronal degeneration and the beginning of astrogliosis in this neurodegenerative disease and reveal a novel spatial relationship that is consistent with the view that astrocytes play an active role in the neuronal degeneration process.
journal_name
Gliajournal_title
Gliaauthors
Levine JB,Kong J,Nadler M,Xu Zsubject
Has Abstractpub_date
1999-12-01 00:00:00pages
215-24issue
3eissn
0894-1491issn
1098-1136pii
10.1002/(SICI)1098-1136(199912)28:3<215::AID-GLIA5journal_volume
28pub_type
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