Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling.

abstract：:The mannose receptor is a pattern-recognition receptor involved in innate and adaptive immunity. The receptor is mainly expressed by macrophages and, within the brain, by astrocytes and microglia. This study reports for the first time the effects of two classical proinflammatory (interferon-gamma, IFNgamma) and anti-i...

journal_title：Glia

authors： Zimmer H,Riese S,Régnier-Vigouroux A

更新日期：2003-04-01 00:00:00

abstract：:We first classified 12 malignant glioma cell lines into three different groups (types 1-3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type 1 (2 of 12) showed constitutive...

journal_title：Glia

authors： Takamura Y,Ikeda H,Kanaseki T,Toyota M,Tokino T,Imai K,Houkin K,Sato N

更新日期：2004-03-01 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor Ascl1 plays crucial roles in both oligodendrocyte development and neuronal development; however, the molecular target of Ascl1 in oligodendrocyte progenitor cells (OPCs) remains elusive. To identify the downstream targets of Ascl1 in OPCs, we performed gene expres...

journal_title：Glia

authors： Ueno T,Ito J,Hoshikawa S,Ohori Y,Fujiwara S,Yamamoto S,Ohtsuka T,Kageyama R,Akai M,Nakamura K,Ogata T

更新日期：2012-10-01 00:00:00

abstract：:Glial growth factors are proteins encoded by the neuregulin gene and are thought to signal via receptor tyrosine kinases. Many neuregulin gene products bind heparin, and we hypothesize that affinity for heparin may implicate cell surface heparan sulfate proteoglycans (HeSPGs) as co-receptors for the soluble neuregulin...

journal_title：Glia

authors： Sudhalter J,Whitehouse L,Rusche JR,Marchionni MA,Mahanthappa NK

更新日期：1996-05-01 00:00:00

abstract：:Neuronal-glial interactions are important for normal brain function and contribute to the maintenance of the brain's extracellular environment. Damage to glial cells following traumatic brain injury (TBI) could therefore be an important contributing factor to brain dysfunction and neuronal injury. We examined the earl...

journal_title：Glia

authors： Zhao X,Ahram A,Berman RF,Muizelaar JP,Lyeth BG

更新日期：2003-11-01 00:00:00

abstract：:Despite the increasing evidence for a prominent role played by the perivascular endfeet of astrocytes in the functional metabolic coupling between astrocytes and neurons, a clear picture of their spatial organization is still lacking. To examine the three-dimensional structure of the astrocyte endfeet and their relati...

journal_title：Glia

authors： Kacem K,Lacombe P,Seylaz J,Bonvento G

更新日期：1998-05-01 00:00:00

abstract：:Increasing evidence supports an essential role for interleukin-6 (IL-6) in the development, differentiation, as well as de- and re-generation of neurons in the central nervous system (CNS). Both IL-6 and its specific receptor (IL-6R) are expressed on neurons and glial cells including astrocytes. In this study, we have...

journal_title：Glia

authors： März P,Heese K,Dimitriades-Schmutz B,Rose-John S,Otten U

更新日期：1999-05-01 00:00:00

abstract：:Integrins are transmembrane receptors that mediate cell-extracellular matrix and cell-cell interactions. The β1-integrin subunit is highly expressed by embryonic neural stem cells (NSCs) and is critical for NSC maintenance in the developing nervous system, but its role in the adult hippocampal niche remains unexplored...

journal_title：Glia

authors： Brooker SM,Bond AM,Peng CY,Kessler JA

更新日期：2016-07-01 00:00:00

abstract：:Measurements of extracellular space volume and imaging of intrinsic optical signals (IOSs) have shown that neuronal activity increases light transmittance by causing cellular swelling. However, the cellular mechanisms underlying these volume changes and the contribution of astrocyte swelling to the changes in tissue v...

journal_title：Glia

authors： MacVicar BA,Feighan D,Brown A,Ransom B

更新日期：2002-02-01 00:00:00

abstract：:We have shown previously that switching of the alpha v-associated beta1 and beta5 integrin subunits during differentiation of myelin-forming oligodendrocytes may regulate important aspects of cell behaviour such as migration (Milner et al., 1996: J Neurosci 16:7240-7252). In this study we have examined the development...

journal_title：Glia

authors： Milner R,Frost E,Nishimura S,Delcommenne M,Streuli C,Pytela R,Ffrench-Constant C

更新日期：1997-12-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the main component of intermediate filaments in astrocytes. To assess its function in astrocyte swelling, we compared astrocyte membrane properties and swelling in spinal cord slices of 8- to 10-day-old wild-type control (GFAP(+/+)) and GFAP-knockout (GFAP(-/-)) mice. Membrane...

journal_title：Glia

authors： Anderová M,Kubinová S,Mazel T,Chvátal A,Eliasson C,Pekny M,Syková E

更新日期：2001-09-01 00:00:00

abstract：:Within the last few years, the expression of voltage-dependent, TTX-sensitive Na+ channels has been demonstrated in several types of neuroglial cells such as astrocytes and Schwann cells. Recently, we reported the occurrence of such Na+ currents in retinal Müller (glial) cells from dog and cat. This paper deals with t...

journal_title：Glia

authors： Chao TI,Skachkov SN,Eberhardt W,Reichenbach A

更新日期：1994-03-01 00:00:00

abstract：:The phenotype of a fully differentiated, mature Schwann cell is apparently largely determined by Schwann cell-axon interactions. In vitro, elevation of intracellular cAMP levels in Schwann cells induces a phenotype which resembles that of a mature, i.e., axon-related, Schwann cell. Therefore, an important role for cAM...

journal_title：Glia

authors： Mews M,Meyer M

更新日期：1993-07-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is a platelet-derived bioactive sphingolipid that evokes a variety of biological responses. To understand the role of S1P in the central nervous system, we have examined the effect of S1P on the production of glial cell line-derived neurotrophic factor (GDNF) and growth regulation of cort...

journal_title：Glia

authors： Yamagata K,Tagami M,Torii Y,Takenaga F,Tsumagari S,Itoh S,Yamori Y,Nara Y

更新日期：2003-01-15 00:00:00

abstract：OBJECTIVE:Neonatal white matter injury (NWMI) is the leading cause of cerebral palsy and other neurocognitive deficits in prematurely-born children, and no restorative therapies exist. Our objective was to determine the fate and effect of glial restricted precursor cell (GRP) transplantation in an ischemic mouse model ...

journal_title：Glia

authors： Porambo M,Phillips AW,Marx J,Ternes K,Arauz E,Pletnikov M,Wilson MA,Rothstein JD,Johnston MV,Fatemi A

更新日期：2015-03-01 00:00:00

abstract：:Water balance between cells and extracellular compartments is essential for proper functioning of the central nervous system, as demonstrated by its perturbations in pathological conditions. Aquaporin 4 (AQP4) is the predominant water channel in brain and spinal cord, where it is present mainly on astrocytic endfeet c...

journal_title：Glia

authors： Vitellaro-Zuccarello L,Mazzetti S,Bosisio P,Monti C,De Biasi S

更新日期：2005-08-01 00:00:00

abstract：:We have attempted to reconstruct in vitro the events that may occur in vivo during reperfusion injury after ischemia in the central nervous system. The phenomenon is induced by previous exposure to low calcium solutions ("calcium paradox") before the reperfusion episode. Intracellular calcium alterations during reperf...

journal_title：Glia

authors： Kim-Lee MH,Stokes BT,Yates AJ

更新日期：1992-01-01 00:00:00

abstract：:Enteric glial cells were first described at the end of the 19th century, but they attracted more interest from researchers only in the last decades of the 20th. Although, they have a different embryological origin, the enteric GLIA share many characteristics with astrocytes, the main glial cell type of the central ner...

journal_title：Glia

authors： Coelho-Aguiar Jde M,Bon-Frauches AC,Gomes AL,Veríssimo CP,Aguiar DP,Matias D,Thomasi BB,Gomes AS,Brito GA,Moura-Neto V

更新日期：2015-06-01 00:00:00

abstract：:Kainate (KA), quisqualate (QA), and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) stimulated gamma-aminobutyric acid [3H]gamma-aminobutyric acid (GABA) release from cultured cerebellar type 2 astrocytes and from their bipotential precursors. The evoked release was prevented by the antagonist 6-cyano-...

journal_title：Glia

authors： Gallo V,Patrizio M,Levi G

更新日期：1991-01-01 00:00:00

abstract：:Astrocytes are arranged in highly organized gap junction-coupled networks, communicating via the propagation of Ca2+ waves. Astrocytes are gap junction-coupled not only to neighboring astrocytes, but also to oligodendrocytes, forming so-called panglial syncytia. It is not known, however, whether glial cells in panglia...

journal_title：Glia

authors： Beiersdorfer A,Scheller A,Kirchhoff F,Lohr C

更新日期：2019-07-01 00:00:00

abstract：:Herpes simplex virus Type I (HSV-1) is a neurotropic virus that is capable of infecting not only neurons, but also microglia and astrocytes and can establish latent infection in the central nervous system (CNS). We investigated whether IFN lambda (IFN-λ), a newly identified member of IFN family, has the ability to inh...

journal_title：Glia

authors： Li J,Hu S,Zhou L,Ye L,Wang X,Ho J,Ho W

更新日期：2011-01-01 00:00:00

abstract：:The idea of a metabolic coupling between neurons and astrocytes in the brain has been entertained for about 100 years. The use recently of simple and well-compartmentalized nervous systems, such as the honeybee retina or purified preparations of neurons and glia, provided strong support for a nutritive function of gli...

journal_title：Glia

authors： Tsacopoulos M,Poitry-Yamate CL,Poitry S,Perrottet P,Veuthey AL

更新日期：1997-09-01 00:00:00

abstract：:In the present study the distribution of astrocytes in the nerve fiber layer (NFL) has been studied in the sparsely vascularized retinae of the guinea pig and horse and in the richly vascularized retina of the Old World monkey (Cercopithecus aethiops) using immunocytochemical methods. In the guinea pig retina glial fi...

journal_title：Glia

authors： Schnitzer J

更新日期：1988-01-01 00:00:00

abstract：:Neurons in organotypic hippocampal slice cultures (OHSCs) are known to preserve morphological and physiological features of the in vivo situation; however, little is known about the properties of microglial cells under these in vitro conditions. In this study, we addressed the question whether microglial cells in OHSC...

journal_title：Glia

authors： Hailer NP,Jarhult JD,Nitsch R

更新日期：1996-12-01 00:00:00

abstract：:Neurons from embryonic (E18) rat hippocampus were chosen to identify and characterize neurite growth-stimulating proteins accumulating in serum-free conditioned media (CM) obtained from primary or secondary cultures of cerebral astrocytes (less than 5% nonglial cells) using a quantitative cell culture bioassay. CM wer...

journal_title：Glia

authors： Matthiessen HP,Schmalenbach C,Müller HW

更新日期：1989-01-01 00:00:00

abstract：:A major role for Müller cells in the retina is to buffer changes in the extracellular K+ concentration ([K+]o) resulting from light-evoked neuronal activity. The primary K+ conductance in Müller cells is the inwardly rectifying K+ channel Kir4.1. Since this channel is constitutively active, K+ can enter or exit Müller...

journal_title：Glia

authors： Connors NC,Kofuji P

更新日期：2006-01-15 00:00:00

abstract：:Transient global ischemia induces CA1 hippocampal neuronal death without astrocyte death, perhaps mediated in part by the toxic translocation of zinc from presynaptic terminals to postsynaptic neurons. We tested the hypothesis that cellular depolarization, which occurs in the ischemic brain due to increased extracellu...

journal_title：Glia

authors： Sheline CT,Takata T,Ying H,Canzoniero LM,Yang A,Yu SP,Choi DW

更新日期：2004-04-01 00:00:00

abstract：:Adult Sprague-Dawley rats were given a single dose of trimethyltin chloride (TMT). Three days following treatment, a neuronal alteration was observed in the CA3c pyramidal cell layer of hippocampus which was not accompanied by any apparent astrocyte reaction. At 1 as well as 2 weeks after treatment, a gliosis in hippo...

journal_title：Glia

authors： Andersson H,Luthman J,Olson L

更新日期：1994-08-01 00:00:00

abstract：:Assembly of the extracellular matrix (ECM) has been tightly linked to compact myelin formation in the peripheral nervous system. We recently demonstrated that myelination of dorsal root ganglion (DRG) axons by Schwann cells may occur in the absence of basal lamina. We have now determined whether laminin deposition occ...

journal_title：Glia

authors： Podratz JL,Rodriguez E,Windebank AJ

更新日期：2001-07-01 00:00:00

abstract：:Under pathological conditions, activated microglia play paradoxical roles and could have neurotoxic or neuroprotective effects. However, the signal determining how activated microglia affects the fate of neuronal cells remains largely unknown. Here we demonstrate that DNAX-activating protein of 12 kDa (DAP12), a trans...

journal_title：Glia

authors： Kobayashi M,Konishi H,Takai T,Kiyama H

更新日期：2015-06-01 00:00:00