Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain.

abstract：:The production of insulin-like growth factor (IGF)-I and -II and their binding proteins (BPs) has been studied in new-born rat astroblasts at confluency in primary culture. Under the influence of fibroblast growth factors (FGFs) (acidic and basic), the morphology of the astroblasts was altered, 125I-deoxyuridine incor...

journal_title：Glia

authors： Loret C,Janet T,Labourdette G,Schneid H,Binoux M

更新日期：1991-01-01 00:00:00

abstract：:Astrocytes release a variety of transmitter molecules, which mediate communication between glial cells in the brain and modulate synaptic transmission. ATP is a major glia-derived transmitter, but the mechanisms and kinetics of ATP release from astrocytes remain largely unknown. Here, we combined epifluorescence and t...

journal_title：Glia

authors： Pryazhnikov E,Khiroug L

更新日期：2008-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system leading to selective destruction of myelin sheaths and/or oligodendrocytes. The immunological mechanisms responsible for myelin destruction and the primary target of the immune response have not yet been identified. Prior studies h...

journal_title：Glia

authors： Kuhlmann T,Lucchinetti C,Zettl UK,Bitsch A,Lassmann H,Brück W

更新日期：1999-10-01 00:00:00

abstract：:N-myc downstream-regulated gene 1 (NDRG1)/RTP/Drg1/Cap43/rit42/TDD5/Ndr1 is expressed ubiquitously and has been proposed to play a role in growth arrest and cell differentiation. A recent study showed that mutation of this gene is responsible for hereditary motor and sensory neuropathy-Lom. However, the role of this g...

journal_title：Glia

authors： Hirata K,Masuda K,Morikawa W,He JW,Kuraoka A,Kuwano M,Kawabuchi M

更新日期：2004-09-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) represents a family of related peptides originally isolated from cardiac atria that have potent natriuretic, diuretic, and vasorelaxant properties. ANP has previously been localized in neurons of the rat brain in regions subserving cardiovascular functions and fluid/electrolyte balance...

journal_title：Glia

authors： McKenzie JC,Berman NE,Thomas CR,Young JK,Compton LY,Cothran LN,Liu WL,Klein RM

更新日期：1994-11-01 00:00:00

abstract：:In the last decade, microRNAs have been increasingly recognized as key modulators of glial development. Recently, we identified miR-125a-3p as a new player in oligodendrocyte physiology, regulating in vitro differentiation of oligodendrocyte precursor cells (OPCs). Here, we show that miR-125a-3p is upregulated in acti...

journal_title：Glia

authors： Marangon D,Boda E,Parolisi R,Negri C,Giorgi C,Montarolo F,Perga S,Bertolotto A,Buffo A,Abbracchio MP,Lecca D

更新日期：2020-10-01 00:00:00

abstract：:Neurosteroids, such as progesterone, influence central nervous system development and function by regulating a broad spectrum of physiological processes. Here, we investigated membrane-initiated actions of progesterone in the retina and identified the membrane-associated progesterone receptor component 1 (PGRMC1). We ...

journal_title：Glia

authors： Swiatek-De Lange M,Stampfl A,Hauck SM,Zischka H,Gloeckner CJ,Deeg CA,Ueffing M

更新日期：2007-08-01 00:00:00

abstract：:We investigated the onset of expression of the myelin/oligodendrocyte glycoprotein (MOG) mRNA and protein in the developing mouse central nervous system. In situ hybridization on brain sections at different stages of embryonic and postnatal development showed that MOG transcripts were first detected at birth in the me...

journal_title：Glia

authors： Solly SK,Thomas JL,Monge M,Demerens C,Lubetzki C,Gardinier MV,Matthieu JM,Zalc B

更新日期：1996-09-01 00:00:00

abstract：:In the brain, glycogen metabolism has been implied in synaptic plasticity and learning, yet the distribution of this molecule has not been fully described. We investigated cerebral glycogen of the mouse by immunohistochemistry (IHC) using two monoclonal antibodies that have different affinities depending on the glycog...

journal_title：Glia

authors： Oe Y,Baba O,Ashida H,Nakamura KC,Hirase H

更新日期：2016-09-01 00:00:00

abstract：:Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage. Although remyelination is considered beneficial in the long term, it is not known, whether this is also the case early in lesion formation. Additionally...

journal_title：Glia

authors： Schultz V,van der Meer F,Wrzos C,Scheidt U,Bahn E,Stadelmann C,Brück W,Junker A

更新日期：2017-08-01 00:00:00

abstract：:Alzheimer's disease (AD) and prion disease are characterized neuropathologically by extracellular deposits of Abeta and PrP amyloid fibrils, respectively. In both disorders, these cerebral amyloid deposits are co-localized with a broad variety of inflammation-related proteins (complement factors, acute-phase protein, ...

journal_title：Glia

authors： Eikelenboom P,Bate C,Van Gool WA,Hoozemans JJ,Rozemuller JM,Veerhuis R,Williams A

更新日期：2002-11-01 00:00:00

abstract：:Historically, the human brain has been conceptually segregated from the periphery and further dichotomized into gray matter (GM) and white matter (WM) based on the whitish appearance of the exceptionally high lipid content of the myelin sheaths encasing neuronal axons. These simplistic dichotomies were unfortunately e...

journal_title：Glia

authors： Haroutunian V,Katsel P,Roussos P,Davis KL,Altshuler LL,Bartzokis G

更新日期：2014-11-01 00:00:00

abstract：:The possibility of a modular organization of non-neuronal elements was analyzed in the opercular region of the striate neocortex in adult New World monkeys. For this purpose, and in order to follow possible correlations in the general organization of neuronal and astroglial elements, immunocytochemical procedures for ...

journal_title：Glia

authors： Colombo JA,Schleicher A,Zilles K

更新日期：1999-01-01 00:00:00

abstract：:Glial cells in vitro express at least two types (H1 and H2) of histamine receptors and three types (EP, FP, and TP) of prostanoid receptors. The receptors expressed by glial cells differ according to the cell type and source in the brain. Furthermore primary astrocytes of same type derived from the same brain region a...

journal_title：Glia

authors： Inagaki N,Wada H

更新日期：1994-06-01 00:00:00

abstract：:Our knowledge of astroglia and their physiological and pathophysiological role(s) in the central nervous system (CNS) has grown during the past decade, revealing a complex picture. It is becoming increasingly clear that glia play a significant role in the homeostasis and function of the CNS and that neurons should no ...

journal_title：Glia

authors： Farahani R,Pina-Benabou MH,Kyrozis A,Siddiq A,Barradas PC,Chiu FC,Cavalcante LA,Lai JC,Stanton PK,Rozental R

更新日期：2005-06-01 00:00:00

abstract：:Glial cells execute essential functions in central nervous system (CNS) development and are also believed to play important roles during gliosis in response to trauma or disease. These developmental and pathological states have also been associated with elevated expression of opioid genes. Because levels of the cytoki...

journal_title：Glia

authors： Negro A,Tavella A,Facci L,Callegaro L,Skaper SD

更新日期：1992-01-01 00:00:00

abstract：:Semaphorin 7A (Sema7A) is involved in the formation of the central nervous system during development by operating axon guidance and neuronal migration. We investigated the expression of the TGFβ-inducible Sema7A following spinal cord injury (SCI). After SCI, Sema7A(+) cells accumulated specifically in lesion areas res...

journal_title：Glia

authors： Kopp MA,Brommer B,Gatzemeier N,Schwab JM,Prüss H

更新日期：2010-11-01 00:00:00

abstract：:The effect of cholinergic agonists and antagonists on the intracellular free Ca2+ concentration ([Ca2+]i) of leech neuropile glial cells was investigated by use of iontophoretically injected fura-2. In neuropile glial cells, cholinergic agonists induced a marked increase in [Ca2+]i that was inhibited by d-tubocurarine...

journal_title：Glia

authors： Hochstrate P,Schlue WR

更新日期：1995-09-01 00:00:00

abstract：:These studies have enabled the first characterization of the properties of ion channels in adult oligodendrocytes. Cell-attached recordings from cultured adult bovine cells showed channel activity with 140 mM KCl in the patch pipette; the amplitude of the currents was increased with increasing membrane hyperpolarizati...

journal_title：Glia

authors： McLarnon JG,Kim SU

更新日期：1989-01-01 00:00:00

abstract：:We have previously shown that cultured astrocytes from neonatal rat cerebral cortex are depolarized by GABA. The underlying ionic mechanism, activation of a Cl- conductance and responses to an agonist and antagonists were found to be similar to those of the neuronal GABAA receptor (Kettenmann et al.: Brain Research 40...

journal_title：Glia

authors： Backus KH,Kettenmann H,Schachner M

更新日期：1988-01-01 00:00:00

abstract：:Injury to the preterm brain has a particular predilection for cerebral white matter. White matter injury (WMI) is the most common cause of brain injury in preterm infants and a major cause of chronic neurological morbidity including cerebral palsy. Factors that predispose to WMI include cerebral oxygenation disturbanc...

journal_title：Glia

authors： Back SA,Rosenberg PA

更新日期：2014-11-01 00:00:00

abstract：:The creatine kinase isoenzymes play an important role in maintaining ATP levels in some cell types during times of high energy demand. We have previously shown in primary cell cultures from rat brain that glial cells express much higher levels of brain creatine kinase (CKB) mRNA than neurons. In a separate earlier stu...

journal_title：Glia

authors： Kuzhikandathil EV,Molloy GR

更新日期：1995-12-01 00:00:00

abstract：:Neural progenitor cells (NPCs) are sequentially specified into neurons and glia during the development of central nervous system. WNT/β-catenin signaling is known to regulate the balance between the proliferation and differentiation of NPCs during neurogenesis. However, the function of WNT/β-catenin signaling during g...

journal_title：Glia

authors： Sun S,Zhu XJ,Huang H,Guo W,Tang T,Xie B,Xu X,Zhang Z,Shen Y,Dai ZM,Qiu M

更新日期：2019-07-01 00:00:00

abstract：:Oligodendrocytes were studied in the anterior medullary velum (AMV) of the rat using the monoclonal antibody Rip, an oligodendrocyte marker of unknown function. Confocal microscopic imaging of double immunofluorescent labelling with antibodies to Rip and carbonic anhydrase II (CAII) revealed two biochemically and morp...

journal_title：Glia

authors： Butt AM,Ibrahim M,Ruge FM,Berry M

更新日期：1995-07-01 00:00:00

abstract：:Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of gray matter. This phenomenon is believed to underlie the migraine aura and similar waves of depolarization may exacerbate injury in a number of neurological disease states. CSD is characterized by massive ion dyshomeostasis, cell swe...

journal_title：Glia

authors： Rosic B,Dukefoss DB,Åbjørsbråten KS,Tang W,Jensen V,Ottersen OP,Enger R,Nagelhus EA

更新日期：2019-06-01 00:00:00

abstract：:Astrocytes can experience large intracellular Na+ changes following the activation of the Na+-coupled glutamate transport. The present study investigated whether cytosolic Na+ changes are transmitted to mitochondria, which could therefore influence their function and contribute to the overall intracellular Na+ regulat...

journal_title：Glia

authors： Bernardinelli Y,Azarias G,Chatton JY

更新日期：2006-10-01 00:00:00

abstract：:Oligodendrocyte differentiation and myelination involve dramatic changes in cell signaling pathways, gene expression patterns, cell shape, and cytoskeletal organization. In a pilot study investigating CNS angiogenesis, oligodendrocytes were intensely labeled by antisera directed against the C-terminal of Tie-2, a 140-...

journal_title：Glia

authors： Terada N,Kidd GJ,Kinter M,Bjartmar C,Moran-Jones K,Trapp BD

更新日期：2005-05-01 00:00:00

abstract：:We first classified 12 malignant glioma cell lines into three different groups (types 1-3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type 1 (2 of 12) showed constitutive...

journal_title：Glia

authors： Takamura Y,Ikeda H,Kanaseki T,Toyota M,Tokino T,Imai K,Houkin K,Sato N

更新日期：2004-03-01 00:00:00

abstract：:Blood macrophages and brain macrophages (microglia) have been implicated in demyelination and destruction of the oligodendrocyte in multiple sclerosis (MS), a disease affecting primarily white matter of the central nervous system (CNS). In this study, we demonstrate that at high effector to target cell ratios, normal ...

journal_title：Glia

authors： Merrill JE,Zimmerman RP

更新日期：1991-01-01 00:00:00

abstract：:Despite the increasing evidence for a prominent role played by the perivascular endfeet of astrocytes in the functional metabolic coupling between astrocytes and neurons, a clear picture of their spatial organization is still lacking. To examine the three-dimensional structure of the astrocyte endfeet and their relati...

journal_title：Glia

authors： Kacem K,Lacombe P,Seylaz J,Bonvento G

更新日期：1998-05-01 00:00:00