Myelin/oligodendrocyte glycoprotein (MOG) expression is associated with myelin deposition.

Abstract:

:We investigated the onset of expression of the myelin/oligodendrocyte glycoprotein (MOG) mRNA and protein in the developing mouse central nervous system. In situ hybridization on brain sections at different stages of embryonic and postnatal development showed that MOG transcripts were first detected at birth in the medulla oblongata. During the first week after birth, cells expressing MOG mRNA were located in the ventral longitudinal funiculus. During the second postnatal week, the pattern of MOG mRNA expression extended rostrally to the mid-forebrain regions and reached completion by the beginning of the third week. MOG transcription was delayed by several days with respect to myelin basic protein (MBP), and it appeared that while the MBP probe labeled both non-myelinating and myelinating oligodendrocytes, only the latter were MOG-positive. In vitro, immunocytochemical analysis of MOG protein expression, performed on myelinating cultures derived from mouse brain embryos at 15 days of gestation, confirmed the strict restriction of MOG expression to myelinating oligodendrocytes. In particular, oligodendrocytes lining up their processes along axons, but not yet having started to deposit a myelin sheath, were still MOG negative. However, in the same cultures, pseudo-myelinating oligodendrocytes (i.e., cells not associated with neurites, but forming whorls of myelin-like figures) were MOG positive. Similarly, rat CG4 cells, an oligodendrocyte-like cell line, expressed MOG only after they had extended sheet-like processes, which suggested that the activation of MOG transcription depends more on an intrinsic oligodendroglial maturation program of myelination than on a neuronal signal.

journal_name

Glia

journal_title

Glia

authors

Solly SK,Thomas JL,Monge M,Demerens C,Lubetzki C,Gardinier MV,Matthieu JM,Zalc B

doi

10.1002/(SICI)1098-1136(199609)18:1<39::AID-GLIA4>

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

39-48

issue

1

eissn

0894-1491

issn

1098-1136

pii

10.1002/(SICI)1098-1136(199609)18:1<39::AID-GLIA4>

journal_volume

18

pub_type

杂志文章

相关文献

GLIA文献大全
  • NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration.

    abstract::Oligodendrocyte precursor cells (OPCs) originate from restricted regions of the brain and migrate into the developing white matter, where they differentiate into oligodendrocytes and myelinate axons in the central nervous system (CNS). The molecular mechanisms that orchestrate these long distance trips of OPCs to popu...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.22578

    authors: Xiao L,Hu C,Yang W,Guo D,Li C,Shen W,Liu X,Aijun H,Dan W,He C

    更新日期:2013-12-01 00:00:00

  • Neu differentiation factor regulates tau protein and mRNA in cultured neonatal oligodendrocytes.

    abstract::Axonal signals activate myelinogenesis via regulation of the extent to which oligodendrocyte (OLG) processes wrap around the axon. The cytoskeleton in OLG processes is actively involved in myelination and is a putative target for axonal regulation of myelination. The axon-associated neuregulins may regulate the cytosk...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.1079

    authors: LoPresti P,Muma NA,De Vries GH

    更新日期:2001-08-01 00:00:00

  • Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice.

    abstract::In this study, we investigated the involvement of the blood-brain barrier (BBB) in the brain of the dystrophin-deficient mdx mouse, an experimental model of Duchenne muscular dystrophy (DMD). To this purpose, we used two tight junction markers, the Zonula occludens (ZO-1) and claudin-1 proteins, and a glial marker, th...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.10216

    authors: Nico B,Frigeri A,Nicchia GP,Corsi P,Ribatti D,Quondamatteo F,Herken R,Girolamo F,Marzullo A,Svelto M,Roncali L

    更新日期:2003-05-01 00:00:00

  • Multidrug resistance-associated protein 4 expression in ammonia-treated cultured rat astrocytes and cerebral cortex of cirrhotic patients with hepatic encephalopathy.

    abstract::Hepatic encephalopathy (HE) is a neuropsychiatric syndrome frequently accompanying liver cirrhosis and reflects the clinical manifestation of a low grade cerebral edema associated with cerebral oxidative/nitrosative stress. The multidrug resistance-associated protein (Mrp) 4 is an export pump which transports metaboli...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.22879

    authors: Jördens MS,Keitel V,Karababa A,Zemtsova I,Bronger H,Häussinger D,Görg B

    更新日期:2015-11-01 00:00:00

  • Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy.

    abstract::Neuronal activity leads to arteriole dilation and increased blood flow in retinal vessels. This response, termed functional hyperemia, is diminished in the retinas of diabetic patients, possibly contributing to the development of diabetic retinopathy. The mechanism responsible for this loss is unknown. Here we show th...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.21068

    authors: Mishra A,Newman EA

    更新日期:2010-12-01 00:00:00

  • Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis.

    abstract::Astrocytes are thought to play a variety of key roles in the adult brain, such as their participation in synaptic transmission, in wound healing upon brain injury, and adult neurogenesis. However, to elucidate these functions in vivo has been difficult because of the lack of astrocyte-specific gene targeting. Here we ...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.20350

    authors: Mori T,Tanaka K,Buffo A,Wurst W,Kühn R,Götz M

    更新日期:2006-07-01 00:00:00

  • The nutritive function of glia is regulated by signals released by neurons.

    abstract::The idea of a metabolic coupling between neurons and astrocytes in the brain has been entertained for about 100 years. The use recently of simple and well-compartmentalized nervous systems, such as the honeybee retina or purified preparations of neurons and glia, provided strong support for a nutritive function of gli...

    journal_title:Glia

    pub_type: 杂志文章

    doi:

    authors: Tsacopoulos M,Poitry-Yamate CL,Poitry S,Perrottet P,Veuthey AL

    更新日期:1997-09-01 00:00:00

  • Loss of inwardly rectifying potassium currents by human retinal glial cells in diseases of the eye.

    abstract::We compared the inward K+ currents of Müller glial cells from healthy and pathologically changed human retinas. To this purpose, the whole-cell voltage-clamp technique was performed on noncultured Müller cells acutely isolated from human retinas. Cells originated from retinas of four healthy organ donors and of 24 pat...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-1136(199707)20:3<210::aid-glia5

    authors: Francke M,Pannicke T,Biedermann B,Faude F,Wiedemann P,Reichenbach A,Reichelt W

    更新日期:1997-07-01 00:00:00

  • Transcriptional regulation of scar gene expression in primary astrocytes.

    abstract::The failure of the adult injured spinal cord to support axonal regeneration is in part attributed to the glial scar. Reactive astrocytes constitute a major cellular component of the glial scar and are heterogeneous with respect to the extracellular matrix proteins that they secrete. Astrocytes may produce antiregenera...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.20537

    authors: Gris P,Tighe A,Levin D,Sharma R,Brown A

    更新日期:2007-08-15 00:00:00

  • Capacitative Ca2+ influx in glial cells is inhibited by glycolytic inhibitors.

    abstract::In non-excitable cells, stimulation of phosphoinositide (PI) turnover and inhibition of the endoplasmic reticulum (ER) Ca2+-ATPase are methods commonly used to deplete calcium stores, resulting in a capacitative Ca2+ influx (i.e., Ca2+ release-activated Ca2+ influx). Since this Ca2+ influx in glial cells has not been ...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-1136(199711)21:3<315::aid-glia6

    authors: Wu ML,Kao EF,Liu IH,Wang BS,Lin-Shiau SY

    更新日期:1997-11-01 00:00:00

  • WNT signaling represses astrogliogenesis via Ngn2-dependent direct suppression of astrocyte gene expression.

    abstract::Neural progenitor cells (NPCs) are sequentially specified into neurons and glia during the development of central nervous system. WNT/β-catenin signaling is known to regulate the balance between the proliferation and differentiation of NPCs during neurogenesis. However, the function of WNT/β-catenin signaling during g...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.23608

    authors: Sun S,Zhu XJ,Huang H,Guo W,Tang T,Xie B,Xu X,Zhang Z,Shen Y,Dai ZM,Qiu M

    更新日期:2019-07-01 00:00:00

  • Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn.

    abstract::The mechanisms underlying neuropathic pain are poorly understood. However, several studies have implied a role for reactive microglia located in the dorsal horn in neuropathic pain. To clarify the roles of activated microglia in neuropathic pain, we investigated the interactions among microglia and other neural compon...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.21053

    authors: Maeda M,Tsuda M,Tozaki-Saitoh H,Inoue K,Kiyama H

    更新日期:2010-11-15 00:00:00

  • LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo.

    abstract::There is increasing evidence that chemokines, specialized regulators of the peripheral immune system, are also involved in the physiology and pathology of the CNS. It is known that glial cells (astrocytes and microglia) express various chemokine receptors like CCR1, -3, -5, and CXCR4. We have investigated the possible...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.10156

    authors: Zuurman MW,Heeroma J,Brouwer N,Boddeke HW,Biber K

    更新日期:2003-03-01 00:00:00

  • Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury.

    abstract::Cyclic AMP suppresses immune cell activation and inflammation. The positive feedback loop of proinflammatory cytokine production and immune activation implies that cytokines may not only be regulated by cyclic AMP but also conversely regulate cyclic AMP. This study examined the effects of tumor necrosis factor (TNF)-α...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.22401

    authors: Ghosh M,Garcia-Castillo D,Aguirre V,Golshani R,Atkins CM,Bramlett HM,Dietrich WD,Pearse DD

    更新日期:2012-12-01 00:00:00

  • Spatial arrangement of microglia in the mouse hippocampus: a stereological study in comparison with astrocytes.

    abstract::Microglia are classically considered to be immune cells in the brain, but have now been proven to be involved in neuronal activity as well. Here we stereologically analyzed the spatial arrangement of microglia in the mouse hippocampus. First, we estimated the numerical densities (NDs) of microglia identified by ionize...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.20552

    authors: Jinno S,Fleischer F,Eckel S,Schmidt V,Kosaka T

    更新日期:2007-10-01 00:00:00

  • Distinct effects of bFGF and PDGF on oligodendrocyte progenitor cells.

    abstract::We have compared the effects of platelet-derived (PDGF) and basic fibroblast (bFGF) growth factors on the shape, migration, and differentiation of oligodendrocyte progenitor cells, the precursors of myelin-forming cells in the CNS. In the presence of bFGF, oligodendrocyte progenitors purified from rat neonatal brain c...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.440070308

    authors: McKinnon RD,Smith C,Behar T,Smith T,Dubois-Dalcq M

    更新日期:1993-03-01 00:00:00

  • Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage.

    abstract::Activation of microglia resulting in exacerbated inflammation expression plays an important role in degeneration of dopaminergic (DA) neurons in the pathogenesis of Parkinson's disease (PD). However, how this enhanced inflammation is induced in microglia remains largely unclear. Here, in the mouse PD model induced by ...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.23153

    authors: He Q,Wang Q,Yuan C,Wang Y

    更新日期:2017-08-01 00:00:00

  • Endothelin-1 increases 2-arachidonoyl glycerol (2-AG) production in astrocytes.

    abstract::Astrocytes play an important role in neuroprotective responses. Recent studies indicate that endothelin-1, a neuropeptide upregulated during brain injury, increases levels of the endocannabinoid anandamide, a lipid with neuroprotective properties, in astrocytes in primary cultures. However, whether this neuropeptide a...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.10270

    authors: Walter L,Stella N

    更新日期:2003-10-01 00:00:00

  • Type I interferon pathway in CNS homeostasis and neurological disorders.

    abstract::Type I interferons (IFNs), IFN-α and IFN-β, represent the major effector cytokines of the host immune response against viruses and other intracellular pathogens. These cytokines are produced via activation of numerous pattern recognition receptors, including the Toll-like receptor signaling network, retinoic acid-indu...

    journal_title:Glia

    pub_type: 杂志文章,评审

    doi:10.1002/glia.23154

    authors: Blank T,Prinz M

    更新日期:2017-09-01 00:00:00

  • Transgenic analysis of GFAP promoter elements.

    abstract::Transcriptional regulation of the glial fibrillary acidic protein gene (GFAP) is of interest because of its astrocyte specificity and its upregulation in response to CNS injuries. We have used a transgenic approach instead of cell transfection to identify promoter elements of the human GFAP gene, since previous observ...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.22536

    authors: Yeo S,Bandyopadhyay S,Messing A,Brenner M

    更新日期:2013-09-01 00:00:00

  • Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors.

    abstract::The mitogenic role of sphingosine-1-phosphate (S1P) and its involvement in basic fibroblast growth factor (bFGF)-induced proliferation were examined in primary cultures of cerebellar astrocytes. Exposure to bFGF resulted in a rapid increase of extracellular S1P formation, bFGF inducing astrocytes to release S1P, but n...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.20324

    authors: Bassi R,Anelli V,Giussani P,Tettamanti G,Viani P,Riboni L

    更新日期:2006-04-15 00:00:00

  • Inducible gene expression in GFAP+ progenitor cells of the SGZ and the dorsal wall of the SVZ-A novel tool to manipulate and trace adult neurogenesis.

    abstract::In the adult mammalian brain, neurogenesis originates from astrocyte-like stem cells. We generated a transgenic mouse line in which the tetracycline dependent transactivator (tTA) is expressed under the control of the murine GFAP promoter. In this mouse line, inducible gene expression targets virtually all GFAP-expres...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.21129

    authors: Weber T,Baier V,Pauly R,Sahay A,Baur M,Herrmann E,Ciccolini F,Hen R,Kronenberg G,Bartsch D

    更新日期:2011-04-01 00:00:00

  • Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory "Barrel" cortex.

    abstract::Accumulative evidence indicates that microglial cells influence the normal development of central nervous system (CNS) synapses. Yet, the functional properties of microglia in relation with synapse development remain unclear. We recently showed that in layer 4 of the whisker-related barrel field of the mouse somatosen...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.22503

    authors: Arnoux I,Hoshiko M,Mandavy L,Avignone E,Yamamoto N,Audinat E

    更新日期:2013-10-01 00:00:00

  • Differential contributions of microglial and neuronal IKKβ to synaptic plasticity and associative learning in alert behaving mice.

    abstract::Microglia are CNS resident immune cells and a rich source of neuroactive mediators, but their contribution to physiological brain processes such as synaptic plasticity, learning, and memory is not fully understood. In this study, we used mice with partial depletion of IκB kinase β, the main activating kinase in the in...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.22756

    authors: Kyrargyri V,Vega-Flores G,Gruart A,Delgado-García JM,Probert L

    更新日期:2015-04-01 00:00:00

  • IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia.

    abstract::Elevated levels of Oncostatin M (OSM), an interleukin-6 family cytokine, have been observed in multiple sclerosis (MS), HIV-associated neurocognitive disorder (HAND), and glioblastoma (GBM); however, its effects within the CNS are not well understood. OSM regulates gene expression primarily by activating the JAK/STAT,...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.20989

    authors: Baker BJ,Park KW,Qin H,Ma X,Benveniste EN

    更新日期:2010-07-01 00:00:00

  • Contrasting effects of mitogenic growth factors on myelination in neuron-oligodendrocyte co-cultures.

    abstract::Mitogenic growth factors play an important role in the initial stages of oligodendrocyte development, but their roles in the process of myelination itself remain less well defined. In order to study directly the effects of different growth factors on myelination, we used a purified in vitro co-culture system with dors...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.20480

    authors: Wang Z,Colognato H,Ffrench-Constant C

    更新日期:2007-04-01 00:00:00

  • Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury.

    abstract::Microglial activation has been reported to promote neurotoxicity and also neuroprotective effects. A possible contributor to this dichotomy of responses may be the degree to which proximal neurons are injured. The aim of this study was to determine whether varying the severity of neuronal injury influenced whether mic...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.20610

    authors: Lai AY,Todd KG

    更新日期:2008-02-01 00:00:00

  • Characterization of the peripheral-type benzodiazepine receptors in cultured astrocytes: evidence for multiplicity.

    abstract::In mammalian brain peripheral benzodiazepine (PBZD) receptors are predominantly localized on astroglial cells. Previous studies utilizing whole membrane preparations from brain and peripheral organs of various species have indicated several distinctions between the drug-receptor interactions of the two prototypic PBZD...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.440090306

    authors: Itzhak Y,Baker L,Norenberg MD

    更新日期:1993-11-01 00:00:00

  • Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain.

    abstract::Transgenic Tg2576 mice expressing human amyloid precursor protein (hAPP) with the Swedish mutation are among the most frequently used animal models to study the amyloid pathology related to Alzheimer's disease (AD). The transgene expression in this model is considered to be neuron-specific. Using a novel hAPP-specific...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.23550

    authors: Heiland T,Zeitschel U,Puchades MA,Kuhn PH,Lichtenthaler SF,Bjaalie JG,Hartlage-Rübsamen M,Roßner S,Höfling C

    更新日期:2019-02-01 00:00:00

  • The transcription factor PU.1 is critical for viability and function of human brain microglia.

    abstract::Microglia are the predominant resident immune cells of the brain and can assume a range of phenotypes. They are critical for normal brain development and function but can also contribute to many disease processes. Although they are widely studied, the transcriptional control of microglial phenotype and activation requ...

    journal_title:Glia

    pub_type: 杂志文章

    doi:10.1002/glia.22486

    authors: Smith AM,Gibbons HM,Oldfield RL,Bergin PM,Mee EW,Faull RL,Dragunow M

    更新日期:2013-06-01 00:00:00