Abstract:
:The interactions between migrating glioma cells and myelinated fiber tracts are poorly understood. We identified that C6 glioma cells can migrate along myelinated chicken retinal axons in a novel coculture, thereby expressing small GTPases of the Rho family and serine/threonine Rho-associated kinases (ROCKs). We found that the ROCK1 isoform is also highly expressed in native human high-grade gliomas. Glioma cells migrated faster in vitro along myelinated axons than on laminin-1, with the former but not the latter being specifically and reversibly blocked by the ROCK inhibitor Y27632. These data suggest that the mechanisms underlying the migration of glioma cells on myelinated axons differ from those underlying the migration on extracellular matrix molecules such as laminin-1.
journal_name
Gliajournal_title
Gliaauthors
Oellers P,Schröer U,Senner V,Paulus W,Thanos Sdoi
10.1002/glia.20777subject
Has Abstractpub_date
2009-04-01 00:00:00pages
499-509issue
5eissn
0894-1491issn
1098-1136journal_volume
57pub_type
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