Brain-immune connection: immuno-regulatory properties of CNS-resident cells.

abstract：:Transplantation of oligodendrocyte precursor cells (OPCs) results in efficient remyelination in animal models of demyelination. However, the experiments so far undertaken have not addressed the need for tissue-type matching to achieve graft-mediated remyelination. Examination of MHC expression (main determinant of all...

journal_title：Glia

authors： Tepavcević V,Blakemore WF

更新日期：2006-12-01 00:00:00

abstract：:Increasing evidence supports an essential role for interleukin-6 (IL-6) in the development, differentiation, as well as de- and re-generation of neurons in the central nervous system (CNS). Both IL-6 and its specific receptor (IL-6R) are expressed on neurons and glial cells including astrocytes. In this study, we have...

journal_title：Glia

authors： März P,Heese K,Dimitriades-Schmutz B,Rose-John S,Otten U

更新日期：1999-05-01 00:00:00

abstract：:Recent evidence suggested that ATP acting via ionotropic (P2X) and metabotropic (P2Y) purinergic receptors might be involved in signaling between glial cells and within glial-neuronal networks. In contrast to their neuronal counterpart, the identity of P2X receptors in CNS glial cells is largely unknown. In the presen...

journal_title：Glia

authors： Kukley M,Barden JA,Steinhäuser C,Jabs R

更新日期：2001-10-01 00:00:00

abstract：:Based on their typical pattern of membrane currents, four populations of glial cells could be identified in thin brain slices of the postnatal hippocampus. In the present study, we applied the patch-clamp technique to glial cells in the hippocampal CA1 region, which are characterized by a complex pattern of different ...

journal_title：Glia

authors： Akopian G,Kressin K,Derouiche A,Steinhäuser C

更新日期：1996-07-01 00:00:00

abstract：:Pax-3 is a paired domain transcription factor that plays many roles during vertebrate development. In the Schwann cell lineage, Pax-3 is expressed at an early stage in Schwann cells precursors of the embryonic nerve, is maintained in the nonmyelinating cells of the adult nerve, and is upregulated in Schwann cells afte...

journal_title：Glia

authors： Doddrell RD,Dun XP,Moate RM,Jessen KR,Mirsky R,Parkinson DB

更新日期：2012-09-01 00:00:00

abstract：:In the cerebellar cortex, Bergmann glia enclose the synapses of both parallel and climbing fiber inputs to the Purkinje neuron. The glia express Ca(2+)-permeable AMPA receptors, and the GLAST and GLT-1 classes of glutamate transporter, which are activated by glutamate released during synaptic transmission. We have pre...

journal_title：Glia

authors： Balakrishnan S,Bellamy TC

更新日期：2009-03-01 00:00:00

abstract：:Astrocytic glycogen, the only storage form of glucose in the brain, has been shown to play a fundamental role in supporting learning and memory, an effect achieved by providing metabolic support for neurons. We have examined the interplay between glycogenolysis and the bioenergetics of astrocytic Ca(2+) homeostasis, b...

journal_title：Glia

authors： Müller MS,Fox R,Schousboe A,Waagepetersen HS,Bak LK

更新日期：2014-04-01 00:00:00

abstract：:We have identified a developmentally regulated, oligodendrocyte-specific protein, designated microtubule-associated protein-2 expressing exon 13 (MAP-2+13), in the human central nervous system (CNS). Monoclonal antibodies directed against MAP-2+13 labeled oligodendrocytes in the white matter of human fetal spinal cord...

journal_title：Glia

authors： Shafit-Zagardo B,Davies P,Rockwood J,Kress Y,Lee SC

更新日期：2000-02-01 00:00:00

abstract：:Integrins are transmembrane receptors that mediate cell-extracellular matrix and cell-cell interactions. The β1-integrin subunit is highly expressed by embryonic neural stem cells (NSCs) and is critical for NSC maintenance in the developing nervous system, but its role in the adult hippocampal niche remains unexplored...

journal_title：Glia

authors： Brooker SM,Bond AM,Peng CY,Kessler JA

更新日期：2016-07-01 00:00:00

abstract：:Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane glycoprotein specifically associated with plasma membrane protrusions. Prominin-1 is expressed by various stem and progenitor cells, notably neuroepithelial progenitors found in the developing embryonic brain. Here, we further investigated its expressi...

journal_title：Glia

authors： Corbeil D,Joester A,Fargeas CA,Jászai J,Garwood J,Hellwig A,Werner HB,Huttner WB

更新日期：2009-06-01 00:00:00

abstract：:In this study, we investigated the involvement of the blood-brain barrier (BBB) in the brain of the dystrophin-deficient mdx mouse, an experimental model of Duchenne muscular dystrophy (DMD). To this purpose, we used two tight junction markers, the Zonula occludens (ZO-1) and claudin-1 proteins, and a glial marker, th...

journal_title：Glia

authors： Nico B,Frigeri A,Nicchia GP,Corsi P,Ribatti D,Quondamatteo F,Herken R,Girolamo F,Marzullo A,Svelto M,Roncali L

更新日期：2003-05-01 00:00:00

abstract：:Secondary progressive multiple sclerosis (SPMS) is an autoimmune disease of the central nervous system (CNS) characterized by progressive motor dysfunction, sensory deficits, and visual problems. The pathological mechanism of SPMS remains poorly understood. In this study, we investigated the role of microglia, immune ...

journal_title：Glia

authors： Tanabe S,Saitoh S,Miyajima H,Itokazu T,Yamashita T

更新日期：2019-09-01 00:00:00

abstract：:Insulin-like growth factor II (IGFII) acts as a potent mitogen for several tumor types and has been reported to positively influence astrocytoma cell growth and motility. In the central nervous system, IGFII bioavailability is mainly modulated by insulin-like growth factor binding protein 2 (IGFBP2), which sequestrate...

journal_title：Glia

authors： Rorive S,Berton A,D'haene N,Takacs CN,Debeir O,Decaestecker C,Salmon I

更新日期：2008-11-15 00:00:00

abstract：:NG2 cells (polydendrocytes) are the fourth major non-neuronal cell type in the central nervous system parenchyma. They exhibit diverse properties, ranging from their well-established role as oligodendrocyte precursors to their ability to respond to neurotransmitters released by synaptic and non-synaptic mechanisms. Th...

journal_title：Glia

authors： Hill RA,Nishiyama A

更新日期：2014-08-01 00:00:00

abstract：:Loss of axons is a major contributor to nonremitting deficits in the inflammatory demyelinating disease multiple sclerosis (MS). Based on biophysical studies showing that activity of axonal sodium channels can trigger axonal degeneration, recent studies have tested sodium channel-blocking drugs in experimental autoimm...

journal_title：Glia

authors： Craner MJ,Damarjian TG,Liu S,Hains BC,Lo AC,Black JA,Newcombe J,Cuzner ML,Waxman SG

更新日期：2005-01-15 00:00:00

abstract：:The biologically active lipid metabolite, platelet-activating factor (PAF), is thought to contribute to inflammatory processes and tissue damage in a variety of central nervous system (CNS) injuries. In previous studies, we found that after contusion spinal cord injury, treatment with a PAF antagonist led to significa...

journal_title：Glia

authors： Hostettler ME,Knapp PE,Carlson SL

更新日期：2002-05-01 00:00:00

abstract：:Schwann cells (SCs) and olfactory ensheathing glia (OEG) have shown promise for spinal cord injury repair. We sought their in vivo identification following transplantation into the contused adult rat spinal cord at 1 week post-injury by: (i) DNA in situ hybridization (ISH) with a Y-chromosome specific probe to identif...

journal_title：Glia

authors： Pearse DD,Sanchez AR,Pereira FC,Andrade CM,Puzis R,Pressman Y,Golden K,Kitay BM,Blits B,Wood PM,Bunge MB

更新日期：2007-07-01 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) originate from restricted regions of the brain and migrate into the developing white matter, where they differentiate into oligodendrocytes and myelinate axons in the central nervous system (CNS). The molecular mechanisms that orchestrate these long distance trips of OPCs to popu...

journal_title：Glia

authors： Xiao L,Hu C,Yang W,Guo D,Li C,Shen W,Liu X,Aijun H,Dan W,He C

更新日期：2013-12-01 00:00:00

abstract：:Astrocytes are thought to play a variety of key roles in the adult brain, such as their participation in synaptic transmission, in wound healing upon brain injury, and adult neurogenesis. However, to elucidate these functions in vivo has been difficult because of the lack of astrocyte-specific gene targeting. Here we ...

journal_title：Glia

authors： Mori T,Tanaka K,Buffo A,Wurst W,Kühn R,Götz M

更新日期：2006-07-01 00:00:00

abstract：:In the brain, glycogen metabolism has been implied in synaptic plasticity and learning, yet the distribution of this molecule has not been fully described. We investigated cerebral glycogen of the mouse by immunohistochemistry (IHC) using two monoclonal antibodies that have different affinities depending on the glycog...

journal_title：Glia

authors： Oe Y,Baba O,Ashida H,Nakamura KC,Hirase H

更新日期：2016-09-01 00:00:00

abstract：:We have analysed in detail the properties of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells derived from the spinal cords of adult rats to gain further insights into the mechanisms that control the generation of oligodendrocytes in the healthy and demyelinated adult central nervous systems (CNS). When O-2A p...

journal_title：Glia

authors： Engel U,Wolswijk G

更新日期：1996-01-01 00:00:00

abstract：:The X-linked mutation rumpshaker (rsh), which is probably an allele of jimpy (jp), causes hypomyelination in the CNS of mice. This study examines the developmental expression of the morphology, glial cells, and immunostaining of myelin proteins in the optic nerve and spinal cord. The optic nerve contains varying numbe...

journal_title：Glia

authors： Fanarraga ML,Griffiths IR,McCulloch MC,Barrie JA,Kennedy PG,Brophy PJ

更新日期：1992-01-01 00:00:00

abstract：:Replication-defective Moloney murine leukemia virus expressing the GAD67 gene under the control of the GFAP promoter was produced using selected clones of a fibroblast-packaging cell line. A spontaneously immortalized astrocyte cell line was infected with this virus and cellular clones expressing GAD67 selected. Astro...

journal_title：Glia

authors： Sacchettoni SA,Benchaibi M,Sindou M,Belin MF,Jacquemont B

更新日期：1998-01-01 00:00:00

abstract：:Nogo-A is a potent glial-derived inhibitor of axon growth in the injured CNS and acts as a negative regulator of developmental angiogenesis by inhibiting vascular endothelial cell migration. However, its function in pathological angiogenesis has never been studied after ischemic injury in the CNS. Using the mouse mode...

journal_title：Glia

authors： Joly S,Dejda A,Rodriguez L,Sapieha P,Pernet V

更新日期：2018-10-01 00:00:00

abstract：:Astrocytes can experience large intracellular Na+ changes following the activation of the Na+-coupled glutamate transport. The present study investigated whether cytosolic Na+ changes are transmitted to mitochondria, which could therefore influence their function and contribute to the overall intracellular Na+ regulat...

journal_title：Glia

authors： Bernardinelli Y,Azarias G,Chatton JY

更新日期：2006-10-01 00:00:00

abstract：:Microglia, the resident macrophages of the central nervous system (CNS), can be distinguished from most other cells of the myelomonocytic lineage by a distinct pattern of membrane currents. In the accompanying paper we have shown that the characteristic morphological feature of microglia, ramification, develops both i...

journal_title：Glia

authors： Schmidtmayer J,Jacobsen C,Miksch G,Sievers J

更新日期：1994-12-01 00:00:00

abstract：:Glial cells in vitro express at least two types (H1 and H2) of histamine receptors and three types (EP, FP, and TP) of prostanoid receptors. The receptors expressed by glial cells differ according to the cell type and source in the brain. Furthermore primary astrocytes of same type derived from the same brain region a...

journal_title：Glia

authors： Inagaki N,Wada H

更新日期：1994-06-01 00:00:00

abstract：:Pruning, the elimination of excess synapses is a phenomenon of fundamental importance for correct wiring of the central nervous system. The establishment of the cerebellar climbing fiber (CF)-to-Purkinje cell (PC) synapse provides a suitable model to study pruning and pruning-relevant processes during early postnatal ...

journal_title：Glia

authors： Kaiser N,Pätz C,Brachtendorf S,Eilers J,Bechmann I

更新日期：2020-11-01 00:00:00

abstract：:Oligodendroglial cells undergo rapid transcriptional and dynamic morphological transformation in order to effectively myelinate neuronal axons. Olig1, a basic helix-loop-helix transcription factor, functions to promote the transcription of myelin-specific genes and promotes differentiation and (re)myelination. While t...

journal_title：Glia

authors： Niu J,Mei F,Wang L,Liu S,Tian Y,Mo W,Li H,Lu QR,Xiao L

更新日期：2012-09-01 00:00:00

abstract：:Within the last few years, the expression of voltage-dependent, TTX-sensitive Na+ channels has been demonstrated in several types of neuroglial cells such as astrocytes and Schwann cells. Recently, we reported the occurrence of such Na+ currents in retinal Müller (glial) cells from dog and cat. This paper deals with t...

journal_title：Glia

authors： Chao TI,Skachkov SN,Eberhardt W,Reichenbach A

更新日期：1994-03-01 00:00:00