Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery.

abstract：:The JAK/STAT pathway is activated in response to cytokines and growth factors. In addition, oxidative stress can activate this pathway, but the causative pro-oxidant forms are not well identified. We exposed cultures of rat glia to H2O2, FeSO4, nitroprussiate, or paraquat. We assessed oxidative stress by measuring rea...

journal_title：Glia

authors： Gorina R,Sanfeliu C,Galitó A,Messeguer A,Planas AM

更新日期：2007-10-01 00:00:00

abstract：:Increasing evidence supports an essential role for interleukin-6 (IL-6) in the development, differentiation, as well as de- and re-generation of neurons in the central nervous system (CNS). Both IL-6 and its specific receptor (IL-6R) are expressed on neurons and glial cells including astrocytes. In this study, we have...

journal_title：Glia

authors： März P,Heese K,Dimitriades-Schmutz B,Rose-John S,Otten U

更新日期：1999-05-01 00:00:00

abstract：:Type I interferons (IFNs), IFN-α and IFN-β, represent the major effector cytokines of the host immune response against viruses and other intracellular pathogens. These cytokines are produced via activation of numerous pattern recognition receptors, including the Toll-like receptor signaling network, retinoic acid-indu...

journal_title：Glia

authors： Blank T,Prinz M

更新日期：2017-09-01 00:00:00

abstract：:Inflammation has been linked to the induction of apneas and Sudden Infant Death Syndrome, whereas proinflammatory mediators inhibit breathing when applied peripherally or directly into the CNS. Considering that peripheral inflammation can activate microglia in the CNS and that this cell type can directly release all p...

journal_title：Glia

authors： Lorea-Hernández JJ,Morales T,Rivera-Angulo AJ,Alcantara-Gonzalez D,Peña-Ortega F

更新日期：2016-04-01 00:00:00

abstract：:In the vertebrate brain, much remains to be understood concerning the origin of glial cell diversity and the potential lineage relationships between the various types of glia. Besides astrocytes and myelin-forming oligodendrocytes, other macroglial cell populations are found in discrete areas of the central nervous sy...

journal_title：Glia

authors： Virard I,Coquillat D,Bancila M,Kaing S,Durbec P

更新日期：2006-02-01 00:00:00

abstract：:Our knowledge of multiple sclerosis (MS) neuropathology has benefited from a number of studies that provided an in-depth description of plaques and, more recently, diffuse alterations of the normal-appearing white or grey matter. However, there have been few studies focusing on the periplaque regions surrounding demye...

journal_title：Glia

authors： Lieury A,Chanal M,Androdias G,Reynolds R,Cavagna S,Giraudon P,Confavreux C,Nataf S

更新日期：2014-10-01 00:00:00

abstract：:Previous in vitro studies using cell cultures or brain slices have demonstrated that phospholipase D (PLD) in the nervous system is involved in the signaling mechanism in response to a variety of agonists. However, little is known about the pathophysiological role of PLD-mediated signaling in the adult brain. We exami...

journal_title：Glia

authors： Lee MY,Kim SY,Min DS,Choi YS,Shin SL,Chun MH,Lee SB,Kim MS,Jo YH

更新日期：2000-05-01 00:00:00

abstract：:Hyperpolarizing responses in neuropil glial cells evoked by nerve root stimulation were studied in the central nervous system of the leech Hirudo medicinalis using intracellular recording and extracellular stimulation techniques. From a mean resting potential of -60.5 +/- 1.0, the glial membrane was hyperpolarized by ...

journal_title：Glia

authors： Schmidt J,Prinz P,Deitmer JW

更新日期：1999-07-01 00:00:00

abstract：:These studies have enabled the first characterization of the properties of ion channels in adult oligodendrocytes. Cell-attached recordings from cultured adult bovine cells showed channel activity with 140 mM KCl in the patch pipette; the amplitude of the currents was increased with increasing membrane hyperpolarizati...

journal_title：Glia

authors： McLarnon JG,Kim SU

更新日期：1989-01-01 00:00:00

abstract：:Regeneration in the adult central nervous system (CNS) is thought to be hampered by the lesion-induced activation of astrocytes and meningeal cells and the consecutive formation of a glial scar. The substrate properties of reactive astrocytes differ significantly from their neonatal counterparts, which promote axon gr...

journal_title：Glia

authors： Hirsch S,Bähr M

更新日期：1999-03-01 00:00:00

abstract：:Astrocytes play an important role in neuroprotective responses. Recent studies indicate that endothelin-1, a neuropeptide upregulated during brain injury, increases levels of the endocannabinoid anandamide, a lipid with neuroprotective properties, in astrocytes in primary cultures. However, whether this neuropeptide a...

journal_title：Glia

authors： Walter L,Stella N

更新日期：2003-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Cerebral edema, a life-threatening medical complication, contributes to elevated intracranial pressure (ICP) and a poor clinical prognosis after TBI. Unfortunately, treatment options to reduce post-traumatic edema remain suboptimal, du...

journal_title：Glia

authors： Laird MD,Shields JS,Sukumari-Ramesh S,Kimbler DE,Fessler RD,Shakir B,Youssef P,Yanasak N,Vender JR,Dhandapani KM

更新日期：2014-01-01 00:00:00

abstract：:Enteric glial cells were first described at the end of the 19th century, but they attracted more interest from researchers only in the last decades of the 20th. Although, they have a different embryological origin, the enteric GLIA share many characteristics with astrocytes, the main glial cell type of the central ner...

journal_title：Glia

authors： Coelho-Aguiar Jde M,Bon-Frauches AC,Gomes AL,Veríssimo CP,Aguiar DP,Matias D,Thomasi BB,Gomes AS,Brito GA,Moura-Neto V

更新日期：2015-06-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are candidates for therapeutic approaches for neural regeneration due to their ability to assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells. We report here that novel lame...

journal_title：Glia

authors： Windus LC,Claxton C,Allen CL,Key B,St John JA

更新日期：2007-12-01 00:00:00

abstract：:Injury to the preterm brain has a particular predilection for cerebral white matter. White matter injury (WMI) is the most common cause of brain injury in preterm infants and a major cause of chronic neurological morbidity including cerebral palsy. Factors that predispose to WMI include cerebral oxygenation disturbanc...

journal_title：Glia

authors： Back SA,Rosenberg PA

更新日期：2014-11-01 00:00:00

abstract：:The myelin basic protein gene (Mbp) encodes for the major myelin structural proteins and it is included in the Golli-Mbp gene complex. Previously, we observed MBP-like proteins in the human central nervous system (CNS) at developmental stages preceding myelination. In an effort to distinguish between Golli (HOG5 and H...

journal_title：Glia

authors： Tosic M,Rakic S,Matthieu J-,Zecevic N

更新日期：2002-03-01 00:00:00

abstract：:Pruning, the elimination of excess synapses is a phenomenon of fundamental importance for correct wiring of the central nervous system. The establishment of the cerebellar climbing fiber (CF)-to-Purkinje cell (PC) synapse provides a suitable model to study pruning and pruning-relevant processes during early postnatal ...

journal_title：Glia

authors： Kaiser N,Pätz C,Brachtendorf S,Eilers J,Bechmann I

更新日期：2020-11-01 00:00:00

abstract：:Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain macrophage (microgl...

journal_title：Glia

authors： Solga AC,Pong WW,Walker J,Wylie T,Magrini V,Apicelli AJ,Griffith M,Griffith OL,Kohsaka S,Wu GF,Brody DL,Mardis ER,Gutmann DH

更新日期：2015-04-01 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is a major output nucleus of the basal ganglia circuitry particularly sensitive to pathological dopamine depletion. Indeed, hyperactivity of SNr neurons is known to be responsible for some motor disorders characteristic of Parkinson's disease. The neuronal processing of basal...

journal_title：Glia

authors： Bosson A,Boisseau S,Buisson A,Savasta M,Albrieux M

更新日期：2015-04-01 00:00:00

abstract：:In the cerebellar cortex, Bergmann glia enclose the synapses of both parallel and climbing fiber inputs to the Purkinje neuron. The glia express Ca(2+)-permeable AMPA receptors, and the GLAST and GLT-1 classes of glutamate transporter, which are activated by glutamate released during synaptic transmission. We have pre...

journal_title：Glia

authors： Balakrishnan S,Bellamy TC

更新日期：2009-03-01 00:00:00

abstract：:In myelinated axons, voltage-gated sodium channels specifically cluster at the nodes of Ranvier, while voltage-gated potassium channels are located at the juxtaparanodes. These characteristic localizations are influenced by myelination. During development, Nav1.2 first appears in the predicted nodes during myelination...

journal_title：Glia

authors： Suzuki A,Hoshi T,Ishibashi T,Hayashi A,Yamaguchi Y,Baba H

更新日期：2004-05-01 00:00:00

abstract：:Increasing evidence has suggested that astrocytes demonstrate striking regionally allocated functional heterogeneity. Here, we discuss how this spatiotemporally encoded diversity determines the astrocytic phenotype along a finely grained spectrum from neuroprotective to deleterious states. With increasing recognition ...

journal_title：Glia

authors： Clarke BE,Taha DM,Tyzack GE,Patani R

更新日期：2021-01-01 00:00:00

abstract：:17beta-estradiol (betaE(2)) is an effective neuroprotectant against hydrogen peroxide (H(2)O(2))-induced retinal neuronal cell death and light-induced photoreceptor degeneration. Müller cells are the principal macroglia responsible for supporting retinal neuronal survival, information processing and removing metabolic...

journal_title：Glia

authors： Li C,Tang Y,Li F,Turner S,Li K,Zhou X,Centola M,Yan X,Cao W

更新日期：2006-03-01 00:00:00

abstract：:Injection of Fluoro-Gold (FG) into the whisker pad of rats yields a stable retrograde labeling of facial motoneurons. After removal of 10 mm from the facial nerve the microglia phagocytose the FG-prelabeled dead neurons and assume the label. A subsequent brightfield immunostaining of the sections with HRP-DAB as end-p...

journal_title：Glia

authors： Angelov DN,Neiss WF,Streppel M,Walther M,Guntinas-Lichius O,Stennert E

更新日期：1996-02-01 00:00:00

abstract：:Microglia show a rich repertoire of activation patterns regulated by a complex ensemble of surface ion channels, receptors, and transporters. We and others have investigated whether microglia vary their K+ channel expression as a means to achieve functional diversity. However, most of the prior studies were conducted ...

journal_title：Glia

authors： Di Lucente J,Nguyen HM,Wulff H,Jin LW,Maezawa I

更新日期：2018-09-01 00:00:00

abstract：:Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane glycoprotein specifically associated with plasma membrane protrusions. Prominin-1 is expressed by various stem and progenitor cells, notably neuroepithelial progenitors found in the developing embryonic brain. Here, we further investigated its expressi...

journal_title：Glia

authors： Corbeil D,Joester A,Fargeas CA,Jászai J,Garwood J,Hellwig A,Werner HB,Huttner WB

更新日期：2009-06-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are a unique type of macroglia required for normal olfactory axonal regeneration throughout the lifetime of an individual. Recent evidence in the literature suggests that OECs transplanted into injured spinal cords may facilitate axonal regeneration. In this study, we evaluated the n...

journal_title：Glia

authors： Boruch AV,Conners JJ,Pipitone M,Deadwyler G,Storer PD,Devries GH,Jones KJ

更新日期：2001-03-01 00:00:00

abstract：:The synthesis, transport, and insertion of jimpy proteolipid protein and DM20 were studied in normal (158N) and jimpy (158JP) immortalized oligodendrocyte lines. Four different expression vectors encoding fusion proteins composed of native PLP and DM20 or jimpy PLP or DM20 were linked to enhanced green fluorescent pro...

journal_title：Glia

authors： Ghandour MS,Feutz AC,Jalabi W,Taleb O,Bessert D,Cypher M,Carlock L,Skoff RP

更新日期：2002-12-01 00:00:00

abstract：:When central nervous system (CNS) homeostasis is altered, microglial cells become rapidly activated, proliferate and release a broad range of molecules. Among the plethora of molecules involved in the regulation of microglial activation, cytokines are considered crucial. Although production of interleukin-10 (IL-10) h...

journal_title：Glia

authors： Recasens M,Shrivastava K,Almolda B,González B,Castellano B

更新日期：2019-04-01 00:00:00

abstract：:All extant vertebrates have a blood-brain barrier (BBB), a specialized layer of cells that controls molecular traffic between blood and brain, and contributes to the regulation (homeostasis) of the brain microenvironment. Such homeostasis is critical for the stable function of synapses and neural networks. The barrier...

journal_title：Glia

authors： Bundgaard M,Abbott NJ

更新日期：2008-05-01 00:00:00