Novel microtubule-associated protein-2 isoform is expressed early in human oligodendrocyte maturation.

Abstract:

:We have identified a developmentally regulated, oligodendrocyte-specific protein, designated microtubule-associated protein-2 expressing exon 13 (MAP-2+13), in the human central nervous system (CNS). Monoclonal antibodies directed against MAP-2+13 labeled oligodendrocytes in the white matter of human fetal spinal cord. Double-label immunofluorescence and confocal microscopy, and immunoelectron microscopy localized MAP-2+13 to the soma and extending processes of fetal oligodendrocytes, but not to the myelin sheath. The immunoreactivity was throughout the perikarya. Ultrastructural examination of the fetal myelin sheaths showed them to be thin and not fully compacted, indicating that myelination was in progress. There was no overlap in staining of GFAP+ astrocytes and MAP-2+13+ oligodendrocytes. MAP-2+13 was also expressed in intermediate filament-negative "radial glia" extending from the central canal to the subpial surface. In the mature CNS, MAP-2+13 also marked cells of oligodendroglial morphology, but these cells were rare. These finding demonstrate that in the human CNS, MAP-2+13 is a novel protein transiently expressed in cells of oligodendroglial lineage.

journal_name

Glia

journal_title

Glia

authors

Shafit-Zagardo B,Davies P,Rockwood J,Kress Y,Lee SC

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

233-45

issue

3

eissn

0894-1491

issn

1098-1136

pii

10.1002/(SICI)1098-1136(20000201)29:3<233::AID-GLI

journal_volume

29

pub_type

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