Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor.

abstract：:Syndecan-1, -2, -3, and -4 are heparan sulfate proteoglycans that are differentially expressed during development and wound repair. To determine whether syndecans are also involved in brain injury, we examined the expression of syndecan core proteins genes in cryo-injured mouse brain, using in situ hybridization. All ...

journal_title：Glia

authors： Iseki K,Hagino S,Mori T,Zhang Y,Yokoya S,Takaki H,Tase C,Murakawa M,Wanaka A

更新日期：2002-07-01 00:00:00

abstract：:Radial glia are neural stem cells that exist only transiently during central nervous system (CNS) development, where they serve as scaffolds for neuronal migration. Their instability makes them difficult to study, and therefore we have isolated stabilized radial glial clones from E14.5 cortical progenitors (e.g., L2.3...

journal_title：Glia

authors： Li H,Chang YW,Mohan K,Su HW,Ricupero CL,Baridi A,Hart RP,Grumet M

更新日期：2008-04-15 00:00:00

abstract：:The p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75(NTR) is strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this receptor on these...

journal_title：Glia

authors： Cragnolini AB,Huang Y,Gokina P,Friedman WJ

更新日期：2009-10-01 00:00:00

abstract：:Nogo-A is a potent glial-derived inhibitor of axon growth in the injured CNS and acts as a negative regulator of developmental angiogenesis by inhibiting vascular endothelial cell migration. However, its function in pathological angiogenesis has never been studied after ischemic injury in the CNS. Using the mouse mode...

journal_title：Glia

authors： Joly S,Dejda A,Rodriguez L,Sapieha P,Pernet V

更新日期：2018-10-01 00:00:00

abstract：:Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane glycoprotein specifically associated with plasma membrane protrusions. Prominin-1 is expressed by various stem and progenitor cells, notably neuroepithelial progenitors found in the developing embryonic brain. Here, we further investigated its expressi...

journal_title：Glia

authors： Corbeil D,Joester A,Fargeas CA,Jászai J,Garwood J,Hellwig A,Werner HB,Huttner WB

更新日期：2009-06-01 00:00:00

abstract：:Niemann-Pick disease type C (NPC) is a deadly neurodegenerative disease often caused by mutation in a gene called NPC1, which results in the accumulation of unesterified cholesterol and glycosphingolipids in the endosomal-lysosomal system. Most studies on the mechanisms of neurodegeneration in NPC have focused on neur...

journal_title：Glia

authors： Chen G,Li HM,Chen YR,Gu XS,Duan S

更新日期：2007-11-15 00:00:00

abstract：:We investigated the effect of receptor blockade induced by an angiotensin II type-1 receptor antagonist (AT(1)-RB) on glial and vascular changes in oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity (ROP). OIR was induced in Sprague-Dawley rats by exposure to 80% oxygen from postnatal (P) days 0-1...

journal_title：Glia

authors： Downie LE,Pianta MJ,Vingrys AJ,Wilkinson-Berka JL,Fletcher EL

更新日期：2008-08-01 00:00:00

abstract：:The present study was focused on identifying the expression of N-methyl D-aspartate receptor (NMDAR) subunits on activated microglia and to determine their role in the pathogenesis of periventricular white matter damage (PWMD) in neonatal rats following hypoxia. One day old wistar rats were subjected to hypoxia (5% O(...

journal_title：Glia

authors： Murugan M,Sivakumar V,Lu J,Ling EA,Kaur C

更新日期：2011-04-01 00:00:00

abstract：:Injury to the mammalian spinal cord is accompanied by a delayed, secondary wave of oligodendrocyte apoptosis that arises several days after the initial injury. A strong candidate to support oligodendrocyte survival after spinal cord injury is the pleiotropic cytokine, leukemia inhibitory factor (LIF). In vitro, LIF po...

journal_title：Glia

authors： Kerr BJ,Patterson PH

更新日期：2005-07-01 00:00:00

abstract：:Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport, and cytoskeletal dynamics. Although abnormalities of myelin are common in lysosomal storage diseases, our understanding of the role of lysosomes in the formation and maintenance of myelin is still limited. Here, we sh...

journal_title：Glia

authors： Chen G,Zhang Z,Wei Z,Cheng Q,Li X,Li W,Duan S,Gu X

更新日期：2012-02-01 00:00:00

abstract：:ATP stimulates arachidonic acid mobilization and eicosanoid production in cultured astrocytes via P2Y-purinergic receptors. To assist in determining the mechanism of phospholipase A2 activation and the role of calcium in eicosanoid production, cultures were pretreated with pertussis toxin (PTx). ATP-evoked eicosanoid ...

journal_title：Glia

authors： Bruner G,Murphy S

更新日期：1993-03-01 00:00:00

abstract：:Astrocytes extend thin lamellate processes in the neuropil, in particular around synapses, where they can modulate synaptic function or mediate glial-neuronal communication. Previous studies have shown that these lamellate perisynaptic processes change their shape in response to neuronal activity, but the underlying m...

journal_title：Glia

authors： Derouiche A,Frotscher M

更新日期：2001-12-01 00:00:00

abstract：:Uptake of radiolabelled L-arginine was studied in four different kinds of glial cultures, in astroglia-rich primary cultures derived from neonatal rat and mouse brains, in pure murine astrocyte cultures, and in rat glioma cells C6-BU-1. A saturable component of uptake was found in all cases with KM values between 15 a...

journal_title：Glia

authors： Schmidlin A,Wiesinger H

更新日期：1994-07-01 00:00:00

abstract：:Astrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor the spatial relationship between astrocytes and injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions in a mouse amyotrophic lateral sclerosis (AL...

journal_title：Glia

authors： Levine JB,Kong J,Nadler M,Xu Z

更新日期：1999-12-01 00:00:00

abstract：:The role of microglia, the brain resident macrophages, in glioma biology is still ill-defined. Despite their cytotoxic potential, these cells that significantly infiltrate the tumor mass seem to support tumor growth rather than tumor eradication. A proper activation of microglia anti-tumor activities within the tumor ...

journal_title：Glia

authors： Mora R,Abschuetz A,Kees T,Dokic I,Joschko N,Kleber S,Geibig R,Mosconi E,Zentgraf H,Martin-Villalba A,Régnier-Vigouroux A

更新日期：2009-04-01 00:00:00

abstract：:Astrocytes play an important role in neuroprotective responses. Recent studies indicate that endothelin-1, a neuropeptide upregulated during brain injury, increases levels of the endocannabinoid anandamide, a lipid with neuroprotective properties, in astrocytes in primary cultures. However, whether this neuropeptide a...

journal_title：Glia

authors： Walter L,Stella N

更新日期：2003-10-01 00:00:00

abstract：:Microglia transform from homeostatic to disease-associated-microglia (DAM) profiles in neurodegeneration. Within DAM, we recently identified distinct pro-inflammatory and anti-inflammatory sub-profiles although transcriptional regulators of homeostatic and distinct DAM profiles remain unclear. Informed by these studie...

journal_title：Glia

authors： Gao T,Jernigan J,Raza SA,Dammer EB,Xiao H,Seyfried NT,Levey AI,Rangaraju S

更新日期：2019-10-01 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is a major output nucleus of the basal ganglia circuitry particularly sensitive to pathological dopamine depletion. Indeed, hyperactivity of SNr neurons is known to be responsible for some motor disorders characteristic of Parkinson's disease. The neuronal processing of basal...

journal_title：Glia

authors： Bosson A,Boisseau S,Buisson A,Savasta M,Albrieux M

更新日期：2015-04-01 00:00:00

abstract：:Astrocytes release a variety of transmitter molecules, which mediate communication between glial cells in the brain and modulate synaptic transmission. ATP is a major glia-derived transmitter, but the mechanisms and kinetics of ATP release from astrocytes remain largely unknown. Here, we combined epifluorescence and t...

journal_title：Glia

authors： Pryazhnikov E,Khiroug L

更新日期：2008-01-01 00:00:00

abstract：:Several lines of evidence indicate that the elaborated calcium signals and the occurrence of calcium waves in astrocytes provide these cells with a specific form of excitability. The identification of the cellular and molecular steps involved in the triggering and transmission of Ca(2+) waves between astrocytes result...

journal_title：Glia

authors： Scemes E,Giaume C

更新日期：2006-11-15 00:00:00

abstract：:Resident microglia of the rat CNS express a unique type of keratan sulfate immunoreactivity (KS-IR) that is lacking on peripheral monocytes/macrophages and associated with a so far unknown proteoglycan core protein. Microglial KS-IR is downregulated during T-cell-mediated autoimmune inflammation but largely preserved ...

journal_title：Glia

authors： Jander S,Schroeter M,Fischer J,Stoll G

更新日期：2000-06-01 00:00:00

abstract：:During action potential conduction, the axonal specializations at the node, together with the adjacent paranodal terminations of the myelin sheath, interact with glial processes that invest the nodal gap. The nature of the mutual signals between axons and myelinating glia, however, are not well understood. Here we hav...

journal_title：Glia

authors： Toews JC,Schram V,Weerth SH,Mignery GA,Russell JT

更新日期：2007-01-15 00:00:00

abstract：:Activation of adenylate cyclase in astroglial cells in culture results in a rapid change in cell shape that appears to occur by the active movement of cytoplasm from peripheral cell regions to the perinuclear space with processes being formed along regions that remain extended. Three series of experiments were designe...

journal_title：Glia

authors： Shain W,Bausback D,Fiero A,Madelian V,Turner JN

更新日期：1992-01-01 00:00:00

abstract：:Neurotrophin-3 (NT-3) and its receptor TrkC are known to be important for neuronal survival. More recently, NT-3 has been implicated as playing a role in oligodendrocyte (OL) proliferation and survival in vitro. Examination of NT-3 and TrkC knockout mice revealed a reduction in NT-3-dependent neurons. To date, no stud...

journal_title：Glia

authors： Kahn MA,Kumar S,Liebl D,Chang R,Parada LF,De Vellis J

更新日期：1999-04-01 00:00:00

abstract：:The mechanisms underlying neuropathic pain are poorly understood. However, several studies have implied a role for reactive microglia located in the dorsal horn in neuropathic pain. To clarify the roles of activated microglia in neuropathic pain, we investigated the interactions among microglia and other neural compon...

journal_title：Glia

authors： Maeda M,Tsuda M,Tozaki-Saitoh H,Inoue K,Kiyama H

更新日期：2010-11-15 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the principal component of the intermediary filaments in mature astrocytes of the central nervous system (CNS). The protein consists of three domains: the head, the coiled-coil, and the tail. Here, we describe the isolation of an evolutionary conserved novel GFAP isoform, GFAP...

journal_title：Glia

authors： Blechingberg J,Holm IE,Nielsen KB,Jensen TH,Jørgensen AL,Nielsen AL

更新日期：2007-04-01 00:00:00

abstract：:Sciatic nerve explants cultured either alone or in the presence of peritoneal macrophages were used to study prostaglandin E(2) (PGE(2)) and 6-keto-PGF(1alpha) production following traumatic peripheral nerve injury. Although barely detectable at early time points (1-3 h in vitro), the production of PGE(2) and 6-keto-P...

journal_title：Glia

authors： Muja N,DeVries GH

更新日期：2004-04-15 00:00:00

abstract：:Assembly of the extracellular matrix (ECM) has been tightly linked to compact myelin formation in the peripheral nervous system. We recently demonstrated that myelination of dorsal root ganglion (DRG) axons by Schwann cells may occur in the absence of basal lamina. We have now determined whether laminin deposition occ...

journal_title：Glia

authors： Podratz JL,Rodriguez E,Windebank AJ

更新日期：2001-07-01 00:00:00

abstract：:To develop effective procedures for improving the regeneration of peripheral nerves and for preventing the formation of neurofibromas, it is necessary to identify the different mitogens that stimulate the proliferation of Schwann cells. Insulin-like growth factor I (IGF-I), which is a potent autocrine growth factor in...

journal_title：Glia

authors： Schumacher M,Jung-Testas I,Robel P,Baulieu EE

更新日期：1993-08-01 00:00:00

abstract：:Reactive astrocytes are a common feature of various pathological conditions within the CNS. Morphological changes of reactive astrocytes include an altered nucleus-cytoplasm relationship, nuclear indentations, an increased amount of intermediate filaments, and an immunologically immature phenotype. Additionally, the n...

journal_title：Glia

authors： Rohlmann A,Gocht A,Wolburg H

更新日期：1992-01-01 00:00:00