Abstract:
:NG2 cells (polydendrocytes) are the fourth major non-neuronal cell type in the central nervous system parenchyma. They exhibit diverse properties, ranging from their well-established role as oligodendrocyte precursors to their ability to respond to neurotransmitters released by synaptic and non-synaptic mechanisms. The functional diversity of NG2 cells has prompted the question of whether they represent a single cellular entity or multiple distinct cell populations. This review first summarizes recent findings on the nature and mechanism underlying the diversity of NG2 cells with regard to their proliferative and differentiation behavior. This will be followed by a synopsis of observations on how their microenvironment, particularly neuronal activity, influences their dynamic behavior, and how these changes in NG2 cells could in turn influence neural function and animal behavior.
journal_name
Gliajournal_title
Gliaauthors
Hill RA,Nishiyama Adoi
10.1002/glia.22664subject
Has Abstractpub_date
2014-08-01 00:00:00pages
1195-210issue
8eissn
0894-1491issn
1098-1136journal_volume
62pub_type
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