Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists.

abstract：:Apart from dedicated oligodendroglial progenitor cells, adult neural stem cells (aNSCs) can also give rise to new oligodendrocytes in the adult central nervous system (CNS). This process mainly confers myelinating glial cell replacement in pathological situations and can hence contribute to glial heterogeneity. Our pr...

journal_title：Glia

authors： Beyer F,Jadasz J,Samper Agrelo I,Schira-Heinen J,Groh J,Manousi A,Bütermann C,Estrada V,Reiche L,Cantone M,Vera J,Viganò F,Dimou L,Müller HW,Hartung HP,Küry P

更新日期：2020-02-01 00:00:00

abstract：:GABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl(-)-specific channels that are modulated by barbiturates an...

journal_title：Glia

authors： Fraser DD,Mudrick-Donnon LA,MacVicar BA

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:Neonatal white matter injury (NWMI) is the leading cause of cerebral palsy and other neurocognitive deficits in prematurely-born children, and no restorative therapies exist. Our objective was to determine the fate and effect of glial restricted precursor cell (GRP) transplantation in an ischemic mouse model ...

journal_title：Glia

authors： Porambo M,Phillips AW,Marx J,Ternes K,Arauz E,Pletnikov M,Wilson MA,Rothstein JD,Johnston MV,Fatemi A

更新日期：2015-03-01 00:00:00

abstract：:Recent research has focused on soluble oligomeric assemblies of beta-amyloid peptides (Abeta) as the proximate cause of neuroinflammation, synaptic loss, and the eventual dementia associated with Alzheimer's disease (AD). In this study, tripchlorolide (T4), an extract of Tripterygium wilfordii Hook. F (TWHF), was stud...

journal_title：Glia

authors： Pan XD,Chen XC,Zhu YG,Chen LM,Zhang J,Huang TW,Ye QY,Huang HP

更新日期：2009-08-15 00:00:00

abstract：:Schwann cells (SCs), the primary glia in the peripheral nervous system (PNS), display remarkable plasticity in that fully mature SCs undergo dedifferentiation and convert to repair SCs upon nerve injury. Dedifferentiated SCs provide essential support for PNS regeneration by producing signals that enhance the survival ...

journal_title：Glia

authors： Hyung S,Im SK,Lee BY,Shin J,Park JC,Lee C,Suh JF,Hur EM

更新日期：2019-02-01 00:00:00

abstract：:Multiple sclerosis (MS) frequently starts near the lateral ventricles, which are lined by subventricular zone (SVZ) progenitor cells that can migrate to lesions and contribute to repair. Because MS-induced inflammation may decrease SVZ proliferation and thus limit repair, we studied the role of galectin-3 (Gal-3), a p...

journal_title：Glia

authors： James RE,Hillis J,Adorján I,Gration B,Mundim MV,Iqbal AJ,Majumdar MM,Yates RL,Richards MM,Goings GE,DeLuca GC,Greaves DR,Miller SD,Szele FG

更新日期：2016-01-01 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) of the optic nerve are generated in the preoptic area, from where they migrate to colonize it entirely. Sonic hedgehog (Shh) induces the proliferation of these cells as well as influencing their migration, acting through its canonical receptor (Ptc-1). However, the multiligand re...

journal_title：Glia

authors： Ortega MC,Cases O,Merchán P,Kozyraki R,Clemente D,de Castro F

更新日期：2012-05-01 00:00:00

abstract：:Neuroinflammation perpetuates neuronal damage in many neurological disorders. Activation of resident microglia and infiltration of monocytes/macrophages contributes to neuronal injury and synaptic damage. Noninvasive imaging of these cells in vivo provides a means to monitor progression of disease as well as assess ef...

journal_title：Glia

authors： Venneti S,Lopresti BJ,Wiley CA

更新日期：2013-01-01 00:00:00

abstract：:Microglia are key players of the immune response in the central nervous system (CNS) and, being the resident innate immune cells, they are responsible for the early control of infections and for the recruitment of cells of the adaptive immune system required for pathogen clearance. The innate and adaptive immune respo...

journal_title：Glia

authors： Lehnardt S

更新日期：2010-02-01 00:00:00

abstract：:Although the peripheral anti-inflammatory effect of norepinephrine (NE) is well documented, the mechanism by which this neurotransmitter functions as an anti-inflammatory/neuroprotective agent in the central nervous system (CNS) is unclear. This article aimed to determine the anti-inflammatory/neuroprotective effects ...

journal_title：Glia

authors： Jiang L,Chen SH,Chu CH,Wang SJ,Oyarzabal E,Wilson B,Sanders V,Xie K,Wang Q,Hong JS

更新日期：2015-06-01 00:00:00

abstract：:Galactosylceramide (GalC) and its sulfated analogue, sulfatide, are major galactosphingolipid components of myelin and oligodendrocyte plasma membranes in the nervous system. We previously hypothesized that these galactolipids play functional roles in the regulation of oligodendrocyte terminal differentiation by actin...

journal_title：Glia

authors： Hirahara Y,Bansal R,Honke K,Ikenaka K,Wada Y

更新日期：2004-02-01 00:00:00

abstract：:Much of the cell death following episodes of anoxia and ischemia in the mammalian central nervous system has been attributed to extracellular accumulation of glutamate and ATP, which causes a rise in [Ca(2+)](i), loss of mitochondrial potential, and cell death. However, restoration of blood flow and reoxygenation are ...

journal_title：Glia

authors： Domercq M,Mato S,Soria FN,Sánchez-gómez MV,Alberdi E,Matute C

更新日期：2013-03-01 00:00:00

abstract：:CNS glia exhibit a variety of gap junctional interactions: between neighboring astrocytes, between neighboring oligodendrocytes, between astrocytes and oligodendrocytes, and as 'reflexive' structures between layers of myelin in oligodendrocytes. Together, these junctions are thought to form a network facilitating abso...

journal_title：Glia

authors： Magnotti LM,Goodenough DA,Paul DL

更新日期：2011-07-01 00:00:00

abstract：:VEGF is an important factor in tumor vascularization and used as target for anti-angiogenic treatment strategies in glioma. In this study, we demonstrate for the first time that VEGF is a modulator of the innate immune response with suppressive effects on the immunologic and pro-angiogenic function of microglia/macrop...

journal_title：Glia

authors： Turkowski K,Brandenburg S,Mueller A,Kremenetskaia I,Bungert AD,Blank A,Felsenstein M,Vajkoczy P

更新日期：2018-01-01 00:00:00

abstract：:Retinoic acid (RA), a metabolite of vitamin A, is required for the regulation of growth and development. Aberrant expression of molecules involved in RA signaling has been reported in various cancer types including glioblastoma multiforme (GBM). Cellular retinoic acid-binding protein 2 (CRABP2) has previously been sho...

journal_title：Glia

authors： Liu RZ,Li S,Garcia E,Glubrecht DD,Poon HY,Easaw JC,Godbout R

更新日期：2016-06-01 00:00:00

abstract：:Cannabinoid agonists might serve as neuroprotective agents in neurodegenerative disorders. Here, we examined this hypothesis in a rat model of Huntington's disease (HD) generated by intrastriatal injection of the mitochondrial complex II inhibitor malonate. Our results showed that only compounds able to activate CB2 r...

journal_title：Glia

authors： Sagredo O,González S,Aroyo I,Pazos MR,Benito C,Lastres-Becker I,Romero JP,Tolón RM,Mechoulam R,Brouillet E,Romero J,Fernández-Ruiz J

更新日期：2009-08-15 00:00:00

abstract：:Segments from adult fish and rat retinae were explanted on myelin-marker expressing oligodendrocytes derived from the regenerating goldfish optic nerve. Fish axons grew in high density and even rat retinal axons regenerated to considerable length on the surface of the fish oligodendrocytes, suggesting that this type o...

journal_title：Glia

authors： Bastmeyer M,Bähr M,Stuermer CA

更新日期：1993-05-01 00:00:00

abstract：:Activation of adenylate cyclase in astroglial cells in culture results in a rapid change in cell shape that appears to occur by the active movement of cytoplasm from peripheral cell regions to the perinuclear space with processes being formed along regions that remain extended. Three series of experiments were designe...

journal_title：Glia

authors： Shain W,Bausback D,Fiero A,Madelian V,Turner JN

更新日期：1992-01-01 00:00:00

abstract：:The possibility of a modular organization of non-neuronal elements was analyzed in the opercular region of the striate neocortex in adult New World monkeys. For this purpose, and in order to follow possible correlations in the general organization of neuronal and astroglial elements, immunocytochemical procedures for ...

journal_title：Glia

authors： Colombo JA,Schleicher A,Zilles K

更新日期：1999-01-01 00:00:00

abstract：:Our knowledge of multiple sclerosis (MS) neuropathology has benefited from a number of studies that provided an in-depth description of plaques and, more recently, diffuse alterations of the normal-appearing white or grey matter. However, there have been few studies focusing on the periplaque regions surrounding demye...

journal_title：Glia

authors： Lieury A,Chanal M,Androdias G,Reynolds R,Cavagna S,Giraudon P,Confavreux C,Nataf S

更新日期：2014-10-01 00:00:00

abstract：:RhoGTPases are molecular switches that integrate extracellular signals to perform diverse cellular responses. This ability relies on the network of proteins regulating RhoGTPases activity and localization, and on the interaction of RhoGTPases with many different cellular effectors. Myelination is an ideal place for Rh...

journal_title：Glia

authors： Feltri ML,Suter U,Relvas JB

更新日期：2008-11-01 00:00:00

abstract：:The adrenergic agonist norepinephrine can exert its influence on cell function by activating both alpha- and beta-adrenergic receptors. In astrocytes, the alpha-adrenergic receptor activity of norepinephrine is known to inhibit the cyclic AMP response elicited by its action at beta-adrenergic receptors. Pharmacologica...

journal_title：Glia

authors： Northam WJ,Bedoy CA,Mobley PL

更新日期：1989-01-01 00:00:00

abstract：:The interactions between migrating glioma cells and myelinated fiber tracts are poorly understood. We identified that C6 glioma cells can migrate along myelinated chicken retinal axons in a novel coculture, thereby expressing small GTPases of the Rho family and serine/threonine Rho-associated kinases (ROCKs). We found...

journal_title：Glia

authors： Oellers P,Schröer U,Senner V,Paulus W,Thanos S

更新日期：2009-04-01 00:00:00

abstract：:The poor regenerative ability of neurons of the central nervous system in mammals, as compared with their counterpart in fish or amphibians, is thought to stem from differences in their immediate nonneuronal environment and its response to axonal injury. We describe one aspect of the environmental response to axonal i...

journal_title：Glia

authors： Cohen I,Sivron T,Lavie V,Blaugrund E,Schwartz M

更新日期：1994-01-01 00:00:00

abstract：:The extrasynaptic region of the squid giant nerve fiber exhibits neuron-Schwann cell interactions that appear to involve glutamate as a mediator. In an earlier work, it was demonstrated that the periaxonal sheaths of such nerves (where the Schwann cells are located) possess the capacity to transport glutamate. However...

journal_title：Glia

authors： García RA

更新日期：1998-08-01 00:00:00

abstract：:Zinc finger transcription factors of the Krüppel-class figure prominently in cell fate specification and differentiation in the nervous system. One of the Krüppel-type genes that was originally cloned from an oligodendrocyte library by virtue of its homology with the prototypic Krüppel motif is the rat rKr2 gene (Pott...

journal_title：Glia

authors： Lovas G,Li W,Pott U,Verga T,Hudson LD

更新日期：2001-04-15 00:00:00

abstract：:We have shown previously that switching of the alpha v-associated beta1 and beta5 integrin subunits during differentiation of myelin-forming oligodendrocytes may regulate important aspects of cell behaviour such as migration (Milner et al., 1996: J Neurosci 16:7240-7252). In this study we have examined the development...

journal_title：Glia

authors： Milner R,Frost E,Nishimura S,Delcommenne M,Streuli C,Pytela R,Ffrench-Constant C

更新日期：1997-12-01 00:00:00

abstract：:Hydrogen sulfide (H2 S) and nitric oxide (NO) have been described as gasotransmitters. Anti-inflammatory activity in the central and peripheral nervous systems may be one of their functions. Previously we demonstrated that several SH(-) donors including H2 S-releasing aspirin (S-ASA) exhibited anti-inflammatory and ne...

journal_title：Glia

authors： Lee M,McGeer E,Kodela R,Kashfi K,McGeer PL

更新日期：2013-10-01 00:00:00

abstract：:The predominant glial cells of the drone retina (outer pigment cells) respond to an increase in extracellular [K+] (Ko) by a net uptake of K+; thus, they contribute to bringing Ko back toward its baseline value. The authors report herein that there is also a different mechanism by which light stimulation of the retina...

journal_title：Glia

authors： Coles JA,Schneider-Picard G

更新日期：1989-01-01 00:00:00

abstract：:Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane glycoprotein specifically associated with plasma membrane protrusions. Prominin-1 is expressed by various stem and progenitor cells, notably neuroepithelial progenitors found in the developing embryonic brain. Here, we further investigated its expressi...

journal_title：Glia

authors： Corbeil D,Joester A,Fargeas CA,Jászai J,Garwood J,Hellwig A,Werner HB,Huttner WB

更新日期：2009-06-01 00:00:00