Abstract:
:Hydrogen sulfide (H2 S) and nitric oxide (NO) have been described as gasotransmitters. Anti-inflammatory activity in the central and peripheral nervous systems may be one of their functions. Previously we demonstrated that several SH(-) donors including H2 S-releasing aspirin (S-ASA) exhibited anti-inflammatory and neuroprotective activity in vitro against toxins released by activated microglia and astrocytes. Here we report that NOSH-ASA, an NO- and H2 S-releasing hybrid of aspirin, has a significantly greater anti-inflammatory and neuroprotective effect than S-ASA or NO-ASA. When activated by LPS/IFNγ, human microglia and THP-1 cells release materials that are toxic to differentiated SH-SY5Y cells. These phenomena also occur with IFNγ-stimulated human astroglia and U373 cells. When the cells were treated with the S-ASA or NO-ASA, there was a significant enhancement of neuroprotection. However, NOSH-ASA had significantly more potent protection properties than NO-ASA or S-ASA. The effect was concentration-dependent, as well as incubation time-dependent. Such treatment not only reduced the release of the TNFα and IL-6, but also attenuated activation of P38 MAPK and NFκB proteins. All the compounds tested were not harmful when applied directly to SH-SY5Y cells. These data suggest that NOSH-ASA has significant anti-inflammatory properties and may be a new candidate for treating neurodegenerative disorders that have a prominent neuroinflammatory component such as Alzheimer disease and Parkinson disease.
journal_name
Gliajournal_title
Gliaauthors
Lee M,McGeer E,Kodela R,Kashfi K,McGeer PLdoi
10.1002/glia.22553subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1724-34issue
10eissn
0894-1491issn
1098-1136journal_volume
61pub_type
杂志文章相关文献
GLIA文献大全abstract::In order to improve understanding of remodeling events in the glaucomatous optic nerve head, the migration of optic nerve head astrocytes was studied in vitro. Since elevated intraocular pressure is an important stress factor identified in glaucomatous eyes, optic nerve head astrocytes were incubated under physical st...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.1052
更新日期:2001-05-01 00:00:00
abstract::Acute liver failure (ALF) is consistently accompanied by alterations in brain energy metabolites and recent nuclear magnetic resonance (NMR) studies suggest disturbances in brain oxidative metabolism in experimental ALF. Glucose transport across the blood-brain barrier is essential to sustain brain energy metabolism a...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20310
更新日期:2006-04-01 00:00:00
abstract::ATP stimulates arachidonic acid mobilization and eicosanoid production in cultured astrocytes via P2Y-purinergic receptors. To assist in determining the mechanism of phospholipase A2 activation and the role of calcium in eicosanoid production, cultures were pretreated with pertussis toxin (PTx). ATP-evoked eicosanoid ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440070305
更新日期:1993-03-01 00:00:00
abstract::In the course of adult hippocampal neurogenesis, new cells go through a series of stages associated with proliferative activity. The most highly proliferative cell type is an intermediate precursor cell, called type-2 cell. We here report that on the level of type-2 cells a transition takes place between features asso...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20407
更新日期:2006-12-01 00:00:00
abstract::The detection of nucleic acids by the innate immune system is an essential host response during viral infection. In recent years, a number of immune sensors capable of recognizing cytosolic DNA have been identified and include the PYHIN family members AIM2, IFI16, and p204 as well as the enzyme, cGAS. Activation of th...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22786
更新日期:2015-05-01 00:00:00
abstract::Despite decades of research, primary brain tumors, gliomas, lack effective treatment options and present a huge clinical challenge. Particularly, the most malignant subtype, Glioblastoma multiforme, proliferates extensively and cells often undergo incomplete cell divisions, resulting in multinucleated cells. We now pr...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20994
更新日期:2010-08-01 00:00:00
abstract::Cells of the adaptive and innate immune systems in the brain parenchyma and in the meningeal spaces contribute to physiologic functions and disease states in the central nervous system (CNS). Animal studies have demonstrated the involvement of immune constituents, along with major histocompatibility complex (MHC) mole...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23746
更新日期:2020-04-01 00:00:00
abstract::The role of microglia, the brain resident macrophages, in glioma biology is still ill-defined. Despite their cytotoxic potential, these cells that significantly infiltrate the tumor mass seem to support tumor growth rather than tumor eradication. A proper activation of microglia anti-tumor activities within the tumor ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20785
更新日期:2009-04-01 00:00:00
abstract::Retinoic acid (RA), a metabolite of vitamin A, is required for the regulation of growth and development. Aberrant expression of molecules involved in RA signaling has been reported in various cancer types including glioblastoma multiforme (GBM). Cellular retinoic acid-binding protein 2 (CRABP2) has previously been sho...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22976
更新日期:2016-06-01 00:00:00
abstract::We recently showed that trisialoganglioside (GT1b) induces cell death of dopaminergic neurons in rat mesencephalic cultures (Chung et al., Neuroreport 12:611-614, 2001). The present study examines the in vivo neurotoxic effects of GT1b on dopaminergic neurons in the substantia nigra (SN) of Sprague-Dawley rats. Seven ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.10047
更新日期:2002-04-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting predominantly motor neurons. Recent studies suggest that the disease progression of ALS is non-cell-autonomous, although the interaction between neurons and glial cells in different disease stages is not entirely clear. Here, we ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.21167
更新日期:2011-06-01 00:00:00
abstract::N-myc downstream-regulated gene 1 (NDRG1)/RTP/Drg1/Cap43/rit42/TDD5/Ndr1 is expressed ubiquitously and has been proposed to play a role in growth arrest and cell differentiation. A recent study showed that mutation of this gene is responsible for hereditary motor and sensory neuropathy-Lom. However, the role of this g...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20037
更新日期:2004-09-01 00:00:00
abstract::Glial fibrillary acidic protein (GFAP) is the main component of intermediate filaments in astrocytes. To assess its function in astrocyte swelling, we compared astrocyte membrane properties and swelling in spinal cord slices of 8- to 10-day-old wild-type control (GFAP(+/+)) and GFAP-knockout (GFAP(-/-)) mice. Membrane...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.1084
更新日期:2001-09-01 00:00:00
abstract::The consequences of sublytic terminal complement complex (TCC) assembly on Schwann cell proliferation and apoptosis were examined by using purified complement proteins (C5*-9) or antibody-sensitized Schwann cells in the presence of a serum that was depleted of the seventh component of complement (C7dHS) and reconstitu...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(200004)30:2<187::aid-glia8
更新日期:2000-04-01 00:00:00
abstract::Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of gray matter. This phenomenon is believed to underlie the migraine aura and similar waves of depolarization may exacerbate injury in a number of neurological disease states. CSD is characterized by massive ion dyshomeostasis, cell swe...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23604
更新日期:2019-06-01 00:00:00
abstract::Previous studies suggest that glial cells contribute to synaptogenesis in specific neurons from the postnatal CNS. Here, we studied whether this is true for Purkinje cells (PCs), which represent a unique neuronal cell type due to their large size, massive synaptic input, and high vulnerability. Using new glia-free cul...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20943
更新日期:2010-04-01 00:00:00
abstract::Radial glial cells play an essential role through their function as guides for neuronal migration during development. Disruption of metabotropic glutamate receptor 5 (mGluR5) function retards the growth of radial glial processes in vitro. Neuregulins (NRG) are activated by proteolytic cleavage and regulate (radial) gl...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23230
更新日期:2018-01-01 00:00:00
abstract::We have employed amoeboid microglia purified from primary cultures of neonatal rat brain to examine the effect of bacterial lipopolysaccharide (LPS), a potent activator of immune cells, on intracellular calcium concentration ([Ca2+]i) in brain macrophages. In single brain macrophages loaded with indo 1, pulse administ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440110406
更新日期:1994-08-01 00:00:00
abstract::The extrasynaptic region of the squid giant nerve fiber exhibits neuron-Schwann cell interactions that appear to involve glutamate as a mediator. In an earlier work, it was demonstrated that the periaxonal sheaths of such nerves (where the Schwann cells are located) possess the capacity to transport glutamate. However...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199808)23:4<298::aid-glia2
更新日期:1998-08-01 00:00:00
abstract::Allograft inflammatory factor-1 (AIF-1) is a Ca2+ binding peptide expressed predominantly by activated monocytes. In order to investigate the role of AIF-1 in autoimmune lesions of the rat nervous system, we have used a synthetic gene to express AIF-1 in E. coli and have produced monoclonal antibodies against AIF-1. A...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199810)24:2<244::aid-glia9
更新日期:1998-10-01 00:00:00
abstract::Injury to the mammalian spinal cord is accompanied by a delayed, secondary wave of oligodendrocyte apoptosis that arises several days after the initial injury. A strong candidate to support oligodendrocyte survival after spinal cord injury is the pleiotropic cytokine, leukemia inhibitory factor (LIF). In vitro, LIF po...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20177
更新日期:2005-07-01 00:00:00
abstract::Increasing evidence supports an essential role for interleukin-6 (IL-6) in the development, differentiation, as well as de- and re-generation of neurons in the central nervous system (CNS). Both IL-6 and its specific receptor (IL-6R) are expressed on neurons and glial cells including astrocytes. In this study, we have...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199905)26:3<191::aid-glia1
更新日期:1999-05-01 00:00:00
abstract::The mechanisms that control microglial activation are of interest, since neuroinflammation, which involves reactive microglia, may be an additional target in the search for therapeutic strategies to treat neurodegenerative diseases. Neuron-microglia interaction through contact-dependent or independent mechanisms is in...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22656
更新日期:2014-06-01 00:00:00
abstract::The identification of myelin oligodendrocyte glycoprotein (MOG) as a target for autoantibody-mediated demyelination in experimental autoimmune encephalomyelitis (EAE) resulted in the re-evaluation of the role of B cell responses to myelin autoantigens in the immunopathogenesis of multiple sclerosis. MOG is a central n...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.1111
更新日期:2001-11-01 00:00:00
abstract::Microglia, the resident macrophages of the central nervous system (CNS), can be distinguished from most other cells of the myelomonocytic lineage by a distinct pattern of membrane currents. In the accompanying paper we have shown that the characteristic morphological feature of microglia, ramification, develops both i...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440120403
更新日期:1994-12-01 00:00:00
abstract::Knowledge of the precise timing of myelination is critical to the success of zebrafish-based in vivo screening strategies for potential remyelination therapies. This study provides a systematic review of the timing of myelination in the zebrafish spinal cord and a critique of techniques by which it may be accurately a...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20964
更新日期:2010-05-01 00:00:00
abstract::Macrophage can adopt several phenotypes, process call polarization, which is crucial for shaping inflammatory responses to injury. It is not known if microglia, a resident brain macrophage population, polarizes in a similar way, and whether specific microglial phenotypes modulate cell death in response to brain injury...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22478
更新日期:2013-05-01 00:00:00
abstract::The red nucleus (RN) has been widely used to study the formation and remodeling of synaptic connections during development and in post-lesion plasticity. Since glial cells are thought to contribute to synaptic plasticity, and information on functional properties of brain stem glia is missing, we analyzed voltage-gated...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract::In this study, we investigated the involvement of the blood-brain barrier (BBB) in the brain of the dystrophin-deficient mdx mouse, an experimental model of Duchenne muscular dystrophy (DMD). To this purpose, we used two tight junction markers, the Zonula occludens (ZO-1) and claudin-1 proteins, and a glial marker, th...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.10216
更新日期:2003-05-01 00:00:00
abstract::The substantia gelatinosa (SG) of the spinal cord processes incoming painful information to ascending projection neurons. Whole-cell patch clamp recordings from SG spinal cord slices documented that in a low Ca(2+) /no Mg(2+) (low X(2+) ) external medium adenosine triphosphate (ATP)/dibenzoyl-ATP, Bz-ATP) caused inwar...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22707
更新日期:2014-10-01 00:00:00