Leukemia inhibitory factor promotes oligodendrocyte survival after spinal cord injury.

abstract：:Parkinson's disease is characterized by a progressive degeneration of substantia nigra (SN) dopaminergic neurons with age. We previously found that a single systemic lipopolysaccharide (LPS, 5 mg/kg, i.p.) injection caused a slow progressive loss of tyrosine hydroxylase immunoreactive (TH+IR) neurons in SN associated ...

journal_title：Glia

authors： Qin L,Liu Y,Hong JS,Crews FT

更新日期：2013-06-01 00:00:00

abstract：:Accumulating evidence has revealed that astrocytes are potential targets for various neurotransmitters. Here we investigated the effects of prostaglandins (PGs) on signal transduction in purified primary cultures of rat type-1 and type-2 astrocytes. PGF2 alpha, PGD2, and 9 alpha,11 beta-PGF2, a metabolite of PGD2 and ...

journal_title：Glia

authors： Ito S,Sugama K,Inagaki N,Fukui H,Giles H,Wada H,Hayaishi O

更新日期：1992-01-01 00:00:00

abstract：:Stellate ganglion neurons, important mediators of cardiopulmonary neurotransmission, are surrounded by satellite glial cells (SGCs), which are essential for the function, maintenance, and development of neurons. However, it remains unknown whether SGCs in adult sympathetic ganglia exhibit any functional diversity, and...

journal_title：Glia

authors： van Weperen VYH,Littman RJ,Arneson DV,Contreras J,Yang X,Ajijola OA

更新日期：2021-01-12 00:00:00

abstract：:The cellular reaction to injury in the mature central nervous system (CNS) has been extensively studied in both man and animals, while a detailed study of the reaction of the immature CNS to injury is lacking in the literature. This study was undertaken to elucidate the response of young astrocytes following injection...

journal_title：Glia

authors： Al-Ali SY,Al-Zuhair AG,Dawod B

更新日期：1988-01-01 00:00:00

abstract：:The nervous system of echinoderms has long been considered too unique to be directly comparable to the nervous system of other Deuterostomia. Using two novel monoclonal antibodies in combination with epifluorescence, confocal, and electron microscopy, we demonstrate here that the central nervous system of the sea cucu...

journal_title：Glia

authors： Mashanov VS,Zueva OR,Garcia-Arraras JE

更新日期：2010-10-01 00:00:00

abstract：:Replication-defective Moloney murine leukemia virus expressing the GAD67 gene under the control of the GFAP promoter was produced using selected clones of a fibroblast-packaging cell line. A spontaneously immortalized astrocyte cell line was infected with this virus and cellular clones expressing GAD67 selected. Astro...

journal_title：Glia

authors： Sacchettoni SA,Benchaibi M,Sindou M,Belin MF,Jacquemont B

更新日期：1998-01-01 00:00:00

abstract：:The distribution of metallothioneins I/II in the mouse brain and their specific area distribution upon physical stress were studied. To induce physical stress, groups of mice were subjected to total darkness for different periods (2 weeks, 1 month, and 2 months). The concentration of metallothioneins, evaluated by imm...

journal_title：Glia

authors： Beltramini M,Di Pisa C,Zambenedetti P,Wittkowski W,Mocchegiani E,Musicco M,Zatta P

更新日期：2004-07-01 00:00:00

abstract：:The idea of a metabolic coupling between neurons and astrocytes in the brain has been entertained for about 100 years. The use recently of simple and well-compartmentalized nervous systems, such as the honeybee retina or purified preparations of neurons and glia, provided strong support for a nutritive function of gli...

journal_title：Glia

authors： Tsacopoulos M,Poitry-Yamate CL,Poitry S,Perrottet P,Veuthey AL

更新日期：1997-09-01 00:00:00

abstract：:Despite decades of research, primary brain tumors, gliomas, lack effective treatment options and present a huge clinical challenge. Particularly, the most malignant subtype, Glioblastoma multiforme, proliferates extensively and cells often undergo incomplete cell divisions, resulting in multinucleated cells. We now pr...

journal_title：Glia

authors： Bomben VC,Sontheimer H

更新日期：2010-08-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting predominantly motor neurons. Recent studies suggest that the disease progression of ALS is non-cell-autonomous, although the interaction between neurons and glial cells in different disease stages is not entirely clear. Here, we ...

journal_title：Glia

authors： Wang R,Yang B,Zhang D

更新日期：2011-06-01 00:00:00

abstract：:The production of insulin-like growth factor (IGF)-I and -II and their binding proteins (BPs) has been studied in new-born rat astroblasts at confluency in primary culture. Under the influence of fibroblast growth factors (FGFs) (acidic and basic), the morphology of the astroblasts was altered, 125I-deoxyuridine incor...

journal_title：Glia

authors： Loret C,Janet T,Labourdette G,Schneid H,Binoux M

更新日期：1991-01-01 00:00:00

abstract：:The interactions between migrating glioma cells and myelinated fiber tracts are poorly understood. We identified that C6 glioma cells can migrate along myelinated chicken retinal axons in a novel coculture, thereby expressing small GTPases of the Rho family and serine/threonine Rho-associated kinases (ROCKs). We found...

journal_title：Glia

authors： Oellers P,Schröer U,Senner V,Paulus W,Thanos S

更新日期：2009-04-01 00:00:00

abstract：:Neural progenitor cells (NPCs) are sequentially specified into neurons and glia during the development of central nervous system. WNT/β-catenin signaling is known to regulate the balance between the proliferation and differentiation of NPCs during neurogenesis. However, the function of WNT/β-catenin signaling during g...

journal_title：Glia

authors： Sun S,Zhu XJ,Huang H,Guo W,Tang T,Xie B,Xu X,Zhang Z,Shen Y,Dai ZM,Qiu M

更新日期：2019-07-01 00:00:00

abstract：:The chemokines CXCL9 and CXCL10 bind to the common receptor CXCR3 and are implicated in the pathogenesis of T-cell-mediated immunity in the central nervous system (CNS). Here we examined the temporal and spatial regulation of the Cxcl9 and Cxcl10 genes in the CNS of mice with myelin oligodendrocyte glycoprotein (MOG)-...

journal_title：Glia

authors： Carter SL,Müller M,Manders PM,Campbell IL

更新日期：2007-12-01 00:00:00

abstract：:Astroglial dysfunction plays an important role in neurodegenerative diseases otherwise attributed to neuronal loss of function. Here we focus on the role of astroglia in ataxia-telangiectasia (A-T), a disease caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. A hallmark of A-T pathology is progressiv...

journal_title：Glia

authors： Campbell A,Bushman J,Munger J,Noble M,Pröschel C,Mayer-Pröschel M

更新日期：2016-02-01 00:00:00

abstract：:Previous studies suggest that glial cells contribute to synaptogenesis in specific neurons from the postnatal CNS. Here, we studied whether this is true for Purkinje cells (PCs), which represent a unique neuronal cell type due to their large size, massive synaptic input, and high vulnerability. Using new glia-free cul...

journal_title：Glia

authors： Buard I,Steinmetz CC,Claudepierre T,Pfrieger FW

更新日期：2010-04-01 00:00:00

abstract：:We have previously shown that cultured astrocytes from neonatal rat cerebral cortex are depolarized by GABA. The underlying ionic mechanism, activation of a Cl- conductance and responses to an agonist and antagonists were found to be similar to those of the neuronal GABAA receptor (Kettenmann et al.: Brain Research 40...

journal_title：Glia

authors： Backus KH,Kettenmann H,Schachner M

更新日期：1988-01-01 00:00:00

abstract：:Neuronal injury in CNS tissues induces a rapid activation and mobilization of resident microglia (MG). It is widely assumed that changes in gene expression drive the morphological transformation of MG and regulate their mobilization during activation. Here, we used acutely excised neonatal rat brain slices to test whe...

journal_title：Glia

authors： Kurpius D,Wilson N,Fuller L,Hoffman A,Dailey ME

更新日期：2006-07-01 00:00:00

abstract：:Accumulative evidence indicates that microglial cells influence the normal development of central nervous system (CNS) synapses. Yet, the functional properties of microglia in relation with synapse development remain unclear. We recently showed that in layer 4 of the whisker-related barrel field of the mouse somatosen...

journal_title：Glia

authors： Arnoux I,Hoshiko M,Mandavy L,Avignone E,Yamamoto N,Audinat E

更新日期：2013-10-01 00:00:00

abstract：:We have attempted to reconstruct in vitro the events that may occur in vivo during reperfusion injury after ischemia in the central nervous system. The phenomenon is induced by previous exposure to low calcium solutions ("calcium paradox") before the reperfusion episode. Intracellular calcium alterations during reperf...

journal_title：Glia

authors： Kim-Lee MH,Stokes BT,Yates AJ

更新日期：1992-01-01 00:00:00

abstract：:Hypoglycemia is a common and serious problem among diabetic patients receiving treatment with insulin or other glucose-lowering drugs. Moderate hypoglycemia impairs neurological function, and severe hypoglycemia leads to death of selectively vulnerable neurons. Recent advances have shed new light on the underlying pro...

journal_title：Glia

authors： Suh SW,Hamby AM,Swanson RA

更新日期：2007-09-01 00:00:00

abstract：:The detection of nucleic acids by the innate immune system is an essential host response during viral infection. In recent years, a number of immune sensors capable of recognizing cytosolic DNA have been identified and include the PYHIN family members AIM2, IFI16, and p204 as well as the enzyme, cGAS. Activation of th...

journal_title：Glia

authors： Cox DJ,Field RH,Williams DG,Baran M,Bowie AG,Cunningham C,Dunne A

更新日期：2015-05-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) play a critical role in immune-mediated demyelinating diseases, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), by regulating the viability of oligodendrocytes. Our previous studies show th...

journal_title：Glia

authors： Stone S,Wu S,Jamison S,Durose W,Pallais JP,Lin W

更新日期：2018-07-01 00:00:00

abstract：:Vestibular schwannomas (VSs) are benign tumors that arise from the Schwann cells (SCs) lining the vestibular nerve. VS cells survive and proliferate far from neurons and axonally derived growth factors. We have previously shown that VSs produce the glial growth factor, neuregulin-1 (NRG1), and its receptors, ErbB2 and...

journal_title：Glia

authors： Hansen MR,Roehm PC,Chatterjee P,Green SH

更新日期：2006-04-15 00:00:00

abstract：:It has been suggested that astrocytic glutamate release or perturbed glutamate metabolism contributes to the proneness to epileptic seizures. Here we investigated whether astrocytic contents of the major glutamate degrading enzymes glutamine synthetase (GS) and glutamate dehydrogenase (GDH) decreases on moving from th...

journal_title：Glia

authors： Hammer J,Alvestad S,Osen KK,Skare Ø,Sonnewald U,Ottersen OP

更新日期：2008-06-01 00:00:00

abstract：:In this study, we investigated the involvement of the blood-brain barrier (BBB) in the brain of the dystrophin-deficient mdx mouse, an experimental model of Duchenne muscular dystrophy (DMD). To this purpose, we used two tight junction markers, the Zonula occludens (ZO-1) and claudin-1 proteins, and a glial marker, th...

journal_title：Glia

authors： Nico B,Frigeri A,Nicchia GP,Corsi P,Ribatti D,Quondamatteo F,Herken R,Girolamo F,Marzullo A,Svelto M,Roncali L

更新日期：2003-05-01 00:00:00

abstract：:External application of bradykinin (BK) to mouse neuroblastoma X mouse fibroblast hybrid NL308 cells and mouse neuroblastoma X rat glioma hybrid NG108-15 cells produced a transient outward (hyperpolarizing) current. In NG108-15 cells, BK also induced an inward (depolarizing) current associated with a decrease in input...

journal_title：Glia

authors： Higashida H,Okano Y,Hoshi N,Yada Y,Yokoyama S,Asaga T,Fu T,Nozawa Y

更新日期：1990-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Cerebral edema, a life-threatening medical complication, contributes to elevated intracranial pressure (ICP) and a poor clinical prognosis after TBI. Unfortunately, treatment options to reduce post-traumatic edema remain suboptimal, du...

journal_title：Glia

authors： Laird MD,Shields JS,Sukumari-Ramesh S,Kimbler DE,Fessler RD,Shakir B,Youssef P,Yanasak N,Vender JR,Dhandapani KM

更新日期：2014-01-01 00:00:00

abstract：:We have previously reported that neonatal rat oligodendrocytes (OLGs) express and secrete neuregulins (NRGs) (Raabe et al., 1997). This laboratory has also shown that NRGs stimulate the differentiation of neonatal rat OLGs and that these cells express the erbB receptors for NRGs (Raabe et al., 1997). In this study, we...

journal_title：Glia

authors： Deadwyler GD,Pouly S,Antel JP,Devries GH

更新日期：2000-12-01 00:00:00

abstract：:Injury to the preterm brain has a particular predilection for cerebral white matter. White matter injury (WMI) is the most common cause of brain injury in preterm infants and a major cause of chronic neurological morbidity including cerebral palsy. Factors that predispose to WMI include cerebral oxygenation disturbanc...

journal_title：Glia

authors： Back SA,Rosenberg PA

更新日期：2014-11-01 00:00:00