Abstract:
:The chemokines CXCL9 and CXCL10 bind to the common receptor CXCR3 and are implicated in the pathogenesis of T-cell-mediated immunity in the central nervous system (CNS). Here we examined the temporal and spatial regulation of the Cxcl9 and Cxcl10 genes in the CNS of mice with myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) and by glial cells in vitro. During peak disease the levels of CXCL9 and CXCL10 mRNA and protein were increased significantly in the cerebellum and spinal cord but were reduced during the recovery phase. Expression of these genes in the CNS was abolished in IFN-gamma-receptor deficient mice with MOG-EAE. In wild-type mice, CXCL9 RNA was localized mainly to infiltrating mononuclear cells including lesion and perilesional microglia, while CXCL10 RNA was seen primarily in more distal astrocytes that surrounded the inflammatory lesions. Examination of cultured glia following treatment with IFN-gamma revealed that while both CXCL9 and CXCL10 mRNA transcripts were induced in microglia, only CXCL10 mRNA was induced in astrocytes. Thus, although IFN-gamma is the pivotal mediator of both Cxcl10 and Cxcl9 gene expression in EAE, this cytokine differentially regulates the expression of these genes by astrocytes and microglia. The differential glial localization of these chemokines in EAE suggests CXCL9 and CXCL10 have specialized functions.
journal_name
Gliajournal_title
Gliaauthors
Carter SL,Müller M,Manders PM,Campbell ILdoi
10.1002/glia.20587subject
Has Abstractpub_date
2007-12-01 00:00:00pages
1728-39issue
16eissn
0894-1491issn
1098-1136journal_volume
55pub_type
杂志文章相关文献
GLIA文献大全abstract::Knowledge of the precise timing of myelination is critical to the success of zebrafish-based in vivo screening strategies for potential remyelination therapies. This study provides a systematic review of the timing of myelination in the zebrafish spinal cord and a critique of techniques by which it may be accurately a...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20964
更新日期:2010-05-01 00:00:00
abstract::RhoGTPases are molecular switches that integrate extracellular signals to perform diverse cellular responses. This ability relies on the network of proteins regulating RhoGTPases activity and localization, and on the interaction of RhoGTPases with many different cellular effectors. Myelination is an ideal place for Rh...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.20752
更新日期:2008-11-01 00:00:00
abstract::The Alzheimer disease-associated multifunctional low-density lipoprotein receptor-related protein-1 is expressed in the brain. Recent studies uncovered a role of this receptor for the appropriate functioning of neural stem cells, oligodendrocytes, and neurons. The constitutive knock-out (KO) of the receptor is embryon...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23869
更新日期:2020-12-01 00:00:00
abstract::Oligodendrocytes were studied in the anterior medullary velum (AMV) of the rat using the monoclonal antibody Rip, an oligodendrocyte marker of unknown function. Confocal microscopic imaging of double immunofluorescent labelling with antibodies to Rip and carbonic anhydrase II (CAII) revealed two biochemically and morp...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440140304
更新日期:1995-07-01 00:00:00
abstract::Oligodendrocyte precursor cells (OPCs) of the optic nerve are generated in the preoptic area, from where they migrate to colonize it entirely. Sonic hedgehog (Shh) induces the proliferation of these cells as well as influencing their migration, acting through its canonical receptor (Ptc-1). However, the multiligand re...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22316
更新日期:2012-05-01 00:00:00
abstract::The normal adult vertebrate nervous system is a relative quiescent tissue in terms of cell proliferation. However, astrocytes in many regions of the central nervous system (CNS) retain the capacity to undergo cell division. To examine the mechanisms that regulate the proliferation of astrocytes in the CNS we have util...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199804)22:4<379::aid-glia7
更新日期:1998-04-01 00:00:00
abstract::The possible consequences of activating bradykinin (Bk) receptors on identified astrocyte subtypes derived from rat cortex have been investigated in terms of: 1) mobilization of intracellular Ca2+; and 2) electrophysiological response. Bk induced a rapid, transient rise in intracellular Ca2+ in 63% of cortical type-1-...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440090405
更新日期:1993-12-01 00:00:00
abstract::Previous in vitro studies using cell cultures or brain slices have demonstrated that phospholipase D (PLD) in the nervous system is involved in the signaling mechanism in response to a variety of agonists. However, little is known about the pathophysiological role of PLD-mediated signaling in the adult brain. We exami...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(200005)30:3<311::aid-glia1
更新日期:2000-05-01 00:00:00
abstract::The phenotype of a fully differentiated, mature Schwann cell is apparently largely determined by Schwann cell-axon interactions. In vitro, elevation of intracellular cAMP levels in Schwann cells induces a phenotype which resembles that of a mature, i.e., axon-related, Schwann cell. Therefore, an important role for cAM...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440080308
更新日期:1993-07-01 00:00:00
abstract::Replication-defective Moloney murine leukemia virus expressing the GAD67 gene under the control of the GFAP promoter was produced using selected clones of a fibroblast-packaging cell line. A spontaneously immortalized astrocyte cell line was infected with this virus and cellular clones expressing GAD67 selected. Astro...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199801)22:1<86::aid-glia8>
更新日期:1998-01-01 00:00:00
abstract::Neurotrophin-3 (NT-3) and its receptor TrkC are known to be important for neuronal survival. More recently, NT-3 has been implicated as playing a role in oligodendrocyte (OL) proliferation and survival in vitro. Examination of NT-3 and TrkC knockout mice revealed a reduction in NT-3-dependent neurons. To date, no stud...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Perisynaptic Schwann cells (PSCs) envelop axonal terminals and are physiologically distinct from the nearby myelinating Schwann cells (MSCs), which surround the same innervating motor axons. PSCs have special functions at the neuromuscular synapse, where they detect and can modulate neurotransmitter release. Although ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199908)27:2<101::aid-glia1
更新日期:1999-08-01 00:00:00
abstract::Whole-cell membrane currents and imaging of intracellular calcium concentrations ([Ca2+]i) were used to investigate the role of calcium in a response to serotonin of C6 glioma cells. Activation of a high-affinity serotonin receptor induced a transient rise in calcium concentration in these cells and activated a predom...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440060206
更新日期:1992-01-01 00:00:00
abstract::Microglia are known to regulate several aspects of the development of the central nervous system. When microglia colonize the spinal cord, from E11.5 in the mouse embryo, they interact with growing central axons of dorsal root ganglion sensory neurons (SNs), which suggests that they may have some functions in SN devel...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23499
更新日期:2018-11-01 00:00:00
abstract::To examine the neurochemical effects of chronic hypoxia on immature nervous tissue in vitro, mixed neuronal-glial cell cultures derived from fetal mice were exposed to 5% O2 for 24 or 48 h. Those cultures subjected to longer hypoxia manifested improved neuronal survival compared to those with the shorter insult, both ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440030506
更新日期:1990-01-01 00:00:00
abstract::The purpose of this study was to investigate whether insulin, fibroblast growth factor (FGF), and mitogen-activated protein kinase (MAPK) pathways protect retinal neurons against excitotoxicity and regulate the proliferation of Müller glia. We found that intraocular injections of insulin or FGF2 had variable effects u...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20868
更新日期:2009-11-01 00:00:00
abstract::Pharmacological and biochemical data suggest that noradrenaline (NA)-containing fibers not only regulate the activity of cortical neurons but also influence the functional state of non-neuronal elements. In the present study, immunocytochemistry with an antiserum against NA, followed by silver-gold intensification of ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1136(199606)17:2<133::AID-GLIA5
更新日期:1996-06-01 00:00:00
abstract::Simvastatin, a lipophilic statin that crosses the blood-brain barrier, is being evaluated as a potential therapy for multiple sclerosis (MS) due to its anti-inflammatory properties. We assessed the effects of simvastatin on cultures of rat newborn and human fetal oligodendrocyte progenitor cells (OPCs) and human adult...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20441
更新日期:2007-01-15 00:00:00
abstract::We have previously shown that cultured astrocytes from neonatal rat cerebral cortex are depolarized by GABA. The underlying ionic mechanism, activation of a Cl- conductance and responses to an agonist and antagonists were found to be similar to those of the neuronal GABAA receptor (Kettenmann et al.: Brain Research 40...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440010205
更新日期:1988-01-01 00:00:00
abstract::Transgenic Tg2576 mice expressing human amyloid precursor protein (hAPP) with the Swedish mutation are among the most frequently used animal models to study the amyloid pathology related to Alzheimer's disease (AD). The transgene expression in this model is considered to be neuron-specific. Using a novel hAPP-specific...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23550
更新日期:2019-02-01 00:00:00
abstract::Accumulating evidence indicates that astrocytes are actively involved in the physiological and pathophysiological functions of the brain. Intracellular Ca2+ signaling, especially Ca2+ release from the endoplasmic reticulum (ER), is considered to be crucial for the regulation of astrocytic functions. Mice with genetic ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23531
更新日期:2019-01-01 00:00:00
abstract::Injection of Fluoro-Gold (FG) into the whisker pad of rats yields a stable retrograde labeling of facial motoneurons. After removal of 10 mm from the facial nerve the microglia phagocytose the FG-prelabeled dead neurons and assume the label. A subsequent brightfield immunostaining of the sections with HRP-DAB as end-p...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1136(199602)16:2<129::AID-GLIA5
更新日期:1996-02-01 00:00:00
abstract::Myelination in corpus callosum plays important role for normal brain functions by transferring neurological information between various brain regions. However, the factors controlling expression of myelin genes in myelination are poorly understood. Here, CXXC5, a recently identified protein with CXXC-type zinc finger ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22932
更新日期:2016-03-01 00:00:00
abstract::Glial fibrillary acidic protein (GFAP) immunoreactivity has been used to study the astroglial response in the rat spinal cord to long-term portacaval shunt (PCS). The astroglial response in PCS rats is heterogeneous. In general, astrocytes show a loss of GFAP immunoreactivity, as well as shrinking and pyknosis in thei...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440040408
更新日期:1991-01-01 00:00:00
abstract::Glial cells have been shown to express several biophysically and pharmacology distinct potassium channel types. However, the molecular identity of most glial K+ channels is unknown. We have developed an antibody specific for the Shaker type potassium channel Kv1.5 protein, and demonstrate by immunohistochemistry the p...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1136(199611)18:3<177::AID-GLIA2
更新日期:1996-11-01 00:00:00
abstract::Astrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor the spatial relationship between astrocytes and injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions in a mouse amyotrophic lateral sclerosis (AL...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::It has become evident recently only that microglia are not only responsible for immunomodulatory functions in the brain but represent vital components of the larger synaptic formation, which also includes pre and postsynaptic neurones as well as astrocytes. Microglia critically contribute to CNS homeostasis by their a...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.22372
更新日期:2013-01-01 00:00:00
abstract::The crosstalk between glial cells and neurons represents an exceptional feature for maintaining the normal function of the central nervous system (CNS). Increasing evidence has revealed the importance of glial progenitor cells in adult neurogenesis, reestablishment of cellular pools, neuroregeneration, and axonal (re)...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23922
更新日期:2021-03-01 00:00:00
abstract::We characterized morphological effects of the endogenous excitotoxin, glutamate in ex vivo retinal segments prepared from 30-day-old rats. Initial changes induced by glutamate consisted of reversible, sodium-dependent Müller cell swelling. This glial swelling was mimicked by glutamate transport substrates but not by i...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:1999-02-15 00:00:00
abstract::Inhibition of Rho-kinase (ROCK) with Y27632 stimulates sprouting by injured corticospinal tract and dorsal column tract axons, and accelerates functional recovery. However, regeneration of these axons across the glial scar was not observed. Here we examined the effects of Y27632 treatment on chondroitin sulfate proteo...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20466
更新日期:2007-03-01 00:00:00