Abstract:
:The distribution of metallothioneins I/II in the mouse brain and their specific area distribution upon physical stress were studied. To induce physical stress, groups of mice were subjected to total darkness for different periods (2 weeks, 1 month, and 2 months). The concentration of metallothioneins, evaluated by immunohistochemistry, as well as area-specific protein expression, were found in the following quantitative order: corpus striatum, cerebellum, mesencephalon, hippocampus with fornix, parts of thalamus, and pons. All other brain areas were marginally affected, or even unaffected, in terms of immunopositive metallothionein reaction. Metallothionein I/II expression was compared with the immunopositivity of glial fibrillary acidic protein (GFAP). It is noteworthy that metallothioneins and GFAP are expressed in different types of astrocytes.
journal_name
Gliajournal_title
Gliaauthors
Beltramini M,Di Pisa C,Zambenedetti P,Wittkowski W,Mocchegiani E,Musicco M,Zatta Pdoi
10.1002/glia.20020subject
Has Abstractpub_date
2004-07-01 00:00:00pages
30-4issue
1eissn
0894-1491issn
1098-1136journal_volume
47pub_type
杂志文章相关文献
GLIA文献大全abstract::The p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75(NTR) is strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this receptor on these...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20857
更新日期:2009-10-01 00:00:00
abstract::Inflammatory changes have been found in Parkinson's disease, in humans intoxicated with the parkinsonian toxin MPTP, and in animal models of the disease. However, it is still not known whether inflammatory changes are responsible for active nerve cell death or if they have a protective role against neurodegeneration. ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20015
更新日期:2004-05-01 00:00:00
abstract::Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures, but neither oligodendrocytes nor neurons, constitutively expressed cell surface MHC class I molecules. Interferon-gamma (IFN-gamma) treatment led to induction of ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440080307
更新日期:1993-07-01 00:00:00
abstract::Cyclic AMP suppresses immune cell activation and inflammation. The positive feedback loop of proinflammatory cytokine production and immune activation implies that cytokines may not only be regulated by cyclic AMP but also conversely regulate cyclic AMP. This study examined the effects of tumor necrosis factor (TNF)-α...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22401
更新日期:2012-12-01 00:00:00
abstract::By promoting cell proliferation, survival and maturation insulin-like growth factor (IGF)-I is essential to the normal growth and development of the central nervous system. It is clear that IGF-I actions are primarily mediated by the type I IGF receptor (IGF1R), and that phosphoinositide 3 (PI3)-Akt kinases and MAP ki...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20984
更新日期:2010-07-01 00:00:00
abstract::This article reviews how the uptake of neurotransmitter by glial amino acid transporters limits the spatial spread of transmitter to preserve the independent operation of nearby synapses, temporally shapes postsynaptic currents, and regulates the effects of tonic transmitter release. We demonstrate the importance of a...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.20027
更新日期:2004-08-15 00:00:00
abstract::Much current knowledge of oligodendrocyte biology, the myelin-forming cells in the central nervous system, comes from cell culture studies mainly from postnatal rat tissue but mouse cells have been much more difficult to produce in large quantities. We have developed a high yield protocol for production of oligodendro...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20702
更新日期:2008-09-01 00:00:00
abstract::Neural progenitor cells (NPCs) are sequentially specified into neurons and glia during the development of central nervous system. WNT/β-catenin signaling is known to regulate the balance between the proliferation and differentiation of NPCs during neurogenesis. However, the function of WNT/β-catenin signaling during g...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23608
更新日期:2019-07-01 00:00:00
abstract::Integrins are transmembrane receptors that mediate cell-extracellular matrix and cell-cell interactions. The β1-integrin subunit is highly expressed by embryonic neural stem cells (NSCs) and is critical for NSC maintenance in the developing nervous system, but its role in the adult hippocampal niche remains unexplored...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22996
更新日期:2016-07-01 00:00:00
abstract::The detection of nucleic acids by the innate immune system is an essential host response during viral infection. In recent years, a number of immune sensors capable of recognizing cytosolic DNA have been identified and include the PYHIN family members AIM2, IFI16, and p204 as well as the enzyme, cGAS. Activation of th...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22786
更新日期:2015-05-01 00:00:00
abstract::The extrasynaptic region of the squid giant nerve fiber exhibits neuron-Schwann cell interactions that appear to involve glutamate as a mediator. In an earlier work, it was demonstrated that the periaxonal sheaths of such nerves (where the Schwann cells are located) possess the capacity to transport glutamate. However...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/(sici)1098-1136(199808)23:4<298::aid-glia2
更新日期:1998-08-01 00:00:00
abstract::After the initial mechanical insult of spinal cord injury (SCI), secondary mediators propagate a massive loss of oligodendrocytes. We previously showed that following SCI both the total phospholipase activity and cytosolic PLA(2)-IV alpha protein expression increased. However, the expression of secreted isoforms of PL...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20867
更新日期:2009-11-01 00:00:00
abstract::Two types of glial cells occur in the retina, Müller cells and astrocytes. These cells share several structural features such as extending endfeet onto blood vessels of the retina. Retinal vessels express a tight blood-retinal barrier which is comparable to the blood-brain barrier (BBB) of the CNS. While astrocytes ha...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440070205
更新日期:1993-02-01 00:00:00
abstract::Accumulating evidence has revealed that astrocytes are potential targets for various neurotransmitters. Here we investigated the effects of prostaglandins (PGs) on signal transduction in purified primary cultures of rat type-1 and type-2 astrocytes. PGF2 alpha, PGD2, and 9 alpha,11 beta-PGF2, a metabolite of PGD2 and ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440060109
更新日期:1992-01-01 00:00:00
abstract::Olfactory ensheathing cells (OECs) are a unique type of macroglia required for normal olfactory axonal regeneration throughout the lifetime of an individual. Recent evidence in the literature suggests that OECs transplanted into injured spinal cords may facilitate axonal regeneration. In this study, we evaluated the n...
journal_title:Glia
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::The X-linked mutation rumpshaker (rsh), which is probably an allele of jimpy (jp), causes hypomyelination in the CNS of mice. This study examines the developmental expression of the morphology, glial cells, and immunostaining of myelin proteins in the optic nerve and spinal cord. The optic nerve contains varying numbe...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440050302
更新日期:1992-01-01 00:00:00
abstract::Microglia have diverse actions, ranging from synapse pruning in development to cytotoxic effects in disease. Brain energy metabolism and substrate availability vary under normal and disease states, but how these variations influence microglial function is relatively unknown. Microglia, like most other cell types, expr...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23271
更新日期:2018-06-01 00:00:00
abstract::IQSEC3, a guanine nucleotide exchange factor for ADP-ribosylation factors (ARF-GEFs) is specifically expressed at GABAergic synapses, and its loss increases seizure susceptibility in mice. However, the contribution of microglia to initiation and/or progression of seizures in IQSEC3-deficient mice has not been investig...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23876
更新日期:2020-12-01 00:00:00
abstract::We demonstrate that there are significantly more p75 neurotrophin receptor- (NTR)-expressing cells in olfactory ensheathing cell (OEC) primary cultures from olfactory nerve rootlets (ONR), but a greater proportion of O4 antigen- and PSA-NCAM-expressing cells in parallel cultures from the nerve fibre layer of the olfac...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20154
更新日期:2005-04-01 00:00:00
abstract::The mitogenic role of sphingosine-1-phosphate (S1P) and its involvement in basic fibroblast growth factor (bFGF)-induced proliferation were examined in primary cultures of cerebellar astrocytes. Exposure to bFGF resulted in a rapid increase of extracellular S1P formation, bFGF inducing astrocytes to release S1P, but n...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20324
更新日期:2006-04-15 00:00:00
abstract::Blood macrophages and brain macrophages (microglia) have been implicated in demyelination and destruction of the oligodendrocyte in multiple sclerosis (MS), a disease affecting primarily white matter of the central nervous system (CNS). In this study, we demonstrate that at high effector to target cell ratios, normal ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440040311
更新日期:1991-01-01 00:00:00
abstract::The glial cells that ensheath olfactory axons are referred to as ensheathing cells. In vivo, these non-myelinating glial cells express a mixture of astrocyte-specific and Schwann cell-specific phenotypic features with the former cellular phenotype predominating, but in vitro can assemble a myelin sheath when co-cultur...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.440100408
更新日期:1994-04-01 00:00:00
abstract::Gliomas are a heterogenous group of malignant primary brain tumors that arise from glia cells or their progenitors and rely on accurate diagnosis for prognosis and treatment strategies. Although recent developments in the molecular biology of glioma have improved diagnosis, classical histological methods and biomarker...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23594
更新日期:2019-08-01 00:00:00
abstract::Transcriptional regulation of the glial fibrillary acidic protein gene (GFAP) is of interest because of its astrocyte specificity and its upregulation in response to CNS injuries. We have used a transgenic approach instead of cell transfection to identify promoter elements of the human GFAP gene, since previous observ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22536
更新日期:2013-09-01 00:00:00
abstract::Minocycline, a derivative of the antibiotic tetracycline, displays neuroprotective properties in various models of neurodegenerative diseases and is now used in clinical trials, because of its relative safety and tolerability. Minocycline passes the blood-brain barrier and is presumed to inhibit microglial activation....
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20268
更新日期:2006-02-01 00:00:00
abstract::Microglia are key players of the immune response in the central nervous system (CNS) and, being the resident innate immune cells, they are responsible for the early control of infections and for the recruitment of cells of the adaptive immune system required for pathogen clearance. The innate and adaptive immune respo...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.20928
更新日期:2010-02-01 00:00:00
abstract::Water balance between cells and extracellular compartments is essential for proper functioning of the central nervous system, as demonstrated by its perturbations in pathological conditions. Aquaporin 4 (AQP4) is the predominant water channel in brain and spinal cord, where it is present mainly on astrocytic endfeet c...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20196
更新日期:2005-08-01 00:00:00
abstract::Hypoglycemia is a common and serious problem among diabetic patients receiving treatment with insulin or other glucose-lowering drugs. Moderate hypoglycemia impairs neurological function, and severe hypoglycemia leads to death of selectively vulnerable neurons. Recent advances have shed new light on the underlying pro...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.20440
更新日期:2007-09-01 00:00:00
abstract::Astrocytes, together with microglia and macrophages, participate in innate inflammatory responses in the CNS. Although inflammatory mediators such as interferons generated by astrocytes may be critical in the defense of the CNS, sustained unopposed cytokine signaling could result in harmful consequences. Interferon re...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.21233
更新日期:2011-12-01 00:00:00
abstract::Astrocytes express gap junction proteins and multiple types of P2Y receptors (P2YRs) that contribute to the propagation of intercellular Ca(2+) waves (ICW). To gain access to the role played by gap junctional communication in ICW propagation generated by P2YR activation, we selectively expressed P2Y(1,2,4)R subtypes a...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.20071
更新日期:2004-11-15 00:00:00