Early activation, motility, and homing of neonatal microglia to injured neurons does not require protein synthesis.

abstract：:The Alzheimer disease-associated multifunctional low-density lipoprotein receptor-related protein-1 is expressed in the brain. Recent studies uncovered a role of this receptor for the appropriate functioning of neural stem cells, oligodendrocytes, and neurons. The constitutive knock-out (KO) of the receptor is embryon...

journal_title：Glia

authors： Bres EE,Safina D,Müller J,Bedner P,Yang H,Helluy X,Shchyglo O,Jansen S,Mark MD,Esser A,Steinhäuser C,Herlitze S,Pietrzik CU,Sirko S,Manahan-Vaughan D,Faissner A

更新日期：2020-12-01 00:00:00

abstract：:Zinc finger transcription factors of the Krüppel-class figure prominently in cell fate specification and differentiation in the nervous system. One of the Krüppel-type genes that was originally cloned from an oligodendrocyte library by virtue of its homology with the prototypic Krüppel motif is the rat rKr2 gene (Pott...

journal_title：Glia

authors： Lovas G,Li W,Pott U,Verga T,Hudson LD

更新日期：2001-04-15 00:00:00

abstract：:Glial cells in vitro express at least two types (H1 and H2) of histamine receptors and three types (EP, FP, and TP) of prostanoid receptors. The receptors expressed by glial cells differ according to the cell type and source in the brain. Furthermore primary astrocytes of same type derived from the same brain region a...

journal_title：Glia

authors： Inagaki N,Wada H

更新日期：1994-06-01 00:00:00

abstract：:Astrocytes express gap junction proteins and multiple types of P2Y receptors (P2YRs) that contribute to the propagation of intercellular Ca(2+) waves (ICW). To gain access to the role played by gap junctional communication in ICW propagation generated by P2YR activation, we selectively expressed P2Y(1,2,4)R subtypes a...

journal_title：Glia

authors： Suadicani SO,Flores CE,Urban-Maldonado M,Beelitz M,Scemes E

更新日期：2004-11-15 00:00:00

abstract：:The removal by phagocytosis of degenerated myelin is central for repair in Wallerian degeneration that follows traumatic injury to axons and in autoimmune demyelinating diseases (e.g., multiple sclerosis). We tested for roles played by the cAMP cascade in the regulation of myelin phagocytosis mediated by complement re...

journal_title：Glia

authors： Makranz C,Cohen G,Reichert F,Kodama T,Rotshenker S

更新日期：2006-03-01 00:00:00

abstract：:The prospects of achieving regeneration in the central nervous system (CNS) have changed, as most recent findings indicate that several species, including humans, can produce neurons in adulthood. Studies targeting this property may be considered as potential therapeutic strategies to respond to injury or the effects ...

journal_title：Glia

authors： Gómez RM,Sánchez MY,Portela-Lomba M,Ghotme K,Barreto GE,Sierra J,Moreno-Flores MT

更新日期：2018-07-01 00:00:00

abstract：:In the central nervous system, glial cells play an important role in inflammatory and immune responses, and opioid peptides have been identified as essential mediators between the nervous and the immune systems. We report the profound upregulation of the opioid-related nociceptin/orphanin FQ (N/OFQ) by inflammatory me...

journal_title：Glia

authors： Buzas B,Rosenberger J,Kim KW,Cox BM

更新日期：2002-09-01 00:00:00

abstract：:Astrocytes extend thin lamellate processes in the neuropil, in particular around synapses, where they can modulate synaptic function or mediate glial-neuronal communication. Previous studies have shown that these lamellate perisynaptic processes change their shape in response to neuronal activity, but the underlying m...

journal_title：Glia

authors： Derouiche A,Frotscher M

更新日期：2001-12-01 00:00:00

abstract：:Human brain macrophages (microglia) have been isolated from mixed brain cell cultures initiated from explants of neurosurgical adult human tissue in one step according to a method developed for rat microglia. Cells were characterized enzyme-histochemically (NDPase) in mixed and immunocytochemically (anti-CD 14) in mix...

journal_title：Glia

authors： Nörenberg W,Illes P,Gebicke-Haerter PJ

更新日期：1994-03-01 00:00:00

abstract：:Within the last few years, the expression of voltage-dependent, TTX-sensitive Na+ channels has been demonstrated in several types of neuroglial cells such as astrocytes and Schwann cells. Recently, we reported the occurrence of such Na+ currents in retinal Müller (glial) cells from dog and cat. This paper deals with t...

journal_title：Glia

authors： Chao TI,Skachkov SN,Eberhardt W,Reichenbach A

更新日期：1994-03-01 00:00:00

abstract：:Astrocytes play a key role regulating aspects of inflammation in the central nervous system (CNS). Several enzymes, such as the inducible nitric oxide synthase (iNOS) or the cyclooxygenase-2 (COX-2), along with different inflammatory mediators such as the free radical nitric oxide (NO) or proinflammatory cytokines, ha...

journal_title：Glia

authors： Ortega-Gutiérrez S,Molina-Holgado E,Guaza C

更新日期：2005-11-01 00:00:00

abstract：:The X-linked mutation rumpshaker (rsh), which is probably an allele of jimpy (jp), causes hypomyelination in the CNS of mice. This study examines the developmental expression of the morphology, glial cells, and immunostaining of myelin proteins in the optic nerve and spinal cord. The optic nerve contains varying numbe...

journal_title：Glia

authors： Fanarraga ML,Griffiths IR,McCulloch MC,Barrie JA,Kennedy PG,Brophy PJ

更新日期：1992-01-01 00:00:00

abstract：:There is increasing evidence that chemokines, specialized regulators of the peripheral immune system, are also involved in the physiology and pathology of the CNS. It is known that glial cells (astrocytes and microglia) express various chemokine receptors like CCR1, -3, -5, and CXCR4. We have investigated the possible...

journal_title：Glia

authors： Zuurman MW,Heeroma J,Brouwer N,Boddeke HW,Biber K

更新日期：2003-03-01 00:00:00

abstract：:Neuroaxonal degeneration is a pathological hallmark of multiple sclerosis (MS) contributing to irreversible neurological disability. Pathological mechanisms leading to axonal damage include autoimmunity to neuronal antigens. In actively demyelinating lesions, myelin is phagocytosed by microglia and blood-borne macroph...

journal_title：Glia

authors： Huizinga R,van der Star BJ,Kipp M,Jong R,Gerritsen W,Clarner T,Puentes F,Dijkstra CD,van der Valk P,Amor S

更新日期：2012-03-01 00:00:00

abstract：:Previous in vitro studies using cell cultures or brain slices have demonstrated that phospholipase D (PLD) in the nervous system is involved in the signaling mechanism in response to a variety of agonists. However, little is known about the pathophysiological role of PLD-mediated signaling in the adult brain. We exami...

journal_title：Glia

authors： Lee MY,Kim SY,Min DS,Choi YS,Shin SL,Chun MH,Lee SB,Kim MS,Jo YH

更新日期：2000-05-01 00:00:00

abstract：:The synthesis, transport, and insertion of jimpy proteolipid protein and DM20 were studied in normal (158N) and jimpy (158JP) immortalized oligodendrocyte lines. Four different expression vectors encoding fusion proteins composed of native PLP and DM20 or jimpy PLP or DM20 were linked to enhanced green fluorescent pro...

journal_title：Glia

authors： Ghandour MS,Feutz AC,Jalabi W,Taleb O,Bessert D,Cypher M,Carlock L,Skoff RP

更新日期：2002-12-01 00:00:00

abstract：:The mechanisms that control microglial activation are of interest, since neuroinflammation, which involves reactive microglia, may be an additional target in the search for therapeutic strategies to treat neurodegenerative diseases. Neuron-microglia interaction through contact-dependent or independent mechanisms is in...

journal_title：Glia

authors： Dentesano G,Serratosa J,Tusell JM,Ramón P,Valente T,Saura J,Solà C

更新日期：2014-06-01 00:00:00

abstract：:The idea of a metabolic coupling between neurons and astrocytes in the brain has been entertained for about 100 years. The use recently of simple and well-compartmentalized nervous systems, such as the honeybee retina or purified preparations of neurons and glia, provided strong support for a nutritive function of gli...

journal_title：Glia

authors： Tsacopoulos M,Poitry-Yamate CL,Poitry S,Perrottet P,Veuthey AL

更新日期：1997-09-01 00:00:00

abstract：:Astrocytes are arranged in highly organized gap junction-coupled networks, communicating via the propagation of Ca2+ waves. Astrocytes are gap junction-coupled not only to neighboring astrocytes, but also to oligodendrocytes, forming so-called panglial syncytia. It is not known, however, whether glial cells in panglia...

journal_title：Glia

authors： Beiersdorfer A,Scheller A,Kirchhoff F,Lohr C

更新日期：2019-07-01 00:00:00

abstract：:Astrocytes are the most numerous cell type in the central nervous system. When cultured, these cells express a wide variety of receptors for neurotransmitters. Nonetheless, it has yet to be firmly established that adult astrocytes in situ express receptors for neurotransmitters. In this report the technique of combine...

journal_title：Glia

authors： Salm AK,McCarthy KD

更新日期：1989-01-01 00:00:00

abstract：:Water balance between cells and extracellular compartments is essential for proper functioning of the central nervous system, as demonstrated by its perturbations in pathological conditions. Aquaporin 4 (AQP4) is the predominant water channel in brain and spinal cord, where it is present mainly on astrocytic endfeet c...

journal_title：Glia

authors： Vitellaro-Zuccarello L,Mazzetti S,Bosisio P,Monti C,De Biasi S

更新日期：2005-08-01 00:00:00

abstract：:We have analysed in detail the properties of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells derived from the spinal cords of adult rats to gain further insights into the mechanisms that control the generation of oligodendrocytes in the healthy and demyelinated adult central nervous systems (CNS). When O-2A p...

journal_title：Glia

authors： Engel U,Wolswijk G

更新日期：1996-01-01 00:00:00

abstract：:Persistence of radial glia within the adult central nervous system is a widespread phenomenon among fish. Based on a series of studies in the teleost species Apteronotus leptorhynchus, we propose that one function of this persistence is the involvement of radial glia in adult neurogenesis, i.e., the generation and fur...

journal_title：Glia

authors： Zupanc GK,Clint SC

更新日期：2003-07-01 00:00:00

abstract：:Injury to the adult brain results in the formation of a glial scar that involves both activated astroglia and microglia/macrophages. Although reactive gliosis has been linked to failure of axonal regeneration in the adult mammalian CNS, the spatio-temporal pattern of the postlesion responses in morphology and distribu...

journal_title：Glia

authors： Stichel CC,Müller HW

更新日期：1994-02-01 00:00:00

abstract：:Individuals with neurofibromatosis 1 (NF1) develop low-grade astrocytomas at an increased frequency. To gain insight into the function of the Nf1 gene product as a growth regulator for astrocytes, we examined mice heterozygous for a targeted Nf1 mutation. In our previous studies, we demonstrated increased numbers of p...

journal_title：Glia

authors： Bajenaru ML,Donahoe J,Corral T,Reilly KM,Brophy S,Pellicer A,Gutmann DH

更新日期：2001-03-15 00:00:00

abstract：:Our previous studies demonstrated the involvement of quinone formation in dopaminergic neuron dysfunction in the L-DOPA-treated parkinsonian model and in methamphetamine (METH) neurotoxicity. We further reported that the cysteine-rich metal-binding metallothionein (MT) family of proteins protects dopaminergic neurons ...

journal_title：Glia

authors： Miyazaki I,Asanuma M,Kikkawa Y,Takeshima M,Murakami S,Miyoshi K,Sogawa N,Kita T

更新日期：2011-03-01 00:00:00

abstract：:In the last decade, microRNAs have been increasingly recognized as key modulators of glial development. Recently, we identified miR-125a-3p as a new player in oligodendrocyte physiology, regulating in vitro differentiation of oligodendrocyte precursor cells (OPCs). Here, we show that miR-125a-3p is upregulated in acti...

journal_title：Glia

authors： Marangon D,Boda E,Parolisi R,Negri C,Giorgi C,Montarolo F,Perga S,Bertolotto A,Buffo A,Abbracchio MP,Lecca D

更新日期：2020-10-01 00:00:00

abstract：:Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport, and cytoskeletal dynamics. Although abnormalities of myelin are common in lysosomal storage diseases, our understanding of the role of lysosomes in the formation and maintenance of myelin is still limited. Here, we sh...

journal_title：Glia

authors： Chen G,Zhang Z,Wei Z,Cheng Q,Li X,Li W,Duan S,Gu X

更新日期：2012-02-01 00:00:00

abstract：:To explore pathways to neuron loss in inflammatory diseases, transgenic mice expressing beta-galactosidase (beta-gal) in either astrocytes or photoreceptor cells, or both, were inoculated with activated, beta-gal-specific cytotoxic CD8 T lymphocytes (CTLs). beta-gal-positive astrocytes in brain were rapidly attacked, ...

journal_title：Glia

authors： McPherson SW,Heuss ND,Roehrich H,Gregerson DS

更新日期：2006-04-01 00:00:00

abstract：:Microglia are CNS resident immune cells and a rich source of neuroactive mediators, but their contribution to physiological brain processes such as synaptic plasticity, learning, and memory is not fully understood. In this study, we used mice with partial depletion of IκB kinase β, the main activating kinase in the in...

journal_title：Glia

authors： Kyrargyri V,Vega-Flores G,Gruart A,Delgado-García JM,Probert L

更新日期：2015-04-01 00:00:00