Abstract:
:An organism's response to stress requires activation of multiple brain regions. This can have long-lasting effects on synaptic transmission and plasticity that likely provide adaptive benefits. Recent evidence implicates not only neurones, but also glial cells in the regulation of the central response to stress. Intense, repeated or uncontrolled stress has been implicated in the emergence of multiple neuropsychiatric conditions. Human studies have consistently observed glial dysfunction in mood and stress disorders such as major depression. Interestingly animal models of stress have recapitulated glial abnormalities that are comparable to the human condition, validating the use of rodent models for the study of stress disorders. In this review we will focus upon one family of glia, the astrocytes, and describe the evidence to date that links astrocytes to possible stress-related disorders.
journal_name
Gliajournal_title
Gliaauthors
Murphy-Royal C,Gordon GR,Bains JSdoi
10.1002/glia.23610subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1806-1820issue
10eissn
0894-1491issn
1098-1136journal_volume
67pub_type
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