Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor.

abstract：:Several lines of evidence indicate that the elaborated calcium signals and the occurrence of calcium waves in astrocytes provide these cells with a specific form of excitability. The identification of the cellular and molecular steps involved in the triggering and transmission of Ca(2+) waves between astrocytes result...

journal_title：Glia

authors： Scemes E,Giaume C

更新日期：2006-11-15 00:00:00

abstract：:The present study describes a method to inhibit selectively the microglial cell proliferation following peripheral nerve injury. Continuous infusion of cytosine-arabinoside (ARA-C) from an osmotic minipump to the fourth ventricle or cisterna magna completely blocks the proliferation of microglial cells that normally o...

journal_title：Glia

authors： Svensson M,Aldskogius H

更新日期：1993-04-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome frequently accompanying liver cirrhosis and reflects the clinical manifestation of a low grade cerebral edema associated with cerebral oxidative/nitrosative stress. The multidrug resistance-associated protein (Mrp) 4 is an export pump which transports metaboli...

journal_title：Glia

authors： Jördens MS,Keitel V,Karababa A,Zemtsova I,Bronger H,Häussinger D,Görg B

更新日期：2015-11-01 00:00:00

abstract：:Oligodendrocyte differentiation and myelination involve dramatic changes in cell signaling pathways, gene expression patterns, cell shape, and cytoskeletal organization. In a pilot study investigating CNS angiogenesis, oligodendrocytes were intensely labeled by antisera directed against the C-terminal of Tie-2, a 140-...

journal_title：Glia

authors： Terada N,Kidd GJ,Kinter M,Bjartmar C,Moran-Jones K,Trapp BD

更新日期：2005-05-01 00:00:00

abstract：:The red nucleus (RN) has been widely used to study the formation and remodeling of synaptic connections during development and in post-lesion plasticity. Since glial cells are thought to contribute to synaptic plasticity, and information on functional properties of brain stem glia is missing, we analyzed voltage-gated...

journal_title：Glia

authors： Akopian G,Kuprijanova E,Kressin K,Steinhüser C

更新日期：1997-03-01 00:00:00

abstract：:Oligodendroglia and Schwann cells synthesize myelin-specific proteins and lipids for the assembly of the highly organized myelin membrane of the motor-sensory axons in the central (CNS) and peripheral nervous system (PNS), respectively, allowing rapid saltatory conduction. The isoforms of the main myelin proteins, the...

journal_title：Glia

authors： Spörkel O,Uschkureit T,Büssow H,Stoffel W

更新日期：2002-01-01 00:00:00

abstract：:IQSEC3, a guanine nucleotide exchange factor for ADP-ribosylation factors (ARF-GEFs) is specifically expressed at GABAergic synapses, and its loss increases seizure susceptibility in mice. However, the contribution of microglia to initiation and/or progression of seizures in IQSEC3-deficient mice has not been investig...

journal_title：Glia

authors： Park D,Kim S,Kim H,Shin J,Jung H,Um JW

更新日期：2020-12-01 00:00:00

abstract：:The goal of this study was to investigate the reaction of the Müller cells to elevated intraocular pressure (IOP). Elevated IOP is one of the risk factors in glaucomatous retinal ganglion cell (RGC) degeneration. Müller cells play an important role in retinal homeostasis. The reaction of Müller cells was examined by e...

journal_title：Glia

authors： Woldemussie E,Wijono M,Ruiz G

更新日期：2004-08-01 00:00:00

abstract：:Recent studies have suggested that Nkx6.2/Gtx and Nkx2.2 homeodomain transcription factors are involved in the regulation of oligodendrocyte maturation and/or myelination which occur predominantly in postnatal stages. However, their cellular specificity in postnatal central nervous system has not been characterized an...

journal_title：Glia

authors： Cai J,Zhu Q,Zheng K,Li H,Qi Y,Cao Q,Qiu M

更新日期：2010-03-01 00:00:00

abstract：:We have shown previously that switching of the alpha v-associated beta1 and beta5 integrin subunits during differentiation of myelin-forming oligodendrocytes may regulate important aspects of cell behaviour such as migration (Milner et al., 1996: J Neurosci 16:7240-7252). In this study we have examined the development...

journal_title：Glia

authors： Milner R,Frost E,Nishimura S,Delcommenne M,Streuli C,Pytela R,Ffrench-Constant C

更新日期：1997-12-01 00:00:00

abstract：:Astrocytes are thought to exert diverse functions in the brain, but it has been difficult to prove this in vivo because of a scarcity of tools to manipulate these cells. Here, we report the generation of new transgenic mouse lines that allow for conditional gene ablation in astrocytes using the tamoxifen- (TAM-) induc...

journal_title：Glia

authors： Slezak M,Göritz C,Niemiec A,Frisén J,Chambon P,Metzger D,Pfrieger FW

更新日期：2007-11-15 00:00:00

abstract：:Apoptosis of dentate granular cells in the hippocampal formation during bacterial meningitis may be mediated by glutamate toxicity. For this reason, we studied the relationship between glutamine synthetase activity and regional neuronal apoptosis in rabbits with experimental pneumococcal meningitis. The duration of me...

journal_title：Glia

authors： Tumani H,Smirnov A,Barchfeld S,Olgemöller U,Maier K,Lange P,Brück W,Nau R

更新日期：2000-03-01 00:00:00

abstract：:To study the role of L-type voltage-gated Ca++ channels in oligodendrocyte development, we used a mouse model of Timothy syndrome (TS) in which a gain-of-function mutation in the α1 subunit of the L-type Ca++ channel Cav1.2 gives rise to an autism spectrum disorder (ASD). Oligodendrocyte progenitor cells (OPCs) isolat...

journal_title：Glia

authors： Cheli VT,Santiago González DA,Zamora NN,Lama TN,Spreuer V,Rasmusson RL,Bett GC,Panagiotakos G,Paez PM

更新日期：2018-11-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP-1) is a ubiquitous nuclear enzyme involved in genomic stability. Excessive oxidative DNA strand breaks lead to PARP-1-induced depletion of cellular NAD(+), glycolytic rate, ATP levels, and eventual cell death. Glutamate neurotransmission is tightly controlled by ATP-dependent astroc...

journal_title：Glia

authors： Tang KS,Suh SW,Alano CC,Shao Z,Hunt WT,Swanson RA,Anderson CM

更新日期：2010-03-01 00:00:00

abstract：:The Alzheimer disease-associated multifunctional low-density lipoprotein receptor-related protein-1 is expressed in the brain. Recent studies uncovered a role of this receptor for the appropriate functioning of neural stem cells, oligodendrocytes, and neurons. The constitutive knock-out (KO) of the receptor is embryon...

journal_title：Glia

authors： Bres EE,Safina D,Müller J,Bedner P,Yang H,Helluy X,Shchyglo O,Jansen S,Mark MD,Esser A,Steinhäuser C,Herlitze S,Pietrzik CU,Sirko S,Manahan-Vaughan D,Faissner A

更新日期：2020-12-01 00:00:00

abstract：:Vestibular schwannomas (VSs) are benign tumors that arise from the Schwann cells (SCs) lining the vestibular nerve. VS cells survive and proliferate far from neurons and axonally derived growth factors. We have previously shown that VSs produce the glial growth factor, neuregulin-1 (NRG1), and its receptors, ErbB2 and...

journal_title：Glia

authors： Hansen MR,Roehm PC,Chatterjee P,Green SH

更新日期：2006-04-15 00:00:00

abstract：:Differentiation of oligodendrocyte precursor cells (OPCs) is the most important event for the myelination of central nervous system (CNS) axons during development and remyelination in demyelinating diseases, while the underlying molecular mechanisms remain largely unknown. Here we show that NMDA receptor (NMDAR) is a ...

journal_title：Glia

authors： Li C,Xiao L,Liu X,Yang W,Shen W,Hu C,Yang G,He C

更新日期：2013-05-01 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor Ascl1 plays crucial roles in both oligodendrocyte development and neuronal development; however, the molecular target of Ascl1 in oligodendrocyte progenitor cells (OPCs) remains elusive. To identify the downstream targets of Ascl1 in OPCs, we performed gene expres...

journal_title：Glia

authors： Ueno T,Ito J,Hoshikawa S,Ohori Y,Fujiwara S,Yamamoto S,Ohtsuka T,Kageyama R,Akai M,Nakamura K,Ogata T

更新日期：2012-10-01 00:00:00

abstract：:Reorganization of the adult dentate gyrus following unilateral entorhinal cortex lesion (ECL) is a well-established model for studying mechanisms of trauma-induced neuronal plasticity. The lesion induces deafferentiation of the outer molecular layer, which is accompanied by a strong astroglial reaction. This glial res...

journal_title：Glia

authors： Schröder W,Hager G,Kouprijanova E,Weber M,Schmitt AB,Seifert G,Steinhäuser C

更新日期：1999-11-01 00:00:00

abstract：:Glial tumor cells derived from primary tissue express large voltage-gated Na(+) currents, whereas glioma cell lines usually lack this feature. We studied the effect of serum deprivation on the expression of Na(+) currents in two astrocytoma cell lines (1321N1 and A172). Serum deprivation for more than 2 days sufficed ...

journal_title：Glia

authors： Kraft R,Basrai D,Benndorf K,Patt S

更新日期：2001-04-01 00:00:00

abstract：:Gliogenesis in the mammalian CNS continues after birth, with astrocytes being generated well into the first two postnatal weeks. In this study, we have isolated an A2B5(+) astrocyte precursor (APC) from the postnatal rat forebrain, which is capable of differentiating into mature astrocytes in serum-free medium without...

journal_title：Glia

authors： Lin G,Goldman JE

更新日期：2009-04-15 00:00:00

abstract：:Focal ischemic stroke (FIS) is a leading cause of human death. Glial scar formation largely caused by reactive astrogliosis in peri-infarct region (PIR) is the hallmark of FIS. Glial cell-derived neurotrophic factor (GDNF) was originally isolated from a rat glioma cell-line supernatant and is a potent survival neurotr...

journal_title：Glia

authors： Zhang N,Zhang Z,He R,Li H,Ding S

更新日期：2020-11-01 00:00:00

abstract：:NG2 is a type 1 integral membrane glycoprotein encoded by the Cspg4 gene. It is expressed on glial progenitor cells known as NG2 glial cells or oligodendrocyte precursor cells that exist widely throughout the developing and mature central nervous system and vascular mural cells but not on mature oligodendrocytes, astr...

journal_title：Glia

authors： Gotoh H,Wood WM,Patel KD,Factor DC,Boshans LL,Nomura T,Tesar PJ,Ono K,Nishiyama A

更新日期：2018-12-01 00:00:00

abstract：:Sulfated glycosaminoglycans (S-GAGs) were isolated from the pericellular (P), intracellular (I), and extracellular (E) compartments of astrocytes cultures from lateral (L) and medial (M) sectors of embryonic mouse midbrain; these sectors differ in their ability to support neurite growth (L, permissive, M, non-permissi...

journal_title：Glia

authors： Garcia-Abreu J,Silva LC,Tovar FF,Onofr- GR,Cavalcante LA,Moura Neto V

更新日期：1996-08-01 00:00:00

abstract：:Microglial cells are the resident macrophages that are involved in brain injuries and infections. Recent studies using transcranial two-photon microscopy have shown that ATP and P2Y receptors mediated rapid chemotactic responses of miroglia to local injury. However, the molecular mechanism for microglial chemotaxis to...

journal_title：Glia

authors： Wu LJ,Vadakkan KI,Zhuo M

更新日期：2007-06-01 00:00:00

abstract：:Semaphorin 7A (Sema7A) is involved in the formation of the central nervous system during development by operating axon guidance and neuronal migration. We investigated the expression of the TGFβ-inducible Sema7A following spinal cord injury (SCI). After SCI, Sema7A(+) cells accumulated specifically in lesion areas res...

journal_title：Glia

authors： Kopp MA,Brommer B,Gatzemeier N,Schwab JM,Prüss H

更新日期：2010-11-01 00:00:00

abstract：:Glial cells have been shown to express several biophysically and pharmacology distinct potassium channel types. However, the molecular identity of most glial K+ channels is unknown. We have developed an antibody specific for the Shaker type potassium channel Kv1.5 protein, and demonstrate by immunohistochemistry the p...

journal_title：Glia

authors： Roy ML,Saal D,Perney T,Sontheimer H,Waxman SG,Kaczmarek LK

更新日期：1996-11-01 00:00:00

abstract：:Injury to the mammalian spinal cord is accompanied by a delayed, secondary wave of oligodendrocyte apoptosis that arises several days after the initial injury. A strong candidate to support oligodendrocyte survival after spinal cord injury is the pleiotropic cytokine, leukemia inhibitory factor (LIF). In vitro, LIF po...

journal_title：Glia

authors： Kerr BJ,Patterson PH

更新日期：2005-07-01 00:00:00

abstract：:Adult Sprague-Dawley rats were given a single dose of trimethyltin chloride (TMT). Three days following treatment, a neuronal alteration was observed in the CA3c pyramidal cell layer of hippocampus which was not accompanied by any apparent astrocyte reaction. At 1 as well as 2 weeks after treatment, a gliosis in hippo...

journal_title：Glia

authors： Andersson H,Luthman J,Olson L

更新日期：1994-08-01 00:00:00

abstract：:Neural progenitor cells (NPCs) are sequentially specified into neurons and glia during the development of central nervous system. WNT/β-catenin signaling is known to regulate the balance between the proliferation and differentiation of NPCs during neurogenesis. However, the function of WNT/β-catenin signaling during g...

journal_title：Glia

authors： Sun S,Zhu XJ,Huang H,Guo W,Tang T,Xie B,Xu X,Zhang Z,Shen Y,Dai ZM,Qiu M

更新日期：2019-07-01 00:00:00