Abstract:
:Epilepsy is characterized by unpredictable recurrent seizures resulting from hypersynchronous discharges from neuron assemblies. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability. Purinergic signaling is central in neuron-glia and glia-glia interactions and dysfunctions in communication pathways involving purinergic receptors have been reported in various CNS pathologies, such as Alzheimer disease, stroke, major depression, schizophrenia, and epilepsy. In the present review we will first discuss the mechanisms by which astrocytes influence neuronal activity. We will then review in more details recent evidence indicating that dysregulation of astrocyte purinergic signaling actively contributes to the appearance of abnormal neuronal activity in epilepsy.
journal_name
Gliajournal_title
Gliaauthors
Nikolic L,Nobili P,Shen W,Audinat Edoi
10.1002/glia.23747subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1677-1691issue
9eissn
0894-1491issn
1098-1136journal_volume
68pub_type
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