abstract：:Visual loss from the complications of advanced diabetic retinopathy now can be managed more effectively by surgical vitrectomy with a significant reduction in operative and postoperative ocular morbidity. Ocular structures are now maintained in a more normal physiologic state, leaving the patient's lens in place, help...

journal_title：Annals of internal medicine

authors： Aaberg TM

更新日期：1983-10-01 00:00:00

abstract：:Wilson's disease is an inherited disorder of copper accumulation that is fatal if untreated. Because penicillamine, the established treatment, is toxic in a substantial number of patients, we studied the efficacy of zinc treatment. We induced a negative or neutral copper balance in five out of five patients with Wilso...

journal_title：Annals of internal medicine

authors： Brewer GJ,Hill GM,Prasad AS,Cossack ZT,Rabbani P

更新日期：1983-09-01 00:00:00

abstract：:The four main conceptual paradigms of basic biomedical research are that the explication of mechanisms is a primary goal of science; that scientific data must be "hard"; that formulation of hypotheses and counter-hypotheses is a principal creative challenge; and that experiments are the main mechanism for using scient...

journal_title：Annals of internal medicine

authors： Feinstein AR

更新日期：1983-09-01 00:00:00

abstract：:Clinical and epidemiologic characteristics of disease associated with a newly described nonhalophilic Vibrio species, Vibrio mimicus, were identified by studying isolates from 21 patients referred to the Centers for Disease Control between 1977 and 1981. Two isolates were from the ears of patients with otitis who had ...

journal_title：Annals of internal medicine

authors： Shandera WX,Johnston JM,Davis BR,Blake PA

更新日期：1983-08-01 00:00:00

abstract：:In recent years there has been increasing attention to the appropriate interpretation of a clinical study. One special concern has been the difficulty inherent in interpreting studies that were not statistically significant: Was the sample size sufficient to detect a clinically important effect if, in fact, it existed...

journal_title：Annals of internal medicine

authors： Young MJ,Bresnitz EA,Strom BL

更新日期：1983-08-01 00:00:00

abstract：:A model of activation, proliferation, and differentiation of human lymphocyte responses is described, and the complex immunoregulatory modulation of this system discussed with regard to normal immune function and the aberrancies expressed in diseases characterized by abnormalities of immune function. Recent advances i...

journal_title：Annals of internal medicine

authors： Fauci AS,Lane HC,Volkman DJ

更新日期：1983-07-01 00:00:00

abstract：:A 34-year-old man had polar extremes of B cell dysfunction: systemic lupus erythematosus evolving into common variable hypogammaglobulinemia. He presented in 1974 with seizures and six other criteria for systemic lupus erythematosus; his antinuclear antibody titer was 1:1024 and IgG level, 2870 mg/dL. After 5 months o...

journal_title：Annals of internal medicine

authors： Sussman GL,Rivera VJ,Kohler PF

更新日期：1983-07-01 00:00:00

abstract：:Therapy of pulmonary hypertension is limited by the low potency and adverse effects of current pulmonary vasodilators. The hemodynamic effects of nitroglycerin in human pulmonary hypertension are not known. We administered nitroglycerin to nine patients with chronic pulmonary hypertension. Nitroglycerin increased card...

journal_title：Annals of internal medicine

authors： Pearl RG,Rosenthal MH,Schroeder JS,Ashton JP

更新日期：1983-07-01 00:00:00

abstract：:Nineteen patients with advanced refractory metastatic breast cancer no longer responsive to chemotherapy were treated in the first phase II efficacy trial of recombinant leukocyte A interferon (IFL-rA), a highly purified single molecular species of alpha interferon prepared by recombinant DNA methods. Patients receive...

journal_title：Annals of internal medicine

authors： Sherwin SA,Mayer D,Ochs JJ,Abrams PG,Knost JA,Foon KA,Fein S,Oldham RK

更新日期：1983-05-01 00:00:00

abstract：:Ninety-six patients with life-threatening ventricular arrhythmias refractory to two or more conventional agents were treated with amiodarone and followed for 6 to 40 months (mean, 15 months). Currently, 75 are alive and well. Seven patients died from nonarrhythmic and five from arrhythmic causes. Nonfatal arrhythmias ...

journal_title：Annals of internal medicine

authors： Nademanee K,Singh BN,Hendrickson J,Intarachot V,Lopez B,Feld G,Cannom DS,Weiss JL

更新日期：1983-05-01 00:00:00

abstract：:The observations that have provided the foundation of the sodium hypothesis of human hypertension are reviewed. Clinical observations made over 125 years ago initiated an investigative effort that has encompassed epidemiologic data, development of salt-related experimental models, and elucidation of theoretical mechan...

journal_title：Annals of internal medicine

authors： Porter GA

更新日期：1983-05-01 00:00:00

abstract：:Essential trace elements such as zinc, iron, and copper participate in various enzyme reactions directly related to the regulation of blood pressure and indirectly related to generation of oxidative metabolic energy, alterations in blood lipid levels, and alterations in taste acuity. The toxicological action of severa...

journal_title：Annals of internal medicine

authors： Saltman P

更新日期：1983-05-01 00:00:00

abstract：:In an effort to prevent cytomegalovirus infection among seronegative patients having marrow transplants, a globulin with high antibody levels against cytomegalovirus was given before and for 11 weeks after transplantation in a randomized trial. Among 36 patients who received no prophylactic granulocyte transfusions, g...

journal_title：Annals of internal medicine

authors： Meyers JD,Leszczynski J,Zaia JA,Flournoy N,Newton B,Snydman DR,Wright GG,Levin MJ,Thomas ED

更新日期：1983-04-01 00:00:00

abstract：:The safety of using inhaled beclomethasone dipropionate for the treatment of severe asthma during pregnancy was evaluated during 45 pregnancies in 40 women. Despite chronic administration of theophylline and, in some women, ephedrine, the asthma was so severe that corticosteroids were essential to prevent emergency ro...

journal_title：Annals of internal medicine

authors： Greenberger PA,Patterson R

更新日期：1983-04-01 00:00:00

abstract：:Kidney transplantation is safe, cost-effective, and beneficial for patients with end-stage renal disease. The number of patients who can receive transplants is severely limited by the availability of donor organs. Because most patients do not have a suitable living, related donor, transplant programs now rely on the u...

journal_title：Annals of internal medicine

authors： Waltzer WC

更新日期：1983-04-01 00:00:00

abstract：:A 53-year-old librarian had recurrent palpable purpura on her ankles and legs that was found to be caused by the fumes released from heat-activated photocopy paper at her place of employment. Behenic acid was identified as the responsible chemical component through a series of challenge studies that simulated her work...

journal_title：Annals of internal medicine

authors： Tencati JR,Novey HS

更新日期：1983-03-01 00:00:00

abstract：:Conventional interpretation of clinical trials relies heavily on the classic p value. The p value, however, represents only a false-positive rate, and does not tell the probability that the investigator's hypothesis is correct, given his observations. This more relevant posterior probability can be quantified by an ex...

journal_title：Annals of internal medicine

authors： Diamond GA,Forrester JS

更新日期：1983-03-01 00:00:00

abstract：:Restrictive cardiomyopathy produced by primary cardiac amyloidosis may have a clinical syndrome identical to noncalcific constrictive pericarditis. We report two patients with amyloidosis and restrictive physiology who had enlarged papillary muscles shown on left ventricular angiocardiogram. Rapid volume expansion wit...

journal_title：Annals of internal medicine

authors： Maule WF,Martin RH

更新日期：1983-02-01 00:00:00

abstract：:Giant cell tumor of bone is a rare, but well-recognized complication of Paget's disease of bone. In contrast, giant cell reparative granuloma (a benign tumor of the jaws occurring primarily in young adults) has never been described in association with Paget's disease. Five patients had giant cell lesions complicating ...

journal_title：Annals of internal medicine

authors： Upchurch KS,Simon LS,Schiller AL,Rosenthal DI,Campion EW,Krane SM

更新日期：1983-01-01 00:00:00

abstract：:To ascertain if mitral valve prolapse is inherited we studied 45 probands and 179 first-degree relatives. Echocardiographic mitral prolapse was present in 54 of 179 first-degree relatives (30%); at least one first-degree relative was affected in 29 families, including members of two generations in 23 families. The num...

journal_title：Annals of internal medicine

authors： Devereux RB,Brown WT,Kramer-Fox R,Sachs I

更新日期：1982-12-01 00:00:00

abstract：:Neuroblastoma, the second commonest solid tumor in children, is a neoplasm of the peripheral autonomic nervous system that usually occurs before children are 6 years old. Therapy of localized tumor (clinical stage I and II) and of a special form of metastatic tumor (clinical stage IV-S) is usually successful, but trea...

journal_title：Annals of internal medicine

authors： Seeger RC,Siegel SE,Sidell N

更新日期：1982-12-01 00:00:00

abstract：:Under the current system of disability determination and workers' compensation for occupational lung disease, disabled workers or their survivors can reasonably count on being compensated. However, by rejecting established scientific truth in order to pay workers' compensation in circumstances where disability or deat...

journal_title：Annals of internal medicine

authors： Richman SI

更新日期：1982-12-01 00:00:00

abstract：:Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine. All patients had previous mucocutaneous reactions to chrysotherapy. Manifestations included pleurisy in five of six patients, rashes in three, nephritis in two, and neurologic disturbances...

journal_title：Annals of internal medicine

authors： Chalmers A,Thompson D,Stein HE,Reid G,Patterson AC

更新日期：1982-11-01 00:00:00

abstract：:A cohort of both active and retired older cotton textile workers was examined prospectively over a 6-year period to establish the nature and extent of chronic lung disease. Respiratory symptoms and lung function were studied in these workers and in a group of similarly aged controls. The cotton textile workers had hig...

journal_title：Annals of internal medicine

authors： Beck GJ,Schachter EN,Maunder LR,Schilling RS

更新日期：1982-11-01 00:00:00

abstract：:Deficiency of fat-soluble vitamins (A,D,E, and K) was evaluated in 15 patients with exocrine pancreatic insufficiency secondary to chronic alcoholic pancreatitis. Mild to moderate steatorrhea was present in all patients despite oral pancreatic enzyme therapy for 27 +/- 4 months (mean +/- SE). Deficiency of a single fa...

journal_title：Annals of internal medicine

authors： Dutta SK,Bustin MP,Russell RM,Costa BS

更新日期：1982-10-01 00:00:00

abstract：:We evaluated 10 patients with hidradenitis suppurative or acne conglobata who developed arthritis. In contrast to patients with acne fulminans and arthritis, all our subjects were adults over 22 years of age; nine were black; and four were women. Nine patients had episodic inflammatory oligoarthritis affecting mainly ...

journal_title：Annals of internal medicine

authors： Rosner IA,Richter DE,Huettner TL,Kuffner GH,Wisnieski JJ,Burg CG

更新日期：1982-10-01 00:00:00

abstract：:A 20-year follow-up evaluation of young men with fixed and reproducible orthostatic proteinuria showed no evidence of progressive renal disease. Follow-up information was obtained on 43 of the original 64 patients and detailed information was secured on 36. All had normal renal function and only six patients continued...

journal_title：Annals of internal medicine

authors： Springberg PD,Garrett LE Jr,Thompson AL Jr,Collins NF,Lordon RE,Robinson RR

更新日期：1982-10-01 00:00:00

abstract：:Between June 1980 and September 1981 we evaluated 24 cases of endocarditis from methicillin-resistant Staphylococcus aureus. All of the cases occurred in drug addicts and all were community-acquired. The patients ranged in age from 21 to 59 years and represented an older population than that generally reported for bac...

journal_title：Annals of internal medicine

authors： Levine DP,Cushing RD,Jui J,Brown WJ

更新日期：1982-09-01 00:00:00

abstract：:Barrett's esophagus denotes the presence of columnar epithelium in the esophagus instead of the usual stratified squamous epithelium. Barrett's esophagus had been thought to represent a mediastinal extension of the stomach in patients with a congenital short esophagus. Subsequent clinical and experimental data have es...

journal_title：Annals of internal medicine

authors： Bozymski EM,Herlihy KJ,Orlando RC

更新日期：1982-07-01 00:00:00

abstract：:To standardize the cutoff points of serum cortisol values in the evaluation of Cushing's syndrome during a low- and high-dose dexamethasone suppression test, daily serum cortisol measurements (0800 hours and 1600 hours) and urinary 17-hydroxycorticosteroids were compared (Study A). Forty-seven subjects were studied (1...

journal_title：Annals of internal medicine

authors： Ashcraft MW,Van Herle AJ,Vener SL,Geffner DL

更新日期：1982-07-01 00:00:00

abstract：:We surveyed the faculty, fellows, and residents of a department of medicine to determine the relative importance of each of eight personal characteristics evaluated during the interview of house staff candidates. A booklet containing all possible pairings of the eight characteristics was distributed to 219 participant...

journal_title：Annals of internal medicine

authors： Greganti MA,McGaghie WC,Finn WF

更新日期：1982-07-01 00:00:00

abstract：:Between 1 January 1980 and 18 October 1981, investigators from the Centers for Disease Control collected information on 1407 cases of toxic shock syndrome using a nationwide passive surveillance system. Ninety-two percent of the reported cases were associated with menstruation. Information available on the type of men...

journal_title：Annals of internal medicine

authors： Reingold AL,Hargrett NT,Shands KN,Dan BB,Schmid GP,Strickland BY,Broome CV

更新日期：1982-06-01 00:00:00

abstract：:Previous epidemiologic studies of staphylococcal infections in newborn infants and surgical patients provide clues to the method of infection in toxic shock syndrome. In newborn infants, staphylococci were shown to be transmitted most often by the hands of nursery personnel to the umbilical stump, which afforded a war...

journal_title：Annals of internal medicine

authors： Mortimer EA

更新日期：1982-06-01 00:00:00

abstract：:Diabetes mellitus is classified into two major categories: type I, which is insulin dependent, and type II, which is not. Insulin resistance in type II diabetes may be related to impaired receptor binding in some forms of the disorder. In the past, diabetes in pregnant women resulted in high rates of maternal and infa...

journal_title：Annals of internal medicine

authors： Kaplan SA,Lippe BM,Brinkman CR,Davidson MB,Geffner ME

更新日期：1982-05-01 00:00:00

abstract：:A platelet transfusion from a blood group O donor, immunized 1 month before with Pneumovax, caused a hemolytic reaction in a blood group A recipient. Forty-five of 59 group O donors (76%) and all of nine group B donors immunized with Pneumovax had a fourfold or higher anti-A response. Half of the anti-A antibody in hi...

journal_title：Annals of internal medicine

authors： Siber GR,Ambrosino DM,Gorgone BC

更新日期：1982-05-01 00:00:00

abstract：:Levels of circulating platelet aggregates and plasma beta-thromboglobulin reflect the degree of platelet activation in vascular injury and repair. Both values were evaluated in 38 patients with scleroderma and 18 control subjects matched for age, sex, and race. Circulating platelet aggregates (expressed as percentage ...

journal_title：Annals of internal medicine

authors： Kahaleh MB,Osborn I,Leroy EC

更新日期：1982-05-01 00:00:00

abstract：:Two patients referred for cancer chemotherapy were found to be chronic, asymptomatic hepatitis B surface antigen (HBsAg) carriers. They had normal serum aminotransferase levels, but their sera were positive for HGsAg and antibody to hepatitis B e antigen. Both patients developed acute, icteric hepatitis within 3 month...

journal_title：Annals of internal medicine

authors： Hoofnagle JH,Dusheiko GM,Schafer DF,Jones EA,Micetich KC,Young RC,Costa J

更新日期：1982-04-01 00:00:00

abstract：:Approximately 3000 people in Bennington, Vermont, 19% of the population, had a diarrheal illness during the first and second weeks of June 1978. Persons affected reported abdominal cramps (86%), diarrhea (82%), malaise (73%), and headache (47%). The mean duration of illness was 4.6 days. The illness was associated wit...

journal_title：Annals of internal medicine

authors： Vogt RL,Sours HE,Barrett T,Feldman RA,Dickinson RJ,Witherell L

更新日期：1982-03-01 00:00:00

abstract：:Physicians treating patients with chronic rheumatoid arthritis spend a considerable amount of time dealing with the psychological and social aspects of the disease. The patients' reaction to the disease can be related to age, experience, personality, and environment at work and at home. Common problems include loss of...

journal_title：Annals of internal medicine

authors： Rogers MP,Liang MH,Partridge AJ

更新日期：1982-03-01 00:00:00

abstract：:Increased adrenocorticotropic hormone (ACTH) levels after bilateral adrenalectomy could be secondary to a pituitary tumor, under replacement with cortisol, or an abnormality in the hypothalamic-pituitary-adrenal feedback loop. To distinguish between these possibilities, ACTH levels were measured before and after corti...

journal_title：Annals of internal medicine

authors： Koletsky RJ,Dluhy RG,Crantz FR,Williams GH

更新日期：1982-03-01 00:00:00