Prevention of cytomegalovirus infection by cytomegalovirus immune globulin after marrow transplantation.

Abstract:

:In an effort to prevent cytomegalovirus infection among seronegative patients having marrow transplants, a globulin with high antibody levels against cytomegalovirus was given before and for 11 weeks after transplantation in a randomized trial. Among 36 patients who received no prophylactic granulocyte transfusions, globulin recipients had significantly fewer infections than controls (2 of 17 versus 8 of 19, p = 0.05 by Fisher's exact test and p = 0.03 by Mantel-Cox test). Conversely, infection rates were high and unchanged by globulin use among patients who received granulocytes from seropositive donors (7 of 8 recipients versus 6 of 7 controls). The lack of effect of the globulin among patients receiving transfusions of granulocytes from seropositive donors may suggest that the dose of antibody was insufficient or that antibody is ineffective against virus transmitted in granulocytes. We conclude that cytomegalovirus infection can be prevented by immunoprophylaxis in seronegative patients having marrow transplants who are not given granulocyte transfusions.

journal_name

Ann Intern Med

authors

Meyers JD,Leszczynski J,Zaia JA,Flournoy N,Newton B,Snydman DR,Wright GG,Levin MJ,Thomas ED

doi

10.7326/0003-4819-98-4-442

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

442-6

issue

4

eissn

0003-4819

issn

1539-3704

journal_volume

98

pub_type

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