Effect of parenterally administered gold therapy on the course of adult rheumatoid arthritis.


OBJECTIVE:To describe the course of rheumatoid arthritis over 5 years in adults and to evaluate the effect of parenterally administered gold salts on that course. DESIGN:A prospective observational study of adults with rheumatoid arthritis. Data derived from annual interviews with patients from 1983 to 1988 and from physician surveys in 1983 and 1987. SETTING:Rheumatology practices in the community. PATIENTS:The study began in 1982 with 822 adults who had rheumatoid arthritis and were under the care of rheumatologists. INTERVENTIONS:Those selected by rheumatologists in the management of their patients. MEASUREMENTS:Information describing sociodemographic and clinical characteristics, course, and therapy was collected from patients and verified by physician reports. Functional status, measured by the Health Assessment Questionnaire, and the number of painful joints were used as outcome variables. Outcome variables were adjusted for age, sex, disease duration, baseline values of the outcome variable, and the use of four disease-remittive agents other than gold. MAIN RESULTS:Multivariate repeated-measures analysis of variance showed no change in the course of rheumatoid arthritis over 5 years. The use of parenteral gold for at least 2 consecutive years at the start of the observation period produced, on average, no change in the course over 5 years in the two outcome variables. CONCLUSION:In our study of a community-based population of adults with rheumatoid arthritis who were under the care of community rheumatologists, we found that there was, on average, no statistically significant change in function or number of painful joints between 1983 and 1988. Patients receiving parenteral gold therapy for at least 2 consecutive years did not show a statistically significant difference in outcome when compared with those not receiving such therapy.


Ann Intern Med


Epstein WV,Henke CJ,Yelin EH,Katz PP




Has Abstract


1991-03-15 00:00:00












  • Principles of appropriate antibiotic use for acute pharyngitis in adults: background.

    abstract::The following principles of appropriate antibiotic use for adults with acute pharyngitis apply to immunocompetent adults without complicated comorbid conditions, such as chronic lung or heart disease, and history of rheumatic fever. They do not apply during known outbreaks of group A streptococcus.1. Group A beta-hemo...

    journal_title:Annals of internal medicine

    pub_type: 指南,杂志文章,实务指引


    authors: Cooper RJ,Hoffman JR,Bartlett JG,Besser RE,Gonzales R,Hickner JM,Sande MA,American Academy of Family Physicians.,American College of Physicians-American Society of Internal Medicine.,Centers for Disease Control.

    更新日期:2001-03-20 00:00:00

  • Ultrasonographic screening before hospital discharge for deep venous thrombosis after arthroplasty: the post-arthroplasty screening study. A randomized, controlled trial.

    abstract:BACKGROUND:The clinical significance of asymptomatic deep venous thrombosis that develops after joint arthroplasty and the value of screening tests to detect thrombi are uncertain. OBJECTIVES:To determine 1) the rate of symptomatic deep venous thrombosis or pulmonary embolism occurring after hospitalization for joint ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Robinson KS,Anderson DR,Gross M,Petrie D,Leighton R,Stanish W,Alexander D,Mitchell M,Flemming B,Gent M

    更新日期:1997-09-15 00:00:00

  • Implantable cardioverter-defibrillators: implications for the nonelectrophysiologist.

    abstract:PURPOSE:To review clinical scenarios in which nonelectrophysiologist physicians may interact with patients who have implantable defibrillators. DATA SOURCES:Peer-reviewed original articles and reviews addressing aspects of implantable defibrillator therapy that are relevant to the clinician. DATA SYNTHESIS:The capaci...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审


    authors: Pinski SL,Trohman RG

    更新日期:1995-05-15 00:00:00

  • Four-Week Direct-Acting Antiviral Regimens in Noncirrhotic Patients With Hepatitis C Virus Genotype 1 Infection: An Open-Label, Nonrandomized Trial.

    abstract:BACKGROUND:Treatment of chronic hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) for 6 weeks achieves sustained virologic response (SVR) rates of 95% in some patients. If effective, shorter therapeutic courses could improve adherence and treatment costs. OBJECTIVE:To determine factors predictive ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章


    authors: Kohli A,Kattakuzhy S,Sidharthan S,Nelson A,McLaughlin M,Seamon C,Wilson E,Meissner EG,Sims Z,Silk R,Gross C,Akoth E,Tang L,Price A,Jolley TA,Emmanuel B,Proschan M,Teferi G,Chavez J,Abbott S,Osinusi A,Mo H,Poli

    更新日期:2015-12-15 00:00:00

  • Cyclophosphamide in the management of advanced Graves' ophthalmopathy. A preliminary report.

    abstract::Three patients with advanced Graves' ophthalmopathy were treated with cyclophosphamide. All had proptosis and diplopia. One patient had disabling iatrogenic Cushing's syndrome from steroid treatment of the ophthalmopathy and had undergone bilateral orbital decompression before cyclophosphamide therapy; steroids could ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Bigos ST,Nisula BC,Daniels GH,Eastman RC,Johnston HH,Kohler PO

    更新日期:1979-06-01 00:00:00

  • Increased incidence of coronary atherosclerosis in type 2 diabetes mellitus: mechanisms and management.

    abstract::Type 2 diabetes mellitus is a metabolic disease of carbohydrate metabolism. However, it should also be considered a vascular disease because diabetic patients have a strong predilection for atherosclerosis. With the increasing prevalence and earlier age at onset of diabetes, the projected effect of diabetes on cardiov...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审


    authors: Hurst RT,Lee RW

    更新日期:2003-11-18 00:00:00

  • In COVID-19, adding lopinavir-ritonavir to usual care did not shorten time to clinical improvement.

    abstract:SOURCE CITATION:Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382:1787-99. 32187464. ...

    journal_title:Annals of internal medicine

    pub_type: 评论,杂志文章


    authors: Yang P,Tekwani S,Martin GS

    更新日期:2020-06-16 00:00:00

  • Treatment of intractable lupus nephritis with total lymphoid irradiation.

    abstract::Ten patients with lupus nephritis and marked proteinuria (3.9 g or more/d) that did not respond adequately to treatment with prednisone alone or prednisone in combination with azathioprine were treated with total lymphoid irradiation in an uncontrolled feasibility study. Within 6 weeks after the start of total lymphoi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Strober S,Field E,Hoppe RT,Kotzin BL,Shemesh O,Engleman E,Ross JC,Myers BD

    更新日期:1985-04-01 00:00:00

  • Effects of a short course of eszopiclone on continuous positive airway pressure adherence: a randomized trial.

    abstract:BACKGROUND:Adherence to short-term continuous positive airway pressure (CPAP) may predict long-term use. Unfortunately, initial CPAP intolerance may lead to poor adherence or abandonment of therapy. OBJECTIVE:To determine whether a short course of eszopiclone at the onset of therapy improves long-term CPAP adherence m...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验


    authors: Lettieri CJ,Shah AA,Holley AB,Kelly WF,Chang AS,Roop SA,CPAP Promotion and Prognosis-The Army Sleep Apnea Program Trial.

    更新日期:2009-11-17 00:00:00

  • Cholesterol reduction and life expectancy. A model incorporating multiple risk factors.

    abstract::In deciding whether to undertake a dietary program to reduce serum cholesterol levels, a person must consider how much benefit to expect. We developed a model that assumes cholesterol reduction is effective and safe in reducing the risk for death from ischemic heart disease. In the model, we considered asymptomatic ad...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Taylor WC,Pass TM,Shepard DS,Komaroff AL

    更新日期:1987-04-01 00:00:00

  • Inhaled or intravenous pentamidine therapy for Pneumocystis carinii pneumonia in AIDS. A randomized trial.

    abstract:OBJECTIVE:To compare inhaled pentamidine with intravenous pentamidine for the treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome (AIDS). DESIGN:A randomized trial. SETTING:Community teaching hospital and hospital-based outpatient treatment center. PATIENTS:Twenty-one homosexual men...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Soo Hoo GW,Mohsenifar Z,Meyer RD

    更新日期:1990-08-01 00:00:00

  • Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinoma.

    abstract:BACKGROUND:The incidence of esophageal adenocarcinoma is increasing rapidly. Gastroesophageal reflux is a strong risk factor for this disease. The increase in incidence of esophageal adenocarcinoma coincided with the introduction of medications that promote reflux by relaxing the lower esophageal sphincter (LES), such ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Lagergren J,Bergström R,Adami HO,Nyrén O

    更新日期:2000-08-01 00:00:00

  • End-of-life care discussions among patients with advanced cancer: a cohort study.

    abstract:BACKGROUND:National guidelines recommend that physicians discuss end-of-life (EOL) care planning with patients with cancer whose life expectancy is less than 1 year. OBJECTIVE:To evaluate the incidence of EOL care discussions for patients with stage IV lung or colorectal cancer and where, when, and with whom these dis...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Mack JW,Cronin A,Taback N,Huskamp HA,Keating NL,Malin JL,Earle CC,Weeks JC

    更新日期:2012-02-07 00:00:00

  • A randomized, double-blind, placebo-controlled trial of rifaximin to prevent travelers' diarrhea.

    abstract:BACKGROUND:Travelers' diarrhea causes substantial morbidity and postinfectious irritable bowel syndrome. OBJECTIVE:To evaluate nonabsorbable rifaximin for prevention of travelers' diarrhea. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Guadalajara, Mexico. PARTICIPANTS:U.S. students. ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: DuPont HL,Jiang ZD,Okhuysen PC,Ericsson CD,de la Cabada FJ,Ke S,DuPont MW,Martinez-Sandoval F

    更新日期:2005-05-17 00:00:00

  • Travel-Associated Zika Virus Disease Acquired in the Americas Through February 2016: A GeoSentinel Analysis.

    abstract:Background:Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective:To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design:Descriptive, using GeoSentinel records. Setting:63 travel and t...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Hamer DH,Barbre KA,Chen LH,Grobusch MP,Schlagenhauf P,Goorhuis A,van Genderen PJ,Molina I,Asgeirsson H,Kozarsky PE,Caumes E,Hagmann SH,Mockenhaupt FP,Eperon G,Barnett ED,Bottieau E,Boggild AK,Gautret P,Hynes NA,Kuhn

    更新日期:2017-01-17 00:00:00

  • Unrecognized adult salicylate intoxication.

    abstract::Adult salicylate intoxication has been considered to be easily recognized and assciated with low morbidity and mortality. In the present study of 73 consecutive adults hospitalized with salicylate intoxication, 27% of patients were undiagnosed for as long as 72 h after admission. The initial physical findings and labo...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Anderson RJ,Potts DE,Gabow PA,Rumack BH,Schrier RW

    更新日期:1976-12-01 00:00:00

  • Exogenous insulin administration and cardiovascular risk in non-insulin-dependent and insulin-dependent diabetes mellitus.

    abstract:PURPOSE:It is currently unknown whether intensive insulin treatment of diabetes decreases the risk for cardiovascular complications by lowering glucose levels or increases the risk by postulated direct atherogenic effects. This article reviews published data from two long-term, randomized clinical trials that compared ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析


    authors: Genuth S

    更新日期:1996-01-01 00:00:00

  • The effect of different attribution rules on individual physician cost profiles.

    abstract:BACKGROUND:Some health plans profile physicians on the basis of their relative costs and use these profiles to assign physicians to cost categories. Physician organizations have questioned whether the rules used to attribute costs to a physician affect the cost category to which that physician is assigned. OBJECTIVE:T...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Mehrotra A,Adams JL,Thomas JW,McGlynn EA

    更新日期:2010-05-18 00:00:00

  • Hepatitis-associated lipid storage myopathy.

    abstract::We report the case of a 23-year-old woman who developed severe myalgias in association with mild hepatitis B surface antigen-positive hepatitis. Muscle biopsy showed myriads of microvacuoles filled with neutral lipid. Prednisone therapy was associated with complete clearing of all clinical and laboratory abnormalities...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Patten BM,Shabot JM,Alperin J,Dodson RF

    更新日期:1977-10-01 00:00:00

  • Barrett's esophagus.

    abstract::Barrett's esophagus denotes the presence of columnar epithelium in the esophagus instead of the usual stratified squamous epithelium. Barrett's esophagus had been thought to represent a mediastinal extension of the stomach in patients with a congenital short esophagus. Subsequent clinical and experimental data have es...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审


    authors: Bozymski EM,Herlihy KJ,Orlando RC

    更新日期:1982-07-01 00:00:00

  • Biliary excretion of aluminum in aluminum osteodystrophy with liver disease.

    abstract::Two patients with chronic liver disease developed elevated serum aluminum concentrations and biopsy-proven osteodystrophy. Neither patient had chronic renal failure but both had received aluminum-containing antacids for long periods. We measured biliary and urinary aluminum excretion during antacid loading in patients...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Williams JW,Vera SR,Peters TG,Luther RW,Bhattacharya S,Spears H,Graham A,Pitcock JA,Crawford AJ,Palmieri GM

    更新日期:1986-06-01 00:00:00

  • Evaluating the impact of hospitalists.

    abstract::The hospital-based generalist physician is a recent organizational innovation in health care in the United States. Does the hospitalist model provide improved health care? The answer to this question lies in a rigorous evaluation of the hospitalist system in the clinical setting. This paper describes key outcomes that...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Showstack J,Katz PP,Weber E

    更新日期:1999-02-16 00:00:00

  • Weight training improves walking endurance in healthy elderly persons.

    abstract:OBJECTIVE:To determine the effect of a resistance-training program on walking endurance in a healthy, community-dwelling elderly population. DESIGN:12- week randomized, controlled trial comparing a resistance- training group with a nonexercising control group. SETTING:Hospital-affiliated outpatient exercise facility....

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ades PA,Ballor DL,Ashikaga T,Utton JL,Nair KS

    更新日期:1996-03-15 00:00:00

  • Thromboendarterectomy for chronic, major-vessel thromboembolic pulmonary hypertension. Immediate and long-term results in 42 patients.

    abstract::Since 1970, forty-two patients with pulmonary hypertension due to chronic, thromboembolic obstruction of the major pulmonary arteries have had pulmonary thromboendarterectomy at the University of California, San Diego, and the San Diego Veterans Medical Centers. Duration of symptoms before admission averaged 4.4 years...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Moser KM,Daily PO,Peterson K,Dembitsky W,Vapnek JM,Shure D,Utley J,Archibald C

    更新日期:1987-10-01 00:00:00

  • Studying symptoms: sampling and measurement issues.

    abstract::Physical symptoms account for more than half of all outpatient visits, but the specific causes and treatments of many common symptoms are frequently not well established. Because clinical research has primarily targeted specific diseases, symptoms-based research is still an emerging field of scientific inquiry, and op...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审


    authors: Kroenke K

    更新日期:2001-05-01 00:00:00

  • The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: a meta-analysis.

    abstract:BACKGROUND:Dietary protein has long been thought to play a role in the progression of chronic renal disease, but clinical trials to date have not consistently shown that dietary protein restriction is beneficial. PURPOSE:To use meta-analysis to assess the efficacy of dietary protein restriction in previously published...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析


    authors: Pedrini MT,Levey AS,Lau J,Chalmers TC,Wang PH

    更新日期:1996-04-01 00:00:00

  • Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians.

    abstract:DESCRIPTION:The American College of Physicians (ACP) developed this guideline to present the available evidence on various pharmacologic treatments to prevent fractures in men and women with low bone density or osteoporosis. METHODS:Published literature on this topic was identified by using MEDLINE (1966 to December 2...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引


    authors: Qaseem A,Snow V,Shekelle P,Hopkins R Jr,Forciea MA,Owens DK,Clinical Efficacy Assessment Subcommittee of the American College of Physicians.

    更新日期:2008-09-16 00:00:00

  • Predicting Bleeding Risk to Guide Aspirin Use for the Primary Prevention of Cardiovascular Disease: A Cohort Study.

    abstract:Background:Many prognostic models for cardiovascular risk can be used to estimate aspirin's absolute benefits, but few bleeding risk models are available to estimate its likely harms. Objective:To develop prognostic bleeding risk models among persons in whom aspirin might be considered for the primary prevention of ca...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Selak V,Jackson R,Poppe K,Wu B,Harwood M,Grey C,Pylypchuk R,Mehta S,Kerr A,Wells S

    更新日期:2019-03-19 00:00:00

  • Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States.

    abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally. OBJECTIVE:To describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery. DESIGN:Single-health system, multihospital retrospective cohort study. SETTING...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Anesi GL,Jablonski J,Harhay MO,Atkins JH,Bajaj J,Baston C,Brennan PJ,Candeloro CL,Catalano LM,Cereda MF,Chandler JM,Christie JD,Collins T,Courtright KR,Fuchs BD,Gordon E,Greenwood JC,Gudowski S,Hanish A,Hanson Iii C

    更新日期:2021-01-19 00:00:00

  • Fixed and reproducible orthostatic proteinuria: results of a 20-year follow-up study.

    abstract::A 20-year follow-up evaluation of young men with fixed and reproducible orthostatic proteinuria showed no evidence of progressive renal disease. Follow-up information was obtained on 43 of the original 64 patients and detailed information was secured on 36. All had normal renal function and only six patients continued...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Springberg PD,Garrett LE Jr,Thompson AL Jr,Collins NF,Lordon RE,Robinson RR

    更新日期:1982-10-01 00:00:00