Pemphigus: current concepts.

abstract：BACKGROUND:Lack of awareness of hypoglycemia is a major limiting factor in the management of type 1 diabetes. OBJECTIVE:To examine whether reduction in the number of episodes of hypoglycemia restores hypoglycemia awareness by influencing beta-adrenergic sensitivity in patients with type 1 diabetes. DESIGN:Controlled ...

journal_title：Annals of internal medicine

authors： Fritsche A,Stefan N,Häring H,Gerich J,Stumvoll M

更新日期：2001-05-01 00:00:00

abstract：:Seventy homosexual men with unexplained persistent diffuse lymphadenopathy enrolled in a prospective natural history study from November 1981 to November 1982. These men had demographic, clinical, and laboratory findings similar to those of homosexual patients with the acquired immunodeficiency syndrome. Pathologic ex...

journal_title：Annals of internal medicine

authors： Abrams DI,Lewis BJ,Beckstead JH,Casavant CA,Drew WL

更新日期：1984-06-01 00:00:00

abstract：OBJECTIVE:To explore how frequently physicians lose medical malpractice cases despite providing standard care and to assess whether severity of patient injury influences the frequency of plaintiff payment. DESIGN:Retrospective cohort study. SETTING:Physicians from the state of New Jersey insured by one insurance comp...

journal_title：Annals of internal medicine

authors： Taragin MI,Willett LR,Wilczek AP,Trout R,Carson JL

更新日期：1992-11-01 00:00:00

abstract：:One hundred ninety-eight patients with chronic myelogenous leukemia received marrow transplants after intensive chemotherapy and total body irradiation. Multivariate analysis showed disease status at time of transplantation to be the most powerful predictor of survival. The probability of long-term survival for alloge...

journal_title：Annals of internal medicine

authors： Thomas ED,Clift RA,Fefer A,Appelbaum FR,Beatty P,Bensinger WI,Buckner CD,Cheever MA,Deeg HJ,Doney K

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:To develop a clinical perspective on bilateral massive adrenal hemorrhage and an algorithm for its diagnosis and treatment. DATA IDENTIFICATION:Case reports were identified through a computer search using MEDLIN (1976 to 1987), and from bibliographies in review articles (up to 1978). STUDY SELECTION:Twelve re...

journal_title：Annals of internal medicine

authors： Rao RH,Vagnucci AH,Amico JA

更新日期：1989-02-01 00:00:00

abstract：:Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report s...

journal_title：Annals of internal medicine

authors： Johnson RH,Lutwick LI,Huntley GA,Vosti KL

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Increased prevalence of adolescent obesity requires effective treatment options beyond behavior therapy. OBJECTIVE:To see whether sibutramine reduced weight more than placebo in obese adolescents who were receiving a behavior therapy program. DESIGN:12-month, 3:1 randomized, double-blind trial conducted fr...

journal_title：Annals of internal medicine

authors： Berkowitz RI,Fujioka K,Daniels SR,Hoppin AG,Owen S,Perry AC,Sothern MS,Renz CL,Pirner MA,Walch JK,Jasinsky O,Hewkin AC,Blakesley VA,Sibutramine Adolescent Study Group.

更新日期：2006-07-18 00:00:00

abstract：DESCRIPTION:New U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for chronic kidney disease (CKD). METHODS:The USPSTF reviewed evidence on screening for CKD, including evidence on screening, accuracy of screening, early treatment, and harms of screening and early treatment. POPULATIO...

journal_title：Annals of internal medicine

authors： Moyer VA,U.S. Preventive Services Task Force.

更新日期：2012-10-16 00:00:00

abstract：:Forty patients with systemic lupus erythematosus randomly received inactivated bivalent (A/NJ and A/Victoria) influenza vaccine or saline in a double-blind study. During 20 weeks of follow-up, no deterioration in major organ function or increase in disease flares was observed in the immunized group as compared with th...

journal_title：Annals of internal medicine

authors： Williams GW,Steinberg AD,Reinertsen JL,Klassen LW,Decker JL,Dolin R

更新日期：1978-06-01 00:00:00

abstract：:The relationship between oral contraceptives and death from thromboembolism shown by studies of vital statistics, and the contribution of cigarette smoking to these deaths are reviewed. In 1968 a British study showed that a slight increase in deaths from thromboembolism had occurred in young women, proportional to th...

journal_title：Annals of internal medicine

authors： Masi AT

更新日期：1970-09-01 00:00:00

abstract：PURPOSE:It is currently unknown whether intensive insulin treatment of diabetes decreases the risk for cardiovascular complications by lowering glucose levels or increases the risk by postulated direct atherogenic effects. This article reviews published data from two long-term, randomized clinical trials that compared ...

journal_title：Annals of internal medicine

authors： Genuth S

更新日期：1996-01-01 00:00:00

abstract：:Coronary artery spasm is an important pathogenetic mechanism in some forms of myocardial ischemic disease. Factors that may be important in the genesis of spasm include the autonomic nervous system, prostaglandins, endoperoxides, thromboxanes, and the calcium availability to the contractile apparatus. Spasm results in...

journal_title：Annals of internal medicine

authors： Luchi RJ,Chahine RA,Raizner AE

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Fibromyalgia is a common chronic pain condition for which patients frequently use acupuncture. OBJECTIVE:To determine whether acupuncture relieves pain in fibromyalgia. DESIGN:Randomized, sham-controlled trial in which participants, data collection staff, and data analysts were blinded to treatment group. ...

journal_title：Annals of internal medicine

authors： Assefi NP,Sherman KJ,Jacobsen C,Goldberg J,Smith WR,Buchwald D

更新日期：2005-07-05 00:00:00

abstract：BACKGROUND:Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT). OBJECTIVE:To determine whether a negative result on a quantitative latex D dimer assay eliminates the need for further investigation in patients with...

journal_title：Annals of internal medicine

authors： Bates SM,Kearon C,Crowther M,Linkins L,O'Donnell M,Douketis J,Lee AY,Weitz JI,Johnston M,Ginsberg JS

更新日期：2003-05-20 00:00:00

abstract：BACKGROUND:Persons with abdominal aortic aneurysm are more likely to have a higher prevalence of risk factors for and clinical manifestations of cardiovascular disease. It is unknown whether these factors explain the high mortality rate associated with abdominal aortic aneurysm. OBJECTIVE:To describe the risk for mort...

journal_title：Annals of internal medicine

authors： Newman AB,Arnold AM,Burke GL,O'Leary DH,Manolio TA

更新日期：2001-02-06 00:00:00

abstract：Background:The 2013 pooled cohort equations (PCEs) are central in prevention guidelines for cardiovascular disease (CVD) but can misestimate CVD risk. Objective:To improve the clinical accuracy of CVD risk prediction by revising the 2013 PCEs using newer data and statistical methods. Design:Derivation and validation ...

journal_title：Annals of internal medicine

authors： Yadlowsky S,Hayward RA,Sussman JB,McClelland RL,Min YI,Basu S

更新日期：2018-07-03 00:00:00

abstract：:A 42-year-old woman developed goitrous hypothyroidism while receiving ethionamide for treatment of an atypical mycobacterial infection. Five weeks after discontinuation of ethionamide therapy, thyroid function had returned to normal. The goitrogenic effect was studied in vitro by incubating ethionamide in various conc...

journal_title：Annals of internal medicine

authors： Drucker D,Eggo MC,Salit IE,Burrow GN

更新日期：1984-06-01 00:00:00

abstract：Background:Difficulties with daily functioning are common in middle-aged adults. However, little is known about the epidemiology or clinical course of these problems, including the extent to which they share common features with functional impairment in older adults. Objective:To determine the epidemiology and clinica...

journal_title：Annals of internal medicine

authors： Brown RT,Diaz-Ramirez LG,Boscardin WJ,Lee SJ,Steinman MA

更新日期：2017-12-05 00:00:00

abstract：:The exocrine pancreas secretes into the gut on demand more than 20 proteins that are indispensable for digestion. In-vivo autodigestion is prevented by an array of natural safeguards. In acute pancreatitis, inappropriate intrapancreatic activation and release of pancreatic hydrolases occur, but the pathogenetic mechan...

journal_title：Annals of internal medicine

authors： Geokas MC,Baltaxe HA,Banks PA,Silva J Jr,Frey CF

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Dietary protein has long been thought to play a role in the progression of chronic renal disease, but clinical trials to date have not consistently shown that dietary protein restriction is beneficial. PURPOSE:To use meta-analysis to assess the efficacy of dietary protein restriction in previously published...

journal_title：Annals of internal medicine

authors： Pedrini MT,Levey AS,Lau J,Chalmers TC,Wang PH

更新日期：1996-04-01 00:00:00

abstract：:The competition for funds to conduct clinical research is intense, and only a minority of grant proposals receive funding. In particular, funding for patient-oriented research lags behind that allocated for basic science research. Grant writing is a skill of fundamental importance to the clinical researcher, and condu...

journal_title：Annals of internal medicine

authors： Inouye SK,Fiellin DA

更新日期：2005-02-15 00:00:00

abstract：:Of 476 patients with multiple myeloma treated during a 9-year period, 11 developed acute myelogenous leukemia or sideroblastic anemia. In all, the myeloma was in remission from chemotherapy with melphalan-prednisone combinations that had been continued for a median duration of 3 years. The incidence of acute leukemia ...

journal_title：Annals of internal medicine

authors： Gonzalez F,Trujillo JM,Alexanian R

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:The effect of physician diagnostic variability on accuracy at a population level depends on the prevalence of diagnoses. OBJECTIVE:To estimate how diagnostic variability affects accuracy from the perspective of a U.S. woman aged 50 to 59 years having a breast biopsy. DESIGN:Applied probability using Bayes'...

journal_title：Annals of internal medicine

authors： Elmore JG,Nelson HD,Pepe MS,Longton GM,Tosteson AN,Geller B,Onega T,Carney PA,Jackson SL,Allison KH,Weaver DL

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:Medical students may be at high risk for occupational exposures to blood. OBJECTIVE:To measure the frequency of medical students' exposure to infectious body substances, to identify factors that affect the probability of such exposure, and to suggest targets for the prevention of such exposure. DESIGN:Revi...

journal_title：Annals of internal medicine

authors： Osborn EH,Papadakis MA,Gerberding JL

更新日期：1999-01-05 00:00:00

abstract：OBJECTIVE:To define the temporal characteristics of cocaine-induced coronary vasoconstriction in humans and to assess the relation between cocaine-induced coronary vasoconstriction and the blood concentration of cocaine and its main metabolites. DESIGN:Randomized, double-blind, controlled clinical trial. SETTING:Card...

journal_title：Annals of internal medicine

authors： Brogan WC 3rd,Lange RA,Glamann DB,Hillis LD

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Whether behavioral approaches for self-management programs benefit individuals with type 1 diabetes mellitus is unclear. PURPOSE:To determine the effects of behavioral programs for patients with type 1 diabetes on behavioral, clinical, and health outcomes and to investigate factors that might moderate effec...

journal_title：Annals of internal medicine

authors： Pillay J,Armstrong MJ,Butalia S,Donovan LE,Sigal RJ,Chordiya P,Dhakal S,Vandermeer B,Hartling L,Nuspl M,Featherstone R,Dryden DM

更新日期：2015-12-01 00:00:00

abstract：:Advances have recently been made in understanding the pharmacokinetics of theophylline. To correlate the new knowledge of theophylline pharmacokinetics with the drug's current status in therapy, we have critically reviewed the relevant investigations of the last 5 years. We consider data on its presumed mechanisms of ...

journal_title：Annals of internal medicine

authors： Bukowskyj M,Nakatsu K,Munt PW

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:To develop criteria for interpreting results of the metyrapone test for the differential diagnosis of the adrenocorticotropin (ACTH)-dependent Cushing syndrome and to compare its diagnostic accuracy with that of the high-dose dexamethasone suppression test. DESIGN:Retrospective cohort study. SETTING:Inpatie...

journal_title：Annals of internal medicine

authors： Avgerinos PC,Yanovski JA,Oldfield EH,Nieman LK,Cutler GB Jr

更新日期：1994-09-01 00:00:00

abstract：:Tax incentives can provide a large financial impetus to change behavior. Current U.S. law establishes a substantial discontinuity in the amount of estate tax that many patients will have to pay in 2010: During this year only, the tax rate drops to zero. This article discusses concerns regarding the sharp change in tax...

journal_title：Annals of internal medicine

authors： Mendenhall GS

更新日期：2008-12-02 00:00:00

abstract：:A platelet transfusion from a blood group O donor, immunized 1 month before with Pneumovax, caused a hemolytic reaction in a blood group A recipient. Forty-five of 59 group O donors (76%) and all of nine group B donors immunized with Pneumovax had a fourfold or higher anti-A response. Half of the anti-A antibody in hi...

journal_title：Annals of internal medicine

authors： Siber GR,Ambrosino DM,Gorgone BC

更新日期：1982-05-01 00:00:00