A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis.

Abstract:

BACKGROUND:Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT). OBJECTIVE:To determine whether a negative result on a quantitative latex D dimer assay eliminates the need for further investigation in patients with a low or moderate pretest probability of DVT. DESIGN:Prospective cohort study. SETTING:Three tertiary care hospitals in Canada. PATIENTS:556 consecutive outpatients with suspected first DVT. INTERVENTION:Patients were categorized as having a low, moderate, or high pretest probability of DVT and then underwent D-dimer testing. Patients with low or moderate pretest probability and a negative D-dimer result had no further diagnostic testing and received no anticoagulant therapy. Serial compression ultrasonography was performed in all other patients. Patients who did not receive a diagnosis of DVT were followed for symptomatic venous thromboembolism. MEASUREMENTS:Objectively confirmed symptomatic venous thromboembolic events during 3 months of follow-up. RESULTS:283 patients (51%) had low or moderate pretest probability and a negative D-dimer result. One of these patients had DVT during follow-up (negative likelihood ratio, 0.05 [CI, 0.01 to 0.23]). The negative likelihood ratio of the d -dimer test in all patients was 0.03 (CI, 0.01 to 0.16). CONCLUSION:A negative result on a quantitative latex d -dimer assay safely eliminates the need for further testing in patients with low or moderate pretest probability of DVT.

journal_name

Ann Intern Med

authors

Bates SM,Kearon C,Crowther M,Linkins L,O'Donnell M,Douketis J,Lee AY,Weitz JI,Johnston M,Ginsberg JS

doi

10.7326/0003-4819-138-10-200305200-00006

subject

Has Abstract

pub_date

2003-05-20 00:00:00

pages

787-94

issue

10

eissn

0003-4819

issn

1539-3704

pii

200305200-00006

journal_volume

138

pub_type

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