Poststreptococcal acute glomerulonephritis: fact and controversy.

Abstract:

:Poststreptococcal acute glomerulonephritis is prototypic of the immunologic glomerulonephritides. It most commonly follows streptococcal infection of the pharynx or skin. The diagnosis is usually not difficult when a nephritic clinical presentation (with such manifestations as hematuria, edema, and hypertension) is associated with serologic evidence of recent streptococcal infection and a depressed serum complement concentration. Currently, however, the nephritogenic antigen(s) has not been identified and has not been shown to be the same antigen for all nephritogenic streptococci; it may not even be a part of the infecting organism. The development of a vaccine to prevent this illness from occurring is therefore still not possible. Whether poststreptococcal acute glomerulonephritis progresses to chronic renal failure is still uncertain. Painstaking laboratory research together with careful, prospective long-term follow-up studies of patients with poststreptococcal acute glomerulonephritis may provide some of the answers to these critical questions.

journal_name

Ann Intern Med

authors

Nissenson AR,Baraff LJ,Fine RN,Knutson DW

doi

10.7326/0003-4819-91-1-76

subject

Has Abstract

pub_date

1979-07-01 00:00:00

pages

76-86

issue

1

eissn

0003-4819

issn

1539-3704

journal_volume

91

pub_type

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