Combination therapy with telaprevir for chronic hepatitis C virus genotype 1 infection in patients with HIV: a randomized trial.

abstract：:Sera of 24 patients with an unexplained pneumonia were tested for the presence of antibodies against the Legionnaires' disease bacterium. Fifteen patients had positive serology. The series comprised 12 male and three female patients ranging in age from 17 to 66 years (mean, 51.1 years). All of the patients had a high ...

journal_title：Annals of internal medicine

authors： Meenhorst PL,van der Meer JW,Borst J

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Four months of rifampin treatment for latent tuberculosis infection is safer, has superior treatment completion rates, and is as effective as 9 months of isoniazid. However, daily medication costs are higher for a 4-month rifampin regimen than a 9-month isoniazid regimen. OBJECTIVE:To compare health care us...

journal_title：Annals of internal medicine

authors： Bastos ML,Campbell JR,Oxlade O,Adjobimey M,Trajman A,Ruslami R,Kim HJ,Baah JO,Toelle BG,Long R,Hoeppner V,Elwood K,Al-Jahdali H,Apriani L,Benedetti A,Schwartzman K,Menzies D

更新日期：2020-08-04 00:00:00

abstract：:Aspirin exerts antiplatelet effects through irreversible inhibition of cyclooxygenase-1, whereas its anticancer effects may be due to inhibition of cyclooxygenase-2 and other pathways. In 2009, the U.S. Preventive Services Task Force endorsed aspirin for primary prevention of cardiovascular disease. However, aspirin's...

journal_title：Annals of internal medicine

authors： Burns RB,Graham K,Sawhney MS,Reynolds EE

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Studies suggest that vitamin D supplementation may reduce cancer and fracture risks. PURPOSE:To examine the benefits and harms of vitamin D with or without calcium supplementation on clinical outcomes of cancer and fractures in adults. DATA SOURCES:English-language studies identified from MEDLINE and the C...

journal_title：Annals of internal medicine

authors： Chung M,Lee J,Terasawa T,Lau J,Trikalinos TA

更新日期：2011-12-20 00:00:00

abstract：:Twenty-three patients with hyperparathyroidism from six families with the multiple endocrine adenomatosis (MEA) I-syndrome were tested by secretin provocation. In nine cases this led to increases in serum gastrin ranging from 298 to 13 300 pg/ml, whereas the maximum rise in gastrin in the other 14 patients was 32 pg/m...

journal_title：Annals of internal medicine

authors： Lamers CB,Buis JT,van Tongeren J

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors slow renal disease progression and reduce cardiac morbidity and mortality in patients with diabetes. Patients' out-of-pocket costs pose a barrier to using this effective therapy. OBJECTIVE:To estimate the cost-effectiveness to Medicare of first-dollar coverage ...

journal_title：Annals of internal medicine

authors： Rosen AB,Hamel MB,Weinstein MC,Cutler DM,Fendrick AM,Vijan S

更新日期：2005-07-19 00:00:00

abstract：BACKGROUND:Screening women for Chlamydia trachomatis in family planning clinics is associated with a reduced incidence of chlamydial sequelae. However, the question of whom to screen to maintain efficient use of resources remains controversial. OBJECTIVE:To assess the cost-effectiveness of chlamydial screening done ac...

journal_title：Annals of internal medicine

authors： Howell MR,Quinn TC,Gaydos CA

更新日期：1998-02-15 00:00:00

abstract：SOURCE CITATION:Mahady SE, Margolis KL, Chan A, et al. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut. 2020. [Epub ahead of print.] 32747412. ...

journal_title：Annals of internal medicine

authors： Hirsch C

更新日期：2021-01-01 00:00:00

abstract：:Five of 70 patients with systemic lupus erythematosus seen over a 5-year period had peripheral blood films suggestive of hyposplenism. Technetium-99m-sulfur colloid scans showed no splenic activity in three patients. One of these three patients, who had a spontaneous remission of persistent thrombocytopenia concurrent...

journal_title：Annals of internal medicine

authors： Dillon AM,Stein HB,English RA

更新日期：1982-01-01 00:00:00

abstract：:The new knowledge of the regulation of cell growth and the genetic and biochemical changes that lead to malignancy have created many new opportunities for cancer drug discovery. These new targets include oncogenes, growth factors and their receptors, signal transduction pathways, and cell differentiation signals. Atte...

journal_title：Annals of internal medicine

authors： Chabner BA

更新日期：1993-04-15 00:00:00

abstract：BACKGROUND:Whether behavioral approaches for self-management programs benefit individuals with type 1 diabetes mellitus is unclear. PURPOSE:To determine the effects of behavioral programs for patients with type 1 diabetes on behavioral, clinical, and health outcomes and to investigate factors that might moderate effec...

journal_title：Annals of internal medicine

authors： Pillay J,Armstrong MJ,Butalia S,Donovan LE,Sigal RJ,Chordiya P,Dhakal S,Vandermeer B,Hartling L,Nuspl M,Featherstone R,Dryden DM

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally. OBJECTIVE:To describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery. DESIGN:Single-health system, multihospital retrospective cohort study. SETTING...

journal_title：Annals of internal medicine

authors： Anesi GL,Jablonski J,Harhay MO,Atkins JH,Bajaj J,Baston C,Brennan PJ,Candeloro CL,Catalano LM,Cereda MF,Chandler JM,Christie JD,Collins T,Courtright KR,Fuchs BD,Gordon E,Greenwood JC,Gudowski S,Hanish A,Hanson Iii C

更新日期：2021-01-19 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of a nurse-managed intervention for smoking cessation in patients who have had a myocardial infarction. DESIGN:Randomized, with a 6-month treatment period and a 6-month follow-up. SETTING:Kaiser Foundation hospitals in Redwood City, Santa Clara, Hayward, and San Jose, Californi...

journal_title：Annals of internal medicine

authors： Taylor CB,Houston-Miller N,Killen JD,DeBusk RF

更新日期：1990-07-15 00:00:00

abstract：OBJECTIVE:To determine whether growth hormone replacement in older men improves functional ability. DESIGN:Randomized, controlled, double-blind trial. SETTING:General community. PATIENTS:52 healthy men older than 69 years of age with well-preserved functional ability but low baseline insulin-like growth factor 1 lev...

journal_title：Annals of internal medicine

authors： Papadakis MA,Grady D,Black D,Tierney MJ,Gooding GA,Schambelan M,Grunfeld C

更新日期：1996-04-15 00:00:00

abstract：BACKGROUND:Because only limited evidence suggests that elastic stockings prevent the post-thrombotic syndrome in patients with symptomatic deep venous thrombosis (DVT), these stockings are not widely used. OBJECTIVE:To evaluate the efficacy of compression elastic stockings for prevention of the post-thrombotic syndrom...

journal_title：Annals of internal medicine

authors： Prandoni P,Lensing AW,Prins MH,Frulla M,Marchiori A,Bernardi E,Tormene D,Mosena L,Pagnan A,Girolami A

更新日期：2004-08-17 00:00:00

abstract：BACKGROUND:Exercise therapy encompasses a heterogeneous group of interventions. There continues to be uncertainty about the most effective exercise approach in chronic low back pain. PURPOSE:To identify particular exercise intervention characteristics that decrease pain and improve function in adults with nonspecific ...

journal_title：Annals of internal medicine

authors： Hayden JA,van Tulder MW,Tomlinson G

更新日期：2005-05-03 00:00:00

abstract：OBJECTIVE:To compare trimethoprim-sulfamethoxazole (TMP-SMZ) and vancomycin regarding efficacy and safety in the therapy of serious Staphylococcus aureus infections. DESIGN:Randomized, double-blind comparative trial. SETTING:A tertiary-care hospital. PATIENTS:One hundred and one intravenous drug users hospitalized w...

journal_title：Annals of internal medicine

authors： Markowitz N,Quinn EL,Saravolatz LD

更新日期：1992-09-01 00:00:00

abstract：:Although thyroid nodules are common, few are malignant and require surgical treatment. A systematic approach to their evaluation is important to avoid unnecessary surgery. Fine-needle aspiration biopsy has resulted in substantial improvements in diagnostic accuracy, cost reductions, and higher malignancy yield at time...

journal_title：Annals of internal medicine

authors： Castro MR,Gharib H

更新日期：2005-06-07 00:00:00

abstract：BACKGROUND:Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. PURPOSE:To systematically review benefits and harms of low-dose aspirin for preventing morbidity and mortality from preeclampsia. DATA SOURCES:MEDLINE, Database of Abstracts of Reviews of Effects, PubMed, and Cochrane Centra...

journal_title：Annals of internal medicine

authors： Henderson JT,Whitlock EP,O'Connor E,Senger CA,Thompson JH,Rowland MG

更新日期：2014-05-20 00:00:00

abstract：:The coexistence of pregnancy and idiopathic hypertrophic subaortic stenosis is a potentially dangerous combination. We report a 23-year-old white woman with idiopathic hypertrophic subaortic stenosis and pregnancy who presented with severe symptoms (Class IV) and modest outflow obstruction associated with marked mitra...

journal_title：Annals of internal medicine

authors： Kolibash AJ,Ruiz DE,Lewis RP

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:Initiation of antiretroviral therapy (ART) during tuberculosis (TB) treatment remains challenging. PURPOSE:To assess evidence from randomized, controlled trials of the timing of ART initiation in HIV-infected adults with newly diagnosed pulmonary TB. DATA SOURCES:PubMed, EMBASE, Cochrane Central Register o...

journal_title：Annals of internal medicine

authors： Uthman OA,Okwundu C,Gbenga K,Volmink J,Dowdy D,Zumla A,Nachega JB

更新日期：2015-07-07 00:00:00

abstract：:Recently developed radioligand binding techniques permit direct investigation of the alpha- and beta-adrenergic receptors for catecholamines in a wide variety of tissues. These techniques allow the receptors to be quantitated, characterized, and studied under varying conditions of physiologic and pathophysiologic inte...

journal_title：Annals of internal medicine

authors： Lefkowitz RJ

更新日期：1979-09-01 00:00:00

abstract：:Meningitis caused by enteric gram-negative bacilli is relatively uncommon but is very difficult to treat despite susceptibility in vitro to many antimicrobics. A major problem appears to be poor entry of many drugs into the central nervous system. Moxalactam is an investigational cephalosporin that attains concentrati...

journal_title：Annals of internal medicine

authors： Olson DA,Hoeprich PD,Nolan SM,Goldstein E

更新日期：1981-09-01 00:00:00

abstract：:The four main conceptual paradigms of basic biomedical research are that the explication of mechanisms is a primary goal of science; that scientific data must be "hard"; that formulation of hypotheses and counter-hypotheses is a principal creative challenge; and that experiments are the main mechanism for using scient...

journal_title：Annals of internal medicine

authors： Feinstein AR

更新日期：1983-09-01 00:00:00

abstract：Background:High-risk human papillomavirus (hrHPV) testing to triage women with minor cervical lesions generates many referrals. Purpose:To evaluate the accuracy of genotyping for HPV types 16 and 18 and its utility as a second triage step after hrHPV testing in women with minor cervical lesions. Data Sources:Searches...

journal_title：Annals of internal medicine

authors： Arbyn M,Xu L,Verdoodt F,Cuzick J,Szarewski A,Belinson JL,Wentzensen N,Gage JC,Khan MJ

更新日期：2017-01-17 00:00:00

abstract：:Of 5379 patients who had received radiation treatment at our institution for benign conditions of the head and neck, 318 developed thyroid cancer 3 to 42 years later. We report follow-up observations (median interval from diagnosis to recurrence or last contact, 10 years; longest interval, 31) for 296 of these patient...

journal_title：Annals of internal medicine

authors： Schneider AB,Recant W,Pinsky SM,Ryo UY,Bekerman C,Shore-Freedman E

更新日期：1986-09-01 00:00:00

abstract：:Fifty-five consecutive patients with advanced recurrent Hodgkin's disease resistant to MOPP chemotherapy (mechlorethamine, vincristine, procarbazine, and prednisone) were given ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine). In 54 patients evaluable for response, complete remission after path...

journal_title：Annals of internal medicine

authors： Santoro A,Bonfante V,Bonadonna G

更新日期：1982-02-01 00:00:00

abstract：PURPOSE:To review the clinical use of noninvasive positive pressure ventilation, including its efficacy with acute and chronic forms of respiratory failure, its mechanism of action, and its implementation. DATA SOURCES:Studies were identified through a MEDLINE search using the key words respiratory failure and mechani...

journal_title：Annals of internal medicine

authors： Meyer TJ,Hill NS

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:To prospectively study the clinical features, pathophysiology, treatment and prognosis of Wegener granulomatosis. DESIGN:Of the 180 patients with Wegener granulomatosis referred to the National Institute of Allergy and Infectious Diseases during the past 24 years, 158 have been followed for 6 months to 24 ye...

journal_title：Annals of internal medicine

authors： Hoffman GS,Kerr GS,Leavitt RY,Hallahan CW,Lebovics RS,Travis WD,Rottem M,Fauci AS

更新日期：1992-03-15 00:00:00

abstract：:Delirium is a common and distressing symptom that constitutes a significant challenge for end-of-life care. However, reliable techniques are available for the diagnosis of delirium, and effective therapies exist as well. This consensus paper uses a case-based format that begins with an overview of the definition and p...

journal_title：Annals of internal medicine

authors： Casarett DJ,Inouye SK,American College of Physicians-American Society of Internal Medicine End-of-Life Care Consensus Panel.

更新日期：2001-07-03 00:00:00