Radiation-induced thyroid carcinoma. Clinical course and results of therapy in 296 patients.

Abstract:

:Of 5379 patients who had received radiation treatment at our institution for benign conditions of the head and neck, 318 developed thyroid cancer 3 to 42 years later. We report follow-up observations (median interval from diagnosis to recurrence or last contact, 10 years; longest interval, 31) for 296 of these patients. Three patients died of thyroid cancer and 40 had recurrences. The rate of recurrence during the 10 years after the detection of thyroid cancer, determined by life-table analysis, was 1.1%/yr. Factors that correlated with the risk of recurrence were tumor size, histologic type, number of lobes involved, vessel invasion, and lymph node metastases. The time from radiation exposure to the discovery of thyroid cancer (latency) and the age at diagnosis both inversely correlated with recurrence. The administration of thyroid hormones reduced the number of recurrences in patients with combined papillary and follicular cancer, but no reductions could be associated with the extent of surgery done or the prophylactic use of radioactive iodine ablation. We conclude that the course of radiation-induced thyroid cancer is the same as that of thyroid cancer found in other settings. We advocate a conservative approach to the treatment of small tumors that have no associated risk for thyroid cancer other than that they developed many years after the patient had been exposed to radiation.

journal_name

Ann Intern Med

authors

Schneider AB,Recant W,Pinsky SM,Ryo UY,Bekerman C,Shore-Freedman E

doi

10.7326/0003-4819-105-3-405

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

405-12

issue

3

eissn

0003-4819

issn

1539-3704

journal_volume

105

pub_type

杂志文章
  • Dopamine effects on diaphragmatic strength during acute respiratory failure in chronic obstructive pulmonary disease.

    abstract:STUDY OBJECTIVE:To assess the effects of dopamine, which has an inotropic effect on the myocardium and increases renal and splanchnic blood flow, on diaphragmatic contraction. DESIGN AND PATIENTS:We studied the changes in transdiaphragmatic pressure during electrical bilateral supramaximal stimulation of the phrenic n...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-110-1-17

    authors: Aubier M,Murciano D,Menu Y,Boczkowski J,Mal H,Pariente R

    更新日期:1989-01-01 00:00:00

  • Reversible renal insufficiency due to angiotensin converting enzyme inhibitors in hypertensive nephrosclerosis.

    abstract:OBJECTIVE:To review the incidence of reversible renal insufficiency in patients with hypertensive nephrosclerosis undergoing antihypertensive therapy. DESIGN:Retrospective analysis of 73 patients in a long-term blood pressure control study that compared the effects of an angiotensin converting enzyme (ACE) inhibitor p...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-115-7-513

    authors: Toto RD,Mitchell HC,Lee HC,Milam C,Pettinger WA

    更新日期:1991-10-01 00:00:00

  • Facial edema and eosinophilia. Evidence for eosinophil degranulation.

    abstract::Two patients had recurrent facial edema and peripheral blood eosinophilia. One patient showed a marked increase in the serum level of the eosinophil granule major basic protein. In both patients, skin biopsy samples showed nonspecific mononuclear cell inflammation with few eosinophils. However, immunofluorescence stai...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-4-503

    authors: Songsiridej V,Peters MS,Dor PJ,Ackerman SJ,Gleich GJ,Busse WW

    更新日期:1985-10-01 00:00:00

  • Diuretics, beta-blockers, and the risk for sudden cardiac death in hypertensive patients.

    abstract:OBJECTIVE:To determine whether the use of non-potassium-sparing diuretics and beta-blockers is associated with an excess risk for sudden cardiac death in hypertensive patients. DESIGN:Case-control study. SETTING:Rotterdam, the Netherlands. PATIENTS:257 case-patients who had died suddenly while receiving drug therapy...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-123-7-199510010-00001

    authors: Hoes AW,Grobbee DE,Lubsen J,Man in 't Veld AJ,van der Does E,Hofman A

    更新日期:1995-10-01 00:00:00

  • Severe candidal infections: clinical perspective, immune defense mechanisms, and current concepts of therapy.

    abstract::Disseminated candidiasis has become an important infection, particularly in immunocompromised and postoperative patients. Although serologic tests may, in some settings, facilitate a premortem diagnosis, the disease is usually diagnosed by comprehensive clinical evaluation. Detection of the relatively newly recognized...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-89-1-91

    authors: Edwards JE Jr,Lehrer RI,Stiehm ER,Fischer TJ,Young LS

    更新日期:1978-07-01 00:00:00

  • Coronary angiography and angioplasty after acute myocardial infarction.

    abstract:PURPOSE:To assess the data that support the use of coronary angiography and angioplasty after acute myocardial infarction, that identify the risks of these procedures, and that analyze their use and costs. DATA SOURCES:English-language articles published between 1970 and June 1995 identified through a search of the ME...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-126-7-199704010-00007

    authors: Bates DW,Miller E,Bernstein SJ,Hauptman PJ,Leape LL

    更新日期:1997-04-01 00:00:00

  • Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis.

    abstract:BACKGROUND:Changes in federal health policy are providing more access to medical care for persons with chronic disease. Providing quality care may require a team approach, which the American College of Physicians calls the "medical home." One new model may involve nurse-managed protocols. PURPOSE:To determine whether ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/M13-2567

    authors: Shaw RJ,McDuffie JR,Hendrix CC,Edie A,Lindsey-Davis L,Nagi A,Kosinski AS,Williams JW Jr

    更新日期:2014-07-15 00:00:00

  • Palliative treatments of last resort: choosing the least harmful alternative. University of Pennsylvania Center for Bioethics Assisted Suicide Consensus Panel.

    abstract::Comprehensive palliative care, as exemplified by many state-of-the-art hospice programs, is the standard of care for the dying. Although palliative care is very effective, physicians, nurses, patients, families, and loved ones regularly face clinically, ethically, legally, and morally challenging decisions throughout ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-132-6-200003210-00011

    authors: Quill TE,Lee BC,Nunn S

    更新日期:2000-03-21 00:00:00

  • Occupational exposures to body fluids among medical students. A seven-year longitudinal study.

    abstract:BACKGROUND:Medical students may be at high risk for occupational exposures to blood. OBJECTIVE:To measure the frequency of medical students' exposure to infectious body substances, to identify factors that affect the probability of such exposure, and to suggest targets for the prevention of such exposure. DESIGN:Revi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-130-1-199901050-00009

    authors: Osborn EH,Papadakis MA,Gerberding JL

    更新日期:1999-01-05 00:00:00

  • Physician manpower expansionism: a policy review.

    abstract::A lack of national health goals has allowed physician manpower policy to be dominated by an expansionist philosophy. Scarce resources have been channeled into the production of specialist physicians trained to provide complex and expensive care for uncommon diseases, using other scare and expensive resources and addin...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-90-2-249

    authors: Bloom BS,Peterson OL

    更新日期:1979-02-01 00:00:00

  • The changing prognosis of classic hemophilia (factor VIII "deficiency").

    abstract:OBJECTIVE:To estimate relative risk of mortality and median life expectancy for patients with classic hemophilia by a life-table analysis, taking into account deaths that may have occurred in infancy or childhood before the onset of symptoms. DESIGN:Retrospective chart review of clinical series. SETTING:Referral-base...

    journal_title:Annals of internal medicine

    pub_type: 历史文章,杂志文章

    doi:10.7326/0003-4819-114-8-641

    authors: Jones PK,Ratnoff OD

    更新日期:1991-04-15 00:00:00

  • Death and taxes.

    abstract::Tax incentives can provide a large financial impetus to change behavior. Current U.S. law establishes a substantial discontinuity in the amount of estate tax that many patients will have to pay in 2010: During this year only, the tax rate drops to zero. This article discusses concerns regarding the sharp change in tax...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-149-11-200812020-00010

    authors: Mendenhall GS

    更新日期:2008-12-02 00:00:00

  • Balloon valvuloplasty in adult aortic stenosis: determinants of clinical outcome.

    abstract:STUDY OBJECTIVE:To determine the clinical variables affecting outcome after balloon aortic valvuloplasty. DESIGN:Longitudinal follow-up of consecutive case series. PATIENTS:Consecutive sample of 36 patients with severe calcific aortic stenosis, and without active infection or left ventricular mural thrombus. INTERVE...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章

    doi:10.7326/0003-4819-110-6-421

    authors: Sherman W,Hershman R,Lazzam C,Cohen M,Ambrose J,Gorlin R

    更新日期:1989-03-15 00:00:00

  • Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location.

    abstract:PURPOSE:To examine studies of normal colon and colorectal cancer for evidence that the location of the primary tumor proximal or distal to the splenic flexure of the colon may determine distinct genetic categories of this disease. DATA IDENTIFICATION:Studies were identified through a manual search of journals, through...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-113-10-779

    authors: Bufill JA

    更新日期:1990-11-15 00:00:00

  • Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline Update.

    abstract:Description:The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a selective update of the prior CKD-MBD guideline published in 2009. The guideline update an...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/M17-2640

    authors: Ketteler M,Block GA,Evenepoel P,Fukagawa M,Herzog CA,McCann L,Moe SM,Shroff R,Tonelli MA,Toussaint ND,Vervloet MG,Leonard MB

    更新日期:2018-03-20 00:00:00

  • Amantadine effect on peripheral airways abnormalities in influenza. A study in 15 students with natural influenza A infection.

    abstract::Amantadine HCl administration has resulted in accelerated resolution of influenza A illness. Prolonged abnormalities in pulmonary function have been described in uncomplicated influenza A. To study the effect of amantadine on these changes, we evaluated young adults with documented natural influenza A with clear chest...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-85-2-177

    authors: Little JW,Hall WJ,Douglas RG Jr,Hyde RW,Speers DM

    更新日期:1976-08-01 00:00:00

  • Brief communication: tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins.

    abstract:BACKGROUND:Although clinicians avoid giving meropenem to patients with penicillin allergy because of potential cross-reactivity, the rate of cross-reactivity between penicillins and meropenem has not been prospectively determined. OBJECTIVE:To assess the tolerability of meropenem in patients with documented penicillin...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.7326/0003-4819-146-4-200702200-00005

    authors: Romano A,Viola M,Guéant-Rodriguez RM,Gaeta F,Valluzzi R,Guéant JL

    更新日期:2007-02-20 00:00:00

  • Patient safety is not enough: targeting quality improvements to optimize the health of the population.

    abstract::Ensuring patient safety is essential for better health care, but preoccupation with niches of medicine, such as patient safety, can inadvertently compromise outcomes if it distracts from other problems that pose a greater threat to health. The greatest benefit for the population comes from a comprehensive view of popu...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-140-1-200401060-00009

    authors: Woolf SH

    更新日期:2004-01-06 00:00:00

  • Azithromycin compared with penicillin G benzathine for treatment of incubating syphilis.

    abstract:BACKGROUND:Preventive therapy is an important element of syphilis control efforts. No currently recommended, single-dose alternatives to penicillin G benzathine are available for treatment of incubating syphilis. OBJECTIVE:To evaluate the use of a single 1.0-g dose of azithromycin for treatment of persons recently exp...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-131-6-199909210-00007

    authors: Hook EW 3rd,Stephens J,Ennis DM

    更新日期:1999-09-21 00:00:00

  • Hearing Loss.

    abstract::Hearing loss is highly prevalent and may significantly affect how we age. Although the population is aging, relatively few adults receive treatment for hearing loss. Internists are a critical partner to audiologists and otolaryngologists in caring for the adult population with hearing loss. This review provides a prim...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/AITC202012010

    authors: Nieman CL,Oh ES

    更新日期:2020-12-01 00:00:00

  • HemoQuant, a new quantitative assay for fecal hemoglobin. Comparison with Hemoccult.

    abstract::HemoQuant, an assay based on heme-derived porphyrin, quantifies both total fecal hemoglobin ant that fraction already converted to porphyrin by gut flora (the intestinal converted fraction). Recovery by HemoQuant of blood added to stools exceeded 99% and was not affected by ascorbic acid, iron, or other additives. Hem...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-101-3-297

    authors: Ahlquist DA,McGill DB,Schwartz S,Taylor WF,Ellefson M,Owen RA

    更新日期:1984-09-01 00:00:00

  • Recovery of ventricular function after myocardial infarction in the reperfusion era: the healing and early afterload reducing therapy study.

    abstract:BACKGROUND:Patients with reduced left ventricular function and ventricular enlargement after myocardial infarction are at significantly greater risk for congestive heart failure and death. Nevertheless, recovery of ventricular function occurs in a significant proportion of patients after myocardial infarction, and mode...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-134-6-200103200-00009

    authors: Solomon SD,Glynn RJ,Greaves S,Ajani U,Rouleau JL,Menapace F,Arnold JM,Hennekens C,Pfeffer MA

    更新日期:2001-03-20 00:00:00

  • A highly automated hospital medication system. Five years' experience and evaluation.

    abstract::Since 1969, medications have been provided to patients at the Johns Hopkins Hospital using a computer system that controls the entire medication process from entry of physician's order to hourly drug distribution. Special envelopes containing patient and dosage information are computer generated for each dose to be ad...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-83-3-342

    authors: Simborg DW,Derewicz HJ

    更新日期:1975-09-01 00:00:00

  • Cyclophosphamide in the management of advanced Graves' ophthalmopathy. A preliminary report.

    abstract::Three patients with advanced Graves' ophthalmopathy were treated with cyclophosphamide. All had proptosis and diplopia. One patient had disabling iatrogenic Cushing's syndrome from steroid treatment of the ophthalmopathy and had undergone bilateral orbital decompression before cyclophosphamide therapy; steroids could ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-6-921

    authors: Bigos ST,Nisula BC,Daniels GH,Eastman RC,Johnston HH,Kohler PO

    更新日期:1979-06-01 00:00:00

  • Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences.

    abstract:BACKGROUND:Benign reductions in neutrophil counts may be more common at certain ages and in certain ethnic groups and may be affected by sex and smoking status. OBJECTIVE:To determine differences in neutrophil counts in the U.S. population according to ethnicity, age, sex, and smoking status. DESIGN:Population-based,...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-146-7-200704030-00004

    authors: Hsieh MM,Everhart JE,Byrd-Holt DD,Tisdale JF,Rodgers GP

    更新日期:2007-04-03 00:00:00

  • Hypocomplementemia in chronic idiopathic urticaria.

    abstract::A discrete evoking factor or presumed pathophysiologic mechanism is not recognized in the majority of patients with chronic urticaria or angioedema. Two cases are reported in which chronic urticaria was the main manifestation of an immune cutaneous vasculitis associated with hypocomplementemia attributable to classic ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-5-534

    authors: Mathison DA,Arroyave CM,Bhat KN,Hurewitz DS,Marnell DJ

    更新日期:1977-05-01 00:00:00

  • Sjögren's syndrome in progressive systemic sclerosis.

    abstract::Thirty-five consecutive patients with progressive systemic sclerosis were prospectively evaluated for evidence of Sjögren's syndrome. Six of the 35 (17%) were judged to have the disorder. This is a higher prevalence than in most reports, but much lower than that recently reportedly by Alarcón-Segovia and associates (7...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-87-5-535

    authors: Cipoletti JF,Buckingham RB,Barnes EL,Peel RL,Mahmood K,Cignetti FE,Pierce JM,Rabin BS,Rodnan GP

    更新日期:1977-11-01 00:00:00

  • Cystic fibrosis diagnosed after age 13. Twenty-five teenage and adult patients including three asymptomatic men.

    abstract::Cystic fibrosis was diagnosed after age 13 in 25 patients. All had an elevated sweat chloride and either a sibling with cystic fibrosis or typical pulmonary infection or digestive symptoms caused by exocrine pancreatic deficiency. Fourteen had long-standing pulmonary or digestive symptoms. In contrast, four of eight p...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-87-2-188

    authors: Stern RC,Boat TF,Doershuk CF,Tucker AS,Miller RB,Matthews LW

    更新日期:1977-08-01 00:00:00

  • Prevalence of advanced colorectal neoplasia in white and black patients undergoing screening colonoscopy in a safety-net hospital.

    abstract:UNLABELLED:Chinese translation BACKGROUND:Black persons are more likely than white persons to be diagnosed with colorectal cancer and to die from it. The extent to which genetic or biological factors versus disparities in screening rates explain this variance remains controversial. OBJECTIVE:To define the prevalence ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-159-1-201307020-00004

    authors: Schroy PC 3rd,Coe A,Chen CA,O'Brien MJ,Heeren TC

    更新日期:2013-07-02 00:00:00

  • Lymphadenopathy-associated virus: from molecular biology to pathogenicity.

    abstract::Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in g...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-5-689

    authors: Montagnier L

    更新日期:1985-11-01 00:00:00