Abstract:
BACKGROUND:Although clinicians avoid giving meropenem to patients with penicillin allergy because of potential cross-reactivity, the rate of cross-reactivity between penicillins and meropenem has not been prospectively determined. OBJECTIVE:To assess the tolerability of meropenem in patients with documented penicillin allergy. DESIGN:Prospective skin testing and antibiotic challenge. SETTING:Allergy units of 2 Italian medical centers. PATIENTS:104 consecutive participants with immediate hypersensitivity reactions to penicillins and positive skin test results to at least 1 penicillin reagent. MEASUREMENTS:Skin tests to meropenem and, if results were negative, challenges with escalating doses of meropenem. RESULTS:One participant (0.9% [95% CI, 0.02% to 5.2%]) had a positive intradermal test result to meropenem. The remaining 103 participants with negative skin test results to meropenem tolerated escalating dose challenges. LIMITATION:Challenges were not followed by therapeutic courses. CONCLUSIONS:These data indicate a low rate of cross-reactivity between penicillins and meropenem. Therefore, the practice of avoiding meropenem therapy in penicillin-allergic patients should be reconsidered. In patients who especially require meropenem treatment, the authors recommend pretreatment skin tests because negative results indicate tolerability.
journal_name
Ann Intern Medjournal_title
Annals of internal medicineauthors
Romano A,Viola M,Guéant-Rodriguez RM,Gaeta F,Valluzzi R,Guéant JLdoi
10.7326/0003-4819-146-4-200702200-00005subject
Has Abstractpub_date
2007-02-20 00:00:00pages
266-9issue
4eissn
0003-4819issn
1539-3704pii
146/4/266journal_volume
146pub_type
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journal_title:Annals of internal medicine
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abstract:OBJECTIVE:To evaluate the influence of a human immunodeficiency virus (HIV) vaccine given to uninfected volunteers on the interpretation of serodiagnostic HIV test results. DESIGN:Retrospective cohort study. SETTING:5 AIDS Vaccine Evaluation Units funded by the National Institute of Allergy and Infectious Diseases. ...
journal_title:Annals of internal medicine
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journal_title:Annals of internal medicine
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更新日期:1988-09-01 00:00:00