Abstract：
:The systemic capillary leak syndrome (SCLS) is a rare disease of reversible plasma extravasation and vascular collapse accompanied by hemoconcentration and hypoalbuminemia. Its cause is unknown, although it is believed to be a manifestation of transient endothelial dysfunction due to endothelial contraction, apoptosis, injury, or a combination of these. Fewer than 150 cases of SCLS have been reported, but the condition is probably underrecognized because of its nonspecific symptoms and signs and high mortality rate. Patients experience shock and massive edema, often after a nonspecific prodrome of weakness, fatigue, and myalgias, and are at risk for ischemia-induced organ failure, rhabdomyolysis and muscle compartment syndromes, and venous thromboembolism. Shock and edema reverse almost as quickly as they begin, at which time patients are at risk for death from flash pulmonary edema during rapid fluid remobilization. Diagnosis is made clinically and by exclusion of other diseases that cause similar symptoms and signs, most notably sepsis, anaphylaxis, and angioedema. Acute episodes are treated with vasopressor therapy and judicious fluid replacement, possibly with colloid solutions for their osmotic effects, to prevent the sequelae of underperfusion. Between episodes, patients may be treated with theophylline and terbutaline, which clinical experience suggests may reduce the severity and frequency of acute episodes. Prognosis is uncertain, but patients who survive an initial severe SCLS episode are estimated to have a 10-year survival rate greater than 70%. Much remains to be learned about SCLS, and clinicians should consider the diagnosis in patients with unexplained edema, increased hematocrit, and hypotension.
journal_name
Ann Intern Medjournal_title
Annals of internal medicineauthors
Druey KM,Greipp PRdoi
10.7326/0003-4819-153-2-201007200-00005subject
Has Abstractpub_date
2010-07-20 00:00:00pages
90-8issue
2eissn
0003-4819issn
1539-3704pii
153/2/90journal_volume
153pub_type
杂志文章,评审abstract：:Much time and effort are spent on designing primary research studies. Similar care must be given to planning systematic reviews. The review should be based on an important, well-focused question that is relevant to patient care. By formulating the question properly, the criteria that primary studies must meet to be in...
journal_title：Annals of internal medicine
pub_type： 杂志文章,评审
doi：10.7326/0003-4819-127-5-199709010-00008
更新日期：1997-09-01 00:00:00
abstract：:Because of difficulties in antemortem diagnosis of systemic aspergillosis, a radioimmunoassay to an Aspergillus fumigatus carbohydrate was developed and evaluated in patients with mycotic or bacterial infections. Antigenemia was detected in sera obtained antemortem from four of seven patients with systemic aspergillos...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-92-6-793
更新日期：1980-06-01 00:00:00
abstract：:Recently acquired knowledge about vitamin D metabolism has improved our understanding in different varieties of osteomalacia. Many new causes of osteomalacia continue to be found. Radiologic and biochemical changes are not always characteristic and may occasionally be misleading. Bone biopsy after a double tetracyclin...
journal_title：Annals of internal medicine
pub_type： 杂志文章,评审
doi：10.7326/0003-4819-89-6-966
更新日期：1978-12-01 00:00:00
abstract：BACKGROUND:Treatment of chronic hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) for 6 weeks achieves sustained virologic response (SVR) rates of 95% in some patients. If effective, shorter therapeutic courses could improve adherence and treatment costs. OBJECTIVE:To determine factors predictive ...
journal_title：Annals of internal medicine
pub_type： 临床试验,杂志文章
doi：10.7326/M15-0642
更新日期：2015-12-15 00:00:00
abstract：:The coexistence of chronic idiopathic thrombocytopenic purpura and myasthenia gravis has been infrequently reported. We report another case and show the coexistence of autoantibodies to the platelet glycoprotein IIb and IIIa complex and the acetylcholine receptor. Autoantibody levels were followed during 8 weeks of tr...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-100-6-829
更新日期：1984-06-01 00:00:00
abstract：BACKGROUND:Recent evidence shows that arthroscopic partial meniscectomy (APM) offers no benefit over conservative treatment of patients with a degenerative meniscus tear. However, patients who report mechanical symptoms (sensations of knee catching or locking) may benefit from APM. OBJECTIVE:To assess whether APM impr...
journal_title：Annals of internal medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.7326/M15-0899
更新日期：2016-04-05 00:00:00
abstract：OBJECTIVE:To determine whether laboratory findings showing antibodies to hepatitis C virus (HCV) in patients with autoimmune hepatitis represent false-positive results and to identify possible explanations for true-positive results in these patients. DESIGN:Cross-sectional. SETTING:University-based hospital. PATIENT...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-116-1-21
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Leukotriene-receptor antagonists (LTRAs) are recommended as an alternative treatment in patients with mild asthma, but their effect compared with placebo is unclear. PURPOSE:To determine the benefits and harms of LTRAs as monotherapy or in combination with inhaled corticosteroids compared with placebo in ad...
journal_title：Annals of internal medicine
pub_type： 杂志文章,meta分析,评审
doi：10.7326/M15-1059
更新日期：2015-11-17 00:00:00
abstract：BACKGROUND:Several adverse outcomes attributed to atypical antipsychotic drugs, specifically quetiapine, risperidone, and olanzapine, are known to cause acute kidney injury (AKI). Such outcomes include hypotension, acute urinary retention, and the neuroleptic malignant syndrome or rhabdomyolysis. OBJECTIVE:To investig...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/M13-2796
更新日期：2014-08-19 00:00:00
abstract：:Approximately 3000 people in Bennington, Vermont, 19% of the population, had a diarrheal illness during the first and second weeks of June 1978. Persons affected reported abdominal cramps (86%), diarrhea (82%), malaise (73%), and headache (47%). The mean duration of illness was 4.6 days. The illness was associated wit...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-96-3-292
更新日期：1982-03-01 00:00:00
abstract：BACKGROUND:Memphis and Shelby County, Tennessee, experienced an epidemic of hepatitis A in 1994 and 1995. More than 1700 cases were reported. OBJECTIVE:To characterize the clinical features of patients hospitalized during a large urban epidemic of hepatitis A. DESIGN:Retrospective chart review. SETTING:15 acute care...
journal_title：Annals of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.7326/0003-4819-128-2-199801150-00006
更新日期：1998-01-15 00:00:00
abstract：:Between 20 July and 15 Octoboer 1975, five cases of human infection with Babesia microti were diagnosed on Nantucket Island, Massachusetts. The illness was characterized by fever, drenching sweats, shaking chills, myalgia, arthralgia, extreme fatigue, and a mild-to-moderate hemolytic anemia. None of the patients had a...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-86-1-6
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVE:To assess the use of L-tryptophan by patients with eosinophilic fasciitis and compare this with its use by patients with progressive systemic sclerosis (scleroderma). DESIGN:Retrospective and prospective analysis. Six patients with eosinophilic fasciitis were identified retrospectively and two prospectively....
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-112-10-758
更新日期：1990-05-15 00:00:00
abstract：:Opioid dependence is a chronic relapsing medical condition with substantial health and societal complications. Recent federal initiatives are designed to enhance the medical treatment of patients with opioid dependence and will expand the role of internists in the care of these patients. These initiatives include a pr...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-137-8-200210150-00014
更新日期：2002-10-15 00:00:00
abstract：STUDY OBJECTIVE:To determine the efficacy of the addition of ifosfamide to cisplatin plus etoposide (VIP), or vinblastine (VeIP), in patients with recurrent germ cell tumors. DESIGN:Nonrandomized, prospective phase II trial. SETTING:Tertiary referral university hospital. PATIENTS:Fifty-six of fifty-eight entered pat...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-109-7-540
更新日期：1988-10-01 00:00:00
abstract：:Pyrimethamine-sulfadoxine has been associated with severe and fatal cutaneous reactions as well as transient liver damage. We report the case of a patient who died of progressive hepatic failure caused by pyrimethamine-sulfadoxine administration. In addition, we summarize reports made to the Food and Drug Administrati...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-106-3-393
更新日期：1987-03-01 00:00:00
abstract：:Subacute encephalitis caused by infection of the central nervous system by the human immunodeficiency virus (HIV) is the most frequent cause of neurologic dysfunction in patients with the acquired immunodeficiency syndrome (AIDS). This disorder results in progressive cognitive, motor, and behavioral abnormalities in a...
journal_title：Annals of internal medicine
pub_type： 杂志文章,评审
doi：10.7326/0003-4819-107-2-383
更新日期：1987-09-01 00:00:00
abstract：:We studied D-penicillamine toxicity in 259 patients with systemic sclerosis treated since 1972. The average daily dose of 635 mg was given for a mean of 1.8 years. Of patients with systemic sclerosis, 47% has side effects from D-penicillamine treatment, similar to the 56% of 807 patients with rheumatoid arthritis in s...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-104-5-699
更新日期：1986-05-01 00:00:00
abstract：:These supplemental recommendations provide guidelines for a monovalent influenza A(H1N1) vaccine for protection against a newly emerged variant of influenza that has recently caused outbreaks among children and young adults in Asia. Guidance is provided for the use of this monovalent vaccine, which contains 15 microgr...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：BACKGROUND:When deep venous thrombosis is suspected, objective testing is required to confirm or refute the diagnosis. OBJECTIVE:To determine whether the combination of a low clinical suspicion and a normal D -dimer result rules out deep venous thrombosis. DESIGN:Prospective cohort study. SETTING:Three tertiary care...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-135-2-200107170-00011
更新日期：2001-07-17 00:00:00
abstract：SOURCE CITATION:Ye Z, Rochwerg B, Wang Y, et al. Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline. CMAJ. 2020;192:E536-45. 32350002. ...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/ACPJ202007210-004
更新日期：2020-07-21 00:00:00
abstract：:An investigation of patient care in four hospitals compared levels of resource use between 1964 and 1974 for patients with a primary diagnosis of pneumonia. Results showed a decreased length of stay in all hospitals. Unique patterns of increases and decreases existed in each hospital for the changing use of diagnostic...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-85-5-648
更新日期：1976-11-01 00:00:00
abstract：:The clinical significance of anatomic substage was assessed in 130 patients with Hodgkin's disease in pathologic stage III-A: stage III1-A includes involvement of spleen, or splenic, celiac, or portal nodes, or any combination of these; stage III2-A includes involvement of para-aortic, iliac, or mesenteric nodes, with...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-92-2-159
更新日期：1980-02-01 00:00:00
abstract：:Expert groups, including the U.S. Preventive Services Task Force (USPSTF), recommend a range of clinical preventive services for persons at average risk for disease. Use of these services often is substantially lower among racial and ethnic minority groups, rural residents, and persons of lower socioeconomic status. O...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/M19-3171
更新日期：2020-02-18 00:00:00
abstract：:Arteriohepatic dysplasia (Alagille's syndrome) is presumed to be one of the familial intrahepatic cholestatic syndromes, all of which present with neonatal jaundice or failure to thrive, or both. We report the findings in five patients with this syndrome, four of whom have been followed into adulthood. In addition to ...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-91-4-520
更新日期：1979-10-01 00:00:00
abstract：:During 1973 and 1974, we looked for cases of Colorado tick fever throughout Colorado; 228 cases were identified. Although 90% of the patients reported exposure to ticks before illness, only 52% were aware of an actual tick bite. Typical symptoms of fever, myalgia, and headache were common, but gastrointestinal symptom...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-88-3-303
更新日期：1978-03-01 00:00:00
abstract：:Adult salicylate intoxication has been considered to be easily recognized and assciated with low morbidity and mortality. In the present study of 73 consecutive adults hospitalized with salicylate intoxication, 27% of patients were undiagnosed for as long as 72 h after admission. The initial physical findings and labo...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-85-6-745
更新日期：1976-12-01 00:00:00
abstract：BACKGROUND:Ear involvement is not unusual in autoimmune diseases, but few data on this problem in the Sjögren syndrome are available. OBJECTIVES:To determine whether the incidence of hearing loss is increased in patients with the Sjögren syndrome and to determine what factors might be involved in the pathogenesis of S...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-126-6-199703150-00005
更新日期：1997-03-15 00:00:00
abstract：OBJECTIVE:To determine whether concurrent treatment with acetaminophen and zidovudine impairs clearance of zidovudine, thereby increasing the risk for zidovudine-induced hematologic toxicity. DESIGN:Dose escalation, drug interaction study. SETTING:University clinical research center. PATIENTS:Patients with the acqui...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-114-11-937
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:Many constituents of fruits and vegetables may reduce the risk for coronary heart disease, but data on the relationship between fruit and vegetable consumption and risk for coronary heart disease are sparse. OBJECTIVE:To evaluate the association of fruit and vegetable consumption with risk for coronary hear...
journal_title：Annals of internal medicine
pub_type： 杂志文章
doi：10.7326/0003-4819-134-12-200106190-00010
更新日期：2001-06-19 00:00:00
