Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States.

Abstract:

BACKGROUND:Memphis and Shelby County, Tennessee, experienced an epidemic of hepatitis A in 1994 and 1995. More than 1700 cases were reported. OBJECTIVE:To characterize the clinical features of patients hospitalized during a large urban epidemic of hepatitis A. DESIGN:Retrospective chart review. SETTING:15 acute care hospitals in Shelby County, Tennessee. PATIENTS:256 patients hospitalized with acute hepatitis A. MEASUREMENTS:Laboratory findings (such as prothrombin time and bilirubin level), complications, and mortality. RESULTS:The median patient age was 26 years. Thirty-nine complications occurred in 35 patients. Twenty patients (8%) had extrahepatic complications, and 5 (2%) died. Patients 40 years of age and older were more likely to have serious complications, including death (P = 0.014). Sixty-seven patients (26%) presented with coagulopathy (prothrombin time > or = 3 seconds prolonged). Fifty-four patients (21%) had a bilirubin level greater than 170 micromol/L (10 mg/dL). CONCLUSIONS:During this epidemic, hepatitis A caused serious illness and death. Complications were more frequent in patients 40 years of age and older, but young, healthy persons were also at risk for severe complications.

journal_name

Ann Intern Med

authors

Willner IR,Uhl MD,Howard SC,Williams EQ,Riely CA,Waters B

doi

10.7326/0003-4819-128-2-199801150-00006

subject

Has Abstract

pub_date

1998-01-15 00:00:00

pages

111-4

issue

2

eissn

0003-4819

issn

1539-3704

journal_volume

128

pub_type

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