Hypocomplementemia in chronic idiopathic urticaria.

Abstract:

:A discrete evoking factor or presumed pathophysiologic mechanism is not recognized in the majority of patients with chronic urticaria or angioedema. Two cases are reported in which chronic urticaria was the main manifestation of an immune cutaneous vasculitis associated with hypocomplementemia attributable to classic and alternative mechanisms of complement activation. Among 72 consecutive patients evaluated for chronic urticaria, 10 additional patients with idiopathic urticaria were found to have hypocomplementemia. Of these, two had evidence of classic and alternative mechanisms of complement activation, five had evidence of only classic pathway activation, and three evidence of predominately or exclusively alternative pathway activation. Circulating immune complexes were found in the majority of patients with classic pathway activation. Hypocomplementemia may provide clues to pathophysiologic mechanisms operative in some patients with chronic urticaria.

journal_name

Ann Intern Med

authors

Mathison DA,Arroyave CM,Bhat KN,Hurewitz DS,Marnell DJ

doi

10.7326/0003-4819-86-5-534

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

534-8

issue

5

eissn

0003-4819

issn

1539-3704

journal_volume

86

pub_type

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