Low doses of interferon-alpha are as effective as higher doses in inducing remissions and prolonging survival in chronic myeloid leukemia.

abstract：:These supplemental recommendations provide guidelines for a monovalent influenza A(H1N1) vaccine for protection against a newly emerged variant of influenza that has recently caused outbreaks among children and young adults in Asia. Guidance is provided for the use of this monovalent vaccine, which contains 15 microgr...

journal_title：Annals of internal medicine

authors：

更新日期：1986-11-01 00:00:00

abstract：:Between 1 January 1980 and 18 October 1981, investigators from the Centers for Disease Control collected information on 1407 cases of toxic shock syndrome using a nationwide passive surveillance system. Ninety-two percent of the reported cases were associated with menstruation. Information available on the type of men...

journal_title：Annals of internal medicine

authors： Reingold AL,Hargrett NT,Shands KN,Dan BB,Schmid GP,Strickland BY,Broome CV

更新日期：1982-06-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the usefulness and safety of hydroxychloroquine in patients with decompensated, treatment-refractory noninsulin-dependent diabetes mellitus. DESIGN:Prospective, randomized, placebo, double-blind 6-month trial. PATIENTS:Thirty-eight patients with noninsulin-dependent diabetes resistant to c...

journal_title：Annals of internal medicine

authors： Quatraro A,Consoli G,Magno M,Caretta F,Nardozza A,Ceriello A,Giugliano D

更新日期：1990-05-01 00:00:00

abstract：:Access to information about clinical trials is important to researchers, health care professionals, and patients. Many have argued for the establishment of clinical trials registries, citing their substantial benefits. Although some registries do exist, it has been difficult to create comprehensive, easily accessible ...

journal_title：Annals of internal medicine

authors： McCray AT

更新日期：2000-10-17 00:00:00

abstract：:The indications for treating patients with subclinical hypothyroidism (normal serum thyroxine and free thyroxine levels, but elevated serum thyrotrophin levels) are poorly defined. In this study, 33 patients with subclinical hypothyroidism were randomly assigned in a double-blind manner to receive placebo or L-thyroxi...

journal_title：Annals of internal medicine

authors： Cooper DS,Halpern R,Wood LC,Levin AA,Ridgway EC

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:The high prevalence of classic cardiac risk factors in patients with non-insulin-dependent diabetes mellitus does not explain the increased cardiovascular-related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. OBJECTIVE:To evaluate the following in patients with n...

journal_title：Annals of internal medicine

authors： Bruno G,Cavallo-Perin P,Bargero G,Borra M,D'Errico N,Pagano G

更新日期：1996-10-15 00:00:00

abstract：PURPOSE:To review the available data on the treatment of chronic stable angina and formulate a rational approach to the use of pharmacologic therapy, percutaneous transluminal coronary angioplasty (PTCA), and coronary artery bypass graft surgery (CABG). DATA SOURCES:A MEDLINE search of English-language literature publ...

journal_title：Annals of internal medicine

authors： Solomon AJ,Gersh BJ

更新日期：1998-02-01 00:00:00

abstract：:Restrictive cardiomyopathy produced by primary cardiac amyloidosis may have a clinical syndrome identical to noncalcific constrictive pericarditis. We report two patients with amyloidosis and restrictive physiology who had enlarged papillary muscles shown on left ventricular angiocardiogram. Rapid volume expansion wit...

journal_title：Annals of internal medicine

authors： Maule WF,Martin RH

更新日期：1983-02-01 00:00:00

abstract：:We recently implemented a full-featured electronic health record in our independent, 4-internist, community-based practice of general internal medicine. We encountered various challenges, some unexpected, in moving from paper to computer. This article describes the effects that use of electronic health records has had...

journal_title：Annals of internal medicine

authors： Baron RJ,Fabens EL,Schiffman M,Wolf E

更新日期：2005-08-02 00:00:00

abstract：:Abdominal aortic aneurysms (AAAs) occur in 1 of 20 older men, remain asymptomatic for many years, and, if left untreated, cause death from rupture in about one third of patients. Ultrasonography is a suitable screening test for AAA, and elective repair can prevent rupture. Although these features suggest a promising t...

journal_title：Annals of internal medicine

authors： Lederle FA

更新日期：2003-09-16 00:00:00

abstract：:Sixty-eight patients clinically suspected of having (33), or at high risk for (35), deep venous thrombosis were studied with contrast venography, radiofibrinogen leg scanning, and impedance plethysmography as well as ventilation and perfusion lung scans. Thrombosis limited to the veins in the calf of the leg (unilater...

journal_title：Annals of internal medicine

authors： Moser KM,LeMoine JR

更新日期：1981-04-01 00:00:00

abstract：:To ascertain if mitral valve prolapse is inherited we studied 45 probands and 179 first-degree relatives. Echocardiographic mitral prolapse was present in 54 of 179 first-degree relatives (30%); at least one first-degree relative was affected in 29 families, including members of two generations in 23 families. The num...

journal_title：Annals of internal medicine

authors： Devereux RB,Brown WT,Kramer-Fox R,Sachs I

更新日期：1982-12-01 00:00:00

abstract：PURPOSE:To examine the cost-effectiveness of test-treatment strategies for patients suspected of having Lyme disease. DATA SOURCES:The medical literature was searched for information on outcomes and costs. Expert opinion was sought for information on utilities. STUDY SELECTION:Articles that described patient populati...

journal_title：Annals of internal medicine

authors： Nichol G,Dennis DT,Steere AC,Lightfoot R,Wells G,Shea B,Tugwell P

更新日期：1998-01-01 00:00:00

abstract：:Palliative care prioritizes symptom management and quality of life throughout the course of serious illness. Regardless of whether care is inpatient or outpatient, primary or subspecialty, a solid understanding of the basics of effective communication, symptom management, and end-of-life care is crucial. This article ...

journal_title：Annals of internal medicine

authors： Swetz KM,Kamal AH

更新日期：2018-03-06 00:00:00

abstract：:Simulation is a versatile technique used in a variety of health care settings for a variety of purposes, but the extent to which simulation may improve patient safety remains unknown. This systematic review examined evidence on the effects of simulation techniques on patient safety outcomes. PubMed and the Cochrane Li...

journal_title：Annals of internal medicine

authors： Schmidt E,Goldhaber-Fiebert SN,Ho LA,McDonald KM

更新日期：2013-03-05 00:00:00

abstract：:We treated 50 patients who ingested packets of cocaine and developed a protocol for conservative medical management. Of the 50 patients, only 3 required emergency surgery. Surgery was precipitated by signs and symptoms of bowel obstruction in all cases. Six patients chose elective surgery. The rest of the patients pas...

journal_title：Annals of internal medicine

authors： Caruana DS,Weinbach B,Goerg D,Gardner LB

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:ClinicalTrials.gov requires reporting of result summaries for many drug and device trials. PURPOSE:To evaluate the consistency of reporting of trials that are registered in the ClinicalTrials.gov results database and published in the literature. DATA SOURCES:ClinicalTrials.gov results database and matched ...

journal_title：Annals of internal medicine

authors： Hartung DM,Zarin DA,Guise JM,McDonagh M,Paynter R,Helfand M

更新日期：2014-04-01 00:00:00

abstract：:Daily change of intravenous (i.v.) infusion administration sets has been recommended by the Center for Disease Control since 1973 to reduce the risk of infusion bacteremia. To evaluate this recommendation, we undertook a prospective, randomized, controlled trial that compared the rates of i.v.-associated bacteremia, i...

journal_title：Annals of internal medicine

authors： Buxton AE,Highsmith AK,Garner JS,West CM,Stamm WE,Dixon RE,McGowan JE Jr

更新日期：1979-05-01 00:00:00

abstract：:Protein S activity may be compromised in patients with the nephrotic syndrome and contribute to a thrombotic diathesis. Protein S is found in two forms in plasma as free and functionally active protein S, and complexed to C4b-binding protein. When compared with controls, patients with nephrotic syndrome had reduced fu...

journal_title：Annals of internal medicine

authors： Vigano-D'Angelo S,D'Angelo A,Kaufman CE Jr,Sholer C,Esmon CT,Comp PC

更新日期：1987-07-01 00:00:00

abstract：:Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report s...

journal_title：Annals of internal medicine

authors： Johnson RH,Lutwick LI,Huntley GA,Vosti KL

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Questions remain about the importance of smoking and smoking cessation after incident myocardial infarction. OBJECTIVE:To assess the association between smoking status and risk for recurrent coronary events. DESIGN:Retrospective, population-based, inception cohort study. SETTING:Health maintenance organiz...

journal_title：Annals of internal medicine

authors： Rea TD,Heckbert SR,Kaplan RC,Smith NL,Lemaitre RN,Psaty BM

更新日期：2002-09-17 00:00:00

abstract：PURPOSE:To review methods of preventing or minimizing the adverse effects associated with the transfusion of passenger leukocytes present in cellular blood components and to define groups of patients who are at risk for adverse effects. DATA SOURCES:English-language articles on transfusion medicine. STUDY SELECTION:O...

journal_title：Annals of internal medicine

authors： Lane TA,Anderson KC,Goodnough LT,Kurtz S,Moroff G,Pisciotto PT,Sayers M,Silberstein LE

更新日期：1992-07-15 00:00:00

abstract：:Twenty-one juvenile-onset diabetic patients with azotemic nephropathy underwent coronary angiography and left ventriculography before renal transplantation or chronic hemodialysis. Two-year survival of 12 patients with no coronary artery disease (group A) was 88% compared to 22% for nine patients with coronary artery ...

journal_title：Annals of internal medicine

authors： Weinrauch LA,D'elia JA,Healy RW,Gleason RE,Takacs FJ,Libertino JA,Leland OS

更新日期：1978-03-01 00:00:00

abstract：:The training of physicians for the delivery of primary care is becoming a national priority. The period of residency training is viewed by many as the focal point for educational change to meet this demand. The Residency Program in Social Medicine at Montefiore Hospital and Medical Center was begun in 1970 and offers ...

journal_title：Annals of internal medicine

authors： Boufford JI

更新日期：1977-09-01 00:00:00

abstract：OBJECTIVE:To determine whether concurrent treatment with acetaminophen and zidovudine impairs clearance of zidovudine, thereby increasing the risk for zidovudine-induced hematologic toxicity. DESIGN:Dose escalation, drug interaction study. SETTING:University clinical research center. PATIENTS:Patients with the acqui...

journal_title：Annals of internal medicine

authors： Sattler FR,Ko R,Antoniskis D,Shields M,Cohen J,Nicoloff J,Leedom J,Koda R

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:To identify and describe patients with hepatotoxicity possibly caused by flutamide, an antiandrogen drug. DESIGN:Case series of reports, submitted to the Adverse Drug Event Reporting System of the Food and Drug Administration. SETTING:Outpatient clinics and physicians' offices in the United States. PATIENT...

journal_title：Annals of internal medicine

authors： Wysowski DK,Freiman JP,Tourtelot JB,Horton ML 3rd

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Impressive decreases in cardiovascular mortality have been achieved through risk factor reduction and clinical intervention, yet cardiovascular disease remains a leading cause of death nationally. OBJECTIVE:To estimate up-to-date preventable fractions of cardiovascular mortality associated with elimination ...

journal_title：Annals of internal medicine

authors： Patel SA,Winkel M,Ali MK,Narayan KM,Mehta NK

更新日期：2015-08-18 00:00:00

abstract：:Eighty-six patients who required heparin therapy were randomly assigned to receive bovine or porcine heparin. Abnormal concentrations of alanine transaminase and aspartate transaminase developed during treatment in 59.3% and 26.7% of patients, respectively. Patient characteristics that significantly influenced the dev...

journal_title：Annals of internal medicine

authors： Dukes GE Jr,Sanders SW,Russo J Jr,Swenson E,Burnakis TG,Saffle JR,Warden GD

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:The choice of antiplatelet therapy after acute coronary syndrome (ACS) is complicated: Ticagrelor and prasugrel are novel alternatives to clopidogrel, patients with some genotypes may not respond to clopidogrel, and low-cost generic formulations of clopidogrel are available. OBJECTIVE:To determine the most ...

journal_title：Annals of internal medicine

authors： Kazi DS,Garber AM,Shah RU,Dudley RA,Mell MW,Rhee C,Moshkevich S,Boothroyd DB,Owens DK,Hlatky MA

更新日期：2014-02-18 00:00:00

abstract：OBJECTIVE:To prospectively study the clinical features, pathophysiology, treatment and prognosis of Wegener granulomatosis. DESIGN:Of the 180 patients with Wegener granulomatosis referred to the National Institute of Allergy and Infectious Diseases during the past 24 years, 158 have been followed for 6 months to 24 ye...

journal_title：Annals of internal medicine

authors： Hoffman GS,Kerr GS,Leavitt RY,Hallahan CW,Lebovics RS,Travis WD,Rottem M,Fauci AS

更新日期：1992-03-15 00:00:00