Association of fibrinogen with glycemic control and albumin excretion rate in patients with non-insulin-dependent diabetes mellitus.

Abstract:

BACKGROUND:The high prevalence of classic cardiac risk factors in patients with non-insulin-dependent diabetes mellitus does not explain the increased cardiovascular-related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. OBJECTIVE:To evaluate the following in patients with non-insulin-dependent diabetes mellitus: 1) the distribution of plasma fibrinogen levels and the prevalence of hyperfibrinogenemia and 2) the association of fibrinogen level with hemoglobin A1c value and albumin excretion rate. DESIGN:Cross-sectional study of a population-based cohort. SETTING:Rural area in northern Italy. PATIENTS:1574 patients with non-insulin-dependent diabetes mellitus who represented 81% of the initial cohort of 1967 patients. MEASUREMENTS:Albumin excretion rate was measured in urine samples obtained during an overnight collection. Venous blood samples were collected while patients fasted. RESULTS:Fibrinogen levels were available for 1525 of the 1574 patients who were examined (669 men and 856 women). The mean age (+/- SD) was 67.3 +/- 10.3 years for men and 70.7 +/- 10.7 years for women. The mean plasma fibrinogen level (+/- SD) was 3.6 +/- 0.9 g/L; levels slightly differed between men and women. In 50.3% of patients, plasma fibrinogen level exceeded 3.5 g/L. In men, fibrinogen level increased with age (P < 0.001). In both men and women, fibrinogen level adjusted for age and sex was significantly and linearly related to hemoglobin A1c value (P < 0.001) and albumin excretion rate (P < 0.001). In a multiple regression analysis, hemoglobin A1c value (b = 0.06; P < 0.001) and albumin excretion rate (b = 0.09; P = 0.005) were associated with fibrinogen level independent of other cardiovascular risk factors (sex, age, hypertensive status, total cholesterol level, smoking habit, and body mass index). CONCLUSIONS:Patients with non-insulin-dependent diabetes mellitus had a high prevalence of hyperfibrinogenemia. Fibrinogen level was independently associated with hemoglobin A1c value and albumin excretion rate, which suggests that fibrinogen may be involved in the increased cardiovascular risk of patients with diabetes mellitus.

journal_name

Ann Intern Med

authors

Bruno G,Cavallo-Perin P,Bargero G,Borra M,D'Errico N,Pagano G

doi

10.7326/0003-4819-125-8-199610150-00005

subject

Has Abstract

pub_date

1996-10-15 00:00:00

pages

653-7

issue

8

eissn

0003-4819

issn

1539-3704

journal_volume

125

pub_type

杂志文章
  • Role of platelets in tumor cell metastases.

    abstract::Platelets may have a role in the development of animal tumor metastases. Ultrastructural studies in vivo have shown arrested tumor emboli surrounded by platelets. Several tumor cell lines induce thrombocytopenia in vivo. Certain tumor cells aggregate platelets in vitro. Correlations exist between the ability of some t...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-95-5-636

    authors: Karpatkin S,Pearlstein E

    更新日期:1981-11-01 00:00:00

  • Screening for dementia and investigating its causes.

    abstract:OBJECTIVE:To examine, from the perspective of primary care physicians, the value of mental status findings and ancillary tests in diagnosing dementia or its causes. DATA SOURCES:Studies identified using MEDLINE and bibliographies of pertinent articles. STUDY SELECTION:Selection based on availability of information on...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-115-2-122

    authors: Siu AL

    更新日期:1991-07-15 00:00:00

  • Sudden cardiac death: management of high-risk patients.

    abstract::Sudden cardiac death remains a leading cause of death in the United States, accounting for more than 350,000 deaths each year, and the survival rate of victims remains low. Most survivors face a significant risk for recurrence. The typical substrate is chronic--abnormal myocardium with fibrosis (often from previous my...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-114-6-499

    authors: Akhtar M,Garan H,Lehmann MH,Troup PJ

    更新日期:1991-03-15 00:00:00

  • The Institute of Medicine report, "A Manpower Policy for Primary Health Care": a commentary from the American College of Physicians.

    abstract::In 1978 the Institute of Medicine issued "A Manpower Policy for Health Care," the report of a study of major issues bearing on the availability of an adequate number of physicians for provision of primary care and on potential strategies for an appropriate manpower policy. The report was analyzed by committees of the ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-92-6-843

    authors: Peterson ML

    更新日期:1980-06-01 00:00:00

  • Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development.

    abstract::Sulfasalazine is metabolized by intestinal bacteria, resulting in the release of sulfapyridine and 5-aminosalicylate. The drug is useful in the treatment of active ulcerative colitis as well as in preventing relapses of the disease in remission. Although effective in active Crohn's disease as well, sulfasalazine appea...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,评审

    doi:10.7326/0003-4819-101-3-377

    authors: Peppercorn MA

    更新日期:1984-09-01 00:00:00

  • The demise of primary care: a diatribe from the trenches.

    abstract::Medical school graduates are avoiding primary care. The very aspects that once attracted students have been subverted. The breadth of practice that was once appealing has become the breadth of heavy-handed scrutiny, as politicians and business leaders have demanded quality--simplistically defined as dogmatic adherence...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-150-10-200905190-00011

    authors: Norenberg DD

    更新日期:2009-05-19 00:00:00

  • Meta-analysis: the effect of dietary counseling for weight loss.

    abstract:BACKGROUND:Dietary and lifestyle modification efforts are the primary treatments for people who are obese or overweight. The effect of dietary counseling on long-term weight change is unclear. PURPOSE:To perform a meta-analysis of the effect of dietary counseling compared with usual care on body mass index (BMI) over ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/0003-4819-147-1-200707030-00007

    authors: Dansinger ML,Tatsioni A,Wong JB,Chung M,Balk EM

    更新日期:2007-07-03 00:00:00

  • A randomized clinical trial of acupuncture compared with sham acupuncture in fibromyalgia.

    abstract:BACKGROUND:Fibromyalgia is a common chronic pain condition for which patients frequently use acupuncture. OBJECTIVE:To determine whether acupuncture relieves pain in fibromyalgia. DESIGN:Randomized, sham-controlled trial in which participants, data collection staff, and data analysts were blinded to treatment group. ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-143-1-200507050-00005

    authors: Assefi NP,Sherman KJ,Jacobsen C,Goldberg J,Smith WR,Buchwald D

    更新日期:2005-07-05 00:00:00

  • Have we treated AIDS too well? Rationing and the future of AIDS exceptionalism.

    abstract::During the past decade, medical therapy for AIDS has become more effective but also prohibitively expensive. A medical tragedy has been transformed into a financial crisis, and society has responded by establishing special programs and sources of funding for AIDS. These maneuvers parallel earlier approaches to HIV tes...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-128-9-199805010-00009

    authors: Casarett DJ,Lantos JD

    更新日期:1998-05-01 00:00:00

  • Coronary morbidity and mortality, pre-existing silent coronary artery disease, and mild hypertension.

    abstract::Experimental findings in animals and epidemiologic studies in humans provide strong evidence that hypertension promotes the onset and progression of atherosclerosis. However, effective antihypertensive therapy has not consistently reduced the incidence of cardiac events in the major trials of treatment for mild hypert...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,评审

    doi:10.7326/0003-4819-110-12-1017

    authors: O'Kelly BF,Massie BM,Tubau JF,Szlachcic J

    更新日期:1989-06-15 00:00:00

  • An additional basic science for clinical medicine: I. The constraining fundamental paradigms.

    abstract::The four main conceptual paradigms of basic biomedical research are that the explication of mechanisms is a primary goal of science; that scientific data must be "hard"; that formulation of hypotheses and counter-hypotheses is a principal creative challenge; and that experiments are the main mechanism for using scient...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章

    doi:10.7326/0003-4819-99-3-393

    authors: Feinstein AR

    更新日期:1983-09-01 00:00:00

  • Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis.

    abstract:BACKGROUND:Changes in federal health policy are providing more access to medical care for persons with chronic disease. Providing quality care may require a team approach, which the American College of Physicians calls the "medical home." One new model may involve nurse-managed protocols. PURPOSE:To determine whether ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/M13-2567

    authors: Shaw RJ,McDuffie JR,Hendrix CC,Edie A,Lindsey-Davis L,Nagi A,Kosinski AS,Williams JW Jr

    更新日期:2014-07-15 00:00:00

  • Ultrasonographic screening for abdominal aortic aneurysms.

    abstract::Abdominal aortic aneurysms (AAAs) occur in 1 of 20 older men, remain asymptomatic for many years, and, if left untreated, cause death from rupture in about one third of patients. Ultrasonography is a suitable screening test for AAA, and elective repair can prevent rupture. Although these features suggest a promising t...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-139-6-200309160-00016

    authors: Lederle FA

    更新日期:2003-09-16 00:00:00

  • Diagnostic and predictive accuracy of blood pressure screening methods with consideration of rescreening intervals: a systematic review for the U.S. Preventive Services Task Force.

    abstract:BACKGROUND:Elevated blood pressure (BP) is the largest contributing risk factor to all-cause and cardiovascular mortality. PURPOSE:To update a systematic review on the benefits and harms of screening for high BP in adults and to summarize evidence on rescreening intervals and diagnostic and predictive accuracy of diff...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/M14-1539

    authors: Piper MA,Evans CV,Burda BU,Margolis KL,O'Connor E,Whitlock EP

    更新日期:2015-02-03 00:00:00

  • Acute leukemia in multiple myeloma.

    abstract::Of 476 patients with multiple myeloma treated during a 9-year period, 11 developed acute myelogenous leukemia or sideroblastic anemia. In all, the myeloma was in remission from chemotherapy with melphalan-prednisone combinations that had been continued for a median duration of 3 years. The incidence of acute leukemia ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-4-440

    authors: Gonzalez F,Trujillo JM,Alexanian R

    更新日期:1977-04-01 00:00:00

  • Discordant thymectomy in identical twins concordant for myasthenia gravis.

    abstract:BACKGROUND:Thymectomy is standard therapy fornonthymomatousmyasthenia gravis despite the absence of randomized clinical trials (1). Myasthenia gravis is uncommonly reported in monozygous twins; disease concordance occurs in approximately one third of such identical twin pairs; and treatment for myasthenia gravis, when ...

    journal_title:Annals of internal medicine

    pub_type: 信件

    doi:10.7326/0003-4819-155-7-201110040-00016

    authors: Riggs KR,Gutmann L,Riggs JE

    更新日期:2011-10-04 00:00:00

  • Benefits, harms, and cost-effectiveness of supplemental ultrasonography screening for women with dense breasts.

    abstract:BACKGROUND:Many states have laws requiring mammography facilities to tell women with dense breasts and negative results on screening mammography to discuss supplemental screening tests with their providers. The most readily available supplemental screening method is ultrasonography, but little is known about its effect...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M14-0692

    authors: Sprague BL,Stout NK,Schechter C,van Ravesteyn NT,Cevik M,Alagoz O,Lee CI,van den Broek JJ,Miglioretti DL,Mandelblatt JS,de Koning HJ,Kerlikowske K,Lehman CD,Tosteson AN

    更新日期:2015-02-03 00:00:00

  • Arizona hinshawii infections. New cases, antimicrobial sensitivities, and literature review.

    abstract::Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report s...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-85-5-587

    authors: Johnson RH,Lutwick LI,Huntley GA,Vosti KL

    更新日期:1976-11-01 00:00:00

  • Blood-group-A-like substance in a preparation of pneumococcal vaccine.

    abstract::A platelet transfusion from a blood group O donor, immunized 1 month before with Pneumovax, caused a hemolytic reaction in a blood group A recipient. Forty-five of 59 group O donors (76%) and all of nine group B donors immunized with Pneumovax had a fourfold or higher anti-A response. Half of the anti-A antibody in hi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-96-5-580

    authors: Siber GR,Ambrosino DM,Gorgone BC

    更新日期:1982-05-01 00:00:00

  • The safety of treadmill exercise stress testing in patients with abdominal aortic aneurysms.

    abstract:BACKGROUND:Exercise stress testing in patients with abdominal aortic aneurysms may cause enlargement or rupture of aneurysms. OBJECTIVE:To evaluate the safety of treadmill exercise stress testing in patients with abdominal aortic aneurysms. DESIGN:Retrospective descriptive study. SETTING:Tertiary care center. PATIE...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-129-8-199810150-00008

    authors: Best PJ,Tajik AJ,Gibbons RJ,Pellikka PA

    更新日期:1998-10-15 00:00:00

  • Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis.

    abstract:BACKGROUND:Although several agents are available to treat osteoporosis, the relative efficacy and toxicity of these agents when used to prevent fractures has not been well described. PURPOSE:To compare the benefits in fracture reduction and the harms from adverse events of various therapies for osteoporosis. DATA SOU...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-148-3-200802050-00198

    authors: MacLean C,Newberry S,Maglione M,McMahon M,Ranganath V,Suttorp M,Mojica W,Timmer M,Alexander A,McNamara M,Desai SB,Zhou A,Chen S,Carter J,Tringale C,Valentine D,Johnsen B,Grossman J

    更新日期:2008-02-05 00:00:00

  • Flushing reactions: consequences and mechanisms.

    abstract::The mechanisms of flushing reactions are pharmacologically and physiologically heterogeneous. Flushing may result from agents acting directly on the vascular smooth muscle or may be mediated by vasomotor nerves. Vasomotor nerves may lead to flushing as a result of events at both peripheral and central sites. In suscep...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-95-4-468

    authors: Wilkin JK

    更新日期:1981-10-01 00:00:00

  • Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source.

    abstract::Three patients with polymyositis had elevated serum levels of creatine kinase MB isoenzyme. The presence of this isoenzyme is used extensively to diagnose myocardial infarction, but the isoenzyme is also found in sera of patients with primary muscular and neuromuscular disorders. We studied cardiac function in two of ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-94-3-341

    authors: Larca LJ,Coppola JT,Honig S

    更新日期:1981-03-01 00:00:00

  • General internal medicine at the crossroads of prosperity and despair: caring for patients with chronic diseases in an aging society.

    abstract::During the past quarter century, general internal medicine has emerged as a vital discipline. In the realm of patient care, it is the integrating discipline par excellence. Ironically, as general internists face the challenge of integrating advances of dizzying speed and complexity, and as their clinical practice beco...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-134-10-200105150-00013

    authors: Larson EB

    更新日期:2001-05-15 00:00:00

  • The common hyperlipoproteinemias: an understanding of disease mechanisms and their control.

    abstract::Our review focuses on low density lipoprotein (LD lipoprotein) and very low density lipoprotein (VLD lipoprotein) in their roles as transporters of cholesterol and triglyceride and as factors contributing to premature arteriovascular disease. We describe the clinical manifestations of the common, primary hyperlipoprot...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-85-4-497

    authors: Fisher WR,Truitt DH

    更新日期:1976-10-01 00:00:00

  • Change in trans fatty acid content of fast-food purchases associated with New York City's restaurant regulation: a pre-post study.

    abstract:BACKGROUND:Dietary trans fat increases risk for coronary heart disease. In 2006, New York City (NYC) passed the first regulation in the United States restricting trans fat use in restaurants. OBJECTIVE:To assess the effect of the NYC regulation on the trans and saturated fat content of fast-food purchases. DESIGN:Cro...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-157-2-201207170-00004

    authors: Angell SY,Cobb LK,Curtis CJ,Konty KJ,Silver LD

    更新日期:2012-07-17 00:00:00

  • Salicylate-induced pulmonary edema. Clinical features and prognosis.

    abstract::To assess the course and prognosis of salicylate-induced pulmonary edema, we reviewed the records of 36 consecutive patients admitted with serum salicylate levels greater than 30 mg/dL. Pulmonary edema developed in eight patients, and pulmonary infiltrates were never seen in 28 patients. Several features distinguished...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-95-4-405

    authors: Heffner JE,Sahn SA

    更新日期:1981-10-01 00:00:00

  • Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): explanation and elaboration.

    abstract::The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the reporting of studies developing, validating, or updating a prediction model, whether for diagnostic or prognostic purposes. The TRIPOD Statement...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M14-0698

    authors: Moons KG,Altman DG,Reitsma JB,Ioannidis JP,Macaskill P,Steyerberg EW,Vickers AJ,Ransohoff DF,Collins GS

    更新日期:2015-01-06 00:00:00

  • Alternative perspectives on the biased foundations of medical technology assessment.

    abstract::Medical technology assessment seeks to improve the care of individual patients (the conventional unit of clinical practice) through evaluation studies conducted in groups of patients (the conventional unit of clinical investigation). This distinction between individuals and groups has practical relevance to the design...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-118-6-199303150-00010

    authors: Diamond GA,Denton TA

    更新日期:1993-03-15 00:00:00

  • Screening for Urinary Incontinence in Women: A Recommendation From the Women's Preventive Services Initiative.

    abstract:Description:Recommendation on screening for urinary incontinence in women by the Women's Preventive Services Initiative (WPSI), a national coalition of women's health professional organizations and patient representatives. The WPSI's recommendations are intended to guide clinical practice and coverage of services for t...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/M18-0595

    authors: O'Reilly N,Nelson HD,Conry JM,Frost J,Gregory KD,Kendig SM,Phipps M,Salganicoff A,Ramos D,Zahn C,Qaseem A,Women's Preventive Services Initiative.

    更新日期:2018-09-04 00:00:00