当前位置： SCI文献检索 > ANNALS OF INTERNAL MEDICINE期刊下所有文献 > Cardiovascular mortality associated with 5 leading risk factors: national and state preventable fractions estimated from survey data.

Cardiovascular mortality associated with 5 leading risk factors: national and state preventable fractions estimated from survey data.

Abstract：

BACKGROUND:Impressive decreases in cardiovascular mortality have been achieved through risk factor reduction and clinical intervention, yet cardiovascular disease remains a leading cause of death nationally. OBJECTIVE:To estimate up-to-date preventable fractions of cardiovascular mortality associated with elimination and reduction of 5 leading risk factors nationally and by state in the United States. DESIGN:Cross-sectional and cohort studies. SETTING:Nationally representative and state-representative samples of the U.S. population. PARTICIPANTS:Adults aged 45 to 79 years. MEASUREMENTS:Self-reported risk factor status in the BRFSS (Behavioral Risk Factor Surveillance System) 2009-2010 was corrected to approximate clinical definitions. The relative hazards of cardiovascular death (International Classification of Diseases, 10th Revision, codes I00 to I99) associated with risk factors were estimated using data from NHANES (National Health and Nutrition Examination Survey) (1988-1994 and 1999-2004, followed through 2006). RESULTS:The preventable fraction of cardiovascular mortality associated with complete elimination of elevated cholesterol levels, diabetes, hypertension, obesity, and smoking was 54.0% for men and 49.6% for women in 2009 to 2010. When the more feasible target of reducing risk factors to the best achieved levels in the states was considered, diabetes (1.7% and 4.1%), hypertension (3.8% and 7.3%), and smoking (5.1% and 4.4%) were independently associated with the largest preventable fractions among men and women, respectively. With both targets, southern states had the largest preventable fractions, and western states had the smallest. LIMITATION:Self-reported state data; mortality hazards relied on baseline risk factor status. CONCLUSION:Major modifiable cardiovascular risk factors collectively accounted for half of cardiovascular deaths in U.S. adults aged 45 to 79 years in 2009 to 2010. Fewer than 10% of cardiovascular deaths nationally could be prevented if all states were to achieve risk factor levels observed in the best-performing states. PRIMARY FUNDING SOURCE:Robert Wood Johnson Foundation.

journal_name

Ann Intern Med

journal_title

Annals of internal medicine

authors

Patel SA,Winkel M,Ali MK,Narayan KM,Mehta NK

doi

10.7326/M14-1753

subject

Has Abstract

pub_date

2015-08-18 00:00:00

pages

245-53

issue

eissn

0003-4819

issn

1539-3704

pii

2362308

journal_volume

163

pub_type

杂志文章

在线工具

Cardiovascular mortality associated with 5 leading risk factors: national and state preventable fractions estimated from survey data.