Sites of conduction disease in aortic stenosis: significance of valve gradient and calcification.

abstract：:Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in six patients with hemophilia...

journal_title：Annals of internal medicine

authors： Lesesne HR,Morgan JE,Blatt PM,Webster WP,Roberts HR

更新日期：1977-06-01 00:00:00

abstract：:Methylation of DNA is a biochemical modification that can influence gene expression and is involved in inactivating one of the two X chromosomes in women. Evidence that has accumulated in the past 10 years suggests that cancer cells usurp this physiologic mechanism and use it to their benefit by inactivating tumor sup...

journal_title：Annals of internal medicine

authors： Santini V,Kantarjian HM,Issa JP

更新日期：2001-04-03 00:00:00

abstract：:To determine the relative sensitivity and specificity of noninvasive methods for detecting aortic insufficiency, we compared the accuracy of auscultation, echocardiography, and pulsed Doppler echocardiography in detecting aortic insufficiency in 106 patients in whom the presence or absence of the lesion was shown by s...

journal_title：Annals of internal medicine

authors： Grayburn PA,Smith MD,Handshoe R,Friedman BJ,DeMaria AN

更新日期：1986-05-01 00:00:00

abstract：:Physical symptoms account for more than half of all outpatient visits, but the specific causes and treatments of many common symptoms are frequently not well established. Because clinical research has primarily targeted specific diseases, symptoms-based research is still an emerging field of scientific inquiry, and op...

journal_title：Annals of internal medicine

authors： Kroenke K

更新日期：2001-05-01 00:00:00

abstract：:9-(1,3-dihydroxy-2-propoxymethyl) guanine (ganciclovir) was used to treat 41 patients (median age, 37 years) with the acquired immunodeficiency syndrome and cytomegalovirus gastrointestinal infection. Sites of infection were the colon in 31, the esophagus in 5, the rectum in 4, and the small bowel in 1. Patients recei...

journal_title：Annals of internal medicine

authors： Chachoua A,Dieterich D,Krasinski K,Greene J,Laubenstein L,Wernz J,Buhles W,Koretz S

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Noninvasive testing for Helicobacter pylori is widely available and has been considered as an initial management strategy for uninvestigated dyspepsia. However, data to guide clinicians in the management of patients with dyspepsia who are seropositive for H. pylori are lacking. OBJECTIVE:To examine the econ...

journal_title：Annals of internal medicine

authors： Ofman JJ,Etchason J,Fullerton S,Kahn KL,Soll AH

更新日期：1997-02-15 00:00:00

abstract：OBJECTIVE:To determine whether the detection of tuberculostearic acid (TBSA) in bronchial aspirate and bronchoalveolar lavage specimens is useful for the rapid diagnosis of active pulmonary tuberculosis in patients suspected of having the disease. SETTING:A pulmonary clinic in a teaching hospital. PATIENTS:Forty pati...

journal_title：Annals of internal medicine

authors： Pang JA,Chan HS,Chan CY,Cheung SW,French GL

更新日期：1989-10-15 00:00:00

abstract：Background:Central line-associated bloodstream infection (CLABSI) remains prevalent in hospitals in the United States. Objective:To evaluate the impact of a multimodal intervention in hospitals with elevated rates of health care-associated infection. Design:Pre-post observational evaluation of a prospective, national...

journal_title：Annals of internal medicine

authors： Patel PK,Greene MT,Jones K,Rolle AJ,Ratz D,Snyder A,Saint S,Chopra V

更新日期：2019-10-01 00:00:00

abstract：:A 53-year-old librarian had recurrent palpable purpura on her ankles and legs that was found to be caused by the fumes released from heat-activated photocopy paper at her place of employment. Behenic acid was identified as the responsible chemical component through a series of challenge studies that simulated her work...

journal_title：Annals of internal medicine

authors： Tencati JR,Novey HS

更新日期：1983-03-01 00:00:00

abstract：:Traditional educational methods change clinical practice only with considerable effort and difficulty. In particular, the teaching of critical appraisal in the setting of journal clubs does not increase the amount of medical research read by trainees. Experiential learning theory, corroborated by the success of proble...

journal_title：Annals of internal medicine

authors： Badgett RG,O'Keefe M,Henderson MC

更新日期：1997-06-01 00:00:00

abstract：:A platelet transfusion from a blood group O donor, immunized 1 month before with Pneumovax, caused a hemolytic reaction in a blood group A recipient. Forty-five of 59 group O donors (76%) and all of nine group B donors immunized with Pneumovax had a fourfold or higher anti-A response. Half of the anti-A antibody in hi...

journal_title：Annals of internal medicine

authors： Siber GR,Ambrosino DM,Gorgone BC

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND:Even with optimal pharmacotherapy, symptomatic heart failure is associated with substantial morbidity and mortality. PURPOSE:To determine the efficacy and safety of cardiac resynchronization therapy in adults with advanced systolic heart failure. DATA SOURCES:The Cochrane Central Register of Controlled Tri...

journal_title：Annals of internal medicine

authors： McAlister FA,Ezekowitz JA,Wiebe N,Rowe B,Spooner C,Crumley E,Hartling L,Klassen T,Abraham W

更新日期：2004-09-07 00:00:00

abstract：BACKGROUND:The sequelae during the first two decades after acute hepatitis C virus (HCV) infection have been well studied, but the outcome thereafter is unknown. OBJECTIVE:To conduct an extended study of the natural history of HCV infection by using archived serum specimens originally collected between 1948 and 1954. ...

journal_title：Annals of internal medicine

authors： Seeff LB,Miller RN,Rabkin CS,Buskell-Bales Z,Straley-Eason KD,Smoak BL,Johnson LD,Lee SR,Kaplan EL

更新日期：2000-01-18 00:00:00

abstract：BACKGROUND:Castleman disease, an unusual condition of unknown cause consisting of a massive proliferation of lymphoid tissue, remains a clinicopathologic diagnosis. Three histologic variants (hyaline vascular, plasma-cell, and mixed) and two clinical types (localized and multicentric) of Castleman disease have been des...

journal_title：Annals of internal medicine

authors： Herrada J,Cabanillas F,Rice L,Manning J,Pugh W

更新日期：1998-04-15 00:00:00

abstract：:Arterial blood gas analysis is used to evaluate oxygen and carbon dioxide gas exchange and acid-base status. Few studies identify indications for arterial blood gas analysis, especially with regard to optimizing the quality of patient care. General indications in severely ill adults usually include pathophysiologic ab...

journal_title：Annals of internal medicine

authors： Raffin TA

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:No regulations govern placebo composition. The composition of placebos can influence trial outcomes and merits reporting. PURPOSE:To assess how often investigators specify the composition of placebos in randomized, placebo-controlled trials. DATA SOURCES:4 English-language general and internal medicine jou...

journal_title：Annals of internal medicine

authors： Golomb BA,Erickson LC,Koperski S,Sack D,Enkin M,Howick J

更新日期：2010-10-19 00:00:00

abstract：OBJECTIVE:To examine, from the perspective of primary care physicians, the value of mental status findings and ancillary tests in diagnosing dementia or its causes. DATA SOURCES:Studies identified using MEDLINE and bibliographies of pertinent articles. STUDY SELECTION:Selection based on availability of information on...

journal_title：Annals of internal medicine

authors： Siu AL

更新日期：1991-07-15 00:00:00

abstract：:The indications for treating patients with subclinical hypothyroidism (normal serum thyroxine and free thyroxine levels, but elevated serum thyrotrophin levels) are poorly defined. In this study, 33 patients with subclinical hypothyroidism were randomly assigned in a double-blind manner to receive placebo or L-thyroxi...

journal_title：Annals of internal medicine

authors： Cooper DS,Halpern R,Wood LC,Levin AA,Ridgway EC

更新日期：1984-07-01 00:00:00

abstract：:Patients with variant angina refractory to medical therapy pose a difficult management problem. We report two patients with variant angina who had focal spasm in coronary arteries with fixed obstructions of less than 20% of the luminal diameter. Ischemic episodes were accompanied by malignant ventricular arrhythmias a...

journal_title：Annals of internal medicine

authors： Sussman EJ,Goldberg S,Poll DS,MacVaugh H 3rd,Simson MB,Silber SA,Kastor JA

更新日期：1981-06-01 00:00:00

abstract：:For over 200 years digitalis compounds have been used to treat atrial fibrillation. The rapid ventricular response to atrial fibrillation is frequently treated with digoxin to produce a controlled heart rate. Digoxin has also been proposed as a treatment for terminating recent-onset atrial fibrillation, for maintainin...

journal_title：Annals of internal medicine

authors： Falk RH,Leavitt JI

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:A sensitive and acceptable screening regimen for women at high risk for breast cancer is essential. Contrast-enhanced magnetic resonance imaging (MRI) of the breast is highly sensitive for diagnosis of breast cancer but has variable specificity. PURPOSE:To summarize the sensitivity, specificity, likelihood ...

journal_title：Annals of internal medicine

authors： Warner E,Messersmith H,Causer P,Eisen A,Shumak R,Plewes D

更新日期：2008-05-06 00:00:00

abstract：OBJECTIVE:To assess the accuracy of Histoplasma capsulatum variety capsulatum polysaccharide antigen testing for the identification of histoplasmosis relapse in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN:A retrospective study using stored specimens. SETTING:A referral center and several priva...

journal_title：Annals of internal medicine

authors： Wheat LJ,Connolly-Stringfield P,Blair R,Connolly K,Garringer T,Katz BP

更新日期：1991-12-15 00:00:00

abstract：BACKGROUND:Understanding the risk factors for ventilator-associated pneumonia can help to assess prognosis and devise and test preventive strategies. OBJECTIVE:To examine the baseline and time-dependent risk factors for ventilator-associated pneumonia and to determine the conditional probability and cumulative risk ov...

journal_title：Annals of internal medicine

authors： Cook DJ,Walter SD,Cook RJ,Griffith LE,Guyatt GH,Leasa D,Jaeschke RZ,Brun-Buisson C

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Alleviating the problems faced by dying persons and their families has drawn substantial public attention, but little is known about the experience of dying. OBJECTIVE:To characterize the experience of dying from the perspective of surrogate decision makers, usually close family members (89%). DESIGN:Prosp...

journal_title：Annals of internal medicine

authors： Lynn J,Teno JM,Phillips RS,Wu AW,Desbiens N,Harrold J,Claessens MT,Wenger N,Kreling B,Connors AF Jr

更新日期：1997-01-15 00:00:00

abstract：:A model of activation, proliferation, and differentiation of human lymphocyte responses is described, and the complex immunoregulatory modulation of this system discussed with regard to normal immune function and the aberrancies expressed in diseases characterized by abnormalities of immune function. Recent advances i...

journal_title：Annals of internal medicine

authors： Fauci AS,Lane HC,Volkman DJ

更新日期：1983-07-01 00:00:00

abstract：:One half of 42 subjects treated for painful shoulders received classic acupuncture, and one half received a placebo in which the needles did not penetrate the skin. Half of each of these groups was treated in a positive setting to encourage the subject, and half in a negative setting designed to keep encouragement at ...

journal_title：Annals of internal medicine

authors： Moore ME,Berk SN

更新日期：1976-04-01 00:00:00

abstract：:Intravenous drug users are the second largest risk group for the acquired immunodeficiency syndrome (AIDS) and a bridge to two other groups: children and heterosexual partners. In the absence of effective treatment or vaccines, control of the epidemic among drug users will rely on efforts to reduce needle sharing. How...

journal_title：Annals of internal medicine

authors： Des Jarlais DC,Friedman SR,Hopkins W

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Dietary and lifestyle modification efforts are the primary treatments for people who are obese or overweight. The effect of dietary counseling on long-term weight change is unclear. PURPOSE:To perform a meta-analysis of the effect of dietary counseling compared with usual care on body mass index (BMI) over ...

journal_title：Annals of internal medicine

authors： Dansinger ML,Tatsioni A,Wong JB,Chung M,Balk EM

更新日期：2007-07-03 00:00:00

abstract：:The 1986 False Claims Act Amendments authorize private citizens to sue on behalf of the U.S. government to recover federal funds from fraudulent recipients. The "relator" receives a share of any proceeds from a successful lawsuit. Originally enacted because of defense procurement scandals, this statute also applies to...

journal_title：Annals of internal medicine

authors： Hsia DC

更新日期：1991-06-15 00:00:00

abstract：OBJECTIVE:To document the effects of treatment with famciclovir on the acute signs and symptoms of herpes zoster and postherpetic neuralgia. DESIGN:A randomized, double-blind, placebo-controlled, multicenter trial. SETTING:36 centers in the United States, Canada, and Australia. PATIENTS:419 immunocompetent adults wi...

journal_title：Annals of internal medicine

authors： Tyring S,Barbarash RA,Nahlik JE,Cunningham A,Marley J,Heng M,Jones T,Rea T,Boon R,Saltzman R

更新日期：1995-07-15 00:00:00