Liver biopsy in hemophilia A.

Abstract:

:Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in six patients with hemophilia A who had the persistence of abnormal liver-function tests for at least 6 months, are described. Three patients had chronic active hepatitis, and three had chronic persistent hepatitis. No complications were encountered as a result of the biopsy procedure. These results suggest that percutaneous liver biopsy should be considered in patients with hemophilia A with continuously abnormal liver-function tests to establish a histologic diagnosis and to guide further therapy.

journal_name

Ann Intern Med

authors

Lesesne HR,Morgan JE,Blatt PM,Webster WP,Roberts HR

doi

10.7326/0003-4819-86-6-703

subject

Has Abstract

pub_date

1977-06-01 00:00:00

pages

703-7

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

86

pub_type

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