Good enough: a primer on the analysis and interpretation of noninferiority trials.

abstract：STUDY OBJECTIVE:To determine the effect of massive cocaine intoxication on lung water and ascites accumulation and the effect of beta- and alpha-adrenergic blockade on survival in massive cocaine intoxication in the mouse. DESIGN:The effect of massive cocaine intoxication on lung water, ascitic fluid accumulation, and...

journal_title：Annals of internal medicine

authors： Robin ED,Wong RJ,Ptashne KA

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Because only limited evidence suggests that elastic stockings prevent the post-thrombotic syndrome in patients with symptomatic deep venous thrombosis (DVT), these stockings are not widely used. OBJECTIVE:To evaluate the efficacy of compression elastic stockings for prevention of the post-thrombotic syndrom...

journal_title：Annals of internal medicine

authors： Prandoni P,Lensing AW,Prins MH,Frulla M,Marchiori A,Bernardi E,Tormene D,Mosena L,Pagnan A,Girolami A

更新日期：2004-08-17 00:00:00

abstract：OBJECTIVE:To determine in female tennis and squash players the effect of biological age (that is, the starting age of playing relative to the age at menarche) at which tennis or squash playing was started on the difference in bone mineral content between the playing and non-playing arms. DESIGN:Cross-sectional study. ...

journal_title：Annals of internal medicine

authors： Kannus P,Haapasalo H,Sankelo M,Sievänen H,Pasanen M,Heinonen A,Oja P,Vuori I

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of all-trans retinoic acid to induce complete remission and to examine its effects on duration of remission and survival in patients with acute promyelocytic leukemia. DESIGN:Phase II evaluation and comparison with historical control patients. SETTING:Tertiary care cancer...

journal_title：Annals of internal medicine

authors： Frankel SR,Eardley A,Heller G,Berman E,Miller WH Jr,Dmitrovsky E,Warrell RP Jr

更新日期：1994-02-15 00:00:00

abstract：OBJECTIVE:To evaluate the 6-month change in cardiovascular (coronary heart disease) risk as a function of diet and drug therapy for mild hypertension. DESIGN:Collaborative randomized, controlled clinical trial to assess the efficacy of alternative regimens in treating mild hypertension. SETTING:Three university-based...

journal_title：Annals of internal medicine

authors： Oberman A,Wassertheil-Smoller S,Langford HG,Blaufox MD,Davis BR,Blaszkowski T,Zimbaldi N,Hawkins CM

更新日期：1990-01-15 00:00:00

abstract：:Neuropathologic and neurochemical studies of older adults with Down's syndrome and those with Alzheimer's disease reveal striking similarities. Genetic studies indicate that near relatives of patients with Alzheimer's disease are at increased risk of developing Alzheimer's disease, and the risk appears to be age speci...

journal_title：Annals of internal medicine

authors： Cutler NR,Heston LL,Davies P,Haxby JV,Schapiro MB

更新日期：1985-10-01 00:00:00

abstract：:To re-evaluate the relationship between Crohn's disease and sarcoidosis, we compared the numbers and types of cells recovered by bronchoalveolar lavage from normal volunteers and patients with Crohn's disease, with other forms of inflammatory bowel disease, and with sarcoidosis. Patients with Crohn's disease, but not ...

journal_title：Annals of internal medicine

authors： Smiéjan JM,Cosnes J,Chollet-Martin S,Soler P,Basset FM,Le Quintrec Y,Hance AJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:New tests, such as magnetic resonance imaging (MRI) and electron-beam computed tomography (CT), are being developed for the diagnosis of coronary artery disease. OBJECTIVE:To determine the conditions that a new test must meet to be a cost-effective alternative to established imaging tests. DESIGN:Decision ...

journal_title：Annals of internal medicine

authors： Hunink MG,Kuntz KM,Fleischmann KE,Brady TJ

更新日期：1999-11-02 00:00:00

abstract：OBJECTIVE:To evaluate the risk for chronic renal disease associated with regular use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs). DESIGN:Multicenter case-control study. PATIENTS:Patients were 554 North Carolina residents (age range, 30 to 79 years) hospitalized between 1980 and 1982 with a discharge d...

journal_title：Annals of internal medicine

authors： Sandler DP,Burr FR,Weinberg CR

更新日期：1991-08-01 00:00:00

abstract：:The expression of ischemic heart disease was studied in a large kindred with familial hypercholesterolemia. Tendon xanthomas, multiple generation transmission, and the appearance of bimodality in the distributions of total and low-density lipoprotein cholesterol were found. The segregation ratio was 0.9 in females and...

journal_title：Annals of internal medicine

authors： Streja D,Steiner G,Kwiterovich PO Jr

更新日期：1978-12-01 00:00:00

abstract：:Internal medicine residencies risk becoming obsolete if they are not adjusted to changing patterns of medical practice. Declining length of hospital stay, increased intensity of hospital care, movement of critical management decisions to outpatient settings, increased proportions of admissions for specific diagnostic ...

journal_title：Annals of internal medicine

authors： Schroeder SA,Showstack JA,Gerbert B

更新日期：1986-04-01 00:00:00

abstract：:The study of events in time is fundamental to biomedical research and public health surveillance. Clinicians have an intuitive appreciation for the relevance of time to health and disease, and patients invariably ask questions relating to time for which clinicians need answers. An appreciation of the picture of health...

journal_title：Annals of internal medicine

authors： Samet JM

更新日期：2000-01-04 00:00:00

abstract：:Disseminated candidiasis has become an important infection, particularly in immunocompromised and postoperative patients. Although serologic tests may, in some settings, facilitate a premortem diagnosis, the disease is usually diagnosed by comprehensive clinical evaluation. Detection of the relatively newly recognized...

journal_title：Annals of internal medicine

authors： Edwards JE Jr,Lehrer RI,Stiehm ER,Fischer TJ,Young LS

更新日期：1978-07-01 00:00:00

abstract：:Intravenous drug users are the second largest risk group for the acquired immunodeficiency syndrome (AIDS) and a bridge to two other groups: children and heterosexual partners. In the absence of effective treatment or vaccines, control of the epidemic among drug users will rely on efforts to reduce needle sharing. How...

journal_title：Annals of internal medicine

authors： Des Jarlais DC,Friedman SR,Hopkins W

更新日期：1985-11-01 00:00:00

abstract：:We observed the course of cytomegalovirus (CMV) retinitis in 21 eyes of 14 immunosuppressed patients. In two patients, other organisms, specifically Toxoplasma and Candida, also appeared to be causing retinal disease simultaneously. Post-mortem examination was done on 10 eyes from seven patients. At initial presentati...

journal_title：Annals of internal medicine

authors： Egbert PR,Pollard RB,Gallagher JG,Merigan TC

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Primary aldosteronism is a common cause of treatment-resistant hypertension. However, evidence from local health systems suggests low rates of testing for primary aldosteronism. OBJECTIVE:To evaluate testing rates for primary aldosteronism and evidence-based hypertension management in patients with treatmen...

journal_title：Annals of internal medicine

authors： Cohen JB,Cohen DL,Herman DS,Leppert JT,Byrd JB,Bhalla V

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Although the efficacy of adjuvant chemotherapy in prolonging survival for women with breast cancer has been well documented, limited population-based information is available on the actual use of chemotherapy. OBJECTIVE:To examine the relationship between age and chemotherapy use. DESIGN:Cohort study. SET...

journal_title：Annals of internal medicine

authors： Du XL,Key CR,Osborne C,Mahnken JD,Goodwin JS

更新日期：2003-01-21 00:00:00

abstract：Background:More than half of enrollees in the U.S. Department of Veterans Affairs (VA) are also covered by Medicare and can choose to receive their prescriptions from VA or from Medicare-participating providers. Such dual-system care may lead to unsafe opioid use if providers in these 2 systems do not coordinate care o...

journal_title：Annals of internal medicine

authors： Moyo P,Zhao X,Thorpe CT,Thorpe JM,Sileanu FE,Cashy JP,Hale JA,Mor MK,Radomski TR,Donohue JM,Hausmann LRM,Hanlon JT,Good CB,Fine MJ,Gellad WF

更新日期：2019-04-02 00:00:00

abstract：:Access to information about clinical trials is important to researchers, health care professionals, and patients. Many have argued for the establishment of clinical trials registries, citing their substantial benefits. Although some registries do exist, it has been difficult to create comprehensive, easily accessible ...

journal_title：Annals of internal medicine

authors： McCray AT

更新日期：2000-10-17 00:00:00

abstract：:All practicing physicians should be prepared to respond to requests from patients for advice about participating in clinical trials research. Even physicians who choose not to conduct clinical trials but rather devote their practice to clinical care may have patients who consider volunteering for research. In advising...

journal_title：Annals of internal medicine

authors： Chen DT,Miller FG,Rosenstein DL

更新日期：2003-04-15 00:00:00

abstract：:Five patients with chronic renal failure who were undergoing maintenance hemodialysis developed a self-limited bullous dermatosis restricted to light exposed areas, primarily involving the dorsa of the hands. Porphyrin levels and phototesting were normal, but histologic sections of the bullae showed thickening of venu...

journal_title：Annals of internal medicine

authors： Gilchrest B,Rowe JW,Mihm MC Jr

更新日期：1975-10-01 00:00:00

abstract：:Fifty-three consecutive patients with inferior myocardial infarction were evaluated prospectively, by physical examination and right heart catheterization within 36 hours of the onset of symptoms, to determine whether physical findings can separate such patients into those with and without associated right ventricular...

journal_title：Annals of internal medicine

authors： Dell'Italia LJ,Starling MR,O'Rourke RA

更新日期：1983-11-01 00:00:00

abstract：:Treatment selection markers, sometimes called predictive markers, are factors that help clinicians select therapies that maximize good outcomes and minimize adverse outcomes for patients. Existing statistical methods for evaluating a treatment selection marker include assessing its prognostic value, evaluating treatme...

journal_title：Annals of internal medicine

authors： Janes H,Pepe MS,Bossuyt PM,Barlow WE

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Few treatments exist for coronavirus disease 2019 (COVID-19). PURPOSE:To evaluate the effectiveness and harms of remdesivir for COVID-19. DATA SOURCES:Several databases, tables of contents of journals, and U.S. Food and Drug Administration and company websites were searched from 1 January through 31 August...

journal_title：Annals of internal medicine

authors： Wilt TJ,Kaka AS,MacDonald R,Greer N,Obley A,Duan-Porter W

更新日期：2020-10-05 00:00:00

abstract：BACKGROUND:The risk for hypertension after kidney donation remains uncertain. PURPOSE:To see whether normotensive adults who donate a kidney develop higher blood pressure and risk for hypertension compared with nondonor adults acting as control participants. DATA SOURCES:MEDLINE, EMBASE, and Science Citation Index we...

journal_title：Annals of internal medicine

authors： Boudville N,Prasad GV,Knoll G,Muirhead N,Thiessen-Philbrook H,Yang RC,Rosas-Arellano MP,Housawi A,Garg AX,Donor Nephrectomy Outcomes Research (DONOR) Network.

更新日期：2006-08-01 00:00:00

abstract：:Patients with serious psychiatric disorders are frequently treated by primary care physicians, who may have difficulty keeping up with recent advances in psychiatry. This paper presents an updated synopsis for three major psychiatric illnesses: major depression, bipolar disorder, and schizophrenia. Current definitions...

journal_title：Annals of internal medicine

authors： Glick ID,Suppes T,DeBattista C,Hu RJ,Marder S

更新日期：2001-01-02 00:00:00

abstract：Background:Difficulties with daily functioning are common in middle-aged adults. However, little is known about the epidemiology or clinical course of these problems, including the extent to which they share common features with functional impairment in older adults. Objective:To determine the epidemiology and clinica...

journal_title：Annals of internal medicine

authors： Brown RT,Diaz-Ramirez LG,Boscardin WJ,Lee SJ,Steinman MA

更新日期：2017-12-05 00:00:00

abstract：OBJECTIVE:To measure changes in spinal and femoral neck bone mineral densities in patients treated for Graves thyrotoxicosis. DESIGN:Cohort study. SETTING:Tertiary care center. PATIENTS:Fifteen women with active Graves thyrotoxicosis. Six patients were premenopausal and nine were postmenopausal. All patients had evi...

journal_title：Annals of internal medicine

authors： Diamond T,Vine J,Smart R,Butler P

更新日期：1994-01-01 00:00:00

abstract：Background:In 1994, 40% of U.S. gun owners who had recently acquired a firearm did so without a background check. No contemporary estimates exist. Objective:To estimate the proportion of current U.S. gun owners who acquired their most recent firearm without a background check, by time since and manner of acquisition, ...

journal_title：Annals of internal medicine

authors： Miller M,Hepburn L,Azrael D

更新日期：2017-02-21 00:00:00

abstract：:Twenty-nine men with stage III or unresectable stage II malignant germ cell tumors and no previous chemotherapy received treatments with the VAB-6 protocol. The VAB-6 regimen is a 1-year program beginning with three successive inductions at 3-to-4-week intervals: day 1--cyclophosphamide, 600 mg/m of body surface area ...

journal_title：Annals of internal medicine

authors： Vugrin D,Herr HW,Whitmore WF Jr,Sogani PC,Golbey RB

更新日期：1981-07-01 00:00:00