Plasma high-density lipoproteins and ischemic heart disease: studies in a large kindred with familial hypercholesterolemia.

Abstract:

:The expression of ischemic heart disease was studied in a large kindred with familial hypercholesterolemia. Tendon xanthomas, multiple generation transmission, and the appearance of bimodality in the distributions of total and low-density lipoprotein cholesterol were found. The segregation ratio was 0.9 in females and 0.43 in males, a difference first apparent during adolescence. The upper quartile of total and low-density lipoprotein cholesterol contained all but two cases of ischemic disease, whereas the lower quartile of high-density lipoprotein cholesterol contained one half of the cases. The ratio of high- to low-density lipoprotein cholesterol (range, 0.06 to 1.6) was less than or equal to 0.20 in each patient with ischemic disease. The association of a low level of high-density lipoprotein cholesterol with ischemic disease persisted after adjustment for differences in other lipids and lipoproteins. A low level of high-density lipoprotein cholesterol, as well as a high level of low-density lipoprotein cholesterol, may influence the development of ischemic heart disease in this disorder.

journal_name

Ann Intern Med

authors

Streja D,Steiner G,Kwiterovich PO Jr

doi

10.7326/0003-4819-89-6-871

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

871-80

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

89

pub_type

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