Clinical research and the physician-patient relationship.

abstract：BACKGROUND:Leukotriene-receptor antagonists (LTRAs) are recommended as an alternative treatment in patients with mild asthma, but their effect compared with placebo is unclear. PURPOSE:To determine the benefits and harms of LTRAs as monotherapy or in combination with inhaled corticosteroids compared with placebo in ad...

journal_title：Annals of internal medicine

authors： Miligkos M,Bannuru RR,Alkofide H,Kher SR,Schmid CH,Balk EM

更新日期：2015-11-17 00:00:00

abstract：:The sharp rise in drug abuse in the past decade has led to the development of new sources of information on drug-abuse trends. These include surveys, drug-related emergencies, drug-abuse treatment, hepatitis rates, and various types of law enforcement information. This paper summarizes data currently available for her...

journal_title：Annals of internal medicine

authors： Greene MH,Nightingale SL,DuPont RL

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND:Menopausal hormone therapy to prevent chronic conditions is currently not recommended because of its adverse effects. PURPOSE:To update evidence about the effectiveness of hormone therapy in reducing risk for chronic conditions and adverse effects, and to examine whether outcomes vary among women in differe...

journal_title：Annals of internal medicine

authors： Nelson HD,Walker M,Zakher B,Mitchell J

更新日期：2012-07-17 00:00:00

abstract：:Plasma lipid and lipoprotein-cholesterol levels were measured in 10 insulin-dependent (Type I) diabetics taking their usual dose of conventionally administered insulin during 6 months of a continuous subcutaneous insulin infusion delivered with a small, portable, battery-powered pump. With this insulin delivery system...

journal_title：Annals of internal medicine

authors： Dunn FL,Pietri A,Raskin P

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Physical activity has been related to enhanced bone mass and improved physical functioning and thus may reduce the risk for osteoporotic fracture. OBJECTIVE:To determine whether higher levels of physical activity are related to lower incidence of hip, wrist, and vertebral fractures. DESIGN:Prospective coho...

journal_title：Annals of internal medicine

authors： Gregg EW,Cauley JA,Seeley DG,Ensrud KE,Bauer DC

更新日期：1998-07-15 00:00:00

abstract：:An investigation of patient care in four hospitals compared levels of resource use between 1964 and 1974 for patients with a primary diagnosis of pneumonia. Results showed a decreased length of stay in all hospitals. Unique patterns of increases and decreases existed in each hospital for the changing use of diagnostic...

journal_title：Annals of internal medicine

authors： Sheeley DR,Sherman H

更新日期：1976-11-01 00:00:00

abstract：:Sleep problems are common in pregnant women. This review examines sleep in normal pregnancy; discusses the physiologic bases for alterations in sleep, including hormonal and mechanical factors; and correlates these factors with changes in sleep of pregnant women, as determined subjectively by surveys and objectively b...

journal_title：Annals of internal medicine

authors： Santiago JR,Nolledo MS,Kinzler W,Santiago TV

更新日期：2001-03-06 00:00:00

abstract：BACKGROUND:Each year, millions of patients worldwide have a perioperative myocardial infarction (MI) after noncardiac surgery. OBJECTIVE:To examine the characteristics and short-term outcome of perioperative MI. DESIGN:Cohort study. (ClinicalTrials.gov registration number: NCT00182039) SETTING:190 centers in 23 coun...

journal_title：Annals of internal medicine

authors： Devereaux PJ,Xavier D,Pogue J,Guyatt G,Sigamani A,Garutti I,Leslie K,Rao-Melacini P,Chrolavicius S,Yang H,Macdonald C,Avezum A,Lanthier L,Hu W,Yusuf S,POISE (PeriOperative ISchemic Evaluation) Investigators.

更新日期：2011-04-19 00:00:00

abstract：:Deficiency of fat-soluble vitamins (A,D,E, and K) was evaluated in 15 patients with exocrine pancreatic insufficiency secondary to chronic alcoholic pancreatitis. Mild to moderate steatorrhea was present in all patients despite oral pancreatic enzyme therapy for 27 +/- 4 months (mean +/- SE). Deficiency of a single fa...

journal_title：Annals of internal medicine

authors： Dutta SK,Bustin MP,Russell RM,Costa BS

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:To review the literature on prevention of intravascular catheter-related infections. DATA SOURCES:The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for relevant articles. Primary authors were contacted directly if data were incomplete. STUDY SE...

journal_title：Annals of internal medicine

authors： Mermel LA

更新日期：2000-03-07 00:00:00

abstract：:Two-dimensional echocardiograms were done during rest and after exercise in 95 patients who subsequently had coronary arteriography. Prior myocardial infarction was present in 36 patients, 35 of whom had wall motion abnormalities. There was no evidence of prior infarction in 59 patients, 44 of whom had coronary diseas...

journal_title：Annals of internal medicine

authors： Armstrong WF,O'Donnell J,Dillon JC,McHenry PL,Morris SN,Feigenbaum H

更新日期：1986-12-01 00:00:00

abstract：:Folate deficiency is a frequent cause of anemia in alcoholics, but little attention has been paid to its prevention. Folic acid was readily soluble in wines of high ethanol content at concentrations of 10 microgram/ml. Lactobacillus casei folate activity of folic acid added to wines was well maintained during a month'...

journal_title：Annals of internal medicine

authors： Kaunitz JD,Lindenbaum J

更新日期：1977-11-01 00:00:00

abstract：PURPOSE:To review epidemiologic studies on the association between homocyst(e)ine level and risk for cardiovascular disease and the potential benefits of homocysteine-decreasing therapies. DATA SOURCES:Computerized and manual searches of the literature on total homocysteine levels and cardiovascular disease. STUDY SE...

journal_title：Annals of internal medicine

authors： Eikelboom JW,Lonn E,Genest J Jr,Hankey G,Yusuf S

更新日期：1999-09-07 00:00:00

abstract：BACKGROUND:Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the most common clotting abnormality in patients with venous thromboembolism. OBJECTIVE:To evaluate the risk for venous thromboembolism associated with the factor V Leiden mutation or with resistance to activated protein C in t...

journal_title：Annals of internal medicine

authors： Rodeghiero F,Tosetto A

更新日期：1999-04-20 00:00:00

abstract：:We retrospectively reviewed the therapeutic efficacy of antithyroid drugs for Graves disease. Sixty-nine patients were divided into three categories according to their response: 28 (40.6%) were unable to achieve a remission; 6 (8.7%) achieved a remission and subsequently had a relapse; and 35 (50.7%) were able to sust...

journal_title：Annals of internal medicine

authors： Solomon BL,Evaul JE,Burman KD,Wartofsky L

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:To investigate the relation between the quantity of human immunodeficiency virus type 1 (HIV-1) RNA in plasma and the risk for the acquired immunodeficiency syndrome (AIDS) or a decline in the CD4+ T-cell count after seroconversion. DESIGN:Prospective study. PATIENTS:62 homosexual men with documented HIV-1 ...

journal_title：Annals of internal medicine

authors： Mellors JW,Kingsley LA,Rinaldo CR Jr,Todd JA,Hoo BS,Kokka RP,Gupta P

更新日期：1995-04-15 00:00:00

abstract：:The latest guidelines from the American College of Cardiology and American Heart Association, released in fall 2013, provide a long-anticipated update to the recommendations of the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol ...

journal_title：Annals of internal medicine

authors： Cook NR,Ridker PM

更新日期：2016-12-06 00:00:00

abstract：:Seventy homosexual men with unexplained persistent diffuse lymphadenopathy enrolled in a prospective natural history study from November 1981 to November 1982. These men had demographic, clinical, and laboratory findings similar to those of homosexual patients with the acquired immunodeficiency syndrome. Pathologic ex...

journal_title：Annals of internal medicine

authors： Abrams DI,Lewis BJ,Beckstead JH,Casavant CA,Drew WL

更新日期：1984-06-01 00:00:00

abstract：:The coexistence of pregnancy and idiopathic hypertrophic subaortic stenosis is a potentially dangerous combination. We report a 23-year-old white woman with idiopathic hypertrophic subaortic stenosis and pregnancy who presented with severe symptoms (Class IV) and modest outflow obstruction associated with marked mitra...

journal_title：Annals of internal medicine

authors： Kolibash AJ,Ruiz DE,Lewis RP

更新日期：1975-06-01 00:00:00

abstract：:Thirty-five consecutives patients with classic or definite rheumatoid arthritis underwent echocardiography to evaluate the motion of the anterior mitral valve leaflet. Adequate echocardiograms were obtained in 31 patients. All 31 patients showed normal valve motion and a normal EF slope. If meticulous technique was no...

journal_title：Annals of internal medicine

authors： Davia JE,Cheitlin MD,de Castro CM,Lawless O,Niemi L

更新日期：1975-10-01 00:00:00

abstract：PURPOSE:To synthesize new data on breast cancer screening for the U.S. Preventive Services Task Force. DATA SOURCES:MEDLINE; the Cochrane Controlled Trials Registry; and reference lists of reviews, editorials, and original studies. STUDY SELECTION:Eight randomized, controlled trials of mammography and 2 trials evalua...

journal_title：Annals of internal medicine

authors： Humphrey LL,Helfand M,Chan BK,Woolf SH

更新日期：2002-09-03 00:00:00

abstract：OBJECTIVE:To determine the toxicity and efficacy of low-dose interferon-alpha therapy in inducing remissions and prolonging survival in patients with chronic myeloid leukemia. DESIGN:Phase II evaluation and comparison with historical control patients and other series in which the investigators used higher interferon-a...

journal_title：Annals of internal medicine

authors： Schofield JR,Robinson WA,Murphy JR,Rovira DK

更新日期：1994-11-15 00:00:00

abstract：:Considerable evidence links elevated blood cholesterol levels to the development of atherosclerosis. The National Cholesterol Education Program (NCEP) has recently published revised guidelines for detecting and treating hypercholesterolemia in adults. Included in these guidelines is the recommendation that all adults ...

journal_title：Annals of internal medicine

authors： LaRosa JC

更新日期：1996-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether obesity preceded knee osteoarthritis and was thus a possible cause. DESIGN:Cohort study with weight and other important variables measured in 1948 to 1951 (mean age of subjects, 37 years) and knee arthritis evaluated in 1983 to 1985 (mean age of subjects, 73 years). SETTING:Popula...

journal_title：Annals of internal medicine

authors： Felson DT,Anderson JJ,Naimark A,Walker AM,Meenan RF

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Medical students may be at high risk for occupational exposures to blood. OBJECTIVE:To measure the frequency of medical students' exposure to infectious body substances, to identify factors that affect the probability of such exposure, and to suggest targets for the prevention of such exposure. DESIGN:Revi...

journal_title：Annals of internal medicine

authors： Osborn EH,Papadakis MA,Gerberding JL

更新日期：1999-01-05 00:00:00

abstract：:Neuroblastoma, the second commonest solid tumor in children, is a neoplasm of the peripheral autonomic nervous system that usually occurs before children are 6 years old. Therapy of localized tumor (clinical stage I and II) and of a special form of metastatic tumor (clinical stage IV-S) is usually successful, but trea...

journal_title：Annals of internal medicine

authors： Seeger RC,Siegel SE,Sidell N

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Hospitals are implementing discharge support programs to reduce readmissions, and these programs have had mixed success. OBJECTIVE:To examine whether a peridischarge, nurse-led intervention decreased emergency department (ED) visits or readmissions among ethnically and linguistically diverse older patients ...

journal_title：Annals of internal medicine

authors： Goldman LE,Sarkar U,Kessell E,Guzman D,Schneidermann M,Pierluissi E,Walter B,Vittinghoff E,Critchfield J,Kushel M

更新日期：2014-10-07 00:00:00

abstract：:Glomerular-fixed antibody was eluted from the kidney of a 17-year-old patient who died 2 weeks after the onset of acute poststreptococcal glomerulonephritis. Elevated titers of antibodies to streptococcal enzymes were found in the serum but not in the glomerular eluate. Streptococcal M protein and anti-M protein react...

journal_title：Annals of internal medicine

authors： Rodríguez-Iturbe B,Rabideau D,García R,Rubio L,McIntosh RM

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally. OBJECTIVE:To describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery. DESIGN:Single-health system, multihospital retrospective cohort study. SETTING...

journal_title：Annals of internal medicine

authors： Anesi GL,Jablonski J,Harhay MO,Atkins JH,Bajaj J,Baston C,Brennan PJ,Candeloro CL,Catalano LM,Cereda MF,Chandler JM,Christie JD,Collins T,Courtright KR,Fuchs BD,Gordon E,Greenwood JC,Gudowski S,Hanish A,Hanson Iii C

更新日期：2021-01-19 00:00:00

abstract：PURPOSE:To assess the data that support the use of coronary angiography and angioplasty after acute myocardial infarction, that identify the risks of these procedures, and that analyze their use and costs. DATA SOURCES:English-language articles published between 1970 and June 1995 identified through a search of the ME...

journal_title：Annals of internal medicine

authors： Bates DW,Miller E,Bernstein SJ,Hauptman PJ,Leape LL

更新日期：1997-04-01 00:00:00