The bioavailability of folic acid added to wine.

Abstract:

:Folate deficiency is a frequent cause of anemia in alcoholics, but little attention has been paid to its prevention. Folic acid was readily soluble in wines of high ethanol content at concentrations of 10 microgram/ml. Lactobacillus casei folate activity of folic acid added to wines was well maintained during a month's storage at room temperature and fell to 61% to 66% of original activity after 3 months. Pteroylglutamic acid, 10 microgram/ml, added to wines and given in doses of the beverages (4 ml/kg body weight that caused inebriation, was well absorbed by six normal human volunteers (mean maximal increment in serum folate concentration +/- SEM, 71 +/- 8 ng/ml) and by seven recently intoxicated chronic alcoholics (mean increment, 94 +/- 4 ng/ml). Folate deficiency in alcoholics could be prevented by the fortification of alcoholic beverages with the vitamin.

journal_name

Ann Intern Med

authors

Kaunitz JD,Lindenbaum J

doi

10.7326/0003-4819-87-5-542

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

542-5

issue

5

eissn

0003-4819

issn

1539-3704

journal_volume

87

pub_type

临床试验,杂志文章,随机对照试验
  • The lessons of SARS.

    abstract::Given the low mortality and morbidity of the severe acute respiratory syndrome (SARS) compared with other public health scourges, is the attention devoted to it misdirected? The SARS experience has provided at least 4 enduring lessons. First, by providing a test of the capacity of each part of the public health system...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-139-7-200310070-00011

    authors: Emanuel EJ

    更新日期:2003-10-07 00:00:00

  • Sites of conduction disease in aortic stenosis: significance of valve gradient and calcification.

    abstract::Electrophysiologic studies were done in 32 patients with aortic stenosis. In 24 patients with intact A-V conduction, A-H intervals ranged from 55 to 145 msec and were prolonged in two. Two had split His bundle potentials. The H-V intervals ranged from 25 to 94 msec and were prolonged in 12. The mean H-V interval was 6...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-87-3-275

    authors: Dhingra RC,Amat-y-Leon F,Pietras RJ,Wyndham C,Deedwania PC,Wu D,Denes P,Rosen KM

    更新日期:1977-09-01 00:00:00

  • The burden of health care costs for patients with dementia in the last 5 years of life.

    abstract:BACKGROUND:Common diseases, particularly dementia, have large social costs for the U.S. population. However, less is known about the end-of-life costs of specific diseases and the associated financial risk for individual households. OBJECTIVE:To examine social costs and financial risks faced by Medicare beneficiaries ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M15-0381

    authors: Kelley AS,McGarry K,Gorges R,Skinner JS

    更新日期:2015-11-17 00:00:00

  • Percutaneous transluminal angioplasty for renal artery stenosis in a solitary functioning kidney.

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    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-91-5-684

    authors: Weinberger MH,Yune HY,Grim CE,Luft FC,Klatte EC,Donohue JP

    更新日期:1979-11-01 00:00:00

  • Atypical antipsychotic drugs and the risk for acute kidney injury and other adverse outcomes in older adults: a population-based cohort study.

    abstract:BACKGROUND:Several adverse outcomes attributed to atypical antipsychotic drugs, specifically quetiapine, risperidone, and olanzapine, are known to cause acute kidney injury (AKI). Such outcomes include hypotension, acute urinary retention, and the neuroleptic malignant syndrome or rhabdomyolysis. OBJECTIVE:To investig...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M13-2796

    authors: Hwang YJ,Dixon SN,Reiss JP,Wald R,Parikh CR,Gandhi S,Shariff SZ,Pannu N,Nash DM,Rehman F,Garg AX

    更新日期:2014-08-19 00:00:00

  • Radiation-Induced Breast Cancer Incidence and Mortality From Digital Mammography Screening: A Modeling Study.

    abstract:BACKGROUND:Estimates of risk for radiation-induced breast cancer from mammography screening have not considered variation in dose exposure or diagnostic work-up after abnormal screening results. OBJECTIVE:To estimate distributions of radiation-induced breast cancer incidence and mortality from digital mammography scre...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M15-1241

    authors: Miglioretti DL,Lange J,van den Broek JJ,Lee CI,van Ravesteyn NT,Ritley D,Kerlikowske K,Fenton JJ,Melnikow J,de Koning HJ,Hubbard RA

    更新日期:2016-02-16 00:00:00

  • Sideroblastic anemia as a preleukemic event in patients treated for Hodgkin's disease.

    abstract::Sideroblastic anemia after treatment for Hogdkin's disease was seen in two patients 3 years after completion of radiation therapy and chemotherapy. This was followed in both by the development of myelomonoblastic leukemia. No evidence of recurrent Hodgkin's disease was present in either patient. Our observation sugges...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-92-5-625

    authors: Kitahara M,Cosgriff TM,Eyre HJ

    更新日期:1980-05-01 00:00:00

  • Splenic atrophy in systemic lupus erythematosus.

    abstract::Five of 70 patients with systemic lupus erythematosus seen over a 5-year period had peripheral blood films suggestive of hyposplenism. Technetium-99m-sulfur colloid scans showed no splenic activity in three patients. One of these three patients, who had a spontaneous remission of persistent thrombocytopenia concurrent...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-96-1-40

    authors: Dillon AM,Stein HB,English RA

    更新日期:1982-01-01 00:00:00

  • Adiposity, fat distribution, and cardiovascular risk.

    abstract:STUDY OBJECTIVE:To determine the relative importance of adiposity and fat distribution to cardiovascular risk profile. DESIGN:A cross-sectional study. SETTING:Clinical research center funded by the National Institutes of Health. PATIENTS:Convenience sample of 33 healthy premenopausal women with a wide range of body ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-110-11-867

    authors: Peiris AN,Sothmann MS,Hoffmann RG,Hennes MI,Wilson CR,Gustafson AB,Kissebah AH

    更新日期:1989-06-01 00:00:00

  • Public expectations and attitudes for annual physical examinations and testing.

    abstract:BACKGROUND:Recent guidelines for adult prevention do not recommend a comprehensive annual physical examination, but current public expectations in light of this change are unknown. OBJECTIVE:To determine public belief in the need for and content of an annual physical examination and to examine the effect of financial ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-136-9-200205070-00007

    authors: Oboler SK,Prochazka AV,Gonzales R,Xu S,Anderson RJ

    更新日期:2002-05-07 00:00:00

  • Community-based urine screening for Chlamydia trachomatis with a ligase chain reaction assay.

    abstract:BACKGROUND:Urine tests for Chlamydia trachomatis permit expansion of screening beyond traditional clinic environments. Prevention of infection in teenagers is a high priority. OBJECTIVE:To define the prevalence of C. trachomatis among teenagers by using the ligase chain reaction assay on urine specimens and to evaluat...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-127-9-199711010-00004

    authors: Marrazzo JM,White CL,Krekeler B,Celum CL,Lafferty WE,Stamm WE,Handsfield HH

    更新日期:1997-11-01 00:00:00

  • Peripheral nerves regenerated in familial amyloid polyneuropathy after liver transplantation.

    abstract:BACKGROUND:Liver transplantation holds promise as a treatment for familial amyloid polyneuropathy. OBJECTIVE:To determine whether peripheral nerves regenerate in patients with familial amyloid polyneuropathy after liver transplantation. DESIGN:Case report. SETTING:University hospital in Matsumoto, Japan. PATIENT:A ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-127-8_part_1-199710150-00006

    authors: Ikeda S,Takei Y,Yanagisawa N,Matsunami H,Hashikura Y,Ikegami T,Kawasaki S

    更新日期:1997-10-15 00:00:00

  • Systematic review: comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritis.

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    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-148-2-200801150-00192

    authors: Donahue KE,Gartlehner G,Jonas DE,Lux LJ,Thieda P,Jonas BL,Hansen RA,Morgan LC,Lohr KN

    更新日期:2008-01-15 00:00:00

  • Comparing costs and quality of care at retail clinics with that of other medical settings for 3 common illnesses.

    abstract:BACKGROUND:Retail clinics are an increasingly popular source for medical care. Concerns have been raised about the effect of these clinics on the cost, quality, and delivery of preventive care. OBJECTIVE:To compare the care received at retail clinics for 3 acute conditions with that received at other care settings. D...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-151-5-200909010-00006

    authors: Mehrotra A,Liu H,Adams JL,Wang MC,Lave JR,Thygeson NM,Solberg LI,McGlynn EA

    更新日期:2009-09-01 00:00:00

  • Self-assessment of tuberculin skin test reactions by New York City firefighters: reliability and cost-effectiveness in an occupational health care setting.

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    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-125-4-199608150-00004

    authors: Prezant DJ,Kelly KJ,Karwa ML,Kavanagh K

    更新日期:1996-08-15 00:00:00

  • Inhaled or intravenous pentamidine therapy for Pneumocystis carinii pneumonia in AIDS. A randomized trial.

    abstract:OBJECTIVE:To compare inhaled pentamidine with intravenous pentamidine for the treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome (AIDS). DESIGN:A randomized trial. SETTING:Community teaching hospital and hospital-based outpatient treatment center. PATIENTS:Twenty-one homosexual men...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-113-3-195

    authors: Soo Hoo GW,Mohsenifar Z,Meyer RD

    更新日期:1990-08-01 00:00:00

  • Prospective study of color duplex ultrasonography compared with contrast venography in patients suspected of having deep venous thrombosis of the upper extremities.

    abstract:BACKGROUND:The optimal strategy for diagnosis of deep venous thrombosis (DVT) is less well established for the upper extremities than for the lower extremities. Duplex color ultrasonography can be difficult to perform in the upper extremities because of their anatomy, and contrast venography is often indicated. Moreove...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-136-12-200206180-00007

    authors: Baarslag HJ,van Beek EJ,Koopman MM,Reekers JA

    更新日期:2002-06-18 00:00:00

  • Successful treatment of gram-negative bacillary meningitis with moxalactam.

    abstract::Meningitis caused by enteric gram-negative bacilli is relatively uncommon but is very difficult to treat despite susceptibility in vitro to many antimicrobics. A major problem appears to be poor entry of many drugs into the central nervous system. Moxalactam is an investigational cephalosporin that attains concentrati...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-95-3-302

    authors: Olson DA,Hoeprich PD,Nolan SM,Goldstein E

    更新日期:1981-09-01 00:00:00

  • Behavioral counseling research and evidence-based practice recommendations: U.S. Preventive Services Task Force perspectives.

    abstract::The U.S. Preventive Services Task Force (USPSTF) makes recommendations on which preventive services to routinely incorporate into primary care for specific populations. Behavioral counseling interventions are preventive services designed to help persons engage in healthy behaviors and limit unhealthy ones. The USPSTF'...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M13-2128

    authors: Curry SJ,Grossman DC,Whitlock EP,Cantu A

    更新日期:2014-03-18 00:00:00

  • Solid-phase radioimmunoassay for immunoglobulin G Staphylococcus aureus antibody in serious staphylococcal infection.

    abstract::Clinical features of 99 patients with staphylococcal infection were reviewed, and sera were tested by solid-phase radioimmunoassay and gel diffusion for staphylococcal antibodies to ascertain whether these variables predict the extent of infection and the need for prolonged therapy. Clinical features, including the pr...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-89-4-467

    authors: Wheat LJ,Kohler RB,White A

    更新日期:1978-10-01 00:00:00

  • Tracheal occlusion pressure: a simple index to monitor respiratory muscle fatigue during acute respiratory failure in patients with chronic obstructive pulmonary disease.

    abstract:STUDY OBJECTIVE:To assess respiratory muscle fatigue in acute respiratory failure in patients with chronic obstructive pulmonary disease and evaluate its influence on weaning patients from mechanical ventilation. DESIGN AND PATIENTS:We studied the time course of tracheal occlusion pressure (P0.1) and high-to-low ratio...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-108-6-800

    authors: Murciano D,Boczkowski J,Lecocguic Y,Emili JM,Pariente R,Aubier M

    更新日期:1988-06-01 00:00:00

  • Redesigning residency education in internal medicine: a position paper from the Association of Program Directors in Internal Medicine.

    abstract::There has been considerable change in the practice of internal medicine in the past quarter century, including the rise of specialization, increasing time pressure, the hospitalist movement, and the rapidly changing responsibilities of internists in inpatient and outpatient settings. Training programs have not adequat...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-144-12-200606200-00010

    authors: Association of Program Directors in Internal Medicine.,Fitzgibbons JP,Bordley DR,Berkowitz LR,Miller BW,Henderson MC

    更新日期:2006-06-20 00:00:00

  • A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis.

    abstract:BACKGROUND:Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT). OBJECTIVE:To determine whether a negative result on a quantitative latex D dimer assay eliminates the need for further investigation in patients with...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.7326/0003-4819-138-10-200305200-00006

    authors: Bates SM,Kearon C,Crowther M,Linkins L,O'Donnell M,Douketis J,Lee AY,Weitz JI,Johnston M,Ginsberg JS

    更新日期:2003-05-20 00:00:00

  • Characteristics of High Cardiovascular Risk in 1.7 Million Chinese Adults.

    abstract:Background:As cardiovascular risk increases in China, interest in strategies to mitigate it is growing. However, national information about the prevalence and treatment of high cardiovascular disease (CVD) risk is limited. Objective:To assess the prevalence and treatment of high CVD risk as well as variations in risk ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.7326/M18-1932

    authors: Lu J,Lu Y,Yang H,Bilige W,Li Y,Schulz W,Masoudi FA,Krumholz HM

    更新日期:2019-03-05 00:00:00

  • Thyrotoxic bone disease in women: a potentially reversible disorder.

    abstract:OBJECTIVE:To measure changes in spinal and femoral neck bone mineral densities in patients treated for Graves thyrotoxicosis. DESIGN:Cohort study. SETTING:Tertiary care center. PATIENTS:Fifteen women with active Graves thyrotoxicosis. Six patients were premenopausal and nine were postmenopausal. All patients had evi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-120-1-199401010-00002

    authors: Diamond T,Vine J,Smart R,Butler P

    更新日期:1994-01-01 00:00:00

  • Acute severe aortic regurgitation. Pathophysiology, clinical recognition, and management.

    abstract::Acute severe aortic regurgitation is a relatively unfamiliar, though life-threatening, disease. We review its diverse causes, anatomic faults, and hemodynamic sequelae and set the stage for an understanding of the clinical manifestations in light of their physiologic mechanisms. Clinical information includes the natur...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-87-2-223

    authors: Morganroth J,Perloff JK,Zeldis SM,Dunkman WB

    更新日期:1977-08-01 00:00:00

  • The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: a meta-analysis.

    abstract:BACKGROUND:Dietary protein has long been thought to play a role in the progression of chronic renal disease, but clinical trials to date have not consistently shown that dietary protein restriction is beneficial. PURPOSE:To use meta-analysis to assess the efficacy of dietary protein restriction in previously published...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-124-7-199604010-00002

    authors: Pedrini MT,Levey AS,Lau J,Chalmers TC,Wang PH

    更新日期:1996-04-01 00:00:00

  • Motor Vehicle Crash Fatalities in States With Primary Versus Secondary Seat Belt Laws: A Time-Series Analysis.

    abstract:BACKGROUND:Motor vehicle crashes (MVCs) remain a leading cause of injury-related deaths in the United States. Primary seat belt laws allow vehicle occupants to be ticketed solely for not wearing seat belts, and secondary laws allow ticketing only for failure to wear seat belts in the setting of other violations. OBJEC...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M14-2368

    authors: Lee LK,Monuteaux MC,Burghardt LC,Fleegler EW,Nigrovic LE,Meehan WP,Schutzman SA,Mannix R

    更新日期:2015-08-04 00:00:00

  • Causes of death in homeless adults in Boston.

    abstract:BACKGROUND:Homeless persons have high mortality rates. OBJECTIVE:To ascertain causes of death in a group of homeless persons. DESIGN:Cohort study. PATIENTS:17,292 adults seen by the Boston Health Care for the Homeless Program from 1988 to 1993. MEASUREMENTS:Cause-specific mortality rates adjusted for race and rate ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-126-8-199704150-00007

    authors: Hwang SW,Orav EJ,O'Connell JJ,Lebow JM,Brennan TA

    更新日期:1997-04-15 00:00:00

  • Hypercalcemia in active pulmonary tuberculosis.

    abstract::We ascertained the incidence of hypercalcemia in 79 consecutive patients with active pulmonary tuberculosis and a control group of 79 patients with chronic obstructive pulmonary disease. Twenty-two patients developed hypercalcemia (serum calcium greater than 10.5 mg/dl) within 4 to 16 weeks after initiation of chemoth...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-3-324

    authors: Abbasi AA,Chemplavil JK,Farah S,Muller BF,Arnstein AR

    更新日期:1979-03-01 00:00:00