Peripheral nerves regenerated in familial amyloid polyneuropathy after liver transplantation.

Abstract:

BACKGROUND:Liver transplantation holds promise as a treatment for familial amyloid polyneuropathy. OBJECTIVE:To determine whether peripheral nerves regenerate in patients with familial amyloid polyneuropathy after liver transplantation. DESIGN:Case report. SETTING:University hospital in Matsumoto, Japan. PATIENT:A 34 year-old-women with familial amyloid polyneuropathy who had liver transplantation and showed marked clinical improvement 3 years after surgery. MEASUREMENTS:Histopathologic examination and morphometric analysis of biopsy specimens taken from sural nerves. RESULTS:Diffuse fiber loss and amyloid deposits were seen in a biopsy specimen of the left sural nerve obtained before liver transplantation (total number of myelinated fibers, 1326/mm2 of the endoneurial area). In the biopsy specimen of the right sural nerve, which was obtained 3 years after transplantation, amyloid deposits remained but the number of myelinated fibers was markedly increased (total number of myelinated fibers, 4740/mm2). CONCLUSION:Peripheral nerves regenerated in a patient with familial amyloid polyneuropathy after liver transplantation.

journal_name

Ann Intern Med

authors

Ikeda S,Takei Y,Yanagisawa N,Matsunami H,Hashikura Y,Ikegami T,Kawasaki S

doi

10.7326/0003-4819-127-8_part_1-199710150-00006

subject

Has Abstract

pub_date

1997-10-15 00:00:00

pages

618-20

issue

8 Pt 1

eissn

0003-4819

issn

1539-3704

journal_volume

127

pub_type

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