NIH conference. Insulin-like growth factors in health and disease.

abstract：:The new knowledge of the regulation of cell growth and the genetic and biochemical changes that lead to malignancy have created many new opportunities for cancer drug discovery. These new targets include oncogenes, growth factors and their receptors, signal transduction pathways, and cell differentiation signals. Atte...

journal_title：Annals of internal medicine

authors： Chabner BA

更新日期：1993-04-15 00:00:00

abstract：Background:The presence of extracranial carotid disease (ECD) is associated with less favorable clinical outcomes in patients with acute ischemic stroke caused by intracranial proximal occlusion. Acute intra-arterial treatment (IAT) in the setting of extracranial and intracranial lesions is considered challenging, and ...

journal_title：Annals of internal medicine

authors： Berkhemer OA,Borst J,Kappelhof M,Yoo AJ,van den Berg LA,Fransen PSS,Beumer D,Schonewille WJ,Nederkoorn PJ,Wermer MJH,Marquering HA,Lingsma HF,Roos YBWEM,van Oostenbrugge RJ,Dippel DWJ,van Zwam WH,Majoie CBLM,Emmer BJ,

更新日期：2017-06-20 00:00:00

abstract：OBJECTIVE:To determine the toxicity and efficacy of low-dose interferon-alpha therapy in inducing remissions and prolonging survival in patients with chronic myeloid leukemia. DESIGN:Phase II evaluation and comparison with historical control patients and other series in which the investigators used higher interferon-a...

journal_title：Annals of internal medicine

authors： Schofield JR,Robinson WA,Murphy JR,Rovira DK

更新日期：1994-11-15 00:00:00

abstract：:We evaluated 10 patients with hidradenitis suppurative or acne conglobata who developed arthritis. In contrast to patients with acne fulminans and arthritis, all our subjects were adults over 22 years of age; nine were black; and four were women. Nine patients had episodic inflammatory oligoarthritis affecting mainly ...

journal_title：Annals of internal medicine

authors： Rosner IA,Richter DE,Huettner TL,Kuffner GH,Wisnieski JJ,Burg CG

更新日期：1982-10-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAAs) occur in 1 of 20 older men, remain asymptomatic for many years, and, if left untreated, cause death from rupture in about one third of patients. Ultrasonography is a suitable screening test for AAA, and elective repair can prevent rupture. Although these features suggest a promising t...

journal_title：Annals of internal medicine

authors： Lederle FA

更新日期：2003-09-16 00:00:00

abstract：:This article applies major economic concepts, such as supply, demand, monopoly, monopsony, adverse selection, and moral hazard, to central features of U.S. health care. These illustrations help explain some of the principal problems of health policy-high cost and the uninsured-and why solutions are difficult to obtain...

journal_title：Annals of internal medicine

authors： Fuchs VR

更新日期：2015-03-03 00:00:00

abstract：:Lung cancer is the commonest cause of death from cancer in both men and women, with approximately 152,000 new cases and 139,000 deaths in 1988. The incidence and mortality rates are increasing rapidly in women. Two main tests have been used to screen for lung cancer: chest roentgenography and sputum cytology. Four rec...

journal_title：Annals of internal medicine

authors： Eddy DM

更新日期：1989-08-01 00:00:00

abstract：OBJECTIVE:To develop criteria for interpreting results of the metyrapone test for the differential diagnosis of the adrenocorticotropin (ACTH)-dependent Cushing syndrome and to compare its diagnostic accuracy with that of the high-dose dexamethasone suppression test. DESIGN:Retrospective cohort study. SETTING:Inpatie...

journal_title：Annals of internal medicine

authors： Avgerinos PC,Yanovski JA,Oldfield EH,Nieman LK,Cutler GB Jr

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To reassess the natural history of polycythemia vera and to obtain reliable estimates of both incidence of thrombosis and survival for use in defining the sample size for therapeutic clinical trials. STUDY DESIGN:Retrospective cohort study of patients with polycythemia who had been followed for 20 years. SE...

journal_title：Annals of internal medicine

authors：

更新日期：1995-11-01 00:00:00

abstract：:Relapsing polychondritis, an uncommon, chronic, multisystem disorder characterized by recurrent episodes of inflammation of cartilaginous tissues, can be life-threatening, debilitating, and difficult to diagnose. This review is based on the authors' experience with 36 patients with relapsing polychondritis who were fo...

journal_title：Annals of internal medicine

authors： Trentham DE,Le CH

更新日期：1998-07-15 00:00:00

abstract：BACKGROUND:Despite convincing evidence that lowering blood pressure decreases cardiovascular morbidity and mortality, the hypertension burden remains high and control rates are poor in developing countries. OBJECTIVE:To assess the effectiveness of 2 community-based interventions on blood pressure in hypertensive adult...

journal_title：Annals of internal medicine

authors： Jafar TH,Hatcher J,Poulter N,Islam M,Hashmi S,Qadri Z,Bux R,Khan A,Jafary FH,Hameed A,Khan A,Badruddin SH,Chaturvedi N,Hypertension Research Group.

更新日期：2009-11-03 00:00:00

abstract：OBJECTIVE:To examine, from the perspective of primary care physicians, the value of mental status findings and ancillary tests in diagnosing dementia or its causes. DATA SOURCES:Studies identified using MEDLINE and bibliographies of pertinent articles. STUDY SELECTION:Selection based on availability of information on...

journal_title：Annals of internal medicine

authors： Siu AL

更新日期：1991-07-15 00:00:00

abstract：STUDY OBJECTIVE:To assess the efficacy and toxicity of cyclosporin A in patients with severe, treatment-refractory rheumatoid arthritis. DESIGN:Prospective randomized, double-blind 6-month trial. PATIENTS:Thirty-one patients who had classic seropositive rheumatoid arthritis with active synovitis unresponsive to conve...

journal_title：Annals of internal medicine

authors： Yocum DE,Klippel JH,Wilder RL,Gerber NL,Austin HA 3rd,Wahl SM,Lesko L,Minor JR,Preuss HG,Yarboro C

更新日期：1988-12-01 00:00:00

abstract：:A patient with a retained bullet developed lead poisoning in association with thyrotoxicosis. The clinical and laboratory data suggest that lead was mobilized from an increased mobile bone pool during the hypermetabolic period with resultant poisoning. The findings give factual support to earlier concepts that lead po...

journal_title：Annals of internal medicine

authors： Cagin CR,Diloy-Puray M,Westerman MP

更新日期：1978-10-01 00:00:00

abstract：Background:Frailty assessment may inform surgical risk and prognosis not captured by conventional surgical risk scores. Purpose:To evaluate the evidence for various frailty instruments used to predict mortality, functional status, or major adverse cardiovascular and cerebrovascular events (MACCEs) in older adults unde...

journal_title：Annals of internal medicine

authors： Kim DH,Kim CA,Placide S,Lipsitz LA,Marcantonio ER

更新日期：2016-11-01 00:00:00

abstract：:Studies of circulating T- and B-lymphocyte rosettes were done in 20 healthy controls and 29 patients with pulmonary tuberculosis, including 18 receiving rifampin chemotherapy. Eight of the 18 patients in the rifampin group (44%) had significant suppression of their T-cell rosettes as compared with patients with tuberc...

journal_title：Annals of internal medicine

authors： Gupta S,Grieco MH,Siegel I

更新日期：1975-04-01 00:00:00

abstract：:Medically unexplained functional or somatization symptoms are somatic disorders that are not adequately explained by physical disease processes. The way in which these disorders have been understood and managed has varied over the history of medicine. However, only in the past 100 years has the "mental" explanation pr...

journal_title：Annals of internal medicine

authors： Sharpe M,Carson A

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To assess safety, pharmacokinetics, and in-vivo virologic activity of five different combination regimens of zidovudine and didanosine compared with zidovudine alone in patients with human immunodeficiency virus type 1 (HIV-1) infection. DESIGN:Open-label, partially randomized, dose-ranging study. SETTING:U...

journal_title：Annals of internal medicine

authors： Collier AC,Coombs RW,Fischl MA,Skolnik PR,Northfelt D,Boutin P,Hooper CJ,Kaplan LD,Volberding PA,Davis LG,Henrard DR,Weller S,Corey L

更新日期：1993-10-15 00:00:00

abstract：OBJECTIVE:To describe how the results of bone densitometry affect women's decisions about measures to prevent fractures and to determine whether labeling women as having below-normal bone density has adverse effects. DESIGN:Mail survey of a random sample of women. SETTING:Four community hospitals in the San Francisco...

journal_title：Annals of internal medicine

authors： Rubin SM,Cummings SR

更新日期：1992-06-15 00:00:00

abstract：:Two patients presenting with nephrotic syndrome but without evidence of collagen vascular disease had organized glomerular immune deposits with a "fingerprint" pattern. This finding has been previously associated with lupus nephritis and, in our institution, has been seen in 6% of the biopsy specimens from patients wi...

journal_title：Annals of internal medicine

authors： Alpers CE,Hopper J Jr,Bernstein MJ,Biava CG

更新日期：1984-01-01 00:00:00

abstract：:Since 1970, forty-two patients with pulmonary hypertension due to chronic, thromboembolic obstruction of the major pulmonary arteries have had pulmonary thromboendarterectomy at the University of California, San Diego, and the San Diego Veterans Medical Centers. Duration of symptoms before admission averaged 4.4 years...

journal_title：Annals of internal medicine

authors： Moser KM,Daily PO,Peterson K,Dembitsky W,Vapnek JM,Shure D,Utley J,Archibald C

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Nurse care management programs for patients with chronic illness have been shown to be safe and effective. OBJECTIVE:To determine whether a telephone-mediated nurse care management program for heart failure reduced the rate of rehospitalization for heart failure and for all causes over a 1-year period. DES...

journal_title：Annals of internal medicine

authors： DeBusk RF,Miller NH,Parker KM,Bandura A,Kraemer HC,Cher DJ,West JA,Fowler MB,Greenwald G

更新日期：2004-10-19 00:00:00

abstract：STUDY OBJECTIVE:To determine the safety of withholding anticoagulant therapy in pregnant patients with clinically suspected deep-vein thrombosis who have negative results by serial impedance plethysmography. DESIGN:Prospective study evaluating prognosis by long-term follow-up to 3 months postpartum in all patients. S...

journal_title：Annals of internal medicine

authors： Hull RD,Raskob GE,Carter CJ

更新日期：1990-05-01 00:00:00

abstract：:Daily change of intravenous (i.v.) infusion administration sets has been recommended by the Center for Disease Control since 1973 to reduce the risk of infusion bacteremia. To evaluate this recommendation, we undertook a prospective, randomized, controlled trial that compared the rates of i.v.-associated bacteremia, i...

journal_title：Annals of internal medicine

authors： Buxton AE,Highsmith AK,Garner JS,West CM,Stamm WE,Dixon RE,McGowan JE Jr

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:Valid measurement of physician performance requires accurate identification of patients for whom a physician is responsible. Among all patients seen by a physician, some will be more strongly connected to their physician than others, but the effect of connectedness on measures of physician performance is not...

journal_title：Annals of internal medicine

authors： Atlas SJ,Grant RW,Ferris TG,Chang Y,Barry MJ

更新日期：2009-03-03 00:00:00

abstract：Background:Patients desire information about health care costs because they are increasingly responsible for these costs. Public Web sites that offer cost information could inform provider-patient discussions of costs at the point of care. Objective:To evaluate tools to facilitate the use of publicly available cost in...

journal_title：Annals of internal medicine

authors： Fox KS,Gray CE,Williamson ME,MacKenzie JA

更新日期：2019-05-07 00:00:00

abstract：:When cytotoxic agents were introduced, their ability to disrupt nucleic acid and protein synthesis led to their effective use for the treatment of neoplastic disease. During the course of this use, however, it became apparent that these agents also suppress the immune system. This usually unwelcome effect was subseque...

journal_title：Annals of internal medicine

authors： Langford CA,Klippel JH,Balow JE,James SP,Sneller MC

更新日期：1998-07-01 00:00:00

abstract：:Questionnaire II of the National Study of Internal Medicine Manpower was directed to all of the 1502 subspecialty training programs in the United States and Puerto Rico. The overall response rate was 86%. For the years 1972-1973 through 1976-1977 the number of fellows in subspecialty training grew at an average rate o...

journal_title：Annals of internal medicine

authors： Tarlov AR,Weil PA,Schleiter MK

更新日期：1979-08-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and toxicity of moricizine in treating patients with serious ventricular arrhythmias and inducible sustained ventricular tachycardia. DESIGN:Uncontrolled clinical trial. SETTING:The intensive care and telemetry units of Northwestern Memorial Hospital, St. Francis Hospital and Medical ...

journal_title：Annals of internal medicine

authors： Damle R,Levine J,Matos J,Greenberg S,Brooks R,Frumkin W,Goldberger J,Kadish AH

更新日期：1992-03-01 00:00:00

abstract：:A variety of forces are converging to reduce the number of internal medicine residency positions offered in this country. This reduction, referred to as downsizing, has been proposed as the solution to several of the problems facing internal medicine. We examine the forces that underlie the current enthusiasm for down...

journal_title：Annals of internal medicine

authors： Asch DA,Ende J

更新日期：1992-11-15 00:00:00