The downsizing of internal medicine residency programs.

abstract：BACKGROUND:Treatment of chronic hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) for 6 weeks achieves sustained virologic response (SVR) rates of 95% in some patients. If effective, shorter therapeutic courses could improve adherence and treatment costs. OBJECTIVE:To determine factors predictive ...

journal_title：Annals of internal medicine

authors： Kohli A,Kattakuzhy S,Sidharthan S,Nelson A,McLaughlin M,Seamon C,Wilson E,Meissner EG,Sims Z,Silk R,Gross C,Akoth E,Tang L,Price A,Jolley TA,Emmanuel B,Proschan M,Teferi G,Chavez J,Abbott S,Osinusi A,Mo H,Poli

更新日期：2015-12-15 00:00:00

abstract：:We compared the effects of quinidine and three alternate antiarrhythmic drugs on serum digoxin concentration in 63 patients before and during administration of quinidine, procainamide, disopyramide, or mexiletine. Quinidine increased digoxin concentration by at least 0.5 nmol/L in 21 of 22 patients: Mean serum digoxin...

journal_title：Annals of internal medicine

authors： Leahey EB Jr,Reiffel JA,Giardina EG,Bigger JT Jr

更新日期：1980-05-01 00:00:00

abstract：:Bioethics has become a common course of study in medical schools, other health professional schools, and graduate and undergraduate programs. An analysis of past ethical scandals, as well as the bioethics apparatus that emerged in response to them, is often central to the discussion of bioethical questions. This histo...

journal_title：Annals of internal medicine

authors： Lerner BH,Caplan AL

更新日期：2016-04-19 00:00:00

abstract：:Two patients with chronic liver disease developed elevated serum aluminum concentrations and biopsy-proven osteodystrophy. Neither patient had chronic renal failure but both had received aluminum-containing antacids for long periods. We measured biliary and urinary aluminum excretion during antacid loading in patients...

journal_title：Annals of internal medicine

authors： Williams JW,Vera SR,Peters TG,Luther RW,Bhattacharya S,Spears H,Graham A,Pitcock JA,Crawford AJ,Palmieri GM

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Bhutan implemented a national program for human papillomavirus (HPV) vaccination in 2010 involving girls aged 12 to 18 years and achieving nearly 90% coverage. OBJECTIVE:To estimate HPV vaccine effectiveness in a city in Bhutan. DESIGN:2 cross-sectional surveys, 2011-2012 and 2018. SETTING:2 hospitals in ...

journal_title：Annals of internal medicine

authors： Baussano I,Tshomo U,Tenet V,Heideman DAM,Wangden T,Franceschi S,Clifford GM

更新日期：2020-12-01 00:00:00

abstract：:Although many manifestations of giant cell arteries are increasingly recognized, little attention has been paid to respiratory symptoms associated with this disorder. We report the cases of 16 patients with giant cell arteritis who had prominent symptoms related to the respiratory tract including cough, sore throat, a...

journal_title：Annals of internal medicine

authors： Larson TS,Hall S,Hepper NG,Hunder GG

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit is questionable. OBJECTIVE:To determine whether LMWH increases ongoing pregnancy and live-birth rates in women with unexplained RPL. ...

journal_title：Annals of internal medicine

authors： Schleussner E,Kamin G,Seliger G,Rogenhofer N,Ebner S,Toth B,Schenk M,Henes M,Bohlmann MK,Fischer T,Brosteanu O,Bauersachs R,Petroff D,ETHIG II group.

更新日期：2015-05-05 00:00:00

abstract：:Glomerular-fixed antibody was eluted from the kidney of a 17-year-old patient who died 2 weeks after the onset of acute poststreptococcal glomerulonephritis. Elevated titers of antibodies to streptococcal enzymes were found in the serum but not in the glomerular eluate. Streptococcal M protein and anti-M protein react...

journal_title：Annals of internal medicine

authors： Rodríguez-Iturbe B,Rabideau D,García R,Rubio L,McIntosh RM

更新日期：1980-04-01 00:00:00

abstract：:Colony-stimulating factors are growth factors responsible for the proliferation and the maturation of bone marrow stem cells to fully differentiated granulocytes and monocytes. In addition to their effects on hematopoiesis, some colony-stimulating factors prime mature cells for enhanced chemotaxis, phagocytosis, and k...

journal_title：Annals of internal medicine

authors： Weisbart RH,Gasson JC,Golde DW

更新日期：1989-02-15 00:00:00

abstract：OBJECTIVE:To evaluate the risk for chronic renal disease associated with regular use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs). DESIGN:Multicenter case-control study. PATIENTS:Patients were 554 North Carolina residents (age range, 30 to 79 years) hospitalized between 1980 and 1982 with a discharge d...

journal_title：Annals of internal medicine

authors： Sandler DP,Burr FR,Weinberg CR

更新日期：1991-08-01 00:00:00

abstract：Background:Older adults with acute myocardial infarction (AMI) have higher prevalence of functional impairments, including deficits in cognition, strength, and sensory domains, than their younger counterparts. Objective:To develop and evaluate the prognostic utility of a risk model for 6-month post-AMI mortality in ol...

journal_title：Annals of internal medicine

authors： Dodson JA,Hajduk AM,Geda M,Krumholz HM,Murphy TE,Tsang S,Tinetti ME,Nanna MG,McNamara R,Gill TM,Chaudhry SI

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:U.S. HIV treatment guidelines recommend branded once-daily, 1-pill efavirenz-emtricitabine-tenofovir as first-line antiretroviral therapy (ART). With the anticipated approval of generic efavirenz in the United States, a once-daily, 3-pill alternative (generic efavirenz, generic lamivudine, and tenofovir) wil...

journal_title：Annals of internal medicine

authors： Walensky RP,Sax PE,Nakamura YM,Weinstein MC,Pei PP,Freedberg KA,Paltiel AD,Schackman BR

更新日期：2013-01-15 00:00:00

abstract：:Coronary artery spasm is an important pathogenetic mechanism in some forms of myocardial ischemic disease. Factors that may be important in the genesis of spasm include the autonomic nervous system, prostaglandins, endoperoxides, thromboxanes, and the calcium availability to the contractile apparatus. Spasm results in...

journal_title：Annals of internal medicine

authors： Luchi RJ,Chahine RA,Raizner AE

更新日期：1979-09-01 00:00:00

abstract：DESCRIPTION:Update of the 2009 U.S. Preventive Services Task Force (USPSTF) recommendation on counseling and interventions to prevent tobacco use and tobacco-related disease in adults, including pregnant women. METHODS:The USPSTF reviewed the evidence on interventions for tobacco smoking cessation that are relevant to...

journal_title：Annals of internal medicine

authors： Siu AL,U.S. Preventive Services Task Force.

更新日期：2015-10-20 00:00:00

abstract：Description:The purpose of this guidance statement is to guide clinicians on colorectal cancer screening in average-risk adults. Methods:This guidance statement is derived from a critical appraisal of guidelines on screening for colorectal cancer in average-risk adults and the evidence presented in these guidelines. N...

journal_title：Annals of internal medicine

authors： Qaseem A,Crandall CJ,Mustafa RA,Hicks LA,Wilt TJ,Clinical Guidelines Committee of the American College of Physicians.

更新日期：2019-11-05 00:00:00

abstract：:Polysaccharide vaccines against diseases caused by Neisseria meningitidis serogroups A and C meningococci are now licensed in the United States. They are prepared as monovalent and as bivalent antigens. This statement summarizes available information on these antigen and offers guidance regarding their role in the con...

journal_title：Annals of internal medicine

authors：

更新日期：1976-02-01 00:00:00

abstract：PURPOSE:To assess the data that support the use of coronary angiography and angioplasty after acute myocardial infarction, that identify the risks of these procedures, and that analyze their use and costs. DATA SOURCES:English-language articles published between 1970 and June 1995 identified through a search of the ME...

journal_title：Annals of internal medicine

authors： Bates DW,Miller E,Bernstein SJ,Hauptman PJ,Leape LL

更新日期：1997-04-01 00:00:00

abstract：:When cytotoxic agents were introduced, their ability to disrupt nucleic acid and protein synthesis led to their effective use for the treatment of neoplastic disease. During the course of this use, however, it became apparent that these agents also suppress the immune system. This usually unwelcome effect was subseque...

journal_title：Annals of internal medicine

authors： Langford CA,Klippel JH,Balow JE,James SP,Sneller MC

更新日期：1998-07-01 00:00:00

abstract：:To understand the factors that distinguish terminally ill, incompetent patients who are given do-not-resuscitate status by physicians against the wishes of the patient's family, I reviewed the charts of 20 such patients (cases) seen in consultation by the ethics committee at the Massachusetts General Hospital over 10 ...

journal_title：Annals of internal medicine

authors： Brennan TA

更新日期：1988-11-15 00:00:00

abstract：BACKGROUND:The optimal strategy for diagnosis of deep venous thrombosis (DVT) is less well established for the upper extremities than for the lower extremities. Duplex color ultrasonography can be difficult to perform in the upper extremities because of their anatomy, and contrast venography is often indicated. Moreove...

journal_title：Annals of internal medicine

authors： Baarslag HJ,van Beek EJ,Koopman MM,Reekers JA

更新日期：2002-06-18 00:00:00

abstract：:To increase the utility of administrative databases, it has been recommended that they include disease-specific, patient-centered outcome measures. This paper reviews practical and theoretical considerations and the critical evidence to support this recommendation. The strengths and weaknesses of the recommended appro...

journal_title：Annals of internal medicine

authors： Liang MH,Shadick N

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND:No effective oral therapy exists for early coronavirus disease 2019 (COVID-19). OBJECTIVE:To investigate whether hydroxychloroquine could reduce COVID-19 severity in adult outpatients. DESIGN:Randomized, double-blind, placebo-controlled trial conducted from 22 March through 20 May 2020. (ClinicalTrials.gov...

journal_title：Annals of internal medicine

authors： Skipper CP,Pastick KA,Engen NW,Bangdiwala AS,Abassi M,Lofgren SM,Williams DA,Okafor EC,Pullen MF,Nicol MR,Nascene AA,Hullsiek KH,Cheng MP,Luke D,Lother SA,MacKenzie LJ,Drobot G,Kelly LE,Schwartz IS,Zarychanski R,M

更新日期：2020-10-20 00:00:00

abstract：OBJECTIVE:To compare generalists' and cardiologists' estimates of baseline cardiovascular risk and the outcomes of preventive therapy. DESIGN:Cross-sectional mail survey using written case simulations of typical patients from primary prevention trials for hypercholesterolemia and isolated systolic hypertension, and te...

journal_title：Annals of internal medicine

authors： Friedmann PD,Brett AS,Mayo-Smith MF

更新日期：1996-02-15 00:00:00

abstract：:The scope of recent literature on the concept of "vulnerable plaque" was reviewed by examining 463 abstracts of primary and review articles identified through MEDLINE (2003 to April 2010). Proposed definition criteria of vulnerable plaque included active inflammation, a thin cap with a large lipid core, endothelial de...

journal_title：Annals of internal medicine

authors： Alsheikh-Ali AA,Kitsios GD,Balk EM,Lau J,Ip S

更新日期：2010-09-21 00:00:00

abstract：:A controlled clinical trial compared three-drug and four-drug combination chemotherapy in 109 patients with advanced small-cell anaplastic carcinoma of the lung. The combination of vincristine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), cyclophosphamide, and methotrexate was significantly superior to the com...

journal_title：Annals of internal medicine

authors： Hansen HH,Dombernowsky P,Hansen M,Hirsch F

更新日期：1978-08-01 00:00:00

abstract：:During the past decade, medical therapy for AIDS has become more effective but also prohibitively expensive. A medical tragedy has been transformed into a financial crisis, and society has responded by establishing special programs and sources of funding for AIDS. These maneuvers parallel earlier approaches to HIV tes...

journal_title：Annals of internal medicine

authors： Casarett DJ,Lantos JD

更新日期：1998-05-01 00:00:00

abstract：Background:A 2007 American College of Physicians guideline addressed pharmacologic options for low back pain. New evidence and medications have now become available. Purpose:To review the current evidence on systemic pharmacologic therapies for acute or chronic nonradicular or radicular low back pain. Data Sources:Ov...

journal_title：Annals of internal medicine

authors： Chou R,Deyo R,Friedly J,Skelly A,Weimer M,Fu R,Dana T,Kraegel P,Griffin J,Grusing S

更新日期：2017-04-04 00:00:00

abstract：:Care of persons with non-insulin-dependent diabetes mellitus (NIDDM) in the United Kingdom resembles that in the United States. However, health care practice in Europe is being influenced by the Saint Vincent Declaration, the joint European World Health Organization-International Diabetes Federation initiative, which ...

journal_title：Annals of internal medicine

authors： Keen H

更新日期：1996-01-01 00:00:00

abstract：:Discovery of the factor V Leiden and prothrombin G20210A mutations has greatly increased the percentage of patients in whom venous thrombosis can be attributed to hereditary thrombophilia. The first step in the diagnostic approach to all patients with venous thrombosis consists of a careful history and physical examin...

journal_title：Annals of internal medicine

authors： Bauer KA

更新日期：2001-09-04 00:00:00

abstract：:The coexistence of pregnancy and idiopathic hypertrophic subaortic stenosis is a potentially dangerous combination. We report a 23-year-old white woman with idiopathic hypertrophic subaortic stenosis and pregnancy who presented with severe symptoms (Class IV) and modest outflow obstruction associated with marked mitra...

journal_title：Annals of internal medicine

authors： Kolibash AJ,Ruiz DE,Lewis RP

更新日期：1975-06-01 00:00:00