Biliary excretion of aluminum in aluminum osteodystrophy with liver disease.

Abstract:

:Two patients with chronic liver disease developed elevated serum aluminum concentrations and biopsy-proven osteodystrophy. Neither patient had chronic renal failure but both had received aluminum-containing antacids for long periods. We measured biliary and urinary aluminum excretion during antacid loading in patients with normal liver function. Our studies show that biliary excretion is an important route of elimination of orally absorbed aluminum, and we suggest that long-term antacid therapy in patients with severe liver disease be monitored with periodic serum and urinary aluminum determinations to avoid aluminum osteodystrophy.

journal_name

Ann Intern Med

authors

Williams JW,Vera SR,Peters TG,Luther RW,Bhattacharya S,Spears H,Graham A,Pitcock JA,Crawford AJ,Palmieri GM

doi

10.7326/0003-4819-104-6-782

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

782-5

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

104

pub_type

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