Characterization of the glomerular antibody in acute poststreptococcal glomerulonephritis.

Abstract:

:Glomerular-fixed antibody was eluted from the kidney of a 17-year-old patient who died 2 weeks after the onset of acute poststreptococcal glomerulonephritis. Elevated titers of antibodies to streptococcal enzymes were found in the serum but not in the glomerular eluate. Streptococcal M protein and anti-M protein reactivity were not detected in the eluate. Immunoglobulin G was the only serum protein demonstrated in the eluate, and it was found to have anti-IgG activity highly concentrated with respect to the serum. These studies appear to indicate that anti-IgG is involved in the immune pathogenesis of acute poststreptococcal glomerulonephritis. Native IgG may be rendered autoimmunogenic by the streptococcus with subsequent antibody production to the neoautoimmunogen. Alernatively, anti-IgG may be produced to the IgG incorporated in an exogenous streptococcal antigen-antibody complex.

journal_name

Ann Intern Med

authors

Rodríguez-Iturbe B,Rabideau D,García R,Rubio L,McIntosh RM

doi

10.7326/0003-4819-92-4-478

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

478-81

issue

4

eissn

0003-4819

issn

1539-3704

journal_volume

92

pub_type

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